HitPredict

Interactor 1: SRSF1 (Q07955)
Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)
Gene: SRSF1

Interactor 2: SRS12 (Q8WXF0)
Serine/arginine-rich splicing factor 12 (35 kDa SR repressor protein) (SRrp35) (Splicing factor, arginine/serine-rich 13B) (Splicing factor, arginine/serine-rich 19)
Gene: SRSF12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000395 - mRNA 5'-splice site recognition GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 1 others more... GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 261
+	At
		1338059 SR30_ARATH (15-204): 1.71e-75: 231: 54.92		SL30A_ARATH (7-237): 1.67e-34: 126: 33.33
+	Hs
		1028634 SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25		PPIE_HUMAN (10-98): 7.46e-34: 126: 33.71
+	Hs
		266979 SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	At
		1093121 SR30_ARATH (15-204): 1.71e-75: 231: 54.92		SRC28_ARATH (7-170): 3.31e-24: 98.8: 32.32
+	At
		186869 SR34_ARATH (14-243): 1.02e-62: 200: 46.42		SL30A_ARATH (7-237): 1.67e-34: 126: 33.33
+	Hs
		1029020 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		SRS12_HUMAN (1-261): 8.09e-38: 135: 100.00
+	Hs
		1028873 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		PPIE_HUMAN (10-98): 7.46e-34: 126: 33.71
+	Hs
		266980 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	Hs
		1028881 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		RBMX2_HUMAN (12-261): 2.44e-31: 119: 18.00
+	Hs
		266981 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		SRS10_HUMAN (1-229): 6.35e-34: 125: 50.00
+	At
		1225836 SR30_ARATH (15-204): 1.71e-75: 231: 54.92		SRC30_ARATH (12-116): 2.12e-13: 70.1: 44.76
+	At
		186861 SR34_ARATH (14-243): 1.02e-62: 200: 46.42		SRC28_ARATH (7-170): 3.31e-24: 98.8: 32.32
+	Hs
		516493 SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25		PABP1_HUMAN (2-101): 3.98e-19: 88.3: 17.00
+	Hs
		951941 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		SRSF3_HUMAN (1-92): 1.68e-23: 95: 32.61
+	Hs
		963976 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		SRSF2_HUMAN (4-90): 1.12e-22: 94.6: 45.65
+	Hs
		951942 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		SRSF3_HUMAN (1-92): 1.68e-23: 95: 32.61
+	At
		186864 SR34_ARATH (14-243): 1.02e-62: 200: 46.42		SRC30_ARATH (12-116): 2.12e-13: 70.1: 44.76
+	Hs
		1028559 SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25		SRSF7_HUMAN (1-108): 2.53e-09: 58.2: 35.78
+	Hs
		1028673 SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48		SRSF7_HUMAN (1-108): 2.53e-09: 58.2: 35.78
+	Hs
		1028936 SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51		SRSF7_HUMAN (1-108): 2.53e-09: 58.2: 35.78