HitPredict

Interactor 1: SRSF1 (Q07955)
Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)
Gene: SRSF1

Interactor 2: RNPS1 (Q15287)
RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2)
Gene: RNPS1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.854

Property	Details
Experiments	37071682, 22365833, 17353931
Identification Methods	cross-linking study, two hybrid, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 1 others more... GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 305
+	Hs
		1028553 SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25		RNPS1_HUMAN (1-234): 2e-34: 128: 100.00
+	Hs
		1028634 SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25		PPIE_HUMAN (159-297): 4.41e-33: 125: 17.73
+	Hs
		853877 SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25		NCBP2_HUMAN (128-271): 1.08e-30: 114: 18.06
+	Hs
		1028873 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		PPIE_HUMAN (159-297): 4.41e-33: 125: 17.73
+	Hs
		1028922 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		RNPS1_HUMAN (1-234): 2e-34: 128: 100.00
+	Dm
		644443 SRR55_DROME (17-183): 2.57e-52: 175: 39.79		Q9VHC0_DROME (37-290): 2.67e-37: 138: 33.73
+	Hs
		1029160 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		PPIE_HUMAN (159-297): 4.41e-33: 125: 17.73
+	Hs
		516493 SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25		PABP1_HUMAN (65-252): 1.33e-21: 96.9: 16.32
+	Hs
		853878 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		NCBP2_HUMAN (128-271): 1.08e-30: 114: 18.06
+	Hs
		993721 SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66		RNPS1_HUMAN (1-234): 2e-34: 128: 100.00
+	Hs
		993869 SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66		PPIE_HUMAN (159-297): 4.41e-33: 125: 17.73
+	Hs
		993014 SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00		RBM8A_HUMAN (95-239): 7.02e-31: 115: 21.38
+	Hs
		474020 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		PAB4L_HUMAN (161-242): 1.56e-18: 86.5: 30.49
+	Hs
		516478 SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00		PABP1_HUMAN (65-252): 1.33e-21: 96.9: 16.32
+	Hs
		516425 PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67		NCBP2_HUMAN (128-271): 1.08e-30: 114: 18.06
+	Mm
		936481 SRSF1_MOUSE (1-235): 1.04e-49: 165: 100.00		TIAR_MOUSE (157-245): 8.06e-18: 85: 26.21
+	Hs
		516339 PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67		PABP1_HUMAN (65-252): 1.33e-21: 96.9: 16.32
+	Hs
		516495 PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67		PABP4_HUMAN (153-248): 4.98e-19: 89.2: 27.08
+	Hs
		516471 PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67		TIAR_HUMAN (155-250): 1.9e-18: 86.5: 27.08
+	Hs
		516689 PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67		PABP3_HUMAN (153-248): 4.53e-17: 83.4: 26.04