HitPredict

Interactor 1: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Interactor 2: RIPP1 (Q0D2K3)
Protein ripply1
Gene: RIPPLY1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.698

Property	Details
Experiments	32296183, 28514442, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, validated two hybrid, anti tag coimmunoprecipitation, two hybrid array, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 197 Hs			1 151
+	Hs
		980929 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		RIPP1_HUMAN (28-131): 2.28e-53: 167: 100.00
+	Hs
		980593 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		RIPP1_HUMAN (28-131): 2.28e-53: 167: 100.00
+	Hs
		980738 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		RIPP1_HUMAN (28-131): 2.28e-53: 167: 100.00
+	Hs
		980940 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		RIPP2_HUMAN (56-142): 1.12e-44: 144: 45.46
+	Hs
		980621 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		RIPP2_HUMAN (56-142): 1.12e-44: 144: 45.46
+	Hs
		980774 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		RIPP2_HUMAN (56-142): 1.12e-44: 144: 45.46
+	Hs
		1000245 Q5T3G3_HUMAN (2-197): 1.07e-99: 290: 61.43		RIPP1_HUMAN (28-131): 2.28e-53: 167: 100.00
+	Hs
		883098 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		DSCR6_HUMAN (57-136): 6.8e-33: 116: 36.47
+	Hs
		883095 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		DSCR6_HUMAN (57-136): 6.8e-33: 116: 36.47
+	Hs
		1000243 Q5JSZ1_HUMAN (2-192): 7.66e-95: 277: 63.11		RIPP1_HUMAN (28-131): 2.28e-53: 167: 100.00
+	Xl
		193804 TLE4_XENLA (2-191): 1.07e-101: 311: 69.27		BOWL_XENLA (54-137): 4.94e-39: 131: 41.67
+	Hs
		883097 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		DSCR6_HUMAN (57-136): 6.8e-33: 116: 36.47
+	Hs
		993463 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		RIPP2_HUMAN (56-142): 1.12e-44: 144: 45.46
+	Hs
		1132993 Q5T3G3_HUMAN (2-197): 1.07e-99: 290: 61.43		RIPP2_HUMAN (56-142): 1.12e-44: 144: 45.46
+	Hs
		1127609 Q5JSZ1_HUMAN (2-192): 7.66e-95: 277: 63.11		RIPP2_HUMAN (56-142): 1.12e-44: 144: 45.46
+	Hs
		980681 TLE2_HUMAN (2-149): 6.71e-80: 253: 71.62		RIPP1_HUMAN (28-131): 2.28e-53: 167: 100.00
+	Hs
		883099 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		DSCR6_HUMAN (57-136): 6.8e-33: 116: 36.47
+	Hs
		980695 TLE2_HUMAN (2-149): 6.71e-80: 253: 71.62		RIPP2_HUMAN (56-142): 1.12e-44: 144: 45.46
+	Hs
		883096 TLE2_HUMAN (2-149): 6.71e-80: 253: 71.62		DSCR6_HUMAN (57-136): 6.8e-33: 116: 36.47