Protein: ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (Protein SITPEC)

Gene: ECSIT
Organism: Homo sapiens
Interactions: 219
UniProt ID: Q9BQ95

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1309260

CIA30
Complex I intermediate-associated protein 30, mitochondrial

6

1

Small-scale

0.736

High

1309232

ACAD9
Complex I assembly factor ACAD9, mitochondrial

6

3

Small-scale

0.733

High

266793

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

4

1

High-throughput

0.699

High

1146372

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

4

2

High-throughput

0.699

High

803207

IF2M
Translation initiation factor IF-2, mitochondrial

4

1

High-throughput

0.694

High

371186

NU4M
NADH-ubiquinone oxidoreductase chain 4

4

0

High-throughput

0.670

High

1216922

T126B
Complex I assembly factor TMEM126B, mitochondrial

4

0

High-throughput

0.670

High

1309210

MGME1
Mitochondrial genome maintenance exonuclease 1

4

0

High-throughput

0.670

High

1309237

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

4

0

High-throughput

0.670

High

832930

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

3

3

High-throughput

0.667

High

1268640

LPAR1
Lysophosphatidic acid receptor 1

3

4

High-throughput

0.667

High

1086751

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

4

0

High-throughput

0.657

High

1309250

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

3

0

High-throughput

0.646

High

1309264

TRAF6
TNF receptor-associated factor 6

3

3

Small-scale

0.640

High

121349

NDUS8
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

3

0

High-throughput

0.638

High

210581

NDUB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

3

0

High-throughput

0.638

High

264784

NDUB1
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

3

0

High-throughput

0.638

High

306422

NDUA3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

3

0

High-throughput

0.638

High

306542

NDUB8
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

3

0

High-throughput

0.638

High

311178

NDUC2
NADH dehydrogenase [ubiquinone] 1 subunit C2

3

0

High-throughput

0.638

High

851962

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

3

0

High-throughput

0.638

High

1309223

COA1
Cytochrome c oxidase assembly factor 1 homolog

3

0

High-throughput

0.638

High

1309248

CLC5A
C-type lectin domain family 5 member A

3

0

High-throughput

0.638

High

1309249

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

3

0

High-throughput

0.638

High

927867

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

2

2

High-throughput

0.628

High

958758

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

2

2

High-throughput

0.628

High

1301115

EFGM
Elongation factor G, mitochondrial

3

0

High-throughput

0.628

High

1309227

P2Y12
P2Y purinoceptor 12

3

2

High-throughput

0.609

High

1309257

MAST1
Microtubule-associated serine/threonine-protein kinase 1

2

0

High-throughput

0.606

High

217589

NDUS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

2

0

High-throughput

0.602

High

258771

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

0

High-throughput

0.602

High

672267

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

0

High-throughput

0.602

High

1233834

MALD2
MARVEL domain-containing protein 2

2

0

High-throughput

0.602

High

1286183

F136A
Protein FAM136A

2

0

High-throughput

0.602

High

1309233

IPPK
Inositol-pentakisphosphate 2-kinase

2

0

High-throughput

0.602

High

1309246

NDUBB
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial

2

0

High-throughput

0.602

High

834341

PSN1
Presenilin-1

1

1

High-throughput

0.599

High

835006

PSN2
Presenilin-2

1

1

High-throughput

0.590

High

259127

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

2

0

High-throughput

0.585

High

371102

NU1M
NADH-ubiquinone oxidoreductase chain 1

2

0

High-throughput

0.585

High

1086387

DECR
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

2

0

High-throughput

0.585

High

1218937

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

0

High-throughput

0.585

High

1309216

TMM70
Transmembrane protein 70, mitochondrial

2

0

High-throughput

0.585

High

58245

SYTC2
Threonine--tRNA ligase 2, cytoplasmic

2

0

High-throughput

0.580

High

180432

MAGB2
Melanoma-associated antigen B2

2

0

High-throughput

0.580

High

874323

GEM
GTP-binding protein GEM

2

0

High-throughput

0.580

High

1200327

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

0

High-throughput

0.580

High

1299512

TSSK3
Testis-specific serine/threonine-protein kinase 3

2

0

High-throughput

0.580

High

1309245

AIRIM
AFG2-interacting ribosome maturation factor

2

0

High-throughput

0.580

High

1309253

NXF1
Nuclear RNA export factor 1

2

0

High-throughput

0.580

High

1309255

CTNA3
Catenin alpha-3

2

0

High-throughput

0.580

High

783718

VIPR2
Vasoactive intestinal polypeptide receptor 2

2

1

High-throughput

0.574

High

1083483

C3AR
C3a anaphylatoxin chemotactic receptor

2

3

High-throughput

0.574

High

1309238

C1QR1
Complement component C1q receptor

2

1

High-throughput

0.574

High

361515

APOE
Apolipoprotein E

1

0

High-throughput

0.565

High

587693

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

Small-scale

0.561

High

978875

TF65
Transcription factor p65

1

1

Small-scale

0.561

High

262937

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

1309256

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.543

High

703529

CP2CI
Cytochrome P450 2C18

1

2

High-throughput

0.541

High

1031829

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

1

2

High-throughput

0.541

High

1273115

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

3

High-throughput

0.541

High

134402

ACKR2
Atypical chemokine receptor 2

1

1

High-throughput

0.536

High

328381

S1PR4
Sphingosine 1-phosphate receptor 4

1

4

High-throughput

0.536

High

469885

CO4A
Complement C4-A

1

1

High-throughput

0.536

High

598770

S1PR1
Sphingosine 1-phosphate receptor 1

1

4

High-throughput

0.536

High

813978

GPR12
G-protein coupled receptor 12

1

4

High-throughput

0.536

High

876184

PAR2
Proteinase-activated receptor 2

1

1

High-throughput

0.536

High

895721

CXCR4
C-X-C chemokine receptor type 4

1

1

High-throughput

0.536

High

993120

CP24A
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

1

3

High-throughput

0.536

High

1135304

ATD3B
ATPase family AAA domain-containing protein 3B

1

1

High-throughput

0.536

High

1309234

LPAR2
Lysophosphatidic acid receptor 2

1

4

High-throughput

0.536

High

1309239

CP26B
Cytochrome P450 26B1

1

1

High-throughput

0.536

High

1219288

TRI59
Tripartite motif-containing protein 59

1

0

Small-scale

0.529

High

636408

DNJB1
DnaJ homolog subfamily B member 1

1

0

High-throughput

0.518

High

685759

PRDX2
Peroxiredoxin-2

1

0

High-throughput

0.518

High

737457

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.518

High

872203

RD23A
UV excision repair protein RAD23 homolog A

1

0

High-throughput

0.518

High

885054

FBXW4
F-box/WD repeat-containing protein 4

1

0

High-throughput

0.518

High

1046251

BLMH
Bleomycin hydrolase

1

0

High-throughput

0.518

High

1065707

SETB1
Histone-lysine N-methyltransferase SETDB1

1

0

High-throughput

0.518

High

1072660

RHEB
GTP-binding protein Rheb

1

0

High-throughput

0.518

High

1082944

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.518

High

1088613

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.518

High

1120310

CEP55
Centrosomal protein of 55 kDa

1

0

High-throughput

0.518

High

1173222

PAXI1
PAX-interacting protein 1

1

0

High-throughput

0.518

High

1251326

EXOC6
Exocyst complex component 6

1

0

High-throughput

0.518

High

1291254

STALP
AMSH-like protease

1

0

High-throughput

0.518

High

1309209

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

High-throughput

0.518

High

1309224

RNF32
RING finger protein 32

1

0

High-throughput

0.518

High

1309240

STRN4
Striatin-4

1

0

High-throughput

0.518

High

1309261

EXOS1
Exosome complex component CSL4

1

0

High-throughput

0.518

High

1309266

AP1M2
AP-1 complex subunit mu-2

1

0

High-throughput

0.518

High

210785

NDUA2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

1

0

High-throughput

0.513

High

217201

EXTL3
Exostosin-like 3

1

0

High-throughput

0.513

High

270939

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

0

High-throughput

0.513

High

326193

TSN15
Tetraspanin-15

1

0

High-throughput

0.513

High

347730

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.513

High

396408

APOD
Apolipoprotein D

1

0

High-throughput

0.513

High

403953

ITB1
Integrin beta-1

1

0

High-throughput

0.513

High

439309

SODE
Extracellular superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

629172

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.513

High

658138

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

High-throughput

0.513

High

1158569

L2GL2
LLGL scribble cell polarity complex component 2

1

0

High-throughput

0.513

High

1232063

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

1243715

VATC2
V-type proton ATPase subunit C 2

1

0

High-throughput

0.513

High

1255459

GPBAR
G-protein coupled bile acid receptor 1

1

0

High-throughput

0.513

High

1285121

TM186
Transmembrane protein 186

1

0

High-throughput

0.513

High

1309215

NDUF3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3

1

0

High-throughput

0.513

High

1309221

GPR88
G protein-coupled receptor 88

1

0

High-throughput

0.513

High

1309225

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

1309235

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

0

High-throughput

0.513

High

1309241

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1309259

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.513

High

1309247

FXL12
F-box/LRR-repeat protein 12

1

0

High-throughput

0.504

High

344557

A2MG
Alpha-2-macroglobulin

1

1

High-throughput

0.494

High

201413

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

Small-scale

0.493

High

156911

FFAR1
Free fatty acid receptor 1

1

2

High-throughput

0.489

High

584534

GGT1
Glutathione hydrolase 1 proenzyme

1

1

High-throughput

0.489

High

600830

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

3

High-throughput

0.489

High

1306428

CML1
Chemerin-like receptor 1

1

3

High-throughput

0.489

High

157470

IFIT3
Interferon-induced protein with tetratricopeptide repeats 3

1

2

High-throughput

0.481

High

496144

CP2C8
Cytochrome P450 2C8

1

2

High-throughput

0.481

High

514719

CP2C9
Cytochrome P450 2C9

1

2

High-throughput

0.481

High

175148

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

265009

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.479

High

270103

RF1M
Peptide chain release factor 1, mitochondrial

1

1

High-throughput

0.479

High

882525

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.479

High

1014471

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.479

High

1128230

SYAM
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.479

High

1185346

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

1

High-throughput

0.479

High

1222085

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.479

High

1242982

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.479

High

1282804

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.479

High

1284516

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

1287977

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

1

High-throughput

0.479

High

1297241

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

2

High-throughput

0.479

High

1297444

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

1302811

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

1309222

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

1309226

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

1

High-throughput

0.479

High

1309243

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

1309254

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

1

High-throughput

0.479

High

1309265

DJC15
DnaJ homolog subfamily C member 15

1

1

High-throughput

0.479

High

395588

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.460

High

591489

RAB3A
Ras-related protein Rab-3A

1

0

High-throughput

0.460

High

1309214

P4K2A
Phosphatidylinositol 4-kinase type 2-alpha

1

0

High-throughput

0.460

High

228501

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

295188

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

327536

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

440694

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

525614

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

632372

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.458

High

777699

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

789947

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

799337

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

827548

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

877856

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

951275

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.458

High

959019

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

981394

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

990272

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1020536

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.458

High

1033805

NNTM
NAD(P) transhydrogenase, mitochondrial

1

0

High-throughput

0.458

High

1036853

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

1045839

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1051060

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.458

High

1074636

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

1148757

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1171439

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1183204

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

1190077

MAVS
Mitochondrial antiviral-signaling protein

1

0

Small-scale

0.458

High

1235328

PAR16
Protein mono-ADP-ribosyltransferase PARP16

1

0

High-throughput

0.458

High

1285736

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

1288972

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

1289100

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

1289287

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

1290479

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.458

High

1309212

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

1309213

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

1309217

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

1309218

TR61B
tRNA

1

0

High-throughput

0.458

High

1309219

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

1309220

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

1309228

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

1309229

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

1309230

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1309231

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1309236

NGRN
Neugrin

1

0

High-throughput

0.458

High

1309242

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1309244

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

1309251

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1309262

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

1309263

MARF1
Meiosis regulator and mRNA stability factor 1

1

0

High-throughput

0.458

High

1309258

COA3
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial

1

0

Small-scale

0.426

High

99669

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

1133157

MRP7
ATP-binding cassette sub-family C member 10

3

0

High-throughput

0.347

High

1287153

FAF2
FAS-associated factor 2

3

0

High-throughput

0.347

High

1016669

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.328

High

1023543

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

2

0

High-throughput

0.316

High

1037533

BFSP2
Phakinin

2

0

High-throughput

0.316

High

1055880

ELAV3
ELAV-like protein 3

1

0

High-throughput

0.282

High

1295059

LOXL4
Lysyl oxidase homolog 4

1

0

High-throughput

0.282

High

206521

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.279

Low

213155

SNG1
Synaptogyrin-1

1

0

High-throughput

0.279

Low

823087

AGRE5
Adhesion G protein-coupled receptor E5

1

0

High-throughput

0.279

Low

886950

T2R19
Taste receptor type 2 member 19

1

0

High-throughput

0.279

Low

986106

KDSR
3-ketodihydrosphingosine reductase

1

0

High-throughput

0.279

Low

1156188

CK087
Uncharacterized protein C11orf87

1

0

High-throughput

0.279

Low

1185039

PCAT2
Lysophosphatidylcholine acyltransferase 2

1

0

High-throughput

0.279

Low

1202363

RETR3
Reticulophagy regulator 3

1

0

High-throughput

0.279

Low

1239949

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.279

Low

1292705

ZDH12
Palmitoyltransferase ZDHHC12

1

0

High-throughput

0.279

Low

1309211

TMM79
Transmembrane protein 79

1

0

High-throughput

0.279

Low

1309252

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low

352234

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

1158845

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.249

Low

1165898

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024