Protein: SRBP1
Sterol regulatory element-binding protein 1 (SREBP-1) (Class D basic helix-loop-helix protein 1) (bHLHd1) (Sterol regulatory element-binding transcription factor 1) [Cleaved into: Processed sterol regulatory element-binding protein 1 (Transcription factor SREBF1)]

Gene: SRBP1, SREBF1
Organism: Homo sapiens
Interactions: 101
UniProt ID: P36956

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000139 - Golgi membrane
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

738987

FBXW7
F-box/WD repeat-containing protein 7

8

13

Small-scale

0.753

High

738982

CBP
CREB-binding protein

5

20

Small-scale

0.725

High

738989

MED15
Mediator of RNA polymerase II transcription subunit 15

5

12

Small-scale

0.721

High

738960

EP300
Histone acetyltransferase p300

5

20

Small-scale

0.720

High

607791

USF1
Upstream stimulatory factor 1

1

18

Small-scale

0.691

High

738961

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

4

17

Small-scale

0.686

High

359716

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

3

5

Small-scale

0.685

High

738979

TWST2
Twist-related protein 2

1

12

Small-scale

0.680

High

738998

MED23
Mediator of RNA polymerase II transcription subunit 23

3

1

Small-scale

0.664

High

738988

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

6

Small-scale

0.656

High

270483

MED6
Mediator of RNA polymerase II transcription subunit 6

3

1

Small-scale

0.655

High

738941

SRBP1
Sterol regulatory element-binding protein 1

1

16

Small-scale

0.647

High

738956

ID2
DNA-binding protein inhibitor ID-2

1

1

Small-scale

0.647

High

738957

ID3
DNA-binding protein inhibitor ID-3

1

1

Small-scale

0.647

High

738962

SRBP2
Sterol regulatory element-binding protein 2

1

19

Small-scale

0.647

High

225352

MED14
Mediator of RNA polymerase II transcription subunit 14

3

14

Small-scale

0.641

High

265308

MED24
Mediator of RNA polymerase II transcription subunit 24

3

1

Small-scale

0.641

High

738986

MED12
Mediator of RNA polymerase II transcription subunit 12

3

15

Small-scale

0.641

High

593885

PRVA
Parvalbumin alpha

2

9

High-throughput

0.628

High

738981

SORL
Sortilin-related receptor

2

4

High-throughput

0.628

High

738951

ATX1
Ataxin-1

2

5

High-throughput

0.620

High

313400

MED26
Mediator of RNA polymerase II transcription subunit 26

3

0

Small-scale

0.613

High

738997

MED13
Mediator of RNA polymerase II transcription subunit 13

3

0

Small-scale

0.613

High

738945

CDK8
Cyclin-dependent kinase 8

2

17

Small-scale

0.613

High

738970

MED1
Mediator of RNA polymerase II transcription subunit 1

2

6

Small-scale

0.608

High

738946

GSK3B
Glycogen synthase kinase-3 beta

2

10

Small-scale

0.602

High

738942

HNF4A
Hepatocyte nuclear factor 4-alpha

2

20

Small-scale

0.595

High

738974

MED25
Mediator of RNA polymerase II transcription subunit 25

2

4

Small-scale

0.595

High

206610

MED7
Mediator of RNA polymerase II transcription subunit 7

2

0

Small-scale

0.592

High

434983

SP1
Transcription factor Sp1

2

20

Small-scale

0.585

High

739001

TRRAP
Transformation/transcription domain-associated protein

2

8

Small-scale

0.584

High

738966

DX39B
Spliceosome RNA helicase DDX39B

1

13

Small-scale

0.573

High

738995

MED17
Mediator of RNA polymerase II transcription subunit 17

2

0

Small-scale

0.569

High

647489

MK03
Mitogen-activated protein kinase 3

1

7

Small-scale

0.569

High

658820

MK01
Mitogen-activated protein kinase 1

1

7

Small-scale

0.569

High

153590

ANM5
Protein arginine N-methyltransferase 5

1

5

Small-scale

0.561

High

487187

ANDR
Androgen receptor

1

20

Small-scale

0.561

High

738950

PLK1
Serine/threonine-protein kinase PLK1

1

5

Small-scale

0.561

High

738984

SMRC1
SWI/SNF complex subunit SMARCC1

1

17

Small-scale

0.561

High

738992

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

8

Small-scale

0.561

High

51225

ZBT7C
Zinc finger and BTB domain-containing protein 7C

1

7

Small-scale

0.552

High

63577

ASB14
Ankyrin repeat and SOCS box protein 14

1

4

High-throughput

0.536

High

738968

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

1

High-throughput

0.536

High

738971

TTMP
TPA-induced transmembrane protein

1

2

High-throughput

0.536

High

738978

KCNG4
Potassium voltage-gated channel subfamily G member 4

1

3

High-throughput

0.536

High

738949

NR0B1
Nuclear receptor subfamily 0 group B member 1

1

20

Small-scale

0.527

High

738943

HD
Huntingtin

1

5

High-throughput

0.515

High

738944

MTR1B
Melatonin receptor type 1B

1

3

High-throughput

0.508

High

130318

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

20

Small-scale

0.501

High

595120

LMNB1
Lamin-B1

1

6

Small-scale

0.501

High

632623

TYY1
Transcriptional repressor protein YY1

1

5

Small-scale

0.501

High

738973

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

5

Small-scale

0.501

High

739000

KLF13
Krueppel-like factor 13

1

20

Small-scale

0.501

High

537722

INSRR
Insulin receptor-related protein

1

13

High-throughput

0.489

High

736139

ACHA7
Neuronal acetylcholine receptor subunit alpha-7

1

2

High-throughput

0.489

High

738972

TM268
Transmembrane protein 268

1

1

High-throughput

0.489

High

738993

TMM9B
Transmembrane protein 9B

1

1

High-throughput

0.489

High

473481

ATX1L
Ataxin-1-like

1

5

High-throughput

0.481

High

738958

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.481

High

122529

MEN1
Menin

1

2

Small-scale

0.479

High

181070

INSI1
Insulin-induced gene 1 protein

1

3

Small-scale

0.479

High

205119

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.479

High

226704

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

239453

PLPL9
85/88 kDa calcium-independent phospholipase A2

1

6

Small-scale

0.479

High

299859

ERLN2
Erlin-2

1

1

Small-scale

0.479

High

312024

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

9

Small-scale

0.479

High

386222

P53
Cellular tumor antigen p53

1

12

Small-scale

0.479

High

414792

CDK1
Cyclin-dependent kinase 1

1

6

Small-scale

0.479

High

431605

HS90A
Heat shock protein HSP 90-alpha

1

8

High-throughput

0.479

High

437954

HS90B
Heat shock protein HSP 90-beta

1

8

High-throughput

0.479

High

538486

CCNB1
G2/mitotic-specific cyclin-B1

1

1

Small-scale

0.479

High

584889

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

Small-scale

0.479

High

603044

OSBP1
Oxysterol-binding protein 1

1

1

Small-scale

0.479

High

624796

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

2

Small-scale

0.479

High

738947

SMCA2
Probable global transcription activator SNF2L2

1

18

Small-scale

0.479

High

738948

SMCA4
Transcription activator BRG1

1

18

Small-scale

0.479

High

738952

H4
Histone H4

1

11

High-throughput

0.479

High

738953

UBC9
SUMO-conjugating enzyme UBC9

1

4

Small-scale

0.479

High

738954

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

738955

MDM2
E3 ubiquitin-protein ligase Mdm2

1

1

Small-scale

0.479

High

738959

TF65
Transcription factor p65

1

9

Small-scale

0.479

High

738963

ATM
Serine-protein kinase ATM

1

8

Small-scale

0.479

High

738964

MED21
Mediator of RNA polymerase II transcription subunit 21

1

1

Small-scale

0.479

High

738965

HDAC1
Histone deacetylase 1

1

11

Small-scale

0.479

High

738967

KLF5
Krueppel-like factor 5

1

20

Small-scale

0.479

High

738969

ZN638
Zinc finger protein 638

1

4

Small-scale

0.479

High

738975

TAD2B
Transcriptional adapter 2-beta

1

5

Small-scale

0.479

High

738980

GCN1
Stalled ribosome sensor GCN1

1

8

Small-scale

0.479

High

738983

KAT2A
Histone acetyltransferase KAT2A

1

20

Small-scale

0.479

High

738985

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

4

Small-scale

0.479

High

738990

SIN3A
Paired amphipathic helix protein Sin3a

1

2

Small-scale

0.479

High

738991

SPRNG
SREBP regulating gene protein

1

1

Small-scale

0.479

High

738994

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

2

Small-scale

0.479

High

738996

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

Small-scale

0.479

High

738999

RUVB2
RuvB-like 2

1

4

Small-scale

0.479

High

739002

INSI2
Insulin-induced gene 2 protein

1

3

Small-scale

0.479

High

267629

TADA3
Transcriptional adapter 3

1

0

Small-scale

0.458

High

738976

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.445

High

351137

EGF
Pro-epidermal growth factor

1

4

Small-scale

0.437

High

738977

GOLM1
Golgi membrane protein 1

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024