HitPredict

Interactor 1: SRSF4 (Q08170)
Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Gene: SRSF4

Interactor 2: ZCRB1 (Q8TBF4)
Zinc finger CCHC-type and RNA-binding motif-containing protein 1 (U11/U12 small nuclear ribonucleoprotein 31 kDa protein) (U11/U12 snRNP 31 kDa protein) (U11/U12-31K)
Gene: ZCRB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0008380 - RNA splicing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 494 Hs			1 217
+	Hs
		1029010 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		ZCRB1_HUMAN (1-217): 1.57e-56: 180: 100.00
+	Hs
		1028744 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		ZCRB1_HUMAN (1-217): 1.57e-56: 180: 100.00
+	Hs
		992875 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		PABP5_HUMAN (1-179): 2.36e-39: 140: 15.54
+	Hs
		474020 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		PAB4L_HUMAN (3-177): 2.05e-39: 140: 20.11
+	Hs
		1028593 SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53		PABP5_HUMAN (1-179): 2.36e-39: 140: 15.54
+	Hs
		992790 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		SRSF7_HUMAN (9-120): 7.54e-35: 125: 32.17
+	Hs
		1028936 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		SRSF7_HUMAN (9-120): 7.54e-35: 125: 32.17
+	Hs
		1028559 SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53		SRSF7_HUMAN (9-120): 7.54e-35: 125: 32.17
+	At
		187124 SR30_ARATH (4-253): 1.45e-54: 185: 36.33		RZ1B_ARATH (9-129): 1.94e-31: 117: 23.26
+	Hs
		993726 SRSF4_HUMAN (1-468): 4.56e-48: 174: 100.00		SRSF7_HUMAN (9-120): 7.54e-35: 125: 32.17
+	Hs
		1028673 SRSF5_HUMAN (3-256): 1.26e-49: 172: 53.85		SRSF7_HUMAN (9-120): 7.54e-35: 125: 32.17
+	Hs
		516478 SRSF1_HUMAN (3-166): 2.36e-57: 192: 41.42		PABP1_HUMAN (11-99): 1.42e-22: 96.9: 19.10
+	Sc
		376750 NOP4_YEAST (1-492): 1.19e-52: 190: 11.82		PABP_YEAST (11-208): 3.81e-23: 98.5: 15.60
+	Mm
		936481 SRSF1_MOUSE (3-166): 2.36e-57: 192: 41.42		TIAR_MOUSE (3-142): 2.86e-18: 83.9: 14.89
+	Hs
		516493 SRSF9_HUMAN (3-216): 2.36e-52: 178: 36.53		PABP1_HUMAN (11-99): 1.42e-22: 96.9: 19.10
+	Mm
		857340 SRSF1_MOUSE (3-166): 2.36e-57: 192: 41.42		TIA1_MOUSE (3-125): 7.02e-18: 82.7: 17.89
+	Mm
		857324 Q542V3_MOUSE (1-468): 2.02e-54: 191: 80.38		TIA1_MOUSE (3-125): 7.02e-18: 82.7: 17.89
+	Cn
		111495 J9VJ75_CRYNH (3-179): 9.05e-43: 161: 30.85		J9VUR9_CRYNH (11-145): 5.87e-25: 103: 14.82
+	Mm
		1208011 SRSF9_MOUSE (3-216): 4.58e-52: 177: 36.53		RBM4_MOUSE (11-103): 3.6e-19: 86.2: 22.58
+	Hs
		1028926 SRSF6_HUMAN (1-180): 4.52e-52: 181: 78.50		SF3B4_HUMAN (101-215): 5.02e-12: 66.1: 9.84