Protein: ACTN3
Alpha-actinin-3 (Alpha-actinin skeletal muscle isoform 3) (F-actin cross-linking protein)

Gene: ACTN3
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q08043

Gene Ontology (top 5):
GO:0005178 - integrin binding
GO:0005509 - calcium ion binding
GO:0005829 - cytosol
GO:0005884 - actin filament
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

211571

ACTN4
Alpha-actinin-4

3

14

High-throughput

0.845

High

521530

ACTN1
Alpha-actinin-1

3

13

High-throughput

0.845

High

993246

ACTN3
Alpha-actinin-3

3

13

High-throughput

0.845

High

993249

PTK6
Protein-tyrosine kinase 6

2

6

High-throughput

0.783

High

993273

MILK2
MICAL-like protein 2

2

15

High-throughput

0.783

High

993297

MYOZ1
Myozenin-1

2

6

High-throughput

0.783

High

725648

ACTN2
Alpha-actinin-2

1

13

Small-scale

0.747

High

993278

TITIN
Titin

1

19

High-throughput

0.698

High

993274

MILK1
MICAL-like protein 1

1

15

High-throughput

0.691

High

117270

PDLI1
PDZ and LIM domain protein 1

3

20

High-throughput

0.667

High

993248

TRAF1
TNF receptor-associated factor 1

3

5

High-throughput

0.654

High

968684

AK17A
A-kinase anchor protein 17A

2

1

High-throughput

0.628

High

993294

PKHG2
Pleckstrin homology domain-containing family G member 2

2

11

High-throughput

0.613

High

159972

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

4

High-throughput

0.606

High

326609

SNAI1
Zinc finger protein SNAI1

2

4

High-throughput

0.606

High

993281

ASB9
Ankyrin repeat and SOCS box protein 9

2

13

High-throughput

0.606

High

993285

PKP2
Plakophilin-2

2

7

High-throughput

0.606

High

993290

CTDS1
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1

2

1

High-throughput

0.606

High

993296

SYP2L
Synaptopodin 2-like protein

2

20

High-throughput

0.606

High

993301

MYOTI
Myotilin

2

13

High-throughput

0.606

High

413036

CHLE
Cholinesterase

2

0

High-throughput

0.602

High

147900

ACPM
Acyl carrier protein, mitochondrial

2

0

High-throughput

0.580

High

252994

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

326920

DDAH2
Putative hydrolase DDAH2

2

0

High-throughput

0.580

High

398350

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

2

0

High-throughput

0.580

High

821649

K2C6C
Keratin, type II cytoskeletal 6C

2

0

High-throughput

0.580

High

993254

ECM1
Extracellular matrix protein 1

2

0

High-throughput

0.580

High

993305

ATP23
Mitochondrial inner membrane protease ATP23 homolog

2

0

High-throughput

0.580

High

993289

LRCC1
Leucine-rich repeat and coiled-coil domain-containing protein 1

2

15

High-throughput

0.574

High

993260

CDC73
Parafibromin

1

3

Small-scale

0.573

High

68631

CMA1B
Ciliary microtubule associated protein 1B

2

1

High-throughput

0.553

High

271077

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

4

High-throughput

0.553

High

723660

HXD12
Homeobox protein Hox-D12

2

1

High-throughput

0.553

High

795857

MAGA6
Melanoma-associated antigen 6

2

1

High-throughput

0.553

High

944018

PO6F2
POU domain, class 6, transcription factor 2

2

1

High-throughput

0.553

High

993250

TRI29
Tripartite motif-containing protein 29

2

4

High-throughput

0.553

High

993252

RTP5
Receptor-transporting protein 5

2

1

High-throughput

0.553

High

993259

PPR18
Phostensin

2

4

High-throughput

0.553

High

993265

NKAP1
Uncharacterized protein NKAPD1

2

2

High-throughput

0.553

High

993277

LNX1
E3 ubiquitin-protein ligase LNX

2

17

High-throughput

0.553

High

993288

GLIS2
Zinc finger protein GLIS2

2

4

High-throughput

0.553

High

325704

LATS1
Serine/threonine-protein kinase LATS1

1

3

High-throughput

0.536

High

529029

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.536

High

974536

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.536

High

993258

K1C39
Keratin, type I cytoskeletal 39

1

2

High-throughput

0.536

High

993268

TSN33
Tetraspanin-33

1

3

High-throughput

0.536

High

260230

ENTP6
Ectonucleoside triphosphate diphosphohydrolase 6

1

0

High-throughput

0.513

High

993271

GRM2A
GRAM domain-containing protein 2A

1

0

High-throughput

0.513

High

993283

MTMR9
Myotubularin-related protein 9

1

0

High-throughput

0.513

High

993284

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.513

High

993269

GPBP1
Vasculin

1

0

High-throughput

0.493

High

993275

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

1

High-throughput

0.489

High

993304

CHTOP
Chromatin target of PRMT1 protein

1

1

High-throughput

0.489

High

282325

NEBL
Nebulette

1

14

High-throughput

0.481

High

749416

BRCA1
Breast cancer type 1 susceptibility protein

1

4

High-throughput

0.481

High

981557

REL
Proto-oncogene c-Rel

1

4

High-throughput

0.481

High

993247

TRAF2
TNF receptor-associated factor 2

1

7

High-throughput

0.481

High

993264

RN111
E3 ubiquitin-protein ligase Arkadia

1

2

High-throughput

0.481

High

993267

MYPN
Myopalladin

1

18

Small-scale

0.481

High

993276

KCTD6
BTB/POZ domain-containing protein KCTD6

1

8

High-throughput

0.481

High

993299

ABI3
ABI gene family member 3

1

11

High-throughput

0.481

High

993303

CAPS1
Calcium-dependent secretion activator 1

1

1

High-throughput

0.481

High

148722

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.479

High

209921

PRC1
Protein regulator of cytokinesis 1

1

11

High-throughput

0.479

High

374109

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

5

High-throughput

0.479

High

993251

SCRIB
Protein scribble homolog

1

10

Small-scale

0.479

High

993253

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

993280

CHM4C
Charged multivesicular body protein 4c

1

15

High-throughput

0.479

High

993293

CHM4B
Charged multivesicular body protein 4b

1

15

High-throughput

0.479

High

993295

ECT2
Protein ECT2

1

8

High-throughput

0.479

High

993298

ANLN
Anillin

1

7

High-throughput

0.479

High

57984

A2RRN7
CADPS protein

1

2

High-throughput

0.470

High

450855

F16P1
Fructose-1,6-bisphosphatase 1

1

0

Small-scale

0.458

High

926965

1433Z
14-3-3 protein zeta/delta

1

12

High-throughput

0.445

High

993262

CA094
Uncharacterized protein C1orf94

1

1

High-throughput

0.439

High

993282

DUX5
Double homeobox protein 5

1

7

High-throughput

0.439

High

517216

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.438

High

308642

KI20A
Kinesin-like protein KIF20A

1

16

High-throughput

0.437

High

215076

DUX1
Double homeobox protein 1

1

6

High-throughput

0.417

High

993263

DUX4C
Double homeobox protein 4C

1

9

High-throughput

0.417

High

993279

ESR2
Estrogen receptor beta

1

11

High-throughput

0.407

High

642842

IVD
Isovaleryl-CoA dehydrogenase, mitochondrial

2

0

High-throughput

0.316

High

791127

CXCL5
C-X-C motif chemokine 5

2

0

High-throughput

0.316

High

942499

CTG1B
Cancer/testis antigen 1

2

0

High-throughput

0.316

High

993256

CTSRT
Cation channel sperm-associated targeting subunit tau

2

0

High-throughput

0.316

High

993257

SOLH1
Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1

2

0

High-throughput

0.316

High

993261

ZN343
Zinc finger protein 343

2

0

High-throughput

0.316

High

993270

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

993287

ZN426
Zinc finger protein 426

2

0

High-throughput

0.316

High

993292

CMIP1
Ciliary microtubule inner protein 1

2

0

High-throughput

0.316

High

993302

LHX3
LIM/homeobox protein Lhx3

2

0

High-throughput

0.316

High

993300

ZN219
Zinc finger protein 219

2

0

High-throughput

0.313

High

376381

REL2
Prorelaxin H2 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

0

High-throughput

0.279

Low

993255

LACB2
Endoribonuclease LACTB2

1

0

High-throughput

0.279

Low

993266

CE024
UPF0461 protein C5orf24

1

0

High-throughput

0.279

Low

993272

T183A
Transmembrane protein 183A

1

0

High-throughput

0.279

Low

993286

ZSA5A
Zinc finger and SCAN domain-containing protein 5A

1

0

High-throughput

0.279

Low

993291

RSH6A
Radial spoke head protein 6 homolog A

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024