HitPredict

Interactor 1: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Interactor 2: H2A2B (Q8IUE6)
Histone H2A type 2-B (H2A-clustered histone 21)
Gene: H2AC21

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.778

Property	Details
Experiments	11691934, 11689448
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HAT_KAT11~Histone
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2414 Hs			1 130
+	Hs
		391671 EP300_HUMAN (1-2414): 0: 1113: 100.00		H2A1B_HUMAN (1-130): 1e-67: 202: 93.85
+	Hs
		998781 EP300_HUMAN (1-2414): 0: 1113: 100.00		H2A2C_HUMAN (1-127): 3.2e-67: 200: 96.06
+	Hs
		555430 EP300_HUMAN (1-2414): 0: 1113: 100.00		H2AX_HUMAN (1-123): 4.57e-66: 198: 95.94
+	Mm
		70932 EP300_MOUSE (1-2414): 0: 1090: 93.01		H2A3_MOUSE (1-130): 6.67e-68: 202: 94.62
+	Hs
		391923 BAZ1A_HUMAN (889-1176): 3.58e-51: 202: 21.31		H2A1B_HUMAN (1-130): 1e-67: 202: 93.85
+	Hs
		555661 BAZ1A_HUMAN (889-1176): 3.58e-51: 202: 21.31		H2AX_HUMAN (1-123): 4.57e-66: 198: 95.94
+	At
		286875 GCN5_ARATH (1000-1159): 2.86e-39: 158: 27.98		H2A3_ARATH (1-129): 1.17e-64: 194: 75.39
+	Hs
		631492 BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20		H2A2B_HUMAN (1-130): 2.22e-71: 211: 100.00
+	Hs
		1067038 BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48		H2A2B_HUMAN (1-130): 2.22e-71: 211: 100.00
+	Hs
		391554 BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20		H2A1B_HUMAN (1-130): 1e-67: 202: 93.85
+	Hs
		1067005 BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48		H2A2A_HUMAN (1-130): 5.07e-68: 202: 94.62
+	Hs
		1066979 BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48		H2A2C_HUMAN (1-127): 3.2e-67: 200: 96.06
+	Hs
		555299 BRD2_HUMAN (1035-1159): 9.57e-30: 131: 31.20		H2AX_HUMAN (1-123): 4.57e-66: 198: 95.94
+	Hs
		555470 BRD3_HUMAN (1055-1159): 9.06e-30: 130: 30.48		H2AX_HUMAN (1-123): 4.57e-66: 198: 95.94
+	Sp
		391996 YK82_SCHPO (990-1155): 2.19e-28: 126: 20.48		H2A1_SCHPO (1-121): 7.16e-54: 167: 83.74
+	Hs
		555434 BPTF_HUMAN (2011-2413): 1.11e-14: 82.9: 12.86		H2AX_HUMAN (1-123): 4.57e-66: 198: 95.94
+	Hs
		554260 MUC1_HUMAN (1949-2412): 4.52e-13: 77.5: 9.23		H2AX_HUMAN (1-123): 4.57e-66: 198: 95.94
+	Hs
		555463 MDC1_HUMAN (455-1061): 8.69e-13: 76.6: 11.82		H2AX_HUMAN (1-123): 4.57e-66: 198: 95.94
+	Hs
		1087066 PHIP_HUMAN (1068-1157): 6.78e-12: 73.6: 42.86		H2A2C_HUMAN (1-127): 3.2e-67: 200: 96.06
+	Sc
		392549 GCN5_YEAST (1074-1156): 2.55e-12: 73.6: 38.55		H2A2_YEAST (16-121): 8.79e-53: 164: 83.96