HitPredict

Interactor 1: DOC11 (A2AF47)
Dedicator of cytokinesis protein 11 (Activated Cdc42-associated guanine nucleotide exchange factor) (ACG) (Zizimin-2)
Gene: Dock11

Interactor 2: CDC42 (P60766)
Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein)
Gene: CDC42

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	15710388
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	DHR-2_Lobe_B~Ras, DHR-2_Lobe_C~Ras, PH~Ras
Common GO terms	GO:0051491 - positive regulation of filopodium assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2073 Mm			1 191
+	Hs
		601317 DOC11_HUMAN (1-2073): 0: 2766: 96.62		RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94
+	Hs
		1206376 DOC11_HUMAN (1-2073): 0: 2766: 96.62		RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17
+	Hs
		988420 DOC11_HUMAN (1-2073): 0: 2766: 96.62		RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31
+	Hs
		955260 DOC11_HUMAN (1-2073): 0: 2766: 96.62		CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00
+	Hs
		581092 DOC11_HUMAN (1-2073): 0: 2766: 96.62		RAC2_HUMAN (1-191): 1.01e-77: 232: 68.75
+	Hs
		953486 DOC11_HUMAN (1-2073): 0: 2766: 96.62		RAC3_HUMAN (1-177): 7.58e-76: 227: 72.32
+	Hs
		601431 DOCK9_HUMAN (2-2035): 0: 2542: 59.00		RHOQ_HUMAN (4-187): 7.38e-91: 266: 67.94
+	Mm
		107030 F8VPN7_MOUSE (30-2062): 0: 2558: 58.69		CDC42_MOUSE (1-191): 9.95e-80: 237: 100.00
+	Hs
		1419478 DOCK9_HUMAN (2-2035): 0: 2542: 59.00		RHOJ_HUMAN (2-188): 2.68e-85: 252: 64.17
+	Hs
		988679 DOCK9_HUMAN (2-2035): 0: 2542: 59.00		RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31
+	Hs
		1015748 DOCK9_HUMAN (2-2035): 0: 2542: 59.00		RHOG_HUMAN (1-191): 7.33e-80: 237: 60.73
+	Hs
		955556 DOCK9_HUMAN (2-2035): 0: 2542: 59.00		CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00
+	Hs
		581269 DOCK9_HUMAN (2-2035): 0: 2542: 59.00		RAC2_HUMAN (1-191): 1.01e-77: 232: 68.75
+	Hs
		953651 DOCK9_HUMAN (2-2035): 0: 2542: 59.00		RAC3_HUMAN (1-177): 7.58e-76: 227: 72.32
+	Mm
		953810 DOC10_MOUSE (4-2073): 0: 2374: 49.23		CDC42_MOUSE (1-191): 9.95e-80: 237: 100.00
+	Hs
		955461 DOC10_HUMAN (4-2049): 0: 2357: 49.66		CDC42_HUMAN (1-191): 9.95e-80: 237: 100.00
+	At
		1342972 SPK1_ARATH (339-2038): 0: 1276: 21.59		RAC9_ARATH (4-191): 7.58e-77: 230: 51.81
+	Hs
		988519 DOCK4_HUMAN (1173-2045): 1.21e-163: 555: 15.00		RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31
+	Hs
		988515 DOCK3_HUMAN (394-1303): 2.35e-106: 382: 12.12		RAC1_HUMAN (1-191): 1.15e-81: 242: 70.31
+	Hs
		581206 DOCK2_HUMAN (394-1079): 1.85e-89: 327: 16.01		RAC2_HUMAN (1-191): 1.01e-77: 232: 68.75