Protein: RPGF2
Rap guanine nucleotide exchange factor 2 (Cyclic nucleotide ras GEF) (CNrasGEF) (Neural RAP guanine nucleotide exchange protein) (nRap GEP) (PDZ domain-containing guanine nucleotide exchange factor 1) (PDZ-GEF1) (RA-GEF-1) (Ras/Rap1-associating GEF-1)

Gene: RPGF2, RAPGEF2
Organism: Homo sapiens
Interactions: 82
UniProt ID: Q9Y4G8

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001568 - blood vessel development
GO:0001764 - neuron migration
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1300702

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

3

9

Small-scale

0.830

High

919687

RAP1A
Ras-related protein Rap-1A

2

20

Small-scale

0.799

High

1021730

GNDS
Ral guanine nucleotide dissociation stimulator

1

3

Small-scale

0.680

High

808335

NEDD4
E3 ubiquitin-protein ligase NEDD4

3

4

Small-scale

0.667

High

809053

YAP1
Transcriptional coactivator YAP1

3

12

Small-scale

0.667

High

1199794

MAGI2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

1

11

Small-scale

0.665

High

1256802

RPGF6
Rap guanine nucleotide exchange factor 6

1

3

High-throughput

0.665

High

349754

RASH
GTPase HRas

1

20

Small-scale

0.647

High

897996

RAP2B
Ras-related protein Rap-2b

1

20

Small-scale

0.647

High

1377163

FBW1A
F-box/WD repeat-containing protein 1A

3

3

Small-scale

0.640

High

905302

1433G
14-3-3 protein gamma

2

20

High-throughput

0.628

High

910200

1433E
14-3-3 protein epsilon

2

4

High-throughput

0.628

High

982658

1433F
14-3-3 protein eta

2

20

High-throughput

0.628

High

1047729

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

1

10

High-throughput

0.621

High

990958

ZO1
Tight junction protein ZO-1

1

6

High-throughput

0.618

High

1020241

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

9

High-throughput

0.618

High

1136442

MAGI3
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3

1

9

High-throughput

0.618

High

1264830

TITIN
Titin

1

4

High-throughput

0.618

High

1296974

SNX27
Sorting nexin-27

1

13

High-throughput

0.618

High

1336377

E41L5
Band 4.1-like protein 5

1

1

High-throughput

0.618

High

927702

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.611

High

1356381

FBW1B
F-box/WD repeat-containing protein 11

2

3

High-throughput

0.584

High

1349052

WWOX
WW domain-containing oxidoreductase

2

0

High-throughput

0.559

High

702998

KINH
Kinesin-1 heavy chain

1

3

High-throughput

0.541

High

1017569

KIF5A
Kinesin heavy chain isoform 5A

1

3

High-throughput

0.541

High

1044308

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.541

High

647416

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

683851

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.536

High

784116

KPCI
Protein kinase C iota type

1

8

High-throughput

0.536

High

792126

HD
Huntingtin

1

1

High-throughput

0.536

High

957804

XIAP
E3 ubiquitin-protein ligase XIAP

1

1

High-throughput

0.536

High

1296812

LLR1
Leucine-rich repeat protein 1

1

1

High-throughput

0.536

High

1327815

RGAP1
Rac GTPase-activating protein 1

1

3

High-throughput

0.536

High

1377582

PHOCN
MOB-like protein phocein

1

0

High-throughput

0.518

High

1055367

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

1

0

High-throughput

0.513

High

1058416

MESD
LRP chaperone MESD

1

0

High-throughput

0.513

High

1150005

BLT3A
Bridge-like lipid transfer protein family member 3A

1

0

High-throughput

0.513

High

1295165

VPS50
Syndetin

1

0

High-throughput

0.513

High

1303648

SEC62
Translocation protein SEC62

1

0

High-throughput

0.513

High

1317412

ANO3
Anoctamin-3

1

0

High-throughput

0.513

High

1299667

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

4

Small-scale

0.501

High

61770

BDP1
Transcription factor TFIIIB component B'' homolog

1

7

High-throughput

0.489

High

796212

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.489

High

1296275

Z512B
Zinc finger protein 512B

1

4

High-throughput

0.489

High

1333982

SP14L
Nuclear body protein SP140-like protein

1

3

High-throughput

0.489

High

59708

WDR91
WD repeat-containing protein 91

1

3

High-throughput

0.479

High

163516

XPO1
Exportin-1

1

2

High-throughput

0.479

High

310110

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

1

3

High-throughput

0.479

High

476625

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.479

High

646347

STOM
Stomatin

1

1

High-throughput

0.479

High

660986

AMPL
Cytosol aminopeptidase

1

1

High-throughput

0.479

High

850248

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

High-throughput

0.479

High

855770

KIF11
Kinesin-like protein KIF11

1

3

High-throughput

0.479

High

909390

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

1052965

FLNC
Filamin-C

1

3

High-throughput

0.479

High

1068714

PLEC
Plectin

1

2

High-throughput

0.479

High

1235399

KCD17
BTB/POZ domain-containing protein KCTD17

1

3

High-throughput

0.479

High

1301587

HMCN1
Hemicentin-1

1

4

High-throughput

0.479

High

1305323

PHB2
Prohibitin-2

1

1

High-throughput

0.479

High

1348081

KCTD5
BTB/POZ domain-containing protein KCTD5

1

3

High-throughput

0.479

High

559306

H15
Histone H1.5

1

1

High-throughput

0.470

High

489634

OSTP
Osteopontin

1

0

Small-scale

0.460

High

360576

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

918198

H4
Histone H4

1

0

High-throughput

0.458

High

974032

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

0

High-throughput

0.458

High

1002080

ARL16
ADP-ribosylation factor-like protein 16

1

0

High-throughput

0.458

High

1037026

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1183055

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.458

High

1244596

NUP43
Nucleoporin Nup43

1

0

High-throughput

0.458

High

103672

G5E9A6
Ubiquitin carboxyl-terminal hydrolase

1

3

High-throughput

0.445

High

225090

ZNRD2
Protein ZNRD2

1

2

High-throughput

0.437

High

1159550

SCYL2
SCY1-like protein 2

1

1

High-throughput

0.437

High

1264920

CTTB2
Cortactin-binding protein 2

1

7

High-throughput

0.437

High

1327676

BRD8
Bromodomain-containing protein 8

1

4

High-throughput

0.437

High

87250

C9J1X0
WD repeat-containing protein 91

1

3

High-throughput

0.407

High

371294

ATP8
ATP synthase protein 8

1

0

High-throughput

0.282

High

203074

ERI3
ERI1 exoribonuclease 3

1

0

High-throughput

0.279

Low

594993

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.279

Low

1238645

SR1IP
Protein SREK1IP1

1

0

High-throughput

0.279

Low

1294749

ATPMK
ATP synthase membrane subunit K, mitochondrial

1

0

High-throughput

0.279

Low

1355970

TRM6
tRNA

1

0

High-throughput

0.279

Low

1086365

H31T
Histone H3.1t

1

0

High-throughput

0.269

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024