Protein: B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

Gene: B2MG, B2M
Organism: Homo sapiens
Interactions: 132
UniProt ID: P61769

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001913 - T cell mediated cytotoxicity
GO:0001916 - positive regulation of T cell mediated cytotoxicity
GO:0002237 - response to molecule of bacterial origin
GO:0002481 - antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

963492

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

13

20

Small-scale

0.986

High

379986

HLAB
HLA class I histocompatibility antigen, B alpha chain

9

20

Small-scale

0.964

High

520804

HLAC
HLA class I histocompatibility antigen, C alpha chain

7

20

Small-scale

0.961

High

705951

CD1B
T-cell surface glycoprotein CD1b

5

20

Small-scale

0.926

High

963515

HFE
Hereditary hemochromatosis protein

4

17

Small-scale

0.900

High

939483

FCGRN
IgG receptor FcRn large subunit p51

4

20

Small-scale

0.899

High

409337

HLAA
HLA class I histocompatibility antigen, A alpha chain

4

20

Small-scale

0.890

High

963525

LIRB2
Leukocyte immunoglobulin-like receptor subfamily B member 2

4

20

Small-scale

0.873

High

963528

LIRB1
Leukocyte immunoglobulin-like receptor subfamily B member 1

4

20

Small-scale

0.873

High

607358

HLAG
HLA class I histocompatibility antigen, alpha chain G

4

19

Small-scale

0.867

High

854620

RAGP1
Ran GTPase-activating protein 1

3

3

High-throughput

0.855

High

719707

HLAF
HLA class I histocompatibility antigen, alpha chain F

3

20

Small-scale

0.847

High

586177

CD1E
T-cell surface glycoprotein CD1e, membrane-associated

2

20

High-throughput

0.811

High

438877

CD1A
T-cell surface glycoprotein CD1a

2

20

Small-scale

0.778

High

586202

CD1D
Antigen-presenting glycoprotein CD1d

2

20

Small-scale

0.768

High

568051

HLAE
HLA class I histocompatibility antigen, alpha chain E

2

20

Small-scale

0.755

High

379087

IGKC
Immunoglobulin kappa constant

2

20

Small-scale

0.754

High

688546

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

2

20

Small-scale

0.754

High

963503

KLRD1
Natural killer cells antigen CD94

2

20

Small-scale

0.754

High

963516

Q5S3G3
HLA class I histocompatibility antigen A alpha chain

2

17

Small-scale

0.754

High

963531

HMR1
Major histocompatibility complex class I-related protein 1

1

17

Small-scale

0.716

High

641546

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

20

High-throughput

0.691

High

626148

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

4

Small-scale

0.665

High

963534

HMCN1
Hemicentin-1

1

1

High-throughput

0.665

High

326248

PRS23
Serine protease 23

1

0

High-throughput

0.663

High

890435

RBP2
E3 SUMO-protein ligase RanBP2

3

5

High-throughput

0.662

High

963502

PUR1
Amidophosphoribosyltransferase

3

2

High-throughput

0.662

High

73195

B1PKZ2
MHC class I antigen

1

20

Small-scale

0.647

High

198265

O19691
MHC class I lymphocyte antigen

1

20

Small-scale

0.647

High

390522

TFR1
Transferrin receptor protein 1

1

5

Small-scale

0.646

High

963510

PCOC1
Procollagen C-endopeptidase enhancer 1

2

8

Small-scale

0.644

High

138663

IMA4
Importin subunit alpha-4

2

4

High-throughput

0.628

High

142519

IMA3
Importin subunit alpha-3

2

4

High-throughput

0.628

High

250928

TPST1
Protein-tyrosine sulfotransferase 1

2

1

High-throughput

0.628

High

963496

UBC9
SUMO-conjugating enzyme UBC9

2

1

High-throughput

0.628

High

193692

TPSN
Tapasin

1

20

Small-scale

0.618

High

351425

NCTR2
Natural cytotoxicity triggering receptor 2

1

1

Small-scale

0.618

High

378904

CD8A
T-cell surface glycoprotein CD8 alpha chain

1

4

Small-scale

0.618

High

688659

NKG2C
NKG2-C type II integral membrane protein

1

20

Small-scale

0.618

High

850771

KI2L1
Killer cell immunoglobulin-like receptor 2DL1

1

20

Small-scale

0.618

High

850799

KI2L2
Killer cell immunoglobulin-like receptor 2DL2

1

20

Small-scale

0.618

High

850864

KI3L1
Killer cell immunoglobulin-like receptor 3DL1

1

20

Small-scale

0.618

High

963506

IL27B
Interleukin-27 subunit beta

1

8

Small-scale

0.618

High

963507

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

1

20

Small-scale

0.618

High

963517

Q5SUL5
HLA class I histocompatibility antigen A alpha chain

1

17

Small-scale

0.618

High

963532

Q95J06
HLA class I histocompatibility antigen A alpha chain

1

17

Small-scale

0.618

High

963547

PD1L1
Programmed cell death 1 ligand 1

1

20

High-throughput

0.618

High

963535

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

3

4

High-throughput

0.604

High

963508

IMB1
Importin subunit beta-1

2

0

High-throughput

0.602

High

963512

DLGP5
Disks large-associated protein 5

2

0

High-throughput

0.602

High

963521

CDCA2
Cell division cycle-associated protein 2

2

0

High-throughput

0.602

High

963499

TAP1
Antigen peptide transporter 1

2

16

Small-scale

0.601

High

550954

PCNA
Proliferating cell nuclear antigen

2

2

Small-scale

0.584

High

515818

RGPD2
RANBP2-like and GRIP domain-containing protein 2

2

4

High-throughput

0.574

High

616285

RCC1
Regulator of chromosome condensation

2

5

High-throughput

0.549

High

466883

ACM4
Muscarinic acetylcholine receptor M4

1

2

High-throughput

0.541

High

856627

BAG6
Large proline-rich protein BAG6

1

2

High-throughput

0.541

High

563533

CFTR
Cystic fibrosis transmembrane conductance regulator

1

6

High-throughput

0.536

High

922416

CLH2
Clathrin heavy chain 2

1

2

High-throughput

0.536

High

963505

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.536

High

963524

BRSK2
Serine/threonine-protein kinase BRSK2

1

1

High-throughput

0.536

High

963529

MK15
Mitogen-activated protein kinase 15

1

5

High-throughput

0.536

High

963542

DDX31
ATP-dependent DNA helicase DDX31

1

1

High-throughput

0.536

High

648343

USF1
Upstream stimulatory factor 1

1

5

Small-scale

0.534

High

963513

USF2
Upstream stimulatory factor 2

1

5

Small-scale

0.534

High

533909

IRF1
Interferon regulatory factor 1

1

5

Small-scale

0.515

High

571581

IRF2
Interferon regulatory factor 2

1

5

Small-scale

0.515

High

643354

OSBP1
Oxysterol-binding protein 1

1

1

High-throughput

0.515

High

963498

IRF8
Interferon regulatory factor 8

1

5

Small-scale

0.515

High

963501

TF65
Transcription factor p65

1

3

Small-scale

0.515

High

963511

IRF4
Interferon regulatory factor 4

1

5

Small-scale

0.515

High

963544

OTOF
Otoferlin

1

2

High-throughput

0.515

High

963520

MAP1S
Microtubule-associated protein 1S

1

0

High-throughput

0.513

High

963545

MOG1
Ran guanine nucleotide release factor

1

0

High-throughput

0.513

High

963494

GRB2
Growth factor receptor-bound protein 2

1

3

High-throughput

0.508

High

963514

HSPB2
Heat shock protein beta-2

1

1

High-throughput

0.508

High

384653

CRYAB
Alpha-crystallin B chain

1

1

Small-scale

0.501

High

956839

CXCR4
C-X-C chemokine receptor type 4

1

4

Small-scale

0.501

High

463935

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.500

High

963554

MORC2
ATPase MORC2

1

0

High-throughput

0.493

High

889388

CLK1
Dual specificity protein kinase CLK1

1

3

High-throughput

0.489

High

369652

A2MG
Alpha-2-macroglobulin

1

0

Small-scale

0.480

High

50394

MEX3A
RNA-binding protein MEX3A

1

5

Small-scale

0.479

High

323276

TRI37
E3 ubiquitin-protein ligase TRIM37

1

3

High-throughput

0.479

High

377492

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

Small-scale

0.479

High

466187

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

550203

PABP1
Polyadenylate-binding protein 1

1

1

Small-scale

0.479

High

580970

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

590855

TIMP2
Metalloproteinase inhibitor 2

1

1

High-throughput

0.479

High

591568

H2AX
Histone H2AX

1

2

Small-scale

0.479

High

606539

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

903300

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

1

High-throughput

0.479

High

910836

IMA1
Importin subunit alpha-1

1

4

Small-scale

0.479

High

947105

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

4

High-throughput

0.479

High

953376

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

955019

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

961922

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

963493

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

963495

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

963497

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

963500

TAP2
Antigen peptide transporter 2

1

16

Small-scale

0.479

High

963518

MARH8
E3 ubiquitin-protein ligase MARCHF8

1

1

Small-scale

0.479

High

963523

MEX3B
RNA-binding protein MEX3B

1

2

Small-scale

0.479

High

963538

CD244
Natural killer cell receptor 2B4

1

11

Small-scale

0.479

High

963539

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

High-throughput

0.479

High

963541

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

963543

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

963546

T106B
Transmembrane protein 106B

1

18

High-throughput

0.479

High

963548

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

963552

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

1

High-throughput

0.479

High

963553

TLN1
Talin-1

1

5

High-throughput

0.479

High

128916

MEN1
Menin

1

0

High-throughput

0.458

High

377266

PTHY
Parathyroid hormone

1

0

High-throughput

0.458

High

963527

ATLA2
Atlastin-2

1

0

High-throughput

0.458

High

963549

HERC5
E3 ISG15--protein ligase HERC5

1

0

Small-scale

0.458

High

963550

SAC2
Phosphatidylinositide phosphatase SAC2

1

0

Small-scale

0.458

High

963509

S39AE
Metal cation symporter ZIP14

1

19

High-throughput

0.445

High

963537

S19A3
Thiamine transporter 2

1

2

High-throughput

0.445

High

360718

COX3
Cytochrome c oxidase subunit 3

1

1

Small-scale

0.437

High

963519

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

7

Small-scale

0.437

High

963540

P63
Tumor protein 63

1

1

Small-scale

0.417

High

161604

RGPD8
RANBP2-like and GRIP domain-containing protein 8

1

4

High-throughput

0.407

High

963504

CTBP1
C-terminal-binding protein 1

1

2

High-throughput

0.407

High

155565

NEMP1
Nuclear envelope integral membrane protein 1

3

0

High-throughput

0.345

High

963536

NUSAP
Nucleolar and spindle-associated protein 1

1

0

High-throughput

0.279

Low

963551

PYGO1
Pygopus homolog 1

1

0

High-throughput

0.268

Low

60537

HEAT9
Protein HEATR9

1

0

High-throughput

0.249

Low

963526

EFCB3
EF-hand calcium-binding domain-containing protein 3

1

0

High-throughput

0.249

Low

963530

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.249

Low

963522

LIN54
Protein lin-54 homolog

1

0

Small-scale

0.232

Low

963533

LIN37
Protein lin-37 homolog

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025