Protein: MOT4
Monocarboxylate transporter 4 (MCT 4) (Solute carrier family 16 member 3)

Gene: MOT4, SLC16A3
Organism: Homo sapiens
Interactions: 106
UniProt ID: O15427

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005886 - plasma membrane
GO:0008028 - monocarboxylic acid transmembrane transporter activity
GO:0015650 - lactate:proton symporter activity
GO:0015718 - monocarboxylic acid transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

190197

MUC18
Cell surface glycoprotein MUC18

1

8

High-throughput

0.618

High

190200

CXA8
Gap junction alpha-8 protein

2

5

High-throughput

0.606

High

190267

UBQL2
Ubiquilin-2

2

7

High-throughput

0.606

High

190271

UBQL1
Ubiquilin-1

2

7

High-throughput

0.606

High

190207

CDC42
Cell division control protein 42 homolog

2

20

High-throughput

0.595

High

190218

DLG1
Disks large homolog 1

2

4

High-throughput

0.585

High

190225

SCRIB
Protein scribble homolog

2

4

High-throughput

0.585

High

190213

HPCA
Neuron-specific calcium-binding protein hippocalcin

2

0

High-throughput

0.580

High

190216

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

3

High-throughput

0.571

High

190241

HDAC7
Histone deacetylase 7

2

5

High-throughput

0.553

High

190196

BASI
Basigin

2

18

High-throughput

0.552

High

190195

PEBP1
Phosphatidylethanolamine-binding protein 1

2

0

High-throughput

0.547

High

190219

PAK1
Serine/threonine-protein kinase PAK 1

2

0

High-throughput

0.547

High

190180

DIAP1
Protein diaphanous homolog 1

1

2

High-throughput

0.536

High

190237

S15A4
Solute carrier family 15 member 4

1

1

Small-scale

0.536

High

190251

TSNAX
Translin-associated protein X

1

0

High-throughput

0.513

High

126375

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

156707

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

178105

NPC1
NPC intracellular cholesterol transporter 1

1

3

High-throughput

0.479

High

190178

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

190184

RASH
GTPase HRas

1

18

High-throughput

0.479

High

190189

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

190192

CD44
CD44 antigen

1

3

Small-scale

0.479

High

190198

MAP1B
Microtubule-associated protein 1B

1

3

High-throughput

0.479

High

190204

RAB25
Ras-related protein Rab-25

1

8

High-throughput

0.479

High

190206

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

190208

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

190210

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

190211

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

190212

UBC9
SUMO-conjugating enzyme UBC9

1

2

Small-scale

0.479

High

190214

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

190227

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

2

High-throughput

0.479

High

190232

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

190243

HDAC2
Histone deacetylase 2

1

2

High-throughput

0.479

High

190246

CHM4C
Charged multivesicular body protein 4c

1

2

High-throughput

0.479

High

190248

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

3

Small-scale

0.479

High

190257

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

190261

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

190187

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

190190

FOLR1
Folate receptor alpha

1

0

High-throughput

0.458

High

190229

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

168590

CSKP
Peripheral plasma membrane protein CASK

1

5

High-throughput

0.445

High

190179

ATP9B
Probable phospholipid-transporting ATPase IIB

1

13

High-throughput

0.445

High

190181

DTNB
Dystrobrevin beta

1

4

High-throughput

0.445

High

190183

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

7

High-throughput

0.445

High

190186

DMD
Dystrophin

1

5

High-throughput

0.445

High

190188

CFTR
Cystic fibrosis transmembrane conductance regulator

1

7

High-throughput

0.445

High

190194

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

7

High-throughput

0.445

High

190199

UTRN
Utrophin

1

4

High-throughput

0.445

High

190201

KNTC1
Kinetochore-associated protein 1

1

1

High-throughput

0.445

High

190205

CD81
CD81 antigen

1

4

High-throughput

0.445

High

190215

AT2C1
Calcium-transporting ATPase type 2C member 1

1

11

High-throughput

0.445

High

190217

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

8

High-throughput

0.445

High

190221

SNTA1
Alpha-1-syntrophin

1

8

High-throughput

0.445

High

190222

SNTB2
Beta-2-syntrophin

1

8

High-throughput

0.445

High

190223

SNTB1
Beta-1-syntrophin

1

9

High-throughput

0.445

High

190224

DAG1
Dystroglycan 1

1

1

High-throughput

0.445

High

190226

ITPR2
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR2

1

3

High-throughput

0.445

High

190230

MPP7
MAGUK p55 subfamily member 7

1

4

High-throughput

0.445

High

190242

TM9S4
Transmembrane 9 superfamily member 4

1

6

High-throughput

0.445

High

190249

IPO9
Importin-9

1

8

High-throughput

0.445

High

190253

REEP2
Receptor expression-enhancing protein 2

1

3

High-throughput

0.445

High

190255

ZDHC5
Palmitoyltransferase ZDHHC5

1

5

High-throughput

0.445

High

190256

TTYH3
Protein tweety homolog 3

1

1

High-throughput

0.445

High

190259

PKHA5
Pleckstrin homology domain-containing family A member 5

1

5

High-throughput

0.445

High

190260

XPO5
Exportin-5

1

8

High-throughput

0.445

High

190269

VPS51
Vacuolar protein sorting-associated protein 51 homolog

1

3

High-throughput

0.445

High

190276

DTNA
Dystrobrevin alpha

1

4

High-throughput

0.445

High

190277

RN114
E3 ubiquitin-protein ligase RNF114

1

4

High-throughput

0.445

High

190182

TRI37
E3 ubiquitin-protein ligase TRIM37

1

4

High-throughput

0.437

High

190202

PLK1
Serine/threonine-protein kinase PLK1

1

1

High-throughput

0.437

High

190209

RB11A
Ras-related protein Rab-11A

1

6

High-throughput

0.437

High

190228

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.437

High

190244

FBXW7
F-box/WD repeat-containing protein 7

1

4

Small-scale

0.437

High

190266

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

190272

FBW1A
F-box/WD repeat-containing protein 1A

1

4

Small-scale

0.437

High

190274

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

190275

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.437

High

190220

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

0

High-throughput

0.426

High

190250

P2RX4
P2X purinoceptor 4

1

0

High-throughput

0.426

High

190265

CTNL1
Alpha-catulin

1

0

High-throughput

0.426

High

190273

EFR3B
Protein EFR3 homolog B

1

0

High-throughput

0.426

High

175455

AREL1
Apoptosis-resistant E3 ubiquitin protein ligase 1

1

4

High-throughput

0.407

High

190185

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

3

High-throughput

0.407

High

190203

SYJ2B
Synaptojanin-2-binding protein

1

8

High-throughput

0.407

High

190231

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.407

High

190234

ZDH17
Palmitoyltransferase ZDHHC17

1

8

High-throughput

0.407

High

190236

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.407

High

190239

NAV1
Neuron navigator 1

1

1

High-throughput

0.407

High

190240

COG1
Conserved oligomeric Golgi complex subunit 1

1

2

High-throughput

0.407

High

190252

METH
Methionine synthase

1

1

High-throughput

0.407

High

190254

RNF26
E3 ubiquitin-protein ligase RNF26

1

1

High-throughput

0.407

High

190258

REEP4
Receptor expression-enhancing protein 4

1

3

High-throughput

0.407

High

190263

TBA8
Tubulin alpha-8 chain

1

7

High-throughput

0.407

High

190268

IPO11
Importin-11

1

8

High-throughput

0.407

High

190233

NR2CA
Nuclear receptor 2C2-associated protein

1

0

High-throughput

0.299

High

190235

FAM9B
Protein FAM9B

1

0

High-throughput

0.299

High

190238

BANP
Protein BANP

1

0

High-throughput

0.299

High

190193

ELK1
ETS domain-containing protein Elk-1

2

0

High-throughput

0.298

High

190264

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.279

Low

190191

TIMP2
Metalloproteinase inhibitor 2

1

0

High-throughput

0.249

Low

143368

E2F3
Transcription factor E2F3

1

0

Small-scale

0.232

Low

190245

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

High-throughput

0.232

Low

190247

SAAL1
Protein SAAL1

1

0

High-throughput

0.232

Low

190262

F1142
Protein FAM114A2

1

0

High-throughput

0.232

Low

190270

TMCC3
Transmembrane and coiled-coil domain protein 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025