HitPredict

Interactor 1: F5GZI3 (F5GZI3)
Par-3 family cell polarity regulator
Gene: PARD3

Interactor 2: PAR6B (Q9BYG5)
Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B)
Gene: PARD6B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	26496610
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PDZ~PDZ
Common GO terms	GO:0005938 - cell cortex GO:0016324 - apical plasma membrane GO:0045197 - establishment or maintenance of epithelial cell apical/basal polarity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 747 Hs			1 372
+	Mm
		1307919 PARD3_MOUSE (1-747): 5.39e-122: 398: 86.71		PAR6B_MOUSE (1-372): 2.86e-154: 440: 91.40
+	Hs
		1256880 PARD3_HUMAN (1-747): 1.15e-121: 397: 95.16		PAR6B_HUMAN (1-372): 2.86e-151: 433: 100.00
+	Hs
		1256879 PARD3_HUMAN (1-747): 1.15e-121: 397: 95.16		PAR6G_HUMAN (1-372): 3.55e-126: 369: 54.73
+	Hs
		99493 F5GZI3_HUMAN (1-747): 1.63e-141: 435: 100.00		PAR6A_HUMAN (1-325): 8.79e-92: 280: 53.37
+	Mm
		1307922 PARD3_MOUSE (1-747): 5.39e-122: 398: 86.71		PAR6A_MOUSE (1-330): 1.1e-95: 290: 52.07
+	Hs
		1256901 PARD3_HUMAN (1-747): 1.15e-121: 397: 95.16		PAR6A_HUMAN (1-325): 8.79e-92: 280: 53.37
+	Hs
		159246 PAR3L_HUMAN (1-739): 9.13e-82: 285: 39.23		CSKP_HUMAN (71-307): 1.87e-55: 197: 19.61
+	Hs
		1050013 PARD3_HUMAN (1-747): 1.15e-121: 397: 95.16		SCRIB_HUMAN (51-247): 8.59e-11: 65.8: 21.83
+	Dm
		332617 X2JFU8_DROME (300-401): 1.23e-20: 99.8: 50.00		O97111_DROME (7-297): 1.98e-90: 277: 53.74
+	Hs
		159200 DLG1_HUMAN (3-518): 8.97e-42: 166: 14.83		CSKP_HUMAN (71-307): 1.87e-55: 197: 19.61
+	Rn
		1144009 DLG1_RAT (3-518): 1.43e-38: 156: 15.09		CSKP_RAT (71-307): 2.75e-55: 196: 19.75
+	Ce
		105560 DLG1_CAEEL (92-697): 5.44e-43: 170: 18.88		Q17549_CAEEL (74-298): 2.84e-38: 147: 16.74
+	Hs
		1021489 DLG1_HUMAN (3-518): 8.97e-42: 166: 14.83		MPP2_HUMAN (55-305): 5.17e-36: 139: 14.74
+	Rn
		292499 DLG1_RAT (3-518): 1.43e-38: 156: 15.09		MPP3_RAT (72-358): 1.07e-37: 144: 17.35
+	Hs
		159190 DLG4_HUMAN (3-101): 5.48e-21: 100: 22.22		CSKP_HUMAN (71-307): 1.87e-55: 197: 19.61
+	Hs
		280053 MPDZ_HUMAN (3-86): 1.24e-23: 109: 19.05		PALS1_HUMAN (82-306): 1.58e-34: 136: 20.17
+	Mm
		1143555 DLG4_MOUSE (3-101): 4.89e-21: 100: 22.22		MPP2_MOUSE (55-305): 1.3e-35: 138: 14.74
+	Hs
		942325 DLG4_HUMAN (3-101): 5.48e-21: 100: 22.22		EM55_HUMAN (107-305): 4.78e-33: 130: 19.40
+	Hs
		91344 DLG1_HUMAN (3-518): 8.97e-42: 166: 14.83		E5RI47_HUMAN (86-237): 1.4e-10: 61.8: 18.42
+	Hs
		1050009 LNX1_HUMAN (146-428): 3.8e-23: 107: 18.52		SCRIB_HUMAN (51-247): 8.59e-11: 65.8: 21.83