HitPredict

Interactor 1: LRP1 (Q07954)
Prolow-density lipoprotein receptor-related protein 1 (LRP-1) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD antigen CD91) [Cleaved into: Low-density lipoprotein receptor-related protein 1 85 kDa subunit (LRP-85); Low-density lipoprotein receptor-related protein 1 515 kDa subunit (LRP-515); Low-density lipoprotein receptor-related protein 1 intracellular domain (LRPICD)]
Gene: LRP1

Interactor 2: APOA5 (Q6Q788)
Apolipoprotein A-V (Apo-AV) (ApoA-V) (Apolipoprotein A5) (Regeneration-associated protein 3)
Gene: APOA5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17326667
Identification Methods	surface plasmon resonance
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome GO:0005794 - Golgi apparatus GO:0070325 - lipoprotein particle receptor binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 4544 Hs			1 366
+	Hs
		361480 LRP1_HUMAN (24-4544): 0: 3520: 100.00		APOE_HUMAN (77-352): 3.9e-10: 62.2: 17.02
+	Hs
		1163080 SORL_HUMAN (4091-4375): 6.29e-11: 71.4: 12.95		APOA5_HUMAN (1-366): 1.05e-107: 321: 100.00
+	Hs
		361474 VLDLR_HUMAN (27-282): 1.03e-11: 73.7: 18.49		APOE_HUMAN (77-352): 3.9e-10: 62.2: 17.02
+	Hs
		361508 SORL_HUMAN (4091-4375): 6.29e-11: 71.4: 12.95		APOE_HUMAN (77-352): 3.9e-10: 62.2: 17.02
+	Hs
		361475 LRP2_HUMAN (4062-4370): 5.25e-10: 68.7: 11.50		APOE_HUMAN (77-352): 3.9e-10: 62.2: 17.02
+	Hs
		351033 LDLR_HUMAN (4062-4338): 4.81e-10: 68.3: 11.95		APOE_HUMAN (77-352): 3.9e-10: 62.2: 17.02
+	Hs
		361485 LRP8_HUMAN (4104-4404): 8.77e-10: 67.6: 11.54		APOE_HUMAN (77-352): 3.9e-10: 62.2: 17.02