Protein: SET1A
Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (Lysine N-methyltransferase 2F) (SET domain-containing protein 1A) (hSET1A) (Set1/Ash2 histone methyltransferase complex subunit SET1)

Gene: SET1A, SETD1A
Organism: Homo sapiens
Interactions: 155
UniProt ID: O15047

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

165657

WDR5
WD repeat-containing protein 5

18

20

Small-scale

0.987

High

165680

RBBP5
Retinoblastoma-binding protein 5

17

20

Small-scale

0.985

High

165726

CXXC1
CXXC-type zinc finger protein 1

17

19

Small-scale

0.985

High

165730

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

15

20

Small-scale

0.985

High

165686

WDR82
WD repeat-containing protein 82

10

20

Small-scale

0.975

High

165661

H31
Histone H3.1

3

20

Small-scale

0.845

High

165673

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

2

1

High-throughput

0.811

High

152553

KMT2D
Histone-lysine N-methyltransferase 2D

2

20

High-throughput

0.754

High

165613

H2A1B
Histone H2A type 1-B/E

2

15

High-throughput

0.754

High

165740

SET1B
Histone-lysine N-methyltransferase SETD1B

2

18

Small-scale

0.754

High

165713

DPY30
Protein dpy-30 homolog

5

7

Small-scale

0.709

High

165649

HCFC1
Host cell factor 1

5

20

Small-scale

0.709

High

165615

H2A1
Histone H2A type 1

1

15

High-throughput

0.691

High

165739

PHF8
Histone lysine demethylase PHF8

1

16

Small-scale

0.691

High

165599

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

4

12

Small-scale

0.683

High

165612

P53
Cellular tumor antigen p53

3

4

Small-scale

0.678

High

165653

ANM2
Protein arginine N-methyltransferase 2

3

5

High-throughput

0.667

High

165734

NUP50
Nuclear pore complex protein Nup50

3

5

High-throughput

0.667

High

165746

HCFC2
Host cell factor 2

3

20

High-throughput

0.667

High

165700

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

3

17

High-throughput

0.656

High

165688

H32
Histone H3.2

1

20

Small-scale

0.647

High

132052

PESC
Pescadillo homolog

2

1

High-throughput

0.628

High

165602

E41L2
Band 4.1-like protein 2

2

9

High-throughput

0.628

High

165722

E41L5
Band 4.1-like protein 5

2

9

High-throughput

0.628

High

165604

BUB3
Mitotic checkpoint protein BUB3

1

20

High-throughput

0.618

High

165624

RO52
E3 ubiquitin-protein ligase TRIM21

1

5

High-throughput

0.618

High

165638

H2B1B
Histone H2B type 1-B

1

20

High-throughput

0.618

High

165650

NEK2
Serine/threonine-protein kinase Nek2

1

2

High-throughput

0.618

High

165658

H4
Histone H4

1

9

High-throughput

0.618

High

165659

TRA2B
Transformer-2 protein homolog beta

1

14

High-throughput

0.618

High

165660

CSK21
Casein kinase II subunit alpha

1

9

High-throughput

0.618

High

165665

KMT2A
Histone-lysine N-methyltransferase 2A

1

18

High-throughput

0.618

High

165666

RBBP4
Histone-binding protein RBBP4

1

20

High-throughput

0.618

High

165672

TIF1B
Transcription intermediary factor 1-beta

1

20

High-throughput

0.618

High

165675

NFYC
Nuclear transcription factor Y subunit gamma

1

2

High-throughput

0.618

High

165677

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.618

High

165679

SUZ12
Polycomb protein SUZ12

1

11

High-throughput

0.618

High

165682

EZH2
Histone-lysine N-methyltransferase EZH2

1

20

High-throughput

0.618

High

165699

KMT2C
Histone-lysine N-methyltransferase 2C

1

18

High-throughput

0.618

High

165701

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

165703

DCAF4
DDB1- and CUL4-associated factor 4

1

2

High-throughput

0.618

High

165711

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

20

Small-scale

0.618

High

165737

KMT2B
Histone-lysine N-methyltransferase 2B

1

19

High-throughput

0.618

High

165738

PRP19
Pre-mRNA-processing factor 19

1

20

Small-scale

0.618

High

165745

MRCKB
Serine/threonine-protein kinase MRCK beta

1

8

High-throughput

0.618

High

165685

RSBN1
Lysine-specific demethylase 9

2

0

High-throughput

0.602

High

165667

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.586

High

165611

MYC
Myc proto-oncogene protein

2

12

High-throughput

0.584

High

165617

MYB
Transcriptional activator Myb

2

6

High-throughput

0.584

High

165626

USF1
Upstream stimulatory factor 1

2

10

Small-scale

0.584

High

165669

TP53B
TP53-binding protein 1

2

11

High-throughput

0.584

High

165681

ELF2
ETS-related transcription factor Elf-2

2

20

High-throughput

0.584

High

165743

E41L3
Band 4.1-like protein 3

2

9

High-throughput

0.574

High

165705

CBP
CREB-binding protein

1

20

Small-scale

0.561

High

165618

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

2

High-throughput

0.536

High

165645

KI67
Proliferation marker protein Ki-67

1

20

High-throughput

0.536

High

165651

IMA1
Importin subunit alpha-1

1

4

High-throughput

0.536

High

165663

ZXDB
Zinc finger X-linked protein ZXDB

1

2

High-throughput

0.536

High

165671

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

1

High-throughput

0.536

High

165694

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

2

High-throughput

0.536

High

165698

ZN784
Zinc finger protein 784

1

4

High-throughput

0.536

High

165702

ARRD2
Arrestin domain-containing protein 2

1

1

High-throughput

0.536

High

165715

E41LB
Band 4.1-like protein 4B

1

9

High-throughput

0.536

High

165732

DAXX
Death domain-associated protein 6

1

3

High-throughput

0.536

High

165707

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.513

High

165729

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.513

High

165619

INSRR
Insulin receptor-related protein

1

4

High-throughput

0.489

High

165695

FGRL1
Fibroblast growth factor receptor-like 1

1

4

High-throughput

0.489

High

165716

E41L1
Band 4.1-like protein 1

1

9

High-throughput

0.489

High

68263

P20L1
PHD finger protein 20-like protein 1

1

11

High-throughput

0.479

High

122367

MEN1
Menin

1

6

High-throughput

0.479

High

154704

TCRG1
Transcription elongation regulator 1

1

8

Small-scale

0.479

High

165600

KDM6A
Lysine-specific demethylase 6A

1

20

High-throughput

0.479

High

165601

TPD54
Tumor protein D54

1

2

High-throughput

0.479

High

165603

ZN207
BUB3-interacting and GLEBS motif-containing protein ZNF207

1

15

High-throughput

0.479

High

165606

CCNK
Cyclin-K

1

4

Small-scale

0.479

High

165607

MTA2
Metastasis-associated protein MTA2

1

11

High-throughput

0.479

High

165608

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

165614

PARP1
Poly [ADP-ribose] polymerase 1

1

13

High-throughput

0.479

High

165620

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

165621

DDX5
Probable ATP-dependent RNA helicase DDX5

1

7

Small-scale

0.479

High

165623

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

165627

CCNE1
G1/S-specific cyclin-E1

1

1

Small-scale

0.479

High

165628

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

11

Small-scale

0.479

High

165629

TYY1
Transcriptional repressor protein YY1

1

9

High-throughput

0.479

High

165630

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

165631

SMCA1
Probable global transcription activator SNF2L1

1

20

Small-scale

0.479

High

165632

RBL1
Retinoblastoma-like protein 1

1

9

Small-scale

0.479

High

165634

DNJA1
DnaJ homolog subfamily A member 1

1

7

Small-scale

0.479

High

165635

1433S
14-3-3 protein sigma

1

19

Small-scale

0.479

High

165637

ELF1
ETS-related transcription factor Elf-1

1

20

High-throughput

0.479

High

165639

MCM7
DNA replication licensing factor MCM7

1

8

Small-scale

0.479

High

165640

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

165641

BRCA1
Breast cancer type 1 susceptibility protein

1

11

High-throughput

0.479

High

165642

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

165643

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

165644

ELK3
ETS domain-containing protein Elk-3

1

20

High-throughput

0.479

High

165646

YAP1
Transcriptional coactivator YAP1

1

15

High-throughput

0.479

High

165647

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

15

High-throughput

0.479

High

165648

CTCF
Transcriptional repressor CTCF

1

1

High-throughput

0.479

High

165652

ATN1
Atrophin-1

1

20

High-throughput

0.479

High

165654

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

165655

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

2

High-throughput

0.479

High

165656

RL37A
Large ribosomal subunit protein eL43

1

3

High-throughput

0.479

High

165662

PRKDC
DNA-dependent protein kinase catalytic subunit

1

3

High-throughput

0.479

High

165664

E2F1
Transcription factor E2F1

1

10

Small-scale

0.479

High

165668

AHNK
Neuroblast differentiation-associated protein AHNAK

1

12

High-throughput

0.479

High

165670

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.479

High

165674

FHL3
Four and a half LIM domains protein 3

1

3

High-throughput

0.479

High

165676

FHL2
Four and a half LIM domains protein 2

1

6

High-throughput

0.479

High

165678

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

165687

PAXI1
PAX-interacting protein 1

1

20

High-throughput

0.479

High

165689

PHF5A
PHD finger-like domain-containing protein 5A

1

1

High-throughput

0.479

High

165690

KANL1
KAT8 regulatory NSL complex subunit 1

1

3

High-throughput

0.479

High

165691

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

7

High-throughput

0.479

High

165693

ZZZ3
ZZ-type zinc finger-containing protein 3

1

3

High-throughput

0.479

High

165696

SIR6
NAD-dependent protein deacylase sirtuin-6

1

8

High-throughput

0.479

High

165704

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

165708

MCRS1
Microspherule protein 1

1

4

High-throughput

0.479

High

165709

FEV
Protein FEV

1

20

High-throughput

0.479

High

165710

ELF4
ETS-related transcription factor Elf-4

1

20

High-throughput

0.479

High

165712

PHF20
PHD finger protein 20

1

18

High-throughput

0.479

High

165717

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.479

High

165718

KAT8
Histone acetyltransferase KAT8

1

6

High-throughput

0.479

High

165719

CSR2B
Cysteine-rich protein 2-binding protein

1

20

High-throughput

0.479

High

165720

KANL2
KAT8 regulatory NSL complex subunit 2

1

3

High-throughput

0.479

High

165721

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

20

High-throughput

0.479

High

165723

MBIP1
MAP3K12-binding inhibitory protein 1

1

3

High-throughput

0.479

High

165725

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

5

High-throughput

0.479

High

165727

KANL3
KAT8 regulatory NSL complex subunit 3

1

4

High-throughput

0.479

High

165728

RERE
Arginine-glutamic acid dipeptide repeats protein

1

20

High-throughput

0.479

High

165731

HDAC6
Histone deacetylase 6

1

20

High-throughput

0.479

High

165733

APC7
Anaphase-promoting complex subunit 7

1

9

High-throughput

0.479

High

165735

ZN608
Zinc finger protein 608

1

10

High-throughput

0.479

High

165736

YETS2
YEATS domain-containing protein 2

1

19

High-throughput

0.479

High

165741

SMC3
Structural maintenance of chromosomes protein 3

1

5

Small-scale

0.479

High

165742

RUVB2
RuvB-like 2

1

6

High-throughput

0.479

High

165744

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.479

High

149951

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

1

0

High-throughput

0.458

High

165605

LANC1
Glutathione S-transferase LANCL1

1

0

High-throughput

0.458

High

165633

MPIP1
M-phase inducer phosphatase 1

1

0

Small-scale

0.458

High

165683

UVSSA
UV-stimulated scaffold protein A

1

0

Small-scale

0.458

High

165724

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

49622

RHG10
Rho GTPase-activating protein 10

1

3

High-throughput

0.437

High

165609

PCNT
Pericentrin

1

16

High-throughput

0.437

High

165636

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

2

High-throughput

0.437

High

165616

CT456
Cancer/testis antigen family 45 member A6

1

1

High-throughput

0.407

High

165706

EDA
Ectodysplasin-A

3

0

High-throughput

0.347

High

165625

MK
Midkine

2

0

High-throughput

0.328

High

165610

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

165692

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.279

Low

165697

SYT2
Synaptotagmin-2

1

0

High-throughput

0.279

Low

165714

CHST5
Carbohydrate sulfotransferase 5

1

0

High-throughput

0.279

Low

165622

LBP
Lipopolysaccharide-binding protein

1

0

High-throughput

0.251

Low

165684

TB10B
TBC1 domain family member 10B

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024