Protein: ORC1
Origin recognition complex subunit 1 (Replication control protein 1)

Gene: ORC1
Organism: Homo sapiens
Interactions: 84
UniProt ID: Q13415

Gene Ontology (top 5):
GO:0000781 - chromosome, telomeric region
GO:0000808 - origin recognition complex
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0003688 - DNA replication origin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1033376

ORC2
Origin recognition complex subunit 2

11

13

Small-scale

0.979

High

217257

ORC5
Origin recognition complex subunit 5

7

19

Small-scale

0.966

High

1033405

ORC3
Origin recognition complex subunit 3

6

13

Small-scale

0.949

High

217798

ORC4
Origin recognition complex subunit 4

5

13

Small-scale

0.921

High

1033398

CDC6
Cell division control protein 6 homolog

3

15

Small-scale

0.882

High

917216

H4
Histone H4

3

7

Small-scale

0.814

High

1033387

H2B2E
Histone H2B type 2-E

2

7

Small-scale

0.789

High

590177

CCNA2
Cyclin-A2

6

7

Small-scale

0.736

High

777978

RFC3
Replication factor C subunit 3

1

7

High-throughput

0.691

High

1033395

PHF3
PHD finger protein 3

1

2

High-throughput

0.691

High

1033383

TERF2
Telomeric repeat-binding factor 2

3

1

Small-scale

0.672

High

1033382

ELOB
Elongin-B

1

0

High-throughput

0.656

High

625409

CDK2
Cyclin-dependent kinase 2

2

12

Small-scale

0.639

High

475021

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

15

Small-scale

0.618

High

1033375

ORC1
Origin recognition complex subunit 1

1

16

Small-scale

0.618

High

1033386

H2A2C
Histone H2A type 2-C

1

5

Small-scale

0.618

High

1033407

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

2

2

Small-scale

0.611

High

1031186

SKP2
S-phase kinase-associated protein 2

2

0

Small-scale

0.607

High

346705

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.584

High

524909

XRCC5
X-ray repair cross-complementing protein 5

2

5

Small-scale

0.584

High

414270

RB
Retinoblastoma-associated protein

1

1

Small-scale

0.578

High

309698

KAT7
Histone acetyltransferase KAT7

1

3

Small-scale

0.573

High

369540

ESR1
Estrogen receptor

2

7

High-throughput

0.571

High

1033390

RFWD3
E3 ubiquitin-protein ligase RFWD3

1

1

Small-scale

0.561

High

62297

GG6L9
Golgin subfamily A member 6-like protein 9

2

3

High-throughput

0.553

High

708627

MCM5
DNA replication licensing factor MCM5

1

20

High-throughput

0.536

High

1033397

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.536

High

1033400

CDT1
DNA replication factor Cdt1

1

2

High-throughput

0.536

High

364882

FRIL
Ferritin light chain

1

2

High-throughput

0.536

High

829264

SYHM
Histidine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

931620

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.536

High

1033388

LARP7
La-related protein 7

1

3

High-throughput

0.536

High

1033391

CHM1B
Charged multivesicular body protein 1b

1

1

High-throughput

0.536

High

1033392

PHF6
PHD finger protein 6

1

1

High-throughput

0.536

High

1033394

PHIP
PH-interacting protein

1

2

High-throughput

0.536

High

1033403

DPOE3
DNA polymerase epsilon subunit 3

1

2

High-throughput

0.536

High

153305

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.513

High

283512

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

948065

RT15
Small ribosomal subunit protein uS15m

1

0

High-throughput

0.513

High

1019297

TRI26
Tripartite motif-containing protein 26

1

0

High-throughput

0.513

High

1033379

EXOS2
Exosome complex component RRP4

1

0

High-throughput

0.513

High

1033380

CIRBP
Cold-inducible RNA-binding protein

1

0

High-throughput

0.513

High

1033384

ZN174
Zinc finger protein 174

1

0

High-throughput

0.513

High

1033393

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.513

High

1033408

DIM1
Probable dimethyladenosine transferase

1

0

High-throughput

0.513

High

800367

CBX5
Chromobox protein homolog 5

1

3

Small-scale

0.501

High

591323

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

6

High-throughput

0.489

High

1033410

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

1

High-throughput

0.489

High

125880

CDC7
Cell division cycle 7-related protein kinase

1

7

Small-scale

0.481

High

552643

RFA2
Replication protein A 32 kDa subunit

1

2

Small-scale

0.481

High

708434

MCM4
DNA replication licensing factor MCM4

1

18

Small-scale

0.481

High

708888

MCM7
DNA replication licensing factor MCM7

1

19

Small-scale

0.481

High

832428

MCM2
DNA replication licensing factor MCM2

1

20

Small-scale

0.481

High

1033381

MCM6
DNA replication licensing factor MCM6

1

20

Small-scale

0.481

High

1033406

DBF4A
Protein DBF4 homolog A

1

1

Small-scale

0.481

High

337462

ABL1
Tyrosine-protein kinase ABL1

1

1

High-throughput

0.479

High

386671

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

412178

FYN
Tyrosine-protein kinase Fyn

1

1

High-throughput

0.479

High

414903

CDK1
Cyclin-dependent kinase 1

1

12

Small-scale

0.479

High

523723

XRCC6
X-ray repair cross-complementing protein 6

1

5

Small-scale

0.479

High

852905

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

1

Small-scale

0.479

High

895425

CKS1
Cyclin-dependent kinases regulatory subunit 1

1

1

Small-scale

0.479

High

898900

PSME3
Proteasome activator complex subunit 3

1

2

Small-scale

0.479

High

928897

SKP1
S-phase kinase-associated protein 1

1

1

Small-scale

0.479

High

1033377

CUL1
Cullin-1

1

3

Small-scale

0.479

High

1033378

CUL4A
Cullin-4A

1

3

High-throughput

0.479

High

1033385

NFIL3
Nuclear factor interleukin-3-regulated protein

1

1

Small-scale

0.479

High

1033396

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

1033401

ZN768
Zinc finger protein 768

1

1

High-throughput

0.479

High

264198

CDC45
Cell division control protein 45 homolog

1

0

Small-scale

0.460

High

564887

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

Small-scale

0.460

High

560405

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

Small-scale

0.458

High

958017

RBM10
RNA-binding protein 10

1

0

Small-scale

0.458

High

1033389

OBI1
ORC ubiquitin ligase 1

1

0

Small-scale

0.458

High

1033404

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

Small-scale

0.458

High

110666

H3BS42
Zinc finger protein 768

1

1

High-throughput

0.445

High

943785

CCNA1
Cyclin-A1

1

7

Small-scale

0.445

High

994850

GOGA2
Golgin subfamily A member 2

1

2

High-throughput

0.439

High

1033399

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.438

High

56617

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

3

High-throughput

0.407

High

156500

SCAM3
Secretory carrier-associated membrane protein 3

1

0

High-throughput

0.279

Low

1033402

MRM3
rRNA methyltransferase 3, mitochondrial

1

0

High-throughput

0.279

Low

1033409

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024