Protein: PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1-alpha) (PtdIns(4)P-5-kinase 1 alpha) (EC 2.7.1.68) (68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha) (Phosphatidylinositol 4-phosphate 5-kinase type I alpha) (PIP5KIalpha)

Gene: PI51A, PIP5K1A
Organism: Homo sapiens
Interactions: 136
UniProt ID: Q99755

Gene Ontology (top 5):
GO:0000285 - 1-phosphatidylinositol-3-phosphate 5-kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

817736

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

2

13

High-throughput

0.811

High

231400

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

2

13

High-throughput

0.789

High

863125

PGTB2
Geranylgeranyl transferase type-2 subunit beta

3

2

High-throughput

0.667

High

1306336

ARI1
E3 ubiquitin-protein ligase ARIH1

3

5

High-throughput

0.667

High

350484

RASK
GTPase KRas

2

3

High-throughput

0.646

High

566467

KPCA
Protein kinase C alpha type

2

2

High-throughput

0.628

High

596091

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

2

1

High-throughput

0.628

High

1039157

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

2

2

High-throughput

0.628

High

1191000

RHG22
Rho GTPase-activating protein 22

2

4

High-throughput

0.628

High

1201622

ZCH18
Zinc finger CCCH domain-containing protein 18

2

2

High-throughput

0.628

High

1293637

SAHH3
Adenosylhomocysteinase 3

2

6

High-throughput

0.628

High

1306311

KLDC3
Kelch domain-containing protein 3

2

1

High-throughput

0.628

High

1135383

PI5L1
Phosphatidylinositol 4-phosphate 5-kinase-like protein 1

1

12

Small-scale

0.618

High

224508

RAD21
Double-strand-break repair protein rad21 homolog

2

1

High-throughput

0.611

High

422564

CENPB
Major centromere autoantigen B

2

2

High-throughput

0.611

High

849065

GPC3
Glypican-3

2

1

High-throughput

0.611

High

975367

TGBR3
Transforming growth factor beta receptor type 3

2

1

High-throughput

0.611

High

1232563

STAG2
Cohesin subunit SA-2

2

1

High-throughput

0.611

High

1295339

DCAF5
DDB1- and CUL4-associated factor 5

2

2

High-throughput

0.611

High

1244890

GP156
Probable G-protein coupled receptor 156

2

0

High-throughput

0.602

High

1262052

KBTB7
Kelch repeat and BTB domain-containing protein 7

2

0

High-throughput

0.602

High

1290965

CCD97
Coiled-coil domain-containing protein 97

2

0

High-throughput

0.602

High

1306329

PFD2
Prefoldin subunit 2

2

0

High-throughput

0.602

High

155433

NRP1
Neuropilin-1

2

0

High-throughput

0.585

High

1306335

NRX3A
Neurexin-3

2

2

High-throughput

0.584

High

56716

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

13

High-throughput

0.575

High

1297519

ZSC31
Zinc finger and SCAN domain-containing protein 31

2

1

High-throughput

0.574

High

1306317

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

1

0

Small-scale

0.568

High

808242

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

5

Small-scale

0.561

High

51231

ZBT7C
Zinc finger and BTB domain-containing protein 7C

1

1

High-throughput

0.536

High

166008

PER2
Period circadian protein homolog 2

1

1

High-throughput

0.536

High

180426

MAGB2
Melanoma-associated antigen B2

1

1

High-throughput

0.536

High

243570

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.536

High

365033

FRIL
Ferritin light chain

1

3

High-throughput

0.536

High

455798

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.536

High

470519

H2A1
Histone H2A type 1

1

1

High-throughput

0.536

High

518751

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.536

High

672724

CD6
T-cell differentiation antigen CD6

1

3

High-throughput

0.536

High

970729

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

4

High-throughput

0.536

High

1029056

SRSF6
Serine/arginine-rich splicing factor 6

1

2

High-throughput

0.536

High

1040009

DGKZ
Diacylglycerol kinase zeta

1

2

High-throughput

0.536

High

1069488

TEBP
Prostaglandin E synthase 3

1

2

High-throughput

0.536

High

1132097

SNPC4
snRNA-activating protein complex subunit 4

1

1

High-throughput

0.536

High

1232783

PGBD5
PiggyBac transposable element-derived protein 5

1

1

High-throughput

0.536

High

1254027

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

1

3

High-throughput

0.536

High

1286807

ZN653
Zinc finger protein 653

1

1

High-throughput

0.536

High

1306322

MED4
Mediator of RNA polymerase II transcription subunit 4

1

3

High-throughput

0.536

High

1306332

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.536

High

1306334

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

2

High-throughput

0.536

High

515930

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.513

High

569007

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.513

High

649689

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

675850

GCH1
GTP cyclohydrolase 1

1

0

High-throughput

0.513

High

724982

MYH9
Myosin-9

1

0

High-throughput

0.513

High

908107

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

1078422

ZKSC8
Zinc finger protein with KRAB and SCAN domains 8

1

0

High-throughput

0.513

High

1082492

SNPC1
snRNA-activating protein complex subunit 1

1

0

High-throughput

0.513

High

1193026

ZN467
Zinc finger protein 467

1

0

High-throughput

0.513

High

1273187

SNPC3
snRNA-activating protein complex subunit 3

1

0

High-throughput

0.513

High

1306330

ITBP2
Integrin beta-1-binding protein 2

1

0

High-throughput

0.513

High

395572

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

1183519

RHOU
Rho-related GTP-binding protein RhoU

1

11

High-throughput

0.501

High

334365

AL1A1
Aldehyde dehydrogenase 1A1

1

0

High-throughput

0.493

High

1299902

CC85A
Coiled-coil domain-containing protein 85A

1

3

High-throughput

0.489

High

129826

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

3

High-throughput

0.479

High

212179

HTSF1
17S U2 SnRNP complex component HTATSF1

1

2

High-throughput

0.479

High

228480

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

295178

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

303444

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

323051

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

349593

RASH
GTPase HRas

1

1

High-throughput

0.479

High

391864

H2A1B
Histone H2A type 1-B/E

1

1

High-throughput

0.479

High

433968

LYN
Tyrosine-protein kinase Lyn

1

1

High-throughput

0.479

High

442427

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.479

High

507202

LAMP1
Lysosome-associated membrane glycoprotein 1

1

4

High-throughput

0.479

High

527745

LAMP2
Lysosome-associated membrane glycoprotein 2

1

4

High-throughput

0.479

High

542912

BRAF
Serine/threonine-protein kinase B-raf

1

3

High-throughput

0.479

High

545583

RAC2
Ras-related C3 botulinum toxin substrate 2

1

8

High-throughput

0.479

High

564659

RHOQ
Rho-related GTP-binding protein RhoQ

1

11

High-throughput

0.479

High

670174

MARCS
Myristoylated alanine-rich C-kinase substrate

1

2

High-throughput

0.479

High

793442

MUC18
Cell surface glycoprotein MUC18

1

1

High-throughput

0.479

High

892558

RAC3
Ras-related C3 botulinum toxin substrate 3

1

9

High-throughput

0.479

High

895240

RAB2A
Ras-related protein Rab-2A

1

2

High-throughput

0.479

High

909007

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

913069

ARF6
ADP-ribosylation factor 6

1

4

High-throughput

0.479

High

915918

RHOB
Rho-related GTP-binding protein RhoB

1

9

High-throughput

0.479

High

925559

RAC1
Ras-related C3 botulinum toxin substrate 1

1

9

High-throughput

0.479

High

951268

RHOG
Rho-related GTP-binding protein RhoG

1

7

High-throughput

0.479

High

1018184

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

5

High-throughput

0.479

High

1116488

LARP7
La-related protein 7

1

5

High-throughput

0.479

High

1152062

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

1203506

SKAP1
Src kinase-associated phosphoprotein 1

1

5

High-throughput

0.479

High

1224525

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

2

High-throughput

0.479

High

1296877

SNX27
Sorting nexin-27

1

4

High-throughput

0.479

High

1306313

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.479

High

1306316

RHOJ
Rho-related GTP-binding protein RhoJ

1

12

High-throughput

0.479

High

1306319

RHOF
Rho-related GTP-binding protein RhoF

1

12

High-throughput

0.479

High

1306320

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

5

Small-scale

0.479

High

1306323

TLR9
Toll-like receptor 9

1

1

Small-scale

0.479

High

1306325

MTMR4
Myotubularin-related protein 4

1

4

High-throughput

0.479

High

1306328

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1306333

FZR1
Fizzy-related protein homolog

1

2

High-throughput

0.479

High

178744

STX7
Syntaxin-7

1

0

High-throughput

0.458

High

338895

EGFR
Epidermal growth factor receptor

1

0

Small-scale

0.458

High

567238

CXA1
Gap junction alpha-1 protein

1

0

High-throughput

0.458

High

707728

H2B1B
Histone H2B type 1-B

1

0

High-throughput

0.458

High

940542

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.458

High

974992

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

1052926

FLNC
Filamin-C

1

0

High-throughput

0.458

High

1070363

RAB35
Ras-related protein Rab-35

1

0

High-throughput

0.458

High

1119604

MIDN
Midnolin

1

0

High-throughput

0.458

High

1239725

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1240944

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1289408

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

Small-scale

0.458

High

1306314

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

High-throughput

0.458

High

1306315

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.458

High

1306326

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

497499

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

1306321

NRX3B
Neurexin-3-beta

1

1

High-throughput

0.445

High

1306331

CAPS1
Calcium-dependent secretion activator 1

1

0

High-throughput

0.438

High

1306327

HECW2
E3 ubiquitin-protein ligase HECW2

1

5

High-throughput

0.437

High

1059352

CASP8
Caspase-8

1

0

High-throughput

0.426

High

1130493

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

1150274

TBC3G
TBC1 domain family member 3G

1

0

High-throughput

0.426

High

1166421

CLC4G
C-type lectin domain family 4 member G

1

0

Small-scale

0.426

High

1306318

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

1235362

KCD17
BTB/POZ domain-containing protein KCTD17

3

0

High-throughput

0.347

High

1306324

GFOD1
Glucose-fructose oxidoreductase domain-containing protein 1

3

0

High-throughput

0.347

High

1261081

TRI41
E3 ubiquitin-protein ligase TRIM41

2

0

High-throughput

0.318

High

300498

FRYL
Protein furry homolog-like

1

0

High-throughput

0.279

Low

1123883

RUN3A
RUN domain-containing protein 3A

1

0

High-throughput

0.279

Low

1166345

PXDC2
Plexin domain-containing protein 2

1

0

High-throughput

0.279

Low

1190561

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

1306312

TMED9
Transmembrane emp24 domain-containing protein 9

1

0

High-throughput

0.279

Low

1136249

RC3H1
Roquin-1

1

0

High-throughput

0.249

Low

1283042

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024