Protein: HDAC2
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) (YY1 transcription factor-binding protein)

Gene: HDAC2
Organism: Mus musculus
Interactions: 89
UniProt ID: P70288

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000792 - heterochromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

140250

HDAC1
Histone deacetylase 1

5

16

Small-scale

0.914

High

936428

MTA2
Metastasis-associated protein MTA2

5

20

Small-scale

0.909

High

936394

SIN3A
Paired amphipathic helix protein Sin3a

5

19

Small-scale

0.704

High

936408

KDM1A
Lysine-specific histone demethylase 1A

4

10

Small-scale

0.683

High

590285

PO5F1
POU domain, class 5, transcription factor 1

3

3

Small-scale

0.656

High

936411

NANOG
Homeobox protein NANOG

3

12

Small-scale

0.656

High

936416

RCOR2
REST corepressor 2

1

20

Small-scale

0.646

High

936419

MTA1
Metastasis-associated protein MTA1

1

20

Small-scale

0.618

High

936430

MBD3
Methyl-CpG-binding domain protein 3

1

12

Small-scale

0.618

High

93753

ZN431
Zinc finger protein 431

1

1

Small-scale

0.589

High

818688

SOX2
Transcription factor SOX-2

2

20

Small-scale

0.588

High

936425

RING2
E3 ubiquitin-protein ligase RING2

2

15

Small-scale

0.584

High

936406

HDAC4
Histone deacetylase 4

1

18

Small-scale

0.575

High

936418

RCOR1
REST corepressor 1

1

20

Small-scale

0.575

High

936422

FOXP3
Forkhead box protein P3

2

15

Small-scale

0.571

High

857947

PDX1
Pancreas/duodenum homeobox protein 1

1

5

Small-scale

0.561

High

936381

CRY1
Cryptochrome-1

1

1

Small-scale

0.561

High

936401

SIX3
Homeobox protein SIX3

1

3

Small-scale

0.561

High

193146

FOG1
Zinc finger protein ZFPM1

1

14

Small-scale

0.536

High

936379

TNIK
Traf2 and NCK-interacting protein kinase

1

12

High-throughput

0.536

High

936389

TF2L1
Transcription factor CP2-like protein 1

1

4

High-throughput

0.536

High

936392

HERC2
E3 ubiquitin-protein ligase HERC2

1

8

High-throughput

0.536

High

936400

ERR2
Steroid hormone receptor ERR2

1

20

High-throughput

0.536

High

936409

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

6

High-throughput

0.536

High

936410

MBB1A
Myb-binding protein 1A

1

3

Small-scale

0.536

High

936413

SALL4
Sal-like protein 4

1

7

High-throughput

0.536

High

250551

GFI1B
Zinc finger protein Gfi-1b

1

8

Small-scale

0.516

High

57763

ARI1A
AT-rich interactive domain-containing protein 1A

1

11

Small-scale

0.515

High

567552

SPI1
Transcription factor PU.1

1

10

Small-scale

0.515

High

918237

H4
Histone H4

1

12

Small-scale

0.501

High

936407

Q6P5E3
Sal-like 1

1

8

Small-scale

0.501

High

936426

DDX20
Probable ATP-dependent RNA helicase DDX20

1

13

Small-scale

0.501

High

503185

PARP1
Poly [ADP-ribose] polymerase 1

1

14

Small-scale

0.500

High

936385

SMCA4
Transcription activator BRG1

1

20

Small-scale

0.500

High

936420

HOP
Homeodomain-only protein

1

2

Small-scale

0.500

High

222461

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

12

Small-scale

0.484

High

936399

Q60I23
SRY

1

20

High-throughput

0.484

High

936404

Q6AXH7
Histone-lysine N-methyltransferase EZH2

1

20

High-throughput

0.484

High

292164

CTBP1
C-terminal-binding protein 1

1

6

High-throughput

0.481

High

936423

HDAC9
Histone deacetylase 9

1

19

High-throughput

0.481

High

56900

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

20

Small-scale

0.479

High

139011

S1PR1
Sphingosine 1-phosphate receptor 1

1

1

Small-scale

0.479

High

250993

SP3
Transcription factor Sp3

1

20

Small-scale

0.479

High

291936

SAP30
Histone deacetylase complex subunit SAP30

1

7

Small-scale

0.479

High

439908

IL6
Interleukin-6

1

1

Small-scale

0.479

High

450547

JUNB
Transcription factor JunB

1

14

Small-scale

0.479

High

526735

FOSB
Protein FosB

1

20

Small-scale

0.479

High

560432

ASSY
Argininosuccinate synthase

1

2

Small-scale

0.479

High

570289

GATA1
Erythroid transcription factor

1

15

Small-scale

0.479

High

603944

TAL1
T-cell acute lymphocytic leukemia protein 1 homolog

1

8

Small-scale

0.479

High

613309

CXA1
Gap junction alpha-1 protein

1

3

Small-scale

0.479

High

658589

APEX1
DNA repair nuclease/redox regulator APEX1

1

4

Small-scale

0.479

High

724589

IRS1
Insulin receptor substrate 1

1

15

Small-scale

0.479

High

783230

CD27
CD27 antigen

1

1

Small-scale

0.479

High

862804

CEBPA
CCAAT/enhancer-binding protein alpha

1

10

Small-scale

0.479

High

886477

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

10

Small-scale

0.479

High

936380

SMYD1
Histone-lysine N-methyltransferase Smyd1

1

4

Small-scale

0.479

High

936382

JDP2
Jun dimerization protein 2

1

17

Small-scale

0.479

High

936383

TYY1
Transcriptional repressor protein YY1

1

10

Small-scale

0.479

High

936384

TF65
Transcription factor p65

1

20

Small-scale

0.479

High

936386

DDB1
DNA damage-binding protein 1

1

8

Small-scale

0.479

High

936387

Q3UM65
Runt-related transcription factor

1

12

Small-scale

0.479

High

936390

TET1
Methylcytosine dioxygenase TET1

1

4

Small-scale

0.479

High

936391

TET2
Methylcytosine dioxygenase TET2

1

4

Small-scale

0.479

High

936395

PRDM1
PR domain zinc finger protein 1

1

6

Small-scale

0.479

High

936396

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

20

Small-scale

0.479

High

936397

PML
Protein PML

1

18

Small-scale

0.479

High

936398

RBBP7
Histone-binding protein RBBP7

1

20

Small-scale

0.479

High

936402

TFE3
Transcription factor E3

1

9

High-throughput

0.479

High

936403

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

20

High-throughput

0.479

High

936412

Q8BPK8
Agenet-like domain-containing protein

1

10

High-throughput

0.479

High

936414

A16L1
Autophagy-related protein 16-1

1

10

High-throughput

0.479

High

936415

Q8C5P6
C2H2-type domain-containing protein

1

14

Small-scale

0.479

High

936421

TF7L2
Transcription factor 7-like 2

1

20

Small-scale

0.479

High

936424

CNTP2
Contactin-associated protein-like 2

1

3

High-throughput

0.479

High

936427

CAF1A
Chromatin assembly factor 1 subunit A

1

7

High-throughput

0.479

High

936429

KLF5
Krueppel-like factor 5

1

20

Small-scale

0.479

High

139834

OGG1
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase

1

0

Small-scale

0.458

High

413182

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.458

High

936405

TEDC2
Tubulin epsilon and delta complex protein 2

1

0

High-throughput

0.458

High

192679

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

5

Small-scale

0.457

High

729446

FMR1
Fragile X messenger ribonucleoprotein 1

1

10

High-throughput

0.445

High

828447

CENPC
Centromere protein C

1

8

High-throughput

0.445

High

936378

TBX5
T-box transcription factor TBX5

1

7

Small-scale

0.445

High

936393

Q5DTP7
DNA helicase

1

20

High-throughput

0.445

High

936417

MT21E
Protein-lysine methyltransferase METTL21E

1

4

High-throughput

0.437

High

857556

HMGA2
High mobility group protein HMGI-C

1

0

High-throughput

0.426

High

353097

IL2RA
Interleukin-2 receptor subunit alpha

1

0

Small-scale

0.249

Low

936388

LCLT1
Lysocardiolipin acyltransferase 1

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024