Protein: KDM5A
Lysine-specific demethylase 5A (EC 1.14.11.67) (Histone demethylase JARID1A) (Jumonji/ARID domain-containing protein 1A) (Retinoblastoma-binding protein 2) (RBBP-2) ([histone H3]-trimethyl-L-lysine(4) demethylase 5A)

Gene: KDM5A
Organism: Homo sapiens
Interactions: 55
UniProt ID: P29375

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0003677 - DNA binding
GO:0003713 - transcription coactivator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

666547

PHF12
PHD finger protein 12

3

9

High-throughput

0.861

High

666553

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

3

7

Small-scale

0.847

High

666543

GATD1
GATA zinc finger domain-containing protein 1

6

1

High-throughput

0.736

High

414184

RB
Retinoblastoma-associated protein

5

4

Small-scale

0.720

High

666552

MO4L1
Mortality factor 4-like protein 1

5

5

Small-scale

0.718

High

666529

HDAC1
Histone deacetylase 1

4

14

High-throughput

0.704

High

257744

SIN3B
Paired amphipathic helix protein Sin3b

4

2

Small-scale

0.699

High

666534

RBBP7
Histone-binding protein RBBP7

4

12

High-throughput

0.699

High

71075

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

1

High-throughput

0.691

High

369044

ESR1
Estrogen receptor

3

20

Small-scale

0.660

High

666538

LARP7
La-related protein 7

1

1

High-throughput

0.618

High

666549

BRD8
Bromodomain-containing protein 8

1

10

High-throughput

0.618

High

666530

MO4L2
Mortality factor 4-like protein 2

2

5

Small-scale

0.611

High

666540

EMSY
BRCA2-interacting transcriptional repressor EMSY

2

8

High-throughput

0.611

High

666546

HDAC2
Histone deacetylase 2

2

14

Small-scale

0.611

High

666528

RBBP4
Histone-binding protein RBBP4

2

12

High-throughput

0.601

High

666522

H31
Histone H3.1

2

20

Small-scale

0.595

High

666527

SUH
Recombining binding protein suppressor of hairless

1

2

Small-scale

0.586

High

638228

RBTN2
Rhombotin-2

1

7

Small-scale

0.573

High

666524

FOXK2
Forkhead box protein K2

1

7

High-throughput

0.536

High

666548

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.513

High

666555

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.513

High

377116

GCR
Glucocorticoid receptor

1

20

Small-scale

0.501

High

487907

RARA
Retinoic acid receptor alpha

1

15

Small-scale

0.501

High

509911

VDR
Vitamin D3 receptor

1

13

Small-scale

0.501

High

660092

RBL1
Retinoblastoma-like protein 1

1

4

Small-scale

0.501

High

666539

H32
Histone H3.2

1

20

Small-scale

0.501

High

666515

TCPZ
T-complex protein 1 subunit zeta

1

11

High-throughput

0.494

High

666521

TBA1B
Tubulin alpha-1B chain

1

4

High-throughput

0.489

High

589790

TBP
TATA-box-binding protein

1

0

Small-scale

0.480

High

267909

EED
Polycomb protein EED

1

12

Small-scale

0.479

High

373737

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

666514

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

2

High-throughput

0.479

High

666516

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

8

High-throughput

0.479

High

666517

ZN131
Zinc finger protein 131

1

1

High-throughput

0.479

High

666518

KLF3
Krueppel-like factor 3

1

7

High-throughput

0.479

High

666520

H4
Histone H4

1

6

High-throughput

0.479

High

666523

H33
Histone H3.3

1

20

High-throughput

0.479

High

666525

1433F
14-3-3 protein eta

1

6

High-throughput

0.479

High

666526

MAD1
Max dimerization protein 1

1

4

Small-scale

0.479

High

666531

SUZ12
Polycomb protein SUZ12

1

6

Small-scale

0.479

High

666532

ELF2
ETS-related transcription factor Elf-2

1

10

High-throughput

0.479

High

666533

EZH2
Histone-lysine N-methyltransferase EZH2

1

16

Small-scale

0.479

High

666536

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

1

High-throughput

0.479

High

666541

PALB2
Partner and localizer of BRCA2

1

1

High-throughput

0.479

High

666542

NUP43
Nucleoporin Nup43

1

16

High-throughput

0.479

High

666545

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

666551

MRGBP
MRG/MORF4L-binding protein

1

1

High-throughput

0.479

High

666554

KLF12
Krueppel-like factor 12

1

7

High-throughput

0.479

High

666550

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.445

High

666537

BLTP1
Bridge-like lipid transfer protein family member 1

1

0

High-throughput

0.426

High

666535

H31T
Histone H3.1t

1

20

High-throughput

0.408

High

666544

TM9S4
Transmembrane 9 superfamily member 4

1

0

High-throughput

0.279

Low

322222

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

666519

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024