Protein: P66B
Transcriptional repressor p66-beta (GATA zinc finger domain-containing protein 2B) (p66/p68)

Gene: P66B, GATAD2B
Organism: Homo sapiens
Interactions: 212
UniProt ID: Q8WXI9

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000781 - chromosome, telomeric region
GO:0000785 - chromatin
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

328620

MBD3
Methyl-CpG-binding domain protein 3

12

7

Small-scale

0.981

High

1263987

MBD2
Methyl-CpG-binding domain protein 2

6

7

Small-scale

0.951

High

296089

MTA2
Metastasis-associated protein MTA2

6

5

Small-scale

0.944

High

1263964

MTA3
Metastasis-associated protein MTA3

5

5

High-throughput

0.927

High

1031915

MTA1
Metastasis-associated protein MTA1

5

5

Small-scale

0.919

High

1263068

MB3L1
Methyl-CpG-binding domain protein 3-like 1

3

7

High-throughput

0.861

High

1038577

HDAC1
Histone deacetylase 1

11

4

Small-scale

0.760

High

1263947

HDAC2
Histone deacetylase 2

10

4

Small-scale

0.756

High

997831

RBBP4
Histone-binding protein RBBP4

8

5

Small-scale

0.755

High

1083331

RBBP7
Histone-binding protein RBBP7

8

5

Small-scale

0.754

High

1059763

CHD4
Chromodomain-helicase-DNA-binding protein 4

8

13

Small-scale

0.749

High

1050729

FHL2
Four and a half LIM domains protein 2

2

0

High-throughput

0.742

High

146846

CDKA1
Cyclin-dependent kinase 2-associated protein 1

6

3

Small-scale

0.732

High

1018610

CHD3
Chromodomain-helicase-DNA-binding protein 3

5

13

High-throughput

0.718

High

1255035

CHD5
Chromodomain-helicase-DNA-binding protein 5

5

13

Small-scale

0.714

High

935042

H31
Histone H3.1

5

5

Small-scale

0.704

High

1246254

MB3L2
Methyl-CpG-binding domain protein 3-like 2

1

7

High-throughput

0.691

High

1263991

TRPS1
Zinc finger transcription factor Trps1

1

10

High-throughput

0.691

High

244708

BRD4
Bromodomain-containing protein 4

4

9

High-throughput

0.676

High

586884

CSK22
Casein kinase II subunit alpha'

3

5

High-throughput

0.667

High

934347

CSK21
Casein kinase II subunit alpha

3

5

High-throughput

0.667

High

1200809

ZBT46
Zinc finger and BTB domain-containing protein 46

3

8

High-throughput

0.667

High

1263986

ZN219
Zinc finger protein 219

3

1

High-throughput

0.667

High

974621

MECOM
Histone-lysine N-methyltransferase MECOM

3

4

High-throughput

0.656

High

228202

PRKN
E3 ubiquitin-protein ligase parkin

3

1

High-throughput

0.640

High

1263972

TXNIP
Thioredoxin-interacting protein

3

0

Small-scale

0.638

High

853667

IMA5
Importin subunit alpha-5

2

4

High-throughput

0.628

High

1263978

MAGE1
Melanoma-associated antigen E1

2

1

High-throughput

0.628

High

1087294

H2B2E
Histone H2B type 2-E

2

4

Small-scale

0.619

High

212478

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

0

High-throughput

0.618

High

68301

P20L1
PHD finger protein 20-like protein 1

2

1

High-throughput

0.611

High

470107

H2AZ
Histone H2A.Z

2

5

High-throughput

0.611

High

1021139

FOXC1
Forkhead box protein C1

2

2

High-throughput

0.611

High

1263953

Z512B
Zinc finger protein 512B

2

2

High-throughput

0.611

High

1263982

SALL1
Sal-like protein 1

2

6

High-throughput

0.611

High

330580

ZBED1
E3 SUMO-protein ligase ZBED1

2

0

High-throughput

0.602

High

1023740

TRAF1
TNF receptor-associated factor 1

2

0

High-throughput

0.601

High

917659

H4
Histone H4

2

1

Small-scale

0.595

High

976485

ERCC6
DNA excision repair protein ERCC-6

2

15

Small-scale

0.595

High

1205784

P66A
Transcriptional repressor p66-alpha

1

0

High-throughput

0.586

High

178983

FOXP2
Forkhead box protein P2

2

7

Small-scale

0.584

High

268195

EED
Polycomb protein EED

2

3

High-throughput

0.584

High

631527

BRD2
Bromodomain-containing protein 2

2

7

High-throughput

0.584

High

1063518

SUZ12
Polycomb protein SUZ12

2

1

High-throughput

0.584

High

1080168

EZH2
Histone-lysine N-methyltransferase EZH2

2

2

High-throughput

0.584

High

1263971

FOXP1
Forkhead box protein P1

2

5

Small-scale

0.584

High

877495

CDN2D
Cyclin-dependent kinase 4 inhibitor D

2

0

High-throughput

0.580

High

1234222

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

2

0

High-throughput

0.580

High

1264003

NDK7
Nucleoside diphosphate kinase homolog 7

2

0

High-throughput

0.580

High

902688

SUMO2
Small ubiquitin-related modifier 2

2

0

High-throughput

0.577

High

1218255

F219A
Protein FAM219A

2

1

High-throughput

0.574

High

1263977

CPNE5
Copine-5

2

1

High-throughput

0.574

High

370097

ESR1
Estrogen receptor

2

7

High-throughput

0.571

High

312078

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

7

Small-scale

0.549

High

536955

TRI27
Zinc finger protein RFP

1

0

High-throughput

0.549

High

1025483

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.549

High

498318

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

0

High-throughput

0.547

High

51228

ZBT7C
Zinc finger and BTB domain-containing protein 7C

1

5

High-throughput

0.536

High

134938

IMA3
Importin subunit alpha-3

1

4

High-throughput

0.536

High

157063

AIM2
Interferon-inducible protein AIM2

1

1

High-throughput

0.536

High

208925

FOXS1
Forkhead box protein S1

1

2

High-throughput

0.536

High

317998

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

3

High-throughput

0.536

High

509070

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.536

High

795779

MAGA3
Melanoma-associated antigen 3

1

1

High-throughput

0.536

High

877625

FOXG1
Forkhead box protein G1

1

3

High-throughput

0.536

High

881239

CTBP2
C-terminal-binding protein 2

1

2

High-throughput

0.536

High

898983

PSME3
Proteasome activator complex subunit 3

1

1

High-throughput

0.536

High

929948

ACTG
Actin, cytoplasmic 2

1

2

High-throughput

0.536

High

1033687

IKZF1
DNA-binding protein Ikaros

1

3

High-throughput

0.536

High

1089315

ZN827
Zinc finger protein 827

1

4

Small-scale

0.536

High

1263946

THRSP
Thyroid hormone-inducible hepatic protein

1

1

High-throughput

0.536

High

1263951

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

2

High-throughput

0.536

High

1263967

FOXQ1
Forkhead box protein Q1

1

4

High-throughput

0.536

High

1263968

BC11B
B-cell lymphoma/leukemia 11B

1

3

High-throughput

0.536

High

1263979

HM20A
High mobility group protein 20A

1

10

High-throughput

0.536

High

1263985

FOXJ2
Forkhead box protein J2

1

4

High-throughput

0.536

High

1263989

TCF20
Transcription factor 20

1

1

High-throughput

0.536

High

1263992

SALL4
Sal-like protein 4

1

6

High-throughput

0.536

High

1263995

IKZF3
Zinc finger protein Aiolos

1

3

High-throughput

0.536

High

1263996

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

7

High-throughput

0.536

High

1220792

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.529

High

995089

GOGA2
Golgin subfamily A member 2

1

1

High-throughput

0.523

High

1236661

USBP1
Harmonin-binding protein USHBP1

1

1

High-throughput

0.523

High

1263954

RPGR1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

1

1

High-throughput

0.523

High

508632

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

515610

SRF
Serum response factor

1

0

High-throughput

0.513

High

804300

NOTC1
Neurogenic locus notch homolog protein 1

1

0

High-throughput

0.513

High

871700

HSP72
Heat shock-related 70 kDa protein 2

1

0

High-throughput

0.513

High

1022954

CDC16
Cell division cycle protein 16 homolog

1

0

High-throughput

0.513

High

1152368

CNDH2
Condensin-2 complex subunit H2

1

0

High-throughput

0.513

High

1241287

ZN784
Zinc finger protein 784

1

0

High-throughput

0.513

High

1263961

PARK7
Parkinson disease protein 7

1

0

Small-scale

0.513

High

1263997

TCF19
Transcription factor 19

1

0

High-throughput

0.513

High

1087067

H2A2C
Histone H2A type 2-C

1

3

Small-scale

0.501

High

1263949

STMN2
Stathmin-2

1

1

High-throughput

0.489

High

1078599

SMAD2
Mothers against decapentaplegic homolog 2

1

0

High-throughput

0.486

High

158833

HAT1
Histone acetyltransferase type B catalytic subunit

1

1

High-throughput

0.479

High

168659

IMA6
Importin subunit alpha-6

1

4

High-throughput

0.479

High

179747

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

2

High-throughput

0.479

High

182845

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

198024

PHF1
PHD finger protein 1

1

3

High-throughput

0.479

High

229451

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

13

High-throughput

0.479

High

257812

SIN3B
Paired amphipathic helix protein Sin3b

1

5

High-throughput

0.479

High

260950

H2AY
Core histone macro-H2A.1

1

5

High-throughput

0.479

High

265233

SAP30
Histone deacetylase complex subunit SAP30

1

1

High-throughput

0.479

High

279812

CDKA2
Cyclin-dependent kinase 2-associated protein 2

1

3

Small-scale

0.479

High

295063

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

301943

TRI37
E3 ubiquitin-protein ligase TRIM37

1

3

High-throughput

0.479

High

303382

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

331854

NSD2
Histone-lysine N-methyltransferase NSD2

1

4

Small-scale

0.479

High

347449

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

387197

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

455703

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

486939

MYBB
Myb-related protein B

1

2

High-throughput

0.479

High

487617

ANDR
Androgen receptor

1

7

High-throughput

0.479

High

553299

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

555563

H2AX
Histone H2AX

1

5

High-throughput

0.479

High

569906

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

651804

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

658713

SMCA1
Probable global transcription activator SNF2L1

1

13

High-throughput

0.479

High

668859

PML
Protein PML

1

1

High-throughput

0.479

High

721027

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

727900

SOX6
Transcription factor SOX-6

1

15

High-throughput

0.479

High

749717

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

779815

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

802465

ATRX
Transcriptional regulator ATRX

1

12

Small-scale

0.479

High

818302

SOX2
Transcription factor SOX-2

1

14

High-throughput

0.479

High

828322

CENPA
Histone H3-like centromeric protein A

1

5

High-throughput

0.479

High

831524

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.479

High

884211

KLF3
Krueppel-like factor 3

1

4

High-throughput

0.479

High

885381

LOXL3
Lysyl oxidase homolog 3

1

2

Small-scale

0.479

High

918556

H2B1C
Histone H2B type 1-C/E/F/G/I

1

4

High-throughput

0.479

High

931765

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.479

High

952503

H33
Histone H3.3

1

5

High-throughput

0.479

High

964375

RUNX1
Runt-related transcription factor 1

1

1

High-throughput

0.479

High

1017330

BPTF
Nucleosome-remodeling factor subunit BPTF

1

18

High-throughput

0.479

High

1022155

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

1024494

CAF1A
Chromatin assembly factor 1 subunit A

1

2

High-throughput

0.479

High

1024572

CAF1B
Chromatin assembly factor 1 subunit B

1

2

High-throughput

0.479

High

1026494

RFA4
Replication protein A 30 kDa subunit

1

2

High-throughput

0.479

High

1035261

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

2

High-throughput

0.479

High

1061769

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

15

High-throughput

0.479

High

1067070

BRD3
Bromodomain-containing protein 3

1

9

High-throughput

0.479

High

1117677

ARI4B
AT-rich interactive domain-containing protein 4B

1

3

High-throughput

0.479

High

1119823

LIN52
Protein lin-52 homolog

1

1

High-throughput

0.479

High

1129637

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

3

High-throughput

0.479

High

1137035

LIN9
Protein lin-9 homolog

1

1

High-throughput

0.479

High

1153883

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.479

High

1171014

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1188628

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1217547

FOXP4
Forkhead box protein P4

1

8

Small-scale

0.479

High

1221059

BAP18
Chromatin complexes subunit BAP18

1

1

High-throughput

0.479

High

1221603

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

1222486

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.479

High

1235578

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

2

High-throughput

0.479

High

1241353

HJURP
Holliday junction recognition protein

1

1

High-throughput

0.479

High

1243538

CSK23
Casein kinase II subunit alpha 3

1

5

High-throughput

0.479

High

1260523

GATD1
GATA zinc finger domain-containing protein 1

1

1

High-throughput

0.479

High

1263945

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

1263948

KAT2B
Histone acetyltransferase KAT2B

1

9

Small-scale

0.479

High

1263952

LIN37
Protein lin-37 homolog

1

1

High-throughput

0.479

High

1263955

PWP2A
PWWP domain-containing protein 2A

1

1

High-throughput

0.479

High

1263956

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

8

Small-scale

0.479

High

1263957

PHF12
PHD finger protein 12

1

10

High-throughput

0.479

High

1263958

CIC
Protein capicua homolog

1

10

High-throughput

0.479

High

1263959

SIN3A
Paired amphipathic helix protein Sin3a

1

5

High-throughput

0.479

High

1263960

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

1263962

TBX5
T-box transcription factor TBX5

1

3

High-throughput

0.479

High

1263963

MEP50
Methylosome protein WDR77

1

1

High-throughput

0.479

High

1263966

DPY30
Protein dpy-30 homolog

1

1

High-throughput

0.479

High

1263969

SP130
Histone deacetylase complex subunit SAP130

1

4

High-throughput

0.479

High

1263970

BC11A
B-cell lymphoma/leukemia 11A

1

3

High-throughput

0.479

High

1263975

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

3

High-throughput

0.479

High

1263976

PRD16
Histone-lysine N-methyltransferase PRDM16

1

4

High-throughput

0.479

High

1263983

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1263984

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1263988

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1263998

ASF1A
Histone chaperone ASF1A

1

1

High-throughput

0.479

High

1264001

MTF2
Metal-response element-binding transcription factor 2

1

3

High-throughput

0.479

High

1263950

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.460

High

385247

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

1116416

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

1174267

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

1198042

KAISO
Transcriptional regulator Kaiso

1

0

High-throughput

0.458

High

1236401

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

Small-scale

0.458

High

1263965

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

1263999

ZBTB1
Zinc finger and BTB domain-containing protein 1

1

0

Small-scale

0.458

High

1039725

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.445

High

1241762

RN169
E3 ubiquitin-protein ligase RNF169

1

1

Small-scale

0.445

High

932289

ACTC
Actin, alpha cardiac muscle 1

1

2

High-throughput

0.437

High

995489

LOXL1
Lysyl oxidase homolog 1

1

2

Small-scale

0.437

High

1199655

ZN598
E3 ubiquitin-protein ligase ZNF598

1

2

High-throughput

0.437

High

1263973

FBX44
F-box only protein 44

1

1

Small-scale

0.437

High

1263974

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1263990

HMGX4
HMG domain-containing protein 4

1

12

High-throughput

0.437

High

1263993

DP13A
DCC-interacting protein 13-alpha

1

0

Small-scale

0.426

High

657681

LYOX
Protein-lysine 6-oxidase

1

2

Small-scale

0.417

High

1070084

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

2

0

High-throughput

0.328

High

1263981

DISC1
Disrupted in schizophrenia 1 protein

2

0

High-throughput

0.316

High

471696

SBK3
Uncharacterized serine/threonine-protein kinase SBK3

2

0

High-throughput

0.316

High

1199958

NOXA1
NADPH oxidase activator 1

2

0

High-throughput

0.316

High

1263980

NGB
Neuroglobin

2

0

High-throughput

0.316

High

1264002

GPSM3
G-protein-signaling modulator 3

2

0

High-throughput

0.316

High

1223112

TEX11
Testis-expressed protein 11

1

0

High-throughput

0.299

High

1245718

CEP70
Centrosomal protein of 70 kDa

1

0

High-throughput

0.299

High

176830

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

High-throughput

0.279

Low

1263994

OCTC
Peroxisomal carnitine O-octanoyltransferase

1

0

High-throughput

0.279

Low

1264000

EMC9
ER membrane protein complex subunit 9

1

0

High-throughput

0.279

Low

815906

MTR1A
Melatonin receptor type 1A

1

0

High-throughput

0.265

Low

149116

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

1163764

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.249

Low

1255290

MIPT3
TRAF3-interacting protein 1

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024