HitPredict

Interactor 1: DDR1 (Q08345)
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
Gene: DDR1

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	22057045
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001558 - regulation of cell growth GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 913 Hs			1 903
+	Dr
		1109027 FGR1A_DANRE (540-905): 1.71e-108: 355: 31.17		Q3KRP0_DANRE (1-900): 0: 736: 31.91
+	Hs
		522850 SRC_HUMAN (361-912): 1.28e-125: 391: 23.60		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		125077 NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27		WWP2_HUMAN (1-903): 0: 816: 54.08
+	Hs
		609205 FGFR3_HUMAN (551-905): 1.32e-110: 360: 32.16		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		601478 FGFR2_HUMAN (583-905): 4.2e-109: 357: 34.05		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		507904 FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		433282 YES_HUMAN (563-907): 1.25e-105: 339: 31.59		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		385368 NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27		NED4L_HUMAN (5-900): 0: 762: 32.14
+	Hs
		384459 NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Hs
		435577 IGF1R_HUMAN (600-908): 4.51e-51: 197: 37.22		NEDD4_HUMAN (90-900): 0: 673: 34.16
+	Zm
		39207 C4JA17_MAIZE (534-907): 7.92e-117: 365: 20.83		A0A1D6MU59_MAIZE (378-901): 1.09e-151: 497: 32.90
+	Hs
		385087 NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27		HUWE1_HUMAN (415-902): 1.81e-160: 523: 34.88
+	Hs
		601595 FGFR2_HUMAN (583-905): 4.2e-109: 357: 34.05		SMUF1_HUMAN (1-535): 1.85e-47: 183: 14.71
+	Mm
		601625 FGFR2_MOUSE (583-905): 4.28e-109: 357: 34.05		SMUF1_MOUSE (1-535): 3.62e-41: 164: 14.07