HitPredict

Interactor 1: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Interactor 2: HES6 (Q96HZ4)
Transcription cofactor HES-6 (C-HAIRY1) (Class B basic helix-loop-helix protein 41) (bHLHb41) (Hairy and enhancer of split 6)
Gene: HES6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005667 - transcription regulator complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 197 Hs			1 224
+	Hs
		980948 TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59		HES6_HUMAN (1-224): 2.14e-63: 198: 100.00
+	Hs
		980638 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		HES6_HUMAN (1-224): 2.14e-63: 198: 100.00
+	Hs
		980840 TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50		HES6_HUMAN (1-224): 2.14e-63: 198: 100.00
+	Hs
		980604 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		HES1_HUMAN (2-220): 9.41e-53: 172: 25.44
+	Mm
		1143960 TLE1_MOUSE (2-197): 2.15e-101: 310: 63.00		HES6_MOUSE (1-224): 2.39e-60: 190: 85.71
+	Hs
		980671 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		HEY1_HUMAN (18-220): 3.7e-43: 149: 24.89
+	Hs
		980651 TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50		HES4_HUMAN (2-224): 2.93e-41: 141: 24.56
+	Hs
		980686 TLE2_HUMAN (2-149): 6.71e-80: 253: 71.62		HES1_HUMAN (2-220): 9.41e-53: 172: 25.44
+	Hs
		62468 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		HELT_HUMAN (16-208): 2.52e-37: 132: 26.64
+	Hs
		146485 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		BHE40_HUMAN (1-195): 1.09e-31: 121: 20.27
+	Hs
		421 TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00		A0A087WSW0_HUMAN (2-208): 2.71e-32: 121: 21.69
+	Dm
		558371 GROU_DROME (2-163): 3.54e-59: 198: 54.44		ESMC_DROME (11-224): 1.69e-46: 154: 25.79
+	Dm
		558377 GROU_DROME (2-163): 3.54e-59: 198: 54.44		DPN_DROME (18-219): 2.63e-43: 152: 28.57
+	Dm
		558369 GROU_DROME (2-163): 3.54e-59: 198: 54.44		ESM3_DROME (18-224): 2.62e-43: 147: 22.32
+	Dm
		558370 GROU_DROME (2-163): 3.54e-59: 198: 54.44		ESMB_DROME (18-224): 6.6e-41: 140: 20.72
+	Dm
		525718 GROU_DROME (2-163): 3.54e-59: 198: 54.44		ESM7_DROME (18-149): 1.41e-40: 139: 30.37
+	Dm
		558372 GROU_DROME (2-163): 3.54e-59: 198: 54.44		ESMD_DROME (11-149): 5.7e-36: 126: 28.08
+	Dm
		534341 GROU_DROME (2-163): 3.54e-59: 198: 54.44		HAIR_DROME (23-204): 1.45e-33: 124: 26.90
+	Dm
		525705 GROU_DROME (2-163): 3.54e-59: 198: 54.44		ESM5_DROME (9-224): 9.82e-35: 123: 18.64
+	Dm
		525743 GROU_DROME (2-163): 3.54e-59: 198: 54.44		ESM8_DROME (19-174): 7.31e-35: 123: 22.02