HitPredict

Interactor 1: RBBP4 (Q09028)
Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)
Gene: RBBP4

Interactor 2: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.878

Property	Details
Experiments	25795299, 34026424, 17079684, 23238014
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	CPSF_A~WD40, MMS1_N~WD40
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032991 - protein-containing complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 425 Hs			1 1140
+	Hs
		1082202 RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Hs
		1082263 WDR5B_HUMAN (92-417): 1.53e-68: 222: 18.54		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Hs
		1082374 TBL1R_HUMAN (109-424): 2.86e-60: 205: 16.52		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Hs
		245605 TBL1X_HUMAN (207-424): 3.72e-35: 138: 17.63		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Hs
		903254 WDR5_HUMAN (267-425): 7.48e-35: 133: 25.61		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Hs
		1082355 GRWD1_HUMAN (263-425): 3.54e-26: 111: 23.56		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	At
		187019 MSI4_ARATH (5-415): 2.7e-81: 260: 31.11		DDB1A_ARATH (2-1140): 0: 1255: 52.09
+	At
		187004 MSI4_ARATH (5-415): 2.7e-81: 260: 31.11		DDB1B_ARATH (3-1140): 0: 1248: 50.92
+	At
		1340748 HTD1_ARATH (175-405): 5.18e-39: 147: 20.41		DDB1A_ARATH (2-1140): 0: 1255: 52.09
+	At
		186944 MSI1_ARATH (2-210): 3.43e-31: 125: 13.22		DDB1A_ARATH (2-1140): 0: 1255: 52.09
+	Hs
		267761 TAF5L_HUMAN (26-422): 3e-74: 244: 22.20		SF3B3_HUMAN (3-1126): 0: 1102: 21.33
+	At
		186951 MSI3_ARATH (273-422): 2.13e-18: 88.7: 20.25		DDB1A_ARATH (2-1140): 0: 1255: 52.09
+	At
		186950 MSI3_ARATH (273-422): 2.13e-18: 88.7: 20.25		DDB1B_ARATH (3-1140): 0: 1248: 50.92
+	Hs
		1073127 GRWD1_HUMAN (263-425): 3.54e-26: 111: 23.56		SF3B3_HUMAN (3-1126): 0: 1102: 21.33
+	Hs
		1073168 NLE1_HUMAN (8-106): 1.77e-21: 98.3: 10.58		SF3B3_HUMAN (3-1126): 0: 1102: 21.33
+	Ce
		219829 LIN53_CAEEL (272-421): 6.33e-22: 99.1: 21.52		O44985_CAEEL (3-1126): 0: 1035: 19.76
+	Hs
		1014128 TAF5_HUMAN (153-417): 2.83e-46: 172: 15.23		CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87
+	Hs
		1014208 NLE1_HUMAN (8-106): 1.77e-21: 98.3: 10.58		CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87
+	Ce
		954081 LIN53_CAEEL (272-421): 6.33e-22: 99.1: 21.52		CPSF1_CAEEL (3-565): 2.56e-112: 384: 22.27