Protein: SXL
Protein sex-lethal

Gene: SXL
Organism: Drosophila melanogaster
Interactions: 94
UniProt ID: P19339

Gene Ontology (top 5):
GO:0000380 - alternative mRNA splicing, via spliceosome
GO:0000381 - regulation of alternative mRNA splicing, via spliceosome
GO:0000900 - mRNA regulatory element binding translation repressor activity
GO:0003723 - RNA binding
GO:0003729 - mRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

620689

SNRPA
U1 small nuclear ribonucleoprotein A

4

20

Small-scale

0.861

High

620682

SXL
Protein sex-lethal

3

19

Small-scale

0.815

High

84710

UNR
RNA-binding protein Unr

1

1

Small-scale

0.731

High

467100

CSK2A
Casein kinase II subunit alpha

1

10

High-throughput

0.656

High

620686

CDK2
Cyclin-dependent kinase 2

1

7

High-throughput

0.656

High

235034

NOI
Splicing factor 3A subunit 3

1

1

High-throughput

0.621

High

620687

FUSED
Serine/threonine-protein kinase fused

1

5

Small-scale

0.618

High

620691

RB27C
Heterogeneous nuclear ribonucleoprotein 27C

1

20

Small-scale

0.618

High

620703

NITO
RNA-binding protein spenito

1

19

Small-scale

0.618

High

620724

Q9VG78
Protein partner of snf, isoform A

1

4

Small-scale

0.618

High

620740

S6KL
Serine/threonine-protein kinase S6KL

1

13

High-throughput

0.590

High

195756

COS
Kinesin-like protein costa

2

7

Small-scale

0.584

High

620683

CI
Transcriptional activator cubitus interruptus

2

2

Small-scale

0.584

High

620707

BRAT
Protein brain tumor

1

7

Small-scale

0.568

High

198132

GBLP
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.508

High

356088

DYL2
Dynein light chain 2, cytoplasmic

1

1

High-throughput

0.508

High

559787

EF2
Eukaryotic translation elongation factor 2

1

4

High-throughput

0.508

High

620684

CCNB
G2/mitotic-specific cyclin-B

1

1

High-throughput

0.508

High

620695

STAT
Signal transducer and transcription activator

1

1

High-throughput

0.508

High

620696

TBB1
Tubulin beta-1 chain

1

2

High-throughput

0.508

High

620700

Q7JZZ3
RE03883p

1

2

High-throughput

0.508

High

620704

PRP39
Pre-mRNA-processing factor 39

1

7

High-throughput

0.508

High

620705

Q7PLI0
Adherens junction protein p120

1

5

High-throughput

0.508

High

620711

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.508

High

620712

ANM5
Protein arginine N-methyltransferase 5

1

9

High-throughput

0.508

High

620715

MED28
Mediator of RNA polymerase II transcription subunit 28

1

1

High-throughput

0.508

High

620725

JMJD4
2-oxoglutarate and iron-dependent oxygenase JMJD4 homolog

1

3

High-throughput

0.508

High

620728

XRN2
5'-3' exoribonuclease 2 homolog

1

4

High-throughput

0.508

High

620732

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

2

High-throughput

0.508

High

620736

Q9VW34
FI03450p

1

2

High-throughput

0.508

High

620751

Q9W579
Insomniac, isoform B

1

5

High-throughput

0.508

High

620754

Q9Y1A7
LD25378p

1

1

High-throughput

0.508

High

620730

Q9VP85
LD32951p

1

1

Small-scale

0.504

High

620692

RB87F
Heterogeneous nuclear ribonucleoprotein 87F

1

20

High-throughput

0.492

High

620697

U2AF2
Splicing factor U2AF 50 kDa subunit

1

19

High-throughput

0.492

High

620709

U2AF1
Splicing factor U2af 38 kDa subunit

1

1

High-throughput

0.492

High

235189

HTH
Homeobox protein homothorax

1

0

High-throughput

0.486

High

578027

ENO
Enolase

1

0

High-throughput

0.486

High

620693

OAZ
Ornithine decarboxylase antizyme

1

0

High-throughput

0.486

High

620701

Q7K180
LD02709p

1

0

High-throughput

0.486

High

620708

Q8SXC2
FI04487p

1

0

High-throughput

0.486

High

620722

Q9VFN9
GEO07882p1

1

0

High-throughput

0.486

High

620733

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.486

High

620734

Q9VTU9
Inositol oxygenase

1

0

High-throughput

0.486

High

620738

NARYA
RING finger protein narya

1

0

High-throughput

0.486

High

620749

Q9W1Y8
Uncharacterized protein, isoform B

1

0

High-throughput

0.486

High

54558

A1Z8R0
Expansion, isoform B

1

3

High-throughput

0.481

High

620706

Q86BS7
Glycogen debranching enzyme

1

1

High-throughput

0.481

High

620742

Q9VXG5
TNF-receptor-associated factor-like, isoform B

1

5

High-throughput

0.481

High

620752

Q9W5E6
Histone H4 transcription factor, isoform C

1

6

High-throughput

0.481

High

144532

HOW
Protein held out wings

1

10

Small-scale

0.479

High

620685

DDX6
ATP-dependent RNA helicase me31b

1

14

Small-scale

0.479

High

620690

IF4E
Eukaryotic translation initiation factor 4E1

1

4

Small-scale

0.479

High

620735

Q9VTZ0
GH08269p

1

4

Small-scale

0.479

High

620739

FLACC
Fl(2)d-associated complex component

1

1

Small-scale

0.479

High

620747

BGCN
Protein benign gonial cell neoplasm

1

6

Small-scale

0.479

High

620699

Q7JR96
SD19533p

1

1

High-throughput

0.464

High

620718

NUP58
Nuclear pore complex protein Nup58

1

3

High-throughput

0.464

High

620726

Q9VK31
LD35592p

1

1

High-throughput

0.464

High

620727

Q9VK57
PIH1 domain-containing protein 1

1

2

High-throughput

0.464

High

620743

Q9VXP3
GH05406p

1

1

High-throughput

0.464

High

620748

NU214
Nuclear pore complex protein Nup214

1

11

High-throughput

0.464

High

620723

Q9VG38
Suppressor of fused homolog

1

0

Small-scale

0.458

High

54563

A1Z8R1
Expansion, isoform A

1

3

High-throughput

0.457

High

305133

O77260
EG:115C2.6 protein

1

6

High-throughput

0.457

High

620710

Q960H6
LP08566p

1

5

High-throughput

0.457

High

620750

Q9W2H8
Glycogen debranching enzyme

1

1

High-throughput

0.457

High

58275

A1ZBJ2
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

2

High-throughput

0.439

High

118185

M9NCL3
Chitin deacetylase-like 5, isoform G

1

2

High-throughput

0.439

High

122039

M9PHF7
Uncharacterized protein, isoform C

1

1

High-throughput

0.439

High

615045

PTC
Protein patched

1

1

Small-scale

0.437

High

620731

Q9VPI4
Chitin deacetylase-like 5, isoform A

1

2

High-throughput

0.417

High

620741

Q9VX43
Uncharacterized protein, isoform B

1

1

High-throughput

0.417

High

620698

Q5BI58
LP10213p

1

1

High-throughput

0.348

High

603700

PH4H
Protein henna

1

0

High-throughput

0.265

Low

620688

CLH
Clathrin heavy chain

1

0

High-throughput

0.265

Low

620702

Q7K4A8
LP01339p

1

0

High-throughput

0.265

Low

620713

Q9V3U6
26-29kD-proteinase

1

0

High-throughput

0.265

Low

620714

Q9V4E0
Complex I-49kD

1

0

High-throughput

0.265

Low

620716

Q9VC79
FI03705p

1

0

High-throughput

0.265

Low

620717

Q9VCH7
RE64534p

1

0

High-throughput

0.265

Low

620719

Q9VFF0
Mitochondrial-processing peptidase subunit beta

1

0

High-throughput

0.265

Low

620720

Q9VFL8
FI01135p

1

0

High-throughput

0.265

Low

620721

Q9VFN5
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.265

Low

620729

Q9VMY2
RE15880p

1

0

High-throughput

0.265

Low

620737

Q9VWD5
LD35087p

1

0

High-throughput

0.265

Low

620744

Q9VYA4
Ribonuclease H2 subunit B

1

0

High-throughput

0.265

Low

620745

Q9VZW1
Phospholipid scramblase

1

0

High-throughput

0.265

Low

620746

Q9W116
RE45222p

1

0

High-throughput

0.265

Low

620753

Q9XZ53
dolichyl-diphosphooligosaccharide--protein glycotransferase

1

0

High-throughput

0.265

Low

58427

A1ZBR8
RT07838p

1

0

High-throughput

0.251

Low

620694

SMO
Protein smoothened

1

0

Small-scale

0.249

Low

87178

SER2
Serine protease 2

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025