Protein: SUV91
Histone-lysine N-methyltransferase SUV39H1 (EC 2.1.1.355) (Histone H3-K9 methyltransferase 1) (H3-K9-HMTase 1) (Lysine N-methyltransferase 1A) (Position-effect variegation 3-9 homolog) (Suppressor of variegation 3-9 homolog 1) (Su(var)3-9 homolog 1)

Gene: SUV91, SUV39H1
Organism: Homo sapiens
Interactions: 238
UniProt ID: O43463

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000183 - rDNA heterochromatin formation
GO:0000775 - chromosome, centromeric region
GO:0000792 - heterochromatin
GO:0000794 - condensed nuclear chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

203638

CBX5
Chromobox protein homolog 5

13

20

Small-scale

0.985

High

203659

H31
Histone H3.1

7

20

Small-scale

0.957

High

203674

CBX3
Chromobox protein homolog 3

5

20

High-throughput

0.931

High

203662

CBX1
Chromobox protein homolog 1

5

20

Small-scale

0.926

High

203690

SETB1
Histone-lysine N-methyltransferase SETDB1

4

16

Small-scale

0.899

High

203794

EHMT1
Histone-lysine N-methyltransferase EHMT1

3

14

Small-scale

0.861

High

123140

CBX4
E3 SUMO-protein ligase CBX4

2

20

Small-scale

0.844

High

203766

EHMT2
Histone-lysine N-methyltransferase EHMT2

2

14

Small-scale

0.811

High

203747

TRI41
E3 ubiquitin-protein ligase TRIM41

2

2

High-throughput

0.783

High

203664

H33
Histone H3.3

2

20

Small-scale

0.768

High

203628

DNMT1
DNA

2

12

Small-scale

0.754

High

203693

EZH2
Histone-lysine N-methyltransferase EZH2

1

15

High-throughput

0.740

High

203703

PHF19
PHD finger protein 19

1

8

High-throughput

0.740

High

203704

DCAF8
DDB1- and CUL4-associated factor 8

1

7

High-throughput

0.740

High

203822

DNM3A
DNA

1

9

Small-scale

0.724

High

203603

H2AY
Core histone macro-H2A.1

1

6

High-throughput

0.691

High

203687

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

4

High-throughput

0.691

High

203696

H2A2C
Histone H2A type 2-C

1

4

High-throughput

0.691

High

203730

H2A2B
Histone H2A type 2-B

1

4

High-throughput

0.691

High

203777

LZTS2
Leucine zipper putative tumor suppressor 2

3

3

High-throughput

0.675

High

203823

V9HWG0
Epididymis luminal protein 25

1

20

High-throughput

0.665

High

203670

MECOM
Histone-lysine N-methyltransferase MECOM

3

5

Small-scale

0.664

High

203756

SPSB1
SPRY domain-containing SOCS box protein 1

1

1

High-throughput

0.662

High

203711

H3C
Histone H3.3C

1

20

High-throughput

0.656

High

203734

WDFY3
WD repeat and FYVE domain-containing protein 3

1

2

High-throughput

0.656

High

203819

MTF2
Metal-response element-binding transcription factor 2

1

8

High-throughput

0.656

High

203597

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

14

Small-scale

0.647

High

203672

RBBP4
Histone-binding protein RBBP4

1

12

Small-scale

0.647

High

203695

RBBP7
Histone-binding protein RBBP7

1

12

Small-scale

0.647

High

203722

H32
Histone H3.2

1

20

Small-scale

0.647

High

203801

DNM3B
DNA

1

9

Small-scale

0.647

High

203759

HOOK2
Protein Hook homolog 2

4

1

High-throughput

0.642

High

203666

MDM2
E3 ubiquitin-protein ligase Mdm2

3

1

Small-scale

0.640

High

203668

RUNX1
Runt-related transcription factor 1

2

2

Small-scale

0.639

High

203679

HDAC1
Histone deacetylase 1

2

11

Small-scale

0.634

High

203750

HDAC2
Histone deacetylase 2

2

11

Small-scale

0.634

High

203758

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

4

Small-scale

0.634

High

203601

MAGC1
Melanoma-associated antigen C1

2

4

High-throughput

0.628

High

203705

DDI2
Protein DDI1 homolog 2

2

1

High-throughput

0.628

High

203719

MCAF1
Activating transcription factor 7-interacting protein 1

2

4

High-throughput

0.628

High

203721

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

2

5

High-throughput

0.628

High

203753

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

2

5

High-throughput

0.628

High

203791

ZN644
Zinc finger protein 644

2

11

High-throughput

0.628

High

203811

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

2

5

High-throughput

0.628

High

203615

RB
Retinoblastoma-associated protein

2

3

Small-scale

0.624

High

203680

CUL4B
Cullin-4B

2

5

Small-scale

0.624

High

203694

DDB1
DNA damage-binding protein 1

2

2

Small-scale

0.624

High

203735

DAW1
Dynein assembly factor with WD repeat domains 1

1

4

High-throughput

0.618

High

203602

H2B1K
Histone H2B type 1-K

1

12

High-throughput

0.618

High

203676

TIF1B
Transcription intermediary factor 1-beta

1

7

Small-scale

0.618

High

203773

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

6

Small-scale

0.618

High

203655

KR107
Keratin-associated protein 10-7

3

1

High-throughput

0.616

High

203724

ZN438
Zinc finger protein 438

2

5

High-throughput

0.606

High

203738

ZBTB2
Zinc finger and BTB domain-containing protein 2

2

3

High-throughput

0.606

High

203742

ZN417
Zinc finger protein 417

2

1

High-throughput

0.606

High

203764

PP16A
Protein phosphatase 1 regulatory subunit 16A

2

1

High-throughput

0.606

High

203804

ZRAN1
Ubiquitin thioesterase ZRANB1

2

1

High-throughput

0.606

High

203689

ABRX2
BRISC complex subunit Abraxas 2

2

0

High-throughput

0.602

High

203780

MCMBP
Mini-chromosome maintenance complex-binding protein

2

0

High-throughput

0.602

High

203796

M1IP1
Mid1-interacting protein 1

2

0

High-throughput

0.602

High

203803

DAXX
Death domain-associated protein 6

2

0

Small-scale

0.585

High

203716

PADI6
Protein-arginine deiminase type-6

2

0

High-throughput

0.580

High

203748

TEKT4
Tektin-4

2

0

High-throughput

0.580

High

203807

MBD1
Methyl-CpG-binding domain protein 1

1

6

Small-scale

0.578

High

203706

H37
Histone H3-7

1

20

High-throughput

0.575

High

203788

ENKD1
Enkurin domain-containing protein 1

2

1

High-throughput

0.574

High

203616

HXC4
Homeobox protein Hox-C4

1

3

High-throughput

0.573

High

203641

HXA1
Homeobox protein Hox-A1

1

2

High-throughput

0.573

High

203643

CLK3
Dual specificity protein kinase CLK3

1

2

High-throughput

0.573

High

203646

RASF2
Ras association domain-containing protein 2

1

2

High-throughput

0.573

High

203667

U2AF1
Splicing factor U2AF 35 kDa subunit

1

1

High-throughput

0.573

High

203673

NR1H3
Oxysterols receptor LXR-alpha

1

20

High-throughput

0.573

High

203737

STX19
Syntaxin-19

1

1

High-throughput

0.573

High

203778

ZN649
Zinc finger protein 649

1

1

High-throughput

0.573

High

203779

ZN670
Zinc finger protein 670

1

6

High-throughput

0.573

High

203782

CDCA4
Cell division cycle-associated protein 4

1

1

High-throughput

0.573

High

203798

RASF1
Ras association domain-containing protein 1

1

2

High-throughput

0.573

High

177134

HDAC3
Histone deacetylase 3

1

12

Small-scale

0.561

High

203619

MYOD1
Myoblast determination protein 1

1

7

Small-scale

0.561

High

203821

CABIN
Calcineurin-binding protein cabin-1

1

5

Small-scale

0.561

High

203786

BC11B
B-cell lymphoma/leukemia 11B

1

0

Small-scale

0.554

High

62248

GG6L9
Golgin subfamily A member 6-like protein 9

2

3

High-throughput

0.553

High

203656

KR108
Keratin-associated protein 10-8

2

1

High-throughput

0.553

High

203752

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

4

High-throughput

0.553

High

203708

TENS2
Tensin-2

2

0

High-throughput

0.551

High

203743

RIN3
Ras and Rab interactor 3

2

0

High-throughput

0.551

High

203608

ATE1
Arginyl-tRNA--protein transferase 1

1

0

High-throughput

0.549

High

203657

PRS4
26S proteasome regulatory subunit 4

1

0

High-throughput

0.549

High

203720

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

0

High-throughput

0.549

High

203785

ZN436
Zinc finger protein 436

1

0

High-throughput

0.549

High

203799

GPT2L
G patch domain-containing protein 2-like

1

0

High-throughput

0.549

High

203816

ZKSC5
Zinc finger protein with KRAB and SCAN domains 5

1

0

High-throughput

0.549

High

203611

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.536

High

203623

TCPA
T-complex protein 1 subunit alpha

1

10

High-throughput

0.536

High

203647

TCPQ
T-complex protein 1 subunit theta

1

14

High-throughput

0.536

High

203648

TCPD
T-complex protein 1 subunit delta

1

9

High-throughput

0.536

High

203688

NUMA1
Nuclear mitotic apparatus protein 1

1

4

High-throughput

0.536

High

203731

MGAP
MAX gene-associated protein

1

1

High-throughput

0.536

High

203755

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

5

High-throughput

0.536

High

203776

KLDC3
Kelch domain-containing protein 3

1

4

High-throughput

0.536

High

203805

PARP2
Poly [ADP-ribose] polymerase 2

1

2

High-throughput

0.536

High

60663

ODAD3
Outer dynein arm-docking complex subunit 3

1

2

High-throughput

0.523

High

203712

CH074
Uncharacterized protein C8orf74

1

1

High-throughput

0.523

High

203745

KLDC4
Kelch domain-containing protein 4

1

4

High-throughput

0.523

High

203741

CEP70
Centrosomal protein of 70 kDa

1

1

High-throughput

0.523

High

203691

Q15156
PML-RAR protein

1

20

Small-scale

0.515

High

203651

RD23A
UV excision repair protein RAD23 homolog A

1

3

High-throughput

0.515

High

203726

Q86V38
Atrophin 1

1

3

High-throughput

0.515

High

203598

ZN292
Zinc finger protein 292

1

0

High-throughput

0.513

High

203626

AKAP5
A-kinase anchor protein 5

1

0

High-throughput

0.513

High

203629

S10A4
Protein S100-A4

1

0

High-throughput

0.513

High

203650

KIF11
Kinesin-like protein KIF11

1

0

High-throughput

0.513

High

203661

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

203783

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.513

High

203793

ARMT1
Damage-control phosphatase ARMT1

1

0

High-throughput

0.513

High

195993

RRP8
Ribosomal RNA-processing protein 8

1

0

Small-scale

0.512

High

182400

ZSC9
Zinc finger and SCAN domain-containing protein 9

1

2

High-throughput

0.508

High

196539

ZBT24
Zinc finger and BTB domain-containing protein 24

1

4

High-throughput

0.508

High

203599

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.508

High

203605

STX11
Syntaxin-11

1

1

High-throughput

0.508

High

203606

MBD4
Methyl-CpG-binding domain protein 4

1

3

High-throughput

0.508

High

203610

WIZ
Protein Wiz

1

10

High-throughput

0.508

High

203614

FYN
Tyrosine-protein kinase Fyn

1

2

High-throughput

0.508

High

203624

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

2

High-throughput

0.508

High

203633

FUS
RNA-binding protein FUS

1

5

High-throughput

0.508

High

203637

ID1
DNA-binding protein inhibitor ID-1

1

2

High-throughput

0.508

High

203644

ZN165
Zinc finger protein 165

1

3

High-throughput

0.508

High

203652

NR1H2
Oxysterols receptor LXR-beta

1

20

High-throughput

0.508

High

203669

ID2
DNA-binding protein inhibitor ID-2

1

2

High-throughput

0.508

High

203682

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

1

1

High-throughput

0.508

High

203684

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

1

4

High-throughput

0.508

High

203710

LHX8
LIM/homeobox protein Lhx8

1

9

High-throughput

0.508

High

203733

SLN12
Ribonuclease SLFN12

1

2

High-throughput

0.508

High

203746

BAHD1
Bromo adjacent homology domain-containing 1 protein

1

2

High-throughput

0.508

High

203769

LENG8
Leukocyte receptor cluster member 8

1

1

High-throughput

0.508

High

203795

ZCC17
Zinc finger CCHC domain-containing protein 17

1

1

High-throughput

0.508

High

203806

KLF15
Krueppel-like factor 15

1

18

High-throughput

0.508

High

203808

CDC23
Cell division cycle protein 23 homolog

1

1

High-throughput

0.508

High

203810

ING4
Inhibitor of growth protein 4

1

1

High-throughput

0.508

High

203820

ZN451
E3 SUMO-protein ligase ZNF451

1

3

High-throughput

0.508

High

203613

ESR1
Estrogen receptor

1

20

Small-scale

0.501

High

203618

THA
Thyroid hormone receptor alpha

1

20

Small-scale

0.501

High

203685

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

3

Small-scale

0.500

High

203635

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.493

High

203751

KLK6
Kallikrein-6

1

0

High-throughput

0.493

High

203612

FRIL
Ferritin light chain

1

1

High-throughput

0.489

High

203636

TCPZ
T-complex protein 1 subunit zeta

1

9

High-throughput

0.489

High

203639

TCPE
T-complex protein 1 subunit epsilon

1

12

High-throughput

0.489

High

203640

TCPG
T-complex protein 1 subunit gamma

1

12

High-throughput

0.489

High

203660

TCPB
T-complex protein 1 subunit beta

1

11

High-throughput

0.489

High

203775

TCPH
T-complex protein 1 subunit eta

1

12

High-throughput

0.489

High

203621

TMM11
Transmembrane protein 11, mitochondrial

1

0

High-throughput

0.486

High

203642

PRI2
DNA primase large subunit

1

0

High-throughput

0.486

High

203702

TEX35
Testis-expressed protein 35

1

0

High-throughput

0.486

High

203714

T2H2L
General transcription factor IIH subunit 2-like protein

1

0

High-throughput

0.486

High

203715

FOXR2
Forkhead box protein R2

1

0

High-throughput

0.486

High

203725

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.486

High

203727

SPA24
Spermatogenesis-associated protein 24

1

0

High-throughput

0.486

High

203740

DBF4B
Protein DBF4 homolog B

1

0

High-throughput

0.486

High

203760

MCRS1
Microspherule protein 1

1

0

High-throughput

0.486

High

203762

CDA7L
Cell division cycle-associated 7-like protein

1

0

High-throughput

0.486

High

203763

MSD3
Myb/SANT-like DNA-binding domain-containing protein 3

1

0

High-throughput

0.486

High

203767

ANM6
Protein arginine N-methyltransferase 6

1

0

High-throughput

0.486

High

203768

FRMD6
FERM domain-containing protein 6

1

0

High-throughput

0.486

High

203771

CRBN
Protein cereblon

1

0

High-throughput

0.486

High

203772

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

0

High-throughput

0.486

High

203784

LDH6B
L-lactate dehydrogenase A-like 6B

1

0

High-throughput

0.486

High

203787

INT2
Integrator complex subunit 2

1

0

High-throughput

0.486

High

203802

MALT1
Mucosa-associated lymphoid tissue lymphoma translocation protein 1

1

0

High-throughput

0.486

High

203739

ZN557
Zinc finger protein 557

1

3

High-throughput

0.481

High

203800

ZN581
Zinc finger protein 581

1

4

High-throughput

0.481

High

203609

HERC2
E3 ubiquitin-protein ligase HERC2

1

3

High-throughput

0.479

High

203617

RARA
Retinoic acid receptor alpha

1

20

Small-scale

0.479

High

203622

TAL1
T-cell acute lymphocytic leukemia protein 1

1

5

Small-scale

0.479

High

203627

MCM3
DNA replication licensing factor MCM3

1

2

High-throughput

0.479

High

203630

RBL1
Retinoblastoma-like protein 1

1

3

Small-scale

0.479

High

203631

PML
Protein PML

1

7

Small-scale

0.479

High

203649

MECP2
Methyl-CpG-binding protein 2

1

6

Small-scale

0.479

High

203653

HDAC4
Histone deacetylase 4

1

14

Small-scale

0.479

High

203663

SMAD3
Mothers against decapentaplegic homolog 3

1

6

Small-scale

0.479

High

203665

VIGLN
Vigilin

1

2

Small-scale

0.479

High

203671

RBL2
Retinoblastoma-like protein 2

1

3

Small-scale

0.479

High

203675

STK3
Serine/threonine-protein kinase 3

1

2

High-throughput

0.479

High

203678

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

3

Small-scale

0.479

High

203681

RUNX3
Runt-related transcription factor 3

1

2

Small-scale

0.479

High

203683

RUNX2
Runt-related transcription factor 2

1

2

Small-scale

0.479

High

203686

MCM6
DNA replication licensing factor MCM6

1

2

High-throughput

0.479

High

203700

ESCO2
N-acetyltransferase ESCO2

1

3

Small-scale

0.479

High

203701

ESCO1
N-acetyltransferase ESCO1

1

3

Small-scale

0.479

High

203707

GFI1B
Zinc finger protein Gfi-1b

1

7

Small-scale

0.479

High

203713

CDC73
Parafibromin

1

1

Small-scale

0.479

High

203723

SPT6H
Transcription elongation factor SPT6

1

3

High-throughput

0.479

High

203729

PHF13
PHD finger protein 13

1

1

Small-scale

0.479

High

203732

PHC2
Polyhomeotic-like protein 2

1

3

High-throughput

0.479

High

203749

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

203754

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

5

Small-scale

0.479

High

203770

PRAM
PML-RARA-regulated adapter molecule 1

1

5

Small-scale

0.479

High

203774

SMAD5
Mothers against decapentaplegic homolog 5

1

6

Small-scale

0.479

High

203809

TPX2
Targeting protein for Xklp2

1

1

High-throughput

0.479

High

203814

HDAC5
Histone deacetylase 5

1

14

Small-scale

0.479

High

203815

RUVB2
RuvB-like 2

1

2

Small-scale

0.479

High

203697

ZN829
Zinc finger protein 829

1

3

High-throughput

0.464

High

203698

CP100
Cilia- and flagella-associated protein 100

1

1

High-throughput

0.464

High

203744

LNX1
E3 ubiquitin-protein ligase LNX

1

3

High-throughput

0.464

High

203600

BRNP1
BMP/retinoic acid-inducible neural-specific protein 1

1

0

Small-scale

0.458

High

203632

CTNB1
Catenin beta-1

1

0

Small-scale

0.458

High

203634

AHR
Aryl hydrocarbon receptor

1

0

Small-scale

0.458

High

203658

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

203736

CCAR2
Cell cycle and apoptosis regulator protein 2

1

0

Small-scale

0.458

High

203757

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

203761

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

High-throughput

0.458

High

203789

FA83D
Protein FAM83D

1

0

High-throughput

0.458

High

203812

SATB2
DNA-binding protein SATB2

1

0

High-throughput

0.458

High

203813

PA2G4
Proliferation-associated protein 2G4

1

0

Small-scale

0.458

High

203709

ZNF57
Zinc finger protein 57

1

1

High-throughput

0.457

High

56568

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

2

High-throughput

0.445

High

148166

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.437

High

203781

GTPB2
GTP-binding protein 2

1

0

High-throughput

0.299

High

203604

SG2A1
Mammaglobin-B

1

0

High-throughput

0.279

Low

203677

PHLP
Phosducin-like protein

1

0

High-throughput

0.279

Low

203797

PYRG2
CTP synthase 2

1

0

High-throughput

0.279

Low

203645

SERPH
Serpin H1

1

0

High-throughput

0.268

Low

200195

SRGP3
SLIT-ROBO Rho GTPase-activating protein 3

1

0

High-throughput

0.265

Low

203620

VATB1
V-type proton ATPase subunit B, kidney isoform

1

0

High-throughput

0.265

Low

203625

IBP4
Insulin-like growth factor-binding protein 4

1

0

High-throughput

0.265

Low

203654

ELOF1
Transcription elongation factor 1 homolog

1

0

High-throughput

0.265

Low

203699

CD017
Uncharacterized protein C4orf17

1

0

High-throughput

0.265

Low

203717

CREL2
Protein disulfide isomerase CRELD2

1

0

High-throughput

0.265

Low

203718

RSPO2
R-spondin-2

1

0

High-throughput

0.265

Low

203728

CQ082
Putative uncharacterized protein LINC02875

1

0

High-throughput

0.265

Low

203765

LOXL4
Lysyl oxidase homolog 4

1

0

High-throughput

0.265

Low

203792

OPA3
Optic atrophy 3 protein

1

0

High-throughput

0.265

Low

203817

KLH20
Kelch-like protein 20

1

0

High-throughput

0.265

Low

203818

MTO1
Protein MTO1 homolog, mitochondrial

1

0

High-throughput

0.265

Low

203692

K1H1
Keratin, type I cuticular Ha1

1

0

High-throughput

0.251

Low

203607

MTMR5
Myotubularin-related protein 5

1

0

Small-scale

0.249

Low

203790

FBX44
F-box only protein 44

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024