Protein: ZN446
Zinc finger protein 446 (Zinc finger protein with KRAB and SCAN domains 20)

Gene: ZN446, ZNF446
Organism: Homo sapiens
Interactions: 108
UniProt ID: Q9NWS9

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0005615 - extracellular space
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

600384

ZNF24
Zinc finger protein 24

11

20

High-throughput

0.979

High

1338610

ZN397
Zinc finger protein 397

11

20

High-throughput

0.979

High

1395534

PGBD1
PiggyBac transposable element-derived protein 1

7

20

High-throughput

0.972

High

1451381

ZN232
Zinc finger protein 232

7

19

High-throughput

0.971

High

193868

ZSC9
Zinc finger and SCAN domain-containing protein 9

8

20

High-throughput

0.970

High

1398882

ZN396
Zinc finger protein 396

7

20

High-throughput

0.962

High

1451376

ZSC32
Zinc finger and SCAN domain-containing protein 32

6

20

High-throughput

0.955

High

892426

ZN165
Zinc finger protein 165

6

20

High-throughput

0.941

High

1380361

ZKSC4
Zinc finger protein with KRAB and SCAN domains 4

5

19

High-throughput

0.933

High

1434436

ZSC16
Zinc finger and SCAN domain-containing protein 16

5

20

High-throughput

0.932

High

1451383

ZSC21
Zinc finger and SCAN domain-containing protein 21

5

19

High-throughput

0.930

High

600050

ZNF18
Zinc finger protein 18

5

19

High-throughput

0.924

High

1394385

ZN496
Zinc finger protein 496

4

20

High-throughput

0.911

High

517605

ZSC22
Zinc finger and SCAN domain-containing protein 22

4

20

High-throughput

0.901

High

171933

ZN263
Zinc finger protein 263

3

20

High-throughput

0.875

High

1353492

ZN483
Zinc finger protein 483

3

20

High-throughput

0.863

High

1291997

ZSC30
Zinc finger and SCAN domain-containing protein 30

3

20

High-throughput

0.861

High

1451375

ZN446
Zinc finger protein 446

3

20

High-throughput

0.861

High

1322361

ZN444
Zinc finger protein 444

3

20

High-throughput

0.861

High

1187285

ZSC23
Zinc finger and SCAN domain-containing protein 23

3

20

High-throughput

0.858

High

1434815

ZN576
Zinc finger protein 576

2

20

High-throughput

0.811

High

944218

SCND1
SCAN domain-containing protein 1

2

20

High-throughput

0.783

High

1311312

ZSC29
Zinc finger and SCAN domain-containing protein 29

2

20

High-throughput

0.783

High

1348728

ZSC18
Zinc finger and SCAN domain-containing protein 18

2

19

High-throughput

0.783

High

600446

ZKSC1
Zinc finger protein with KRAB and SCAN domains 1

2

18

High-throughput

0.776

High

1451378

ZN215
Zinc finger protein 215

2

19

High-throughput

0.776

High

1240377

Q6P088
ZNF483 protein

2

20

High-throughput

0.770

High

213431

ZSC12
Zinc finger and SCAN domain-containing protein 12

2

18

High-throughput

0.769

High

1451377

ZKSC7
Zinc finger protein with KRAB and SCAN domains 7

1

20

High-throughput

0.740

High

1109403

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

4

1

High-throughput

0.698

High

1152389

ZN174
Zinc finger protein 174

1

20

High-throughput

0.691

High

1153673

ZKSC8
Zinc finger protein with KRAB and SCAN domains 8

1

20

High-throughput

0.691

High

1451379

SUFU
Suppressor of fused homolog

3

3

High-throughput

0.667

High

1257259

RFPLB
Ret finger protein-like 4B

3

19

High-throughput

0.667

High

1200629

Q53Z40
HCG1 protein

1

20

High-throughput

0.665

High

890687

RGS3
Regulator of G-protein signaling 3

2

5

High-throughput

0.628

High

1181441

P3H1
Prolyl 3-hydroxylase 1

2

5

High-throughput

0.628

High

1230286

K1C40
Keratin, type I cytoskeletal 40

3

10

High-throughput

0.616

High

297036

CCNK
Cyclin-K

2

1

High-throughput

0.606

High

300514

KRT34
Keratin, type I cuticular Ha4

2

10

High-throughput

0.606

High

1049025

REL
Proto-oncogene c-Rel

2

2

High-throughput

0.606

High

1081496

INCA1
Protein INCA1

2

1

High-throughput

0.606

High

1146190

K1H1
Keratin, type I cuticular Ha1

2

10

High-throughput

0.606

High

1146286

ANKR1
Ankyrin repeat domain-containing protein 1

2

7

High-throughput

0.606

High

1290992

TAXB1
Tax1-binding protein 1

2

8

High-throughput

0.606

High

1348542

LNX1
E3 ubiquitin-protein ligase LNX

2

10

High-throughput

0.606

High

1367987

KRT35
Keratin, type I cuticular Ha5

2

10

High-throughput

0.606

High

1382641

MGN2
Protein mago nashi homolog 2

2

2

High-throughput

0.606

High

1396311

EHMT2
Histone-lysine N-methyltransferase EHMT2

2

7

High-throughput

0.606

High

1407114

MDFI
MyoD family inhibitor

2

2

High-throughput

0.606

High

722816

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

2

0

High-throughput

0.602

High

1122360

SCRIB
Protein scribble homolog

3

7

High-throughput

0.587

High

186275

SIVA
Apoptosis regulatory protein Siva

2

0

High-throughput

0.580

High

249013

EVI5
Ecotropic viral integration site 5 protein homolog

2

0

High-throughput

0.580

High

958720

CSN2
COP9 signalosome complex subunit 2

2

0

High-throughput

0.580

High

1277428

NT2NA
Notch homolog 2 N-terminal-like protein A

2

19

High-throughput

0.578

High

1157962

DDB1
DNA damage-binding protein 1

1

4

High-throughput

0.575

High

1413732

DPH7
Diphthine methyltransferase

2

6

High-throughput

0.574

High

572243

TRI27
Zinc finger protein RFP

1

19

High-throughput

0.573

High

1411339

LZTS2
Leucine zipper putative tumor suppressor 2

2

12

High-throughput

0.571

High

1050552

UBE3A
Ubiquitin-protein ligase E3A

1

1

High-throughput

0.560

High

65176

GG6L9
Golgin subfamily A member 6-like protein 9

2

11

High-throughput

0.553

High

70510

CRTP1
Cysteine-rich tail protein 1

2

3

High-throughput

0.553

High

220311

FRS3
Fibroblast growth factor receptor substrate 3

2

1

High-throughput

0.553

High

1059753

KRA11
Keratin-associated protein 1-1

2

20

High-throughput

0.553

High

1307465

KRA13
Keratin-associated protein 1-3

2

20

High-throughput

0.553

High

1415243

KIFC3
Kinesin-like protein KIFC3

2

5

High-throughput

0.553

High

1419486

FRMD8
FERM domain-containing protein 8

2

2

High-throughput

0.553

High

1439673

XAGE1
X antigen family member 1

2

1

High-throughput

0.549

High

1216163

FHL5
Four and a half LIM domains protein 5

1

11

High-throughput

0.541

High

1417711

DGC6L
Protein DGCR6L

1

2

High-throughput

0.541

High

1047759

NOTC2
Neurogenic locus notch homolog protein 2

1

20

High-throughput

0.536

High

1232845

SMYD5
Protein-lysine N-trimethyltransferase SMYD5

1

1

High-throughput

0.536

High

1370550

FGF13
Fibroblast growth factor 13

1

9

High-throughput

0.536

High

1386603

OPTN
Optineurin

1

11

High-throughput

0.515

High

773794

ACTN2
Alpha-actinin-2

1

2

High-throughput

0.494

High

567098

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

2

High-throughput

0.489

High

1398137

CC140
Coiled-coil domain-containing protein 140

1

2

High-throughput

0.489

High

1448366

PICK1
PRKCA-binding protein

1

5

High-throughput

0.489

High

993776

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.481

High

1120883

DGCR6
Protein DGCR6

1

2

High-throughput

0.481

High

1401413

CIC
Protein capicua homolog

1

11

High-throughput

0.479

High

517124

NT2NC
Notch homolog 2 N-terminal-like protein C

1

19

High-throughput

0.470

High

1270732

Q7KZS0
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.470

High

415894

HSPB1
Heat shock protein beta-1

1

5

High-throughput

0.445

High

679270

DNJB1
DnaJ homolog subfamily B member 1

1

6

High-throughput

0.445

High

718025

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

2

High-throughput

0.445

High

727991

DNJA1
DnaJ homolog subfamily A member 1

1

7

High-throughput

0.445

High

1340823

COP1
E3 ubiquitin-protein ligase COP1

1

7

High-throughput

0.445

High

1371549

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

6

High-throughput

0.445

High

1389915

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

2

High-throughput

0.445

High

1428252

TGIF2
Homeobox protein TGIF2

1

10

High-throughput

0.445

High

1451380

CHIP
E3 ubiquitin-protein ligase CHIP

1

5

High-throughput

0.445

High

1451384

MAGD1
Melanoma-associated antigen D1

1

3

High-throughput

0.445

High

644

NBPFJ
NBPF family member NBPF19

1

5

High-throughput

0.439

High

950020

KR103
Keratin-associated protein 10-3

1

20

High-throughput

0.439

High

1428858

NIF3L
NIF3-like protein 1

1

0

High-throughput

0.438

High

408176

TBB4A
Tubulin beta-4A chain

1

0

High-throughput

0.426

High

840811

RS27
Small ribosomal subunit protein eS27

1

0

High-throughput

0.426

High

1451386

X5DP20
DiGeorge syndrome critical region 6 isoform D

1

2

High-throughput

0.417

High

175234

SC16A
Protein transport protein Sec16A

1

2

High-throughput

0.407

High

189290

IPO8
Importin-8

1

20

High-throughput

0.407

High

347369

BAG2
BAG family molecular chaperone regulator 2

1

6

High-throughput

0.407

High

1090569

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.407

High

1451382

SL9A8
Sodium/hydrogen exchanger 8

1

7

High-throughput

0.407

High

1419139

KRA31
Keratin-associated protein 3-1

2

0

High-throughput

0.316

High

1451385

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025