Protein: DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1)

Gene: DYRK2
Organism: Homo sapiens
Interactions: 167
UniProt ID: Q92630

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000287 - magnesium ion binding
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1082306

DDB1
DNA damage-binding protein 1

3

9

Small-scale

0.875

High

1268597

DYRK4
Dual specificity tyrosine-phosphorylation-regulated kinase 4

1

17

High-throughput

0.777

High

432121

HS90A
Heat shock protein HSP 90-alpha

2

20

Small-scale

0.754

High

1128065

CEP78
Centrosomal protein of 78 kDa

2

3

Small-scale

0.754

High

1033689

IKZF1
DNA-binding protein Ikaros

1

4

High-throughput

0.740

High

1268612

DCAF1
DDB1- and CUL4-associated factor 1

5

14

Small-scale

0.720

High

1130393

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

12

High-throughput

0.692

High

47828

RBM47
RNA-binding protein 47

1

8

High-throughput

0.691

High

60384

POTEF
POTE ankyrin domain family member F

1

10

High-throughput

0.691

High

212164

HTSF1
17S U2 SnRNP complex component HTATSF1

1

19

High-throughput

0.691

High

236811

CCNT1
Cyclin-T1

1

20

High-throughput

0.691

High

267037

SRS10
Serine/arginine-rich splicing factor 10

1

20

High-throughput

0.691

High

498321

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

7

High-throughput

0.691

High

678573

MK04
Mitogen-activated protein kinase 4

1

19

High-throughput

0.691

High

833940

CLK2
Dual specificity protein kinase CLK2

1

18

High-throughput

0.691

High

853953

NCBP2
Nuclear cap-binding protein subunit 2

1

18

High-throughput

0.691

High

942850

SRPK2
SRSF protein kinase 2

1

19

High-throughput

0.691

High

1014174

CPSF1
Cleavage and polyadenylation specificity factor subunit 1

1

9

High-throughput

0.691

High

1040371

TRA2A
Transformer-2 protein homolog alpha

1

20

High-throughput

0.691

High

1116424

LARP7
La-related protein 7

1

20

High-throughput

0.691

High

1264773

TITIN
Titin

1

9

High-throughput

0.691

High

1268606

G3BP2
Ras GTPase-activating protein-binding protein 2

1

10

High-throughput

0.691

High

1268607

SET1B
Histone-lysine N-methyltransferase SETD1B

1

8

High-throughput

0.691

High

304271

UBR5
E3 ubiquitin-protein ligase UBR5

3

14

Small-scale

0.678

High

257676

ANR17
Ankyrin repeat domain-containing protein 17

1

2

High-throughput

0.618

High

275919

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

14

High-throughput

0.618

High

282702

RNF8
E3 ubiquitin-protein ligase RNF8

1

12

Small-scale

0.618

High

438406

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

575518

EGR1
Early growth response protein 1

1

5

High-throughput

0.618

High

665300

EPHA2
Ephrin type-A receptor 2

1

9

High-throughput

0.618

High

835914

GSK3B
Glycogen synthase kinase-3 beta

1

19

Small-scale

0.618

High

980482

NOTC2
Neurogenic locus notch homolog protein 2

1

6

High-throughput

0.618

High

1023086

STK4
Serine/threonine-protein kinase 4

1

19

High-throughput

0.618

High

1033900

SNTB2
Beta-2-syntrophin

1

2

High-throughput

0.618

High

1185238

TAOK1
Serine/threonine-protein kinase TAO1

1

12

High-throughput

0.618

High

1268583

RBM14
RNA-binding protein 14

1

17

High-throughput

0.618

High

1268591

TARA
TRIO and F-actin-binding protein

1

20

Small-scale

0.618

High

1268604

TBK1
Serine/threonine-protein kinase TBK1

1

19

Small-scale

0.618

High

1268581

DCAF5
DDB1- and CUL4-associated factor 5

2

18

Small-scale

0.611

High

1268595

XPP3
Xaa-Pro aminopeptidase 3

2

1

Small-scale

0.611

High

395359

A4
Amyloid-beta precursor protein

2

7

High-throughput

0.602

High

603215

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

2

3

Small-scale

0.584

High

199130

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

8

Small-scale

0.578

High

1044006

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

18

High-throughput

0.575

High

201962

WDR62
WD repeat-containing protein 62

1

13

High-throughput

0.573

High

617347

SP100
Nuclear autoantigen Sp-100

1

16

High-throughput

0.573

High

1268578

ZBTB9
Zinc finger and BTB domain-containing protein 9

1

4

High-throughput

0.573

High

1268586

LZTS2
Leucine zipper putative tumor suppressor 2

1

20

High-throughput

0.573

High

265420

KTNA1
Katanin p60 ATPase-containing subunit A1

1

13

Small-scale

0.561

High

265875

NR1I2
Nuclear receptor subfamily 1 group I member 2

1

16

Small-scale

0.561

High

962893

MDM2
E3 ubiquitin-protein ligase Mdm2

1

4

Small-scale

0.561

High

1268574

FBXW7
F-box/WD repeat-containing protein 7

1

19

Small-scale

0.561

High

1068840

PCM1
Pericentriolar material 1 protein

1

1

High-throughput

0.554

High

1162628

LARP1
La-related protein 1

1

16

High-throughput

0.554

High

1268572

KIFA3
Kinesin-associated protein 3

1

15

High-throughput

0.554

High

1268590

NDEL1
Nuclear distribution protein nudE-like 1

1

20

High-throughput

0.554

High

1268596

BIRC6
Baculoviral IAP repeat-containing protein 6

1

11

High-throughput

0.554

High

1268600

BCLF1
Bcl-2-associated transcription factor 1

1

17

High-throughput

0.554

High

1268608

SRRM2
Serine/arginine repetitive matrix protein 2

1

20

High-throughput

0.554

High

1268611

KIF3A
Kinesin-like protein KIF3A

1

7

High-throughput

0.554

High

267583

RMXL2
RNA-binding motif protein, X-linked-like-2

1

18

Small-scale

0.553

High

1268614

RA54B
DNA repair and recombination protein RAD54B

1

8

High-throughput

0.541

High

154037

TERT
Telomerase reverse transcriptase

1

0

Small-scale

0.537

High

124241

TAF4
Transcription initiation factor TFIID subunit 4

1

5

High-throughput

0.536

High

365003

FRIL
Ferritin light chain

1

1

High-throughput

0.536

High

396386

APOD
Apolipoprotein D

1

1

High-throughput

0.536

High

813117

CAZA2
F-actin-capping protein subunit alpha-2

1

3

High-throughput

0.536

High

903402

WDR5
WD repeat-containing protein 5

1

14

High-throughput

0.536

High

929595

RACK1
Small ribosomal subunit protein RACK1

1

16

High-throughput

0.536

High

960547

PURA
Transcriptional activator protein Pur-alpha

1

4

High-throughput

0.536

High

998138

NCBP1
Nuclear cap-binding protein subunit 1

1

1

High-throughput

0.536

High

1070751

RBBP5
Retinoblastoma-binding protein 5

1

14

High-throughput

0.536

High

1074800

TAF5
Transcription initiation factor TFIID subunit 5

1

12

High-throughput

0.536

High

1158792

TAF2
Transcription initiation factor TFIID subunit 2

1

3

High-throughput

0.536

High

1164854

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

2

High-throughput

0.536

High

1166704

WDR82
WD repeat-containing protein 82

1

19

High-throughput

0.536

High

1174827

LARP4
La-related protein 4

1

16

High-throughput

0.536

High

1183956

DHX30
ATP-dependent RNA helicase DHX30

1

8

High-throughput

0.536

High

1184239

MEPCE
7SK snRNA methylphosphate capping enzyme

1

2

High-throughput

0.536

High

1201571

ZCH18
Zinc finger CCCH domain-containing protein 18

1

20

High-throughput

0.536

High

1231710

CLASR
CLK4-associating serine/arginine rich protein

1

6

High-throughput

0.536

High

1255636

RBCC1
RB1-inducible coiled-coil protein 1

1

20

High-throughput

0.536

High

1255825

ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

1

15

High-throughput

0.536

High

1266088

DDX1
ATP-dependent RNA helicase DDX1

1

15

High-throughput

0.536

High

1268589

SRRT
Serrate RNA effector molecule homolog

1

1

High-throughput

0.536

High

1268594

MOV10
Helicase MOV-10

1

7

High-throughput

0.536

High

1268598

DBLOH
Diablo IAP-binding mitochondrial protein

1

1

High-throughput

0.536

High

1268599

NDE1
Nuclear distribution protein nudE homolog 1

1

20

High-throughput

0.536

High

1268602

CXXC1
CXXC-type zinc finger protein 1

1

8

High-throughput

0.536

High

1268603

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

14

High-throughput

0.536

High

1268593

CCSE2
Serine-rich coiled-coil domain-containing protein 2

1

0

High-throughput

0.530

High

1268609

CHSP1
Calcium-regulated heat-stable protein 1

1

0

Small-scale

0.513

High

64545

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

High-throughput

0.513

High

307842

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

1

0

High-throughput

0.513

High

836258

TAF6
Transcription initiation factor TFIID subunit 6

1

0

High-throughput

0.513

High

1062772

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.513

High

1158961

XRRA1
X-ray radiation resistance-associated protein 1

1

0

High-throughput

0.513

High

1268588

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.513

High

1268615

CFA20
Cilia- and flagella-associated protein 20

1

0

High-throughput

0.513

High

497376

TAU
Microtubule-associated protein tau

1

13

Small-scale

0.501

High

849388

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

6

Small-scale

0.501

High

1025663

EI2BE
Translation initiation factor eIF2B subunit epsilon

1

6

Small-scale

0.501

High

1031576

ATM
Serine-protein kinase ATM

1

5

Small-scale

0.501

High

947617

RT05
Small ribosomal subunit protein uS5m

1

3

High-throughput

0.489

High

1268605

PNMA2
Paraneoplastic antigen Ma2

1

3

High-throughput

0.489

High

1268610

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

1

2

High-throughput

0.489

High

117192

DX39A
ATP-dependent RNA helicase DDX39A

1

15

High-throughput

0.479

High

155184

KIF3C
Kinesin-like protein KIF3C

1

8

High-throughput

0.479

High

166379

KIF3B
Kinesin-like protein KIF3B

1

8

High-throughput

0.479

High

200642

CP110
Centriolar coiled-coil protein of 110 kDa

1

2

Small-scale

0.479

High

387216

P53
Cellular tumor antigen p53

1

12

High-throughput

0.479

High

401017

RLA0
Large ribosomal subunit protein uL10

1

4

Small-scale

0.479

High

418510

NPM
Nucleophosmin

1

5

Small-scale

0.479

High

449781

HMGB1
High mobility group protein B1

1

17

High-throughput

0.479

High

502387

BIP
Endoplasmic reticulum chaperone BiP

1

12

Small-scale

0.479

High

504495

HSP7C
Heat shock cognate 71 kDa protein

1

9

Small-scale

0.479

High

505863

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

3

Small-scale

0.479

High

535894

MIF
Macrophage migration inhibitory factor

1

1

High-throughput

0.479

High

550880

RS2
Small ribosomal subunit protein uS5

1

3

Small-scale

0.479

High

564141

HSP76
Heat shock 70 kDa protein 6

1

9

Small-scale

0.479

High

571531

DDX5
Probable ATP-dependent RNA helicase DDX5

1

8

High-throughput

0.479

High

575126

RL7
Large ribosomal subunit protein uL30

1

3

Small-scale

0.479

High

642490

RL13
Large ribosomal subunit protein eL13

1

3

High-throughput

0.479

High

651838

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

Small-scale

0.479

High

684246

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

736622

RL4
Large ribosomal subunit protein uL4

1

2

Small-scale

0.479

High

739212

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

Small-scale

0.479

High

805745

RL27A
Large ribosomal subunit protein uL15

1

1

High-throughput

0.479

High

899530

MGN
Protein mago nashi homolog

1

2

High-throughput

0.479

High

902983

DCAF7
DDB1- and CUL4-associated factor 7

1

20

Small-scale

0.479

High

908057

RS16
Small ribosomal subunit protein uS9

1

3

High-throughput

0.479

High

909877

1433E
14-3-3 protein epsilon

1

13

High-throughput

0.479

High

913660

RL7A
Large ribosomal subunit protein eL8

1

3

Small-scale

0.479

High

928153

SUMO1
Small ubiquitin-related modifier 1

1

6

High-throughput

0.479

High

930324

UBC9
SUMO-conjugating enzyme UBC9

1

12

High-throughput

0.479

High

942430

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1

7

High-throughput

0.479

High

944350

PRKDC
DNA-dependent protein kinase catalytic subunit

1

4

High-throughput

0.479

High

946653

SSBP2
Single-stranded DNA-binding protein 2

1

4

Small-scale

0.479

High

962254

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

15

Small-scale

0.479

High

973780

AKA12
A-kinase anchor protein 12

1

20

High-throughput

0.479

High

989876

RL18
Large ribosomal subunit protein eL18

1

2

Small-scale

0.479

High

1113816

GRDN
Girdin

1

20

High-throughput

0.479

High

1134124

UBAP2
Ubiquitin-associated protein 2

1

10

High-throughput

0.479

High

1167942

GGYF2
GRB10-interacting GYF protein 2

1

20

High-throughput

0.479

High

1230493

CCAR2
Cell cycle and apoptosis regulator protein 2

1

1

High-throughput

0.479

High

1234416

NKAP
NF-kappa-B-activating protein

1

1

High-throughput

0.479

High

1268573

RENT1
Regulator of nonsense transcripts 1

1

6

High-throughput

0.479

High

1268576

MGN2
Protein mago nashi homolog 2

1

2

High-throughput

0.479

High

1268577

MOAP1
Modulator of apoptosis 1

1

3

Small-scale

0.479

High

1268580

FUBP3
Far upstream element-binding protein 3

1

15

High-throughput

0.479

High

1268585

TBA1C
Tubulin alpha-1C chain

1

15

Small-scale

0.479

High

1268587

KIFC1
Kinesin-like protein KIFC1

1

6

High-throughput

0.479

High

1268592

SAV1
Protein salvador homolog 1

1

13

High-throughput

0.479

High

1268613

YTHD2
YTH domain-containing family protein 2

1

8

High-throughput

0.479

High

846174

RT29
Small ribosomal subunit protein mS29

1

0

Small-scale

0.458

High

1023908

RM28
Large ribosomal subunit protein bL28m

1

0

High-throughput

0.458

High

1102148

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.458

High

1268579

LTV1
Protein LTV1 homolog

1

0

High-throughput

0.458

High

1268601

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.458

High

540750

CX6B1
Cytochrome c oxidase subunit 6B1

1

1

High-throughput

0.437

High

959269

S25A3
Solute carrier family 25 member 3

1

15

Small-scale

0.437

High

1252621

SHKB1
SH3KBP1-binding protein 1

1

2

High-throughput

0.437

High

1087780

RTN1
Reticulon-1

2

0

High-throughput

0.328

High

1268584

KXDL1
KxDL motif-containing protein 1

1

0

High-throughput

0.299

High

147108

NEMP1
Nuclear envelope integral membrane protein 1

1

0

High-throughput

0.249

Low

1268575

RM24
Large ribosomal subunit protein uL24m

1

0

High-throughput

0.249

Low

1268582

CC138
Coiled-coil domain-containing protein 138

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024