HitPredict

Interactor 1: SYGP1 (F6SEU4)
Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)
Gene: Syngap1

Interactor 2: NMDE4 (Q03391)
Glutamate receptor ionotropic, NMDA 2D (GluN2D) (Glutamate [NMDA] receptor subunit epsilon-4) (N-methyl D-aspartate receptor subtype 2D) (NMDAR2D) (NR2D)
Gene: Grin2d

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	27507650, 28706196, 28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0045202 - synapse GO:0098978 - glutamatergic synapse
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1340 Mm			1 1323
+	Mm
		99963 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		NMDE2_MOUSE (7-942): 0: 759: 50.32
+	Mm
		99919 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		NMDE1_MOUSE (11-906): 0: 739: 54.61
+	Mm
		99913 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		GRIA1_MOUSE (28-938): 0: 689: 19.12
+	Mm
		100110 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		GRIA3_MOUSE (37-886): 0: 673: 18.76
+	Mm
		99914 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		GRIA2_MOUSE (46-886): 0: 662: 18.36
+	Mm
		99920 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		NMDZ1_MOUSE (16-924): 0: 635: 22.70
+	Mm
		57143 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		A2AI21_MOUSE (16-924): 0: 628: 22.25
+	Rn
		88548 D3ZCL8_RAT (16-1292): 0: 1012: 98.91		GRIA4_RAT (22-914): 0: 671: 19.13
+	Rn
		723634 SYGP1_RAT (1-1298): 0: 1033: 98.69		NMDZ1_RAT (16-924): 0: 636: 22.81
+	Mm
		963718 NF1_MOUSE (408-712): 3.83e-82: 300: 23.51		NMDE2_MOUSE (7-942): 0: 759: 50.32
+	Mm
		723574 NF1_MOUSE (408-712): 3.83e-82: 300: 23.51		NMDZ1_MOUSE (16-924): 0: 635: 22.70