HitPredict

Interactor 1: SYGP1 (F6SEU4)
Ras/Rap GTPase-activating protein SynGAP (Neuronal RasGAP) (Synaptic Ras GTPase-activating protein 1) (Synaptic Ras-GAP 1)
Gene: Syngap1

Interactor 2: AGAP2 (Q3UHD9)
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (Phosphatidylinositol 3-kinase enhancer) (PIKE)
Gene: AGAP2

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	28706196, 27507650, 28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ras~RasGAP
Common GO terms	GO:0005096 - GTPase activator activity GO:0019901 - protein kinase binding GO:0043524 - negative regulation of neuron apoptotic process GO:0098978 - glutamatergic synapse
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1340 Mm			1 1186
+	Mm
		1012208 Q0VAV5_MOUSE (17-1338): 0: 890: 43.23		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		93233 E9PW37_MOUSE (17-1338): 0: 887: 43.30		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		1112542 DAB2P_MOUSE (97-1339): 0: 850: 47.79		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		93411 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		E9Q3K3_MOUSE (80-1145): 0: 783: 43.63
+	Mm
		100045 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		AGAP1_MOUSE (384-1145): 0: 710: 53.70
+	Mm
		99881 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		F8VQE9_MOUSE (384-1150): 0: 660: 51.54
+	Hs
		1355995 NGAP_HUMAN (84-1338): 0: 800: 43.48		AGAP1_HUMAN (384-1145): 0: 713: 53.70
+	Mm
		1112670 RASL1_MOUSE (162-688): 1.39e-121: 399: 19.26		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		1112565 IQGA2_MOUSE (216-731): 3.33e-115: 398: 14.09		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		100015 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		ASAP2_MOUSE (690-1168): 1.01e-99: 341: 21.08
+	Mm
		88329 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		D3YX85_MOUSE (690-1168): 1.11e-97: 335: 21.08
+	Mm
		1112651 IQGA1_MOUSE (219-731): 1.36e-107: 377: 13.95		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		100001 SYGP1_MOUSE (1-1340): 0: 1075: 100.00		GIT1_MOUSE (932-1139): 6.25e-72: 258: 32.88
+	Mm
		980214 NF1_MOUSE (408-712): 3.83e-82: 300: 23.51		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Mm
		99872 F6QQP6_MOUSE (942-1316): 8.91e-32: 135: 19.75		AGAP2_MOUSE (1-1186): 0: 1024: 100.00
+	Hs
		598546 NF1_HUMAN (408-712): 2.96e-82: 301: 23.21		AGAP1_HUMAN (384-1145): 0: 713: 53.70
+	Sc
		533758 BUD2_YEAST (133-715): 2.17e-113: 385: 18.48		RSR1_YEAST (398-656): 8.23e-79: 262: 17.91
+	Hs
		596403 RASA1_HUMAN (184-715): 9.24e-130: 428: 23.82		ACAP2_HUMAN (634-1166): 2.28e-51: 197: 13.44
+	Hs
		809252 IQGA1_HUMAN (219-723): 6.44e-107: 374: 13.97		RAP1A_HUMAN (398-567): 1.81e-70: 235: 23.03