Protein: VPS72
Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1)

Gene: VPS72
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q15906

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000786 - nucleosome
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1155337

RUVB2
RuvB-like 2

7

5

Small-scale

0.960

High

1155338

RUVB1
RuvB-like 1

6

5

Small-scale

0.949

High

501999

H2AZ
Histone H2A.Z

4

6

Small-scale

0.892

High

1155314

H2B1A
Histone H2B type 1-A

4

6

High-throughput

0.892

High

980793

H2B1C
Histone H2B type 1-C/E/F/G/I

3

7

High-throughput

0.827

High

355222

ACL6A
Actin-like protein 6A

2

2

Small-scale

0.759

High

1155312

KAT5
Histone acetyltransferase KAT5

7

1

Small-scale

0.746

High

1155316

EP400
E1A-binding protein p400

2

4

Small-scale

0.737

High

1155335

MO4L1
Mortality factor 4-like protein 1

6

1

Small-scale

0.727

High

1155332

MRGBP
MRG/MORF4L-binding protein

6

1

Small-scale

0.727

High

340332

YETS4
YEATS domain-containing protein 4

5

1

Small-scale

0.716

High

1136777

MO4L2
Mortality factor 4-like protein 2

5

1

Small-scale

0.709

High

1155331

DMAP1
DNA methyltransferase 1-associated protein 1

5

4

Small-scale

0.706

High

952847

ACTB
Actin, cytoplasmic 1

1

2

High-throughput

0.691

High

1155292

H2B2E
Histone H2B type 2-E

1

7

High-throughput

0.691

High

1155303

H2B3B
Histone H2B type 3-B

1

7

High-throughput

0.691

High

211645

ZNHI1
Zinc finger HIT domain-containing protein 1

4

1

Small-scale

0.683

High

372129

MYC
Myc proto-oncogene protein

4

2

High-throughput

0.676

High

553747

MYCL
Protein L-Myc

3

2

Small-scale

0.667

High

1155296

FOXR1
Forkhead box protein R1

3

2

High-throughput

0.667

High

1155297

FOXR2
Forkhead box protein R2

3

2

High-throughput

0.667

High

1155313

H2B1H
Histone H2B type 1-H

1

7

High-throughput

0.665

High

1155340

TRRAP
Transformation/transcription domain-associated protein

4

0

Small-scale

0.661

High

1155328

EAF6
Chromatin modification-related protein MEAF6

4

0

Small-scale

0.658

High

1155326

BRD8
Bromodomain-containing protein 8

3

2

Small-scale

0.650

High

1155327

EPC1
Enhancer of polycomb homolog 1

3

1

Small-scale

0.650

High

1155339

CARD8
Caspase recruitment domain-containing protein 8

3

0

High-throughput

0.638

High

848781

MAGAA
Melanoma-associated antigen 10

3

0

High-throughput

0.622

High

1155320

MDFI
MyoD family inhibitor

2

0

High-throughput

0.618

High

256867

H2B1K
Histone H2B type 1-K

1

7

High-throughput

0.618

High

959587

MAX
Protein max

2

2

Small-scale

0.611

High

1155307

NF2IP
NFATC2-interacting protein

2

0

High-throughput

0.602

High

1155293

EPC2
Enhancer of polycomb homolog 2

2

1

Small-scale

0.601

High

1155333

ING3
Inhibitor of growth protein 3

2

1

Small-scale

0.601

High

1032995

EWS
RNA-binding protein EWS

2

0

High-throughput

0.588

High

1119552

NFYC
Nuclear transcription factor Y subunit gamma

1

0

High-throughput

0.586

High

1053294

MBTD1
MBT domain-containing protein 1

2

0

Small-scale

0.585

High

269211

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

911254

IMA5
Importin subunit alpha-5

2

0

High-throughput

0.576

High

1155298

SRCAP
Helicase SRCAP

1

4

Small-scale

0.575

High

1155323

ARP6
Actin-related protein 6

1

5

Small-scale

0.575

High

396194

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

1155295

HMBX1
Homeobox-containing protein 1

1

0

High-throughput

0.549

High

625410

CSK22
Casein kinase II subunit alpha'

1

1

High-throughput

0.536

High

997738

CSK21
Casein kinase II subunit alpha

1

1

High-throughput

0.536

High

1155310

ING5
Inhibitor of growth protein 5

1

1

High-throughput

0.536

High

1155294

TET2
Methylcytosine dioxygenase TET2

1

0

High-throughput

0.529

High

943769

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

0

High-throughput

0.518

High

1095649

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.518

High

1154364

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.518

High

1154515

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.518

High

487358

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.513

High

601694

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.513

High

682493

S100P
Protein S100-P

1

0

High-throughput

0.513

High

1022680

ZXDB
Zinc finger X-linked protein ZXDB

1

0

High-throughput

0.513

High

1099685

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1155300

JAZF1
Juxtaposed with another zinc finger protein 1

1

0

High-throughput

0.513

High

1155306

IN80E
INO80 complex subunit E

1

0

High-throughput

0.513

High

1155321

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.508

High

339758

KLF8
Krueppel-like factor 8

1

5

High-throughput

0.479

High

474016

NFIC
Nuclear factor 1 C-type

1

1

High-throughput

0.479

High

738986

ELF1
ETS-related transcription factor Elf-1

1

6

High-throughput

0.479

High

832528

ETV3
ETS translocation variant 3

1

6

High-throughput

0.479

High

833954

HNF4A
Hepatocyte nuclear factor 4-alpha

1

2

High-throughput

0.479

High

837048

ELK3
ETS domain-containing protein Elk-3

1

6

High-throughput

0.479

High

862171

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.479

High

877517

LHX1
LIM/homeobox protein Lhx1

1

1

High-throughput

0.479

High

890327

NU153
Nuclear pore complex protein Nup153

1

1

High-throughput

0.479

High

895720

LHX2
LIM/homeobox protein Lhx2

1

1

High-throughput

0.479

High

944660

KLF3
Krueppel-like factor 3

1

5

High-throughput

0.479

High

1008552

ELF3
ETS-related transcription factor Elf-3

1

6

High-throughput

0.479

High

1067380

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

1133430

NFIX
Nuclear factor 1 X-type

1

1

High-throughput

0.479

High

1152693

ELF2
ETS-related transcription factor Elf-2

1

5

High-throughput

0.479

High

1155308

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.479

High

1155311

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

1155317

FEV
Protein FEV

1

5

High-throughput

0.479

High

1155318

ELF4
ETS-related transcription factor Elf-4

1

6

High-throughput

0.479

High

1155319

KLF6
Krueppel-like factor 6

1

5

High-throughput

0.479

High

1155322

KLF16
Krueppel-like factor 16

1

4

High-throughput

0.479

High

1155325

WWTR1
WW domain-containing transcription regulator protein 1

1

1

High-throughput

0.479

High

1155336

KLF15
Krueppel-like factor 15

1

5

High-throughput

0.479

High

1155341

KLF12
Krueppel-like factor 12

1

5

High-throughput

0.479

High

143442

E2F3
Transcription factor E2F3

1

0

Small-scale

0.458

High

180830

TIF1A
Transcription intermediary factor 1-alpha

1

0

High-throughput

0.458

High

190926

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

413916

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

675519

TYY1
Transcriptional repressor protein YY1

1

0

High-throughput

0.458

High

776073

SOX5
Transcription factor SOX-5

1

0

High-throughput

0.458

High

886900

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

Small-scale

0.458

High

979725

H4
Histone H4

1

0

High-throughput

0.458

High

994234

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

0

Small-scale

0.458

High

1037798

IRF8
Interferon regulatory factor 8

1

0

High-throughput

0.458

High

1097311

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

1155301

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1155305

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1155315

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.458

High

1155324

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

1155334

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1056750

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.438

High

1155302

FAM9B
Protein FAM9B

1

0

High-throughput

0.426

High

1144762

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

3

0

High-throughput

0.347

High

1155329

PLAC1
Placenta-specific protein 1

3

0

High-throughput

0.347

High

1155299

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

3

0

High-throughput

0.345

High

1155304

MIA40
Mitochondrial intermembrane space import and assembly protein 40

2

0

High-throughput

0.313

High

347052

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

1155309

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.279

Low

105997

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

1155330

RAB18
Ras-related protein Rab-18

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025