Protein: PPM1B
Protein phosphatase 1B (EC 3.1.3.16) (Protein phosphatase 2C isoform beta) (PP2C-beta)

Gene: PPM1B
Organism: Homo sapiens
Interactions: 199
UniProt ID: O75688

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005634 - nucleus
GO:0005730 - nucleolus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

273383

PPM1A
Protein phosphatase 1A

3

2

High-throughput

0.861

High

158354

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

18

Small-scale

0.785

High

273495

TBK1
Serine/threonine-protein kinase TBK1

2

20

Small-scale

0.754

High

273434

KPCD1
Serine/threonine-protein kinase D1

2

8

High-throughput

0.737

High

273366

CDK2
Cyclin-dependent kinase 2

1

4

Small-scale

0.710

High

273419

CDK6
Cyclin-dependent kinase 6

1

7

Small-scale

0.710

High

128952

PLK4
Serine/threonine-protein kinase PLK4

1

18

High-throughput

0.691

High

273402

NEK4
Serine/threonine-protein kinase Nek4

1

15

High-throughput

0.691

High

273432

NR1I3
Nuclear receptor subfamily 1 group I member 3

3

2

High-throughput

0.667

High

273461

MINY2
Ubiquitin carboxyl-terminal hydrolase MINDY-2

3

1

High-throughput

0.667

High

167428

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

Small-scale

0.665

High

255266

HIP1R
Huntingtin-interacting protein 1-related protein

2

1

High-throughput

0.628

High

273348

PMGE
Bisphosphoglycerate mutase

2

1

High-throughput

0.628

High

273438

CERKL
Ceramide kinase-like protein

2

1

High-throughput

0.628

High

273331

LATS1
Serine/threonine-protein kinase LATS1

1

2

High-throughput

0.618

High

273369

MARK3
MAP/microtubule affinity-regulating kinase 3

1

5

Small-scale

0.618

High

273401

PPM1F
Protein phosphatase 1F

1

3

High-throughput

0.618

High

273466

AURKB
Aurora kinase B

1

13

High-throughput

0.618

High

273343

ISG15
Ubiquitin-like protein ISG15

2

4

Small-scale

0.611

High

273364

VDAC1
Voltage-dependent anion-selective channel protein 1

2

1

High-throughput

0.611

High

201147

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

6

Small-scale

0.608

High

273421

MLRA
Myosin regulatory light chain 2, atrial isoform

2

3

High-throughput

0.606

High

273498

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

2

2

High-throughput

0.606

High

273360

PVR
Poliovirus receptor

2

0

High-throughput

0.602

High

273451

HTR5A
HEAT repeat-containing protein 5A

2

0

High-throughput

0.602

High

273478

PAXX
Protein PAXX

2

0

High-throughput

0.602

High

273479

THUM3
tRNA

2

0

High-throughput

0.602

High

273365

ERBB3
Receptor tyrosine-protein kinase erbB-3

3

12

High-throughput

0.596

High

273344

K1C18
Keratin, type I cytoskeletal 18

2

0

High-throughput

0.576

High

273405

TERA
Transitional endoplasmic reticulum ATPase

2

0

High-throughput

0.576

High

273470

SNX27
Sorting nexin-27

2

0

High-throughput

0.576

High

273355

FGFR1
Fibroblast growth factor receptor 1

2

8

High-throughput

0.571

High

273385

PPARG
Peroxisome proliferator-activated receptor gamma

1

2

Small-scale

0.561

High

273453

RBM45
RNA-binding protein 45

1

1

High-throughput

0.554

High

273492

KS6B2
Ribosomal protein S6 kinase beta-2

1

1

Small-scale

0.553

High

273362

RAB5A
Ras-related protein Rab-5A

2

0

High-throughput

0.547

High

273371

ELK4
ETS domain-containing protein Elk-4

2

0

High-throughput

0.547

High

273375

PEBP1
Phosphatidylethanolamine-binding protein 1

2

0

High-throughput

0.547

High

273435

PTPRR
Receptor-type tyrosine-protein phosphatase R

2

0

High-throughput

0.547

High

273334

EGFR
Epidermal growth factor receptor

1

10

High-throughput

0.541

High

273378

RYK
Tyrosine-protein kinase RYK

1

6

High-throughput

0.541

High

273384

VGFR2
Vascular endothelial growth factor receptor 2

1

6

High-throughput

0.541

High

273422

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

14

High-throughput

0.541

High

273427

PTK7
Inactive tyrosine-protein kinase 7

1

5

High-throughput

0.541

High

273436

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

10

High-throughput

0.541

High

273446

LMTK1
Serine/threonine-protein kinase LMTK1

1

12

High-throughput

0.541

High

260683

H2AY
Core histone macro-H2A.1

1

3

High-throughput

0.536

High

273324

SEGN
Secretagogin

1

1

High-throughput

0.536

High

273333

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

273341

H2A1B
Histone H2A type 1-B/E

1

2

High-throughput

0.536

High

273353

H2A1
Histone H2A type 1

1

2

High-throughput

0.536

High

273358

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

1

High-throughput

0.536

High

273377

ARRB2
Beta-arrestin-2

1

3

High-throughput

0.536

High

273381

SOAT1
Sterol O-acyltransferase 1

1

2

High-throughput

0.536

High

273382

TIMP3
Metalloproteinase inhibitor 3

1

1

High-throughput

0.536

High

273386

LICH
Lysosomal acid lipase/cholesteryl ester hydrolase

1

1

High-throughput

0.536

High

273399

ARRB1
Beta-arrestin-1

1

3

High-throughput

0.536

High

273415

ACTS
Actin, alpha skeletal muscle

1

1

High-throughput

0.536

High

273420

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

2

High-throughput

0.536

High

273430

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

2

High-throughput

0.536

High

273452

H2A2B
Histone H2A type 2-B

1

2

High-throughput

0.536

High

273489

DPOE3
DNA polymerase epsilon subunit 3

1

1

High-throughput

0.536

High

273337

ANXA1
Annexin A1

1

1

High-throughput

0.515

High

273342

S10A8
Protein S100-A8

1

2

High-throughput

0.515

High

273345

GELS
Gelsolin

1

1

High-throughput

0.515

High

273346

ANXA2
Annexin A2

1

1

High-throughput

0.515

High

273428

PABP4
Polyadenylate-binding protein 4

1

1

High-throughput

0.515

High

273505

NEMO
NF-kappa-B essential modulator

1

2

Small-scale

0.515

High

273448

NEK10
Serine/threonine-protein kinase Nek10

1

18

High-throughput

0.514

High

273350

VIME
Vimentin

1

0

High-throughput

0.513

High

273404

HSP72
Heat shock-related 70 kDa protein 2

1

0

High-throughput

0.513

High

273425

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

273444

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.513

High

273462

SETD7
Histone-lysine N-methyltransferase SETD7

1

0

High-throughput

0.513

High

273463

NGN1
Neurogenin-1

1

0

High-throughput

0.513

High

273473

PARK7
Parkinson disease protein 7

1

0

High-throughput

0.513

High

273481

PRD13
PR domain zinc finger protein 13

1

0

High-throughput

0.513

High

273483

ROP1A
Ropporin-1A

1

0

High-throughput

0.513

High

273486

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.513

High

273503

SP16H
FACT complex subunit SPT16

1

0

High-throughput

0.513

High

273403

VAV2
Guanine nucleotide exchange factor VAV2

1

2

High-throughput

0.508

High

273423

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

12

High-throughput

0.494

High

273328

GRP1
RAS guanyl-releasing protein 1

1

0

High-throughput

0.493

High

273388

TXLNA
Alpha-taxilin

1

0

High-throughput

0.493

High

273412

1433E
14-3-3 protein epsilon

1

0

Small-scale

0.493

High

273363

S1PR1
Sphingosine 1-phosphate receptor 1

1

1

High-throughput

0.489

High

273372

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

273457

PGAM4
Probable phosphoglycerate mutase 4

1

1

High-throughput

0.489

High

273468

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

1

High-throughput

0.489

High

273472

RB40C
Ras-related protein Rab-40C

1

1

High-throughput

0.489

High

273476

RSLBB
Ras-like protein family member 11B

1

1

High-throughput

0.489

High

273480

IL25
Interleukin-25

1

1

High-throughput

0.489

High

273485

LPAR2
Lysophosphatidic acid receptor 2

1

1

High-throughput

0.489

High

273417

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

0

Small-scale

0.480

High

130666

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

2

High-throughput

0.479

High

162268

XPO1
Exportin-1

1

1

High-throughput

0.479

High

226072

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

241924

PAGE4
P antigen family member 4

1

1

High-throughput

0.479

High

273330

HERC2
E3 ubiquitin-protein ligase HERC2

1

1

High-throughput

0.479

High

273336

ESR1
Estrogen receptor

1

2

High-throughput

0.479

High

273349

HS90B
Heat shock protein HSP 90-beta

1

3

High-throughput

0.479

High

273359

MIF
Macrophage migration inhibitory factor

1

1

High-throughput

0.479

High

273361

CXA1
Gap junction alpha-1 protein

1

1

Small-scale

0.479

High

273370

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

273389

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.479

High

273392

MAGA3
Melanoma-associated antigen 3

1

2

Small-scale

0.479

High

273393

MAGA6
Melanoma-associated antigen 6

1

2

High-throughput

0.479

High

273394

RS9
Small ribosomal subunit protein uS4

1

1

High-throughput

0.479

High

273396

TCPE
T-complex protein 1 subunit epsilon

1

1

High-throughput

0.479

High

273406

NP1L1
Nucleosome assembly protein 1-like 1

1

1

High-throughput

0.479

High

273409

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

273416

H31
Histone H3.1

1

1

High-throughput

0.479

High

273439

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

1

High-throughput

0.479

High

273442

ECM29
Proteasome adapter and scaffold protein ECM29

1

2

High-throughput

0.479

High

273454

TRI59
Tripartite motif-containing protein 59

1

1

Small-scale

0.479

High

273455

FANCM
Fanconi anemia group M protein

1

1

High-throughput

0.479

High

273464

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

1

High-throughput

0.479

High

273465

RNF31
E3 ubiquitin-protein ligase RNF31

1

2

High-throughput

0.479

High

273474

TCPH
T-complex protein 1 subunit eta

1

1

High-throughput

0.479

High

273475

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

273487

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

1

High-throughput

0.479

High

273491

UBP35
Ubiquitin carboxyl-terminal hydrolase 35

1

1

Small-scale

0.479

High

273494

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

273499

FBXL4
F-box/LRR-repeat protein 4

1

1

Small-scale

0.479

High

273351

VILI
Villin-1

1

1

High-throughput

0.470

High

124541

CLIC1
Chloride intracellular channel protein 1

1

0

High-throughput

0.458

High

233112

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

243714

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

259255

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

0

Small-scale

0.458

High

273325

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.458

High

273326

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

273332

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

273335

FOS
Protein c-Fos

1

0

High-throughput

0.458

High

273340

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

273352

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

273357

SKI
Ski oncogene

1

0

Small-scale

0.458

High

273367

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

273368

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.458

High

273376

GCH1
GTP cyclohydrolase 1

1

0

Small-scale

0.458

High

273379

NOS2
Nitric oxide synthase, inducible

1

0

High-throughput

0.458

High

273380

K1C9
Keratin, type I cytoskeletal 9

1

0

High-throughput

0.458

High

273387

IF4A3
Eukaryotic initiation factor 4A-III

1

0

High-throughput

0.458

High

273390

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

273391

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

273395

RS5
Small ribosomal subunit protein uS7

1

0

High-throughput

0.458

High

273397

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.458

High

273398

FNTB
Protein farnesyltransferase subunit beta

1

0

High-throughput

0.458

High

273400

SYAC
Alanine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

273408

HDAC4
Histone deacetylase 4

1

0

High-throughput

0.458

High

273410

MGN
Protein mago nashi homolog

1

0

High-throughput

0.458

High

273411

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

273418

SARNP
SAP domain-containing ribonucleoprotein

1

0

High-throughput

0.458

High

273424

TLE4
Transducin-like enhancer protein 4

1

0

Small-scale

0.458

High

273429

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

0

High-throughput

0.458

High

273433

SYK
Lysine--tRNA ligase

1

0

High-throughput

0.458

High

273437

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

273443

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

273450

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.458

High

273458

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

273469

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

273477

OVOL2
Transcription factor Ovo-like 2

1

0

Small-scale

0.458

High

273482

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

273484

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

273488

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

273490

KIF15
Kinesin-like protein KIF15

1

0

High-throughput

0.458

High

273496

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

273500

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

273501

PRP19
Pre-mRNA-processing factor 19

1

0

High-throughput

0.458

High

273502

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

47371

RPSA2
Small ribosomal subunit protein uS2B

1

2

High-throughput

0.445

High

273338

PRIO
Major prion protein

1

1

High-throughput

0.445

High

273354

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

273413

GRB2
Growth factor receptor-bound protein 2

1

1

High-throughput

0.445

High

273441

H37
Histone H3-7

1

1

High-throughput

0.445

High

273356

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.438

High

100319

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

273347

TRY1
Serine protease 1

1

1

High-throughput

0.437

High

273447

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

273493

KLK11
Kallikrein-11

1

1

High-throughput

0.437

High

273414

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

0

Small-scale

0.426

High

273426

IFT88
Intraflagellar transport protein 88 homolog

1

0

High-throughput

0.426

High

273440

S1A7B
Protein S100-A7-like 2

1

3

High-throughput

0.407

High

273456

CA087
Uncharacterized protein C1orf87

2

0

High-throughput

0.328

High

273497

FEZ2
Fasciculation and elongation protein zeta-2

2

0

High-throughput

0.328

High

273374

ECHM
Enoyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.282

High

273329

APOM
Apolipoprotein M

1

0

High-throughput

0.279

Low

273431

LRC32
Transforming growth factor beta activator LRRC32

1

0

High-throughput

0.279

Low

273449

COX15
Heme A synthase COX15

1

0

High-throughput

0.279

Low

273467

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.279

Low

49063

A0N4V7
HCG2039797

1

0

High-throughput

0.249

Low

273327

NDUA7
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7

1

0

High-throughput

0.249

Low

273339

OAT
Ornithine aminotransferase, mitochondrial

1

0

High-throughput

0.249

Low

273373

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.249

Low

273407

ATP5E
ATP synthase subunit epsilon, mitochondrial

1

0

High-throughput

0.249

Low

273459

DC4L2
DDB1- and CUL4-associated factor 4-like protein 2

1

0

Small-scale

0.249

Low

273460

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

273471

ZDH15
Palmitoyltransferase ZDHHC15

1

0

Small-scale

0.249

Low

273504

INSI2
Insulin-induced gene 2 protein

1

0

High-throughput

0.249

Low

273445

CLC4G
C-type lectin domain family 4 member G

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024