Protein: EPS15
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)

Gene: EPS15
Organism: Homo sapiens
Interactions: 217
UniProt ID: P42566

Gene Ontology (top 5):
GO:0001921 - positive regulation of receptor recycling
GO:0005509 - calcium ion binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

787954

STON2
Stonin-2

5

12

Small-scale

0.946

High

475452

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

9

13

Small-scale

0.751

High

787997

EPN1
Epsin-1

7

20

Small-scale

0.745

High

787959

AP2M1
AP-2 complex subunit mu

6

12

High-throughput

0.738

High

338077

EGFR
Epidermal growth factor receptor

7

10

Small-scale

0.735

High

321504

AP2A1
AP-2 complex subunit alpha-1

6

20

Small-scale

0.732

High

302112

AP2A2
AP-2 complex subunit alpha-2

5

20

Small-scale

0.717

High

787861

CRK
Adapter molecule crk

5

19

Small-scale

0.716

High

787877

AP2S1
AP-2 complex subunit sigma

4

11

High-throughput

0.704

High

787902

FCHO2
F-BAR domain only protein 2

4

19

Small-scale

0.699

High

787890

AP2B1
AP-2 complex subunit beta

4

20

High-throughput

0.699

High

147146

FCHO1
F-BAR domain only protein 1

4

20

Small-scale

0.698

High

159921

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

4

6

Small-scale

0.697

High

787860

EPS15
Epidermal growth factor receptor substrate 15

4

16

Small-scale

0.694

High

160427

AURKA
Aurora kinase A

4

3

High-throughput

0.694

High

787868

NUMB
Protein numb homolog

4

18

Small-scale

0.692

High

787920

ITSN1
Intersectin-1

4

17

Small-scale

0.681

High

787994

UBQL1
Ubiquilin-1

3

9

Small-scale

0.677

High

566956

CXA1
Gap junction alpha-1 protein

4

6

Small-scale

0.676

High

787963

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

3

12

Small-scale

0.674

High

787907

PICAL
Phosphatidylinositol-binding clathrin assembly protein

3

12

High-throughput

0.670

High

787889

GRB2
Growth factor receptor-bound protein 2

3

19

Small-scale

0.667

High

451645

CLCB
Clathrin light chain B

3

8

High-throughput

0.667

High

787903

AP1B1
AP-1 complex subunit beta-1

3

20

Small-scale

0.667

High

787974

SPC25
Kinetochore protein Spc25

3

1

High-throughput

0.667

High

787875

AGFG1
Arf-GAP domain and FG repeat-containing protein 1

3

11

Small-scale

0.662

High

787986

SH3B4
SH3 domain-binding protein 4

3

1

Small-scale

0.656

High

212604

AP1G1
AP-1 complex subunit gamma-1

2

20

Small-scale

0.629

High

787926

RUN3A
RUN domain-containing protein 3A

2

4

High-throughput

0.628

High

787939

LSR
Lipolysis-stimulated lipoprotein receptor

2

2

High-throughput

0.628

High

787982

NECP2
Adaptin ear-binding coat-associated protein 2

2

5

High-throughput

0.628

High

787987

EP15R
Epidermal growth factor receptor substrate 15-like 1

2

17

High-throughput

0.628

High

237877

AP180
Clathrin coat assembly protein AP180

2

10

Small-scale

0.619

High

451386

CLCA
Clathrin light chain A

2

8

High-throughput

0.611

High

787862

CRKL
Crk-like protein

2

12

High-throughput

0.611

High

787864

IQGA1
Ras GTPase-activating-like protein IQGAP1

2

2

High-throughput

0.611

High

787876

PLK1
Serine/threonine-protein kinase PLK1

2

6

High-throughput

0.611

High

787895

CLH1
Clathrin heavy chain 1

2

7

Small-scale

0.611

High

640219

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

10

Small-scale

0.608

High

473612

CC172
Coiled-coil domain-containing protein 172

2

0

High-throughput

0.602

High

787960

STALP
AMSH-like protease

2

0

High-throughput

0.602

High

581515

VCAM1
Vascular cell adhesion protein 1

2

2

High-throughput

0.601

High

787995

RNF11
RING finger protein 11

3

2

Small-scale

0.594

High

787958

OPTN
Optineurin

2

16

Small-scale

0.586

High

787985

ITSN2
Intersectin-2

2

17

High-throughput

0.586

High

150896

DVL2
Segment polarity protein dishevelled homolog DVL-2

2

9

Small-scale

0.584

High

337383

ABL1
Tyrosine-protein kinase ABL1

2

8

High-throughput

0.584

High

503606

HSP7C
Heat shock cognate 71 kDa protein

2

6

High-throughput

0.584

High

787990

UBQL2
Ubiquilin-2

2

8

Small-scale

0.584

High

787993

MYO6
Unconventional myosin-VI

2

6

Small-scale

0.584

High

787929

SPOPL
Speckle-type POZ protein-like

1

4

Small-scale

0.578

High

403607

AP2A
Transcription factor AP-2-alpha

2

0

Small-scale

0.577

High

369137

ESR1
Estrogen receptor

2

10

High-throughput

0.571

High

777015

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

2

Small-scale

0.561

High

787882

CORO7
Coronin-7

1

2

Small-scale

0.561

High

787952

REPS2
RalBP1-associated Eps domain-containing protein 2

1

16

Small-scale

0.561

High

226756

PRKN
E3 ubiquitin-protein ligase parkin

1

14

Small-scale

0.536

High

161630

GAK
Cyclin-G-associated kinase

1

9

High-throughput

0.536

High

253734

AUXI
Auxilin

1

3

High-throughput

0.536

High

280780

KRT36
Keratin, type I cuticular Ha6

1

19

High-throughput

0.536

High

362910

FINC
Fibronectin

1

6

High-throughput

0.536

High

597995

FLNA
Filamin-A

1

3

High-throughput

0.536

High

724698

MYH9
Myosin-9

1

4

High-throughput

0.536

High

787885

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

7

High-throughput

0.536

High

787905

TRAF2
TNF receptor-associated factor 2

1

7

High-throughput

0.536

High

787917

RNPS1
RNA-binding protein with serine-rich domain 1

1

3

High-throughput

0.536

High

787923

DREB
Drebrin

1

2

High-throughput

0.536

High

787932

MACC1
Metastasis-associated in colon cancer protein 1

1

1

High-throughput

0.536

High

787946

SYNPO
Synaptopodin

1

3

High-throughput

0.536

High

787961

MYO19
Unconventional myosin-XIX

1

8

High-throughput

0.536

High

787966

WNK3
Serine/threonine-protein kinase WNK3

1

1

High-throughput

0.536

High

787973

SYNCI
Syncoilin

1

17

High-throughput

0.536

High

787975

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

1

High-throughput

0.536

High

787978

PDLI7
PDZ and LIM domain protein 7

1

4

High-throughput

0.536

High

787980

BMP2K
BMP-2-inducible protein kinase

1

12

High-throughput

0.536

High

787989

LIMA1
LIM domain and actin-binding protein 1

1

4

High-throughput

0.536

High

787943

SPART
Spartin

1

4

Small-scale

0.527

High

573606

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

11

Small-scale

0.516

High

787904

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

12

Small-scale

0.516

High

609745

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

High-throughput

0.513

High

787865

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

787869

TIG1
Retinoic acid receptor responder protein 1

1

0

High-throughput

0.513

High

787919

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

787977

ANLN
Anillin

1

0

High-throughput

0.513

High

787983

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.513

High

787866

MTR1A
Melatonin receptor type 1A

1

3

High-throughput

0.508

High

673252

WEE1
Wee1-like protein kinase

1

8

High-throughput

0.501

High

787863

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

3

Small-scale

0.501

High

787873

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

4

Small-scale

0.501

High

787874

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

4

Small-scale

0.501

High

787884

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

4

Small-scale

0.501

High

787886

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

Small-scale

0.501

High

787888

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

4

Small-scale

0.501

High

787897

ANK2
Ankyrin-2

1

12

High-throughput

0.501

High

787913

EPN4
Clathrin interactor 1

1

20

Small-scale

0.501

High

787918

DLGP5
Disks large-associated protein 5

1

2

High-throughput

0.501

High

787921

MK14
Mitogen-activated protein kinase 14

1

3

Small-scale

0.501

High

787925

AR13B
ADP-ribosylation factor-like protein 13B

1

5

High-throughput

0.501

High

787935

S31E1
Spermatogenesis-associated protein 31E1

1

7

High-throughput

0.501

High

787970

UBQL3
Ubiquilin-3

1

8

High-throughput

0.501

High

787981

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

2

High-throughput

0.501

High

787991

NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

1

2

Small-scale

0.501

High

787924

INSY1
Inhibitory synaptic factor 1

1

1

High-throughput

0.489

High

787933

RUFY4
RUN and FYVE domain-containing protein 4

1

16

High-throughput

0.489

High

787942

SYCE1
Synaptonemal complex central element protein 1

1

1

High-throughput

0.489

High

787953

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

787909

LAPM5
Lysosomal-associated transmembrane protein 5

1

0

High-throughput

0.486

High

168349

SCAM1
Secretory carrier-associated membrane protein 1

1

1

Small-scale

0.481

High

72432

TM114
Transmembrane protein 114

1

0

High-throughput

0.480

High

787870

TSC2
Tuberin

1

0

High-throughput

0.480

High

787891

ABCA4
Retinal-specific phospholipid-transporting ATPase ABCA4

1

0

High-throughput

0.480

High

787948

DRAM1
DNA damage-regulated autophagy modulator protein 1

1

0

High-throughput

0.480

High

162475

XPO1
Exportin-1

1

4

High-throughput

0.479

High

213932

KRT86
Keratin, type II cuticular Hb6

1

13

High-throughput

0.479

High

277020

STAM2
Signal transducing adapter molecule 2

1

17

Small-scale

0.479

High

280539

KRT34
Keratin, type I cuticular Ha4

1

20

High-throughput

0.479

High

280860

KRT37
Keratin, type I cuticular Ha7

1

20

High-throughput

0.479

High

280957

KRT38
Keratin, type I cuticular Ha8

1

20

High-throughput

0.479

High

318787

K2C75
Keratin, type II cytoskeletal 75

1

10

High-throughput

0.479

High

359311

K1C14
Keratin, type I cytoskeletal 14

1

20

High-throughput

0.479

High

359470

K2C6A
Keratin, type II cytoskeletal 6A

1

12

High-throughput

0.479

High

380575

K2C1
Keratin, type II cytoskeletal 1

1

11

High-throughput

0.479

High

384432

NTRK1
High affinity nerve growth factor receptor

1

13

High-throughput

0.479

High

398333

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

1

High-throughput

0.479

High

412069

FYN
Tyrosine-protein kinase Fyn

1

8

High-throughput

0.479

High

430085

PROF1
Profilin-1

1

1

High-throughput

0.479

High

445014

K1C16
Keratin, type I cytoskeletal 16

1

18

High-throughput

0.479

High

501791

BIP
Endoplasmic reticulum chaperone BiP

1

11

High-throughput

0.479

High

506537

BCR
Breakpoint cluster region protein

1

15

High-throughput

0.479

High

517742

K2C3
Keratin, type II cytoskeletal 3

1

12

High-throughput

0.479

High

521783

CADH1
Cadherin-1

1

4

High-throughput

0.479

High

531330

K1C10
Keratin, type I cytoskeletal 10

1

18

High-throughput

0.479

High

531538

K2C5
Keratin, type II cytoskeletal 5

1

11

High-throughput

0.479

High

557629

NCK1
SH2/SH3 adapter protein NCK1

1

19

High-throughput

0.479

High

607906

FGFR4
Fibroblast growth factor receptor 4

1

14

High-throughput

0.479

High

653929

MAP4
Microtubule-associated protein 4

1

6

High-throughput

0.479

High

665162

EPHA2
Ephrin type-A receptor 2

1

5

Small-scale

0.479

High

668492

PML
Protein PML

1

6

High-throughput

0.479

High

713920

HS71L
Heat shock 70 kDa protein 1-like

1

6

High-throughput

0.479

High

719877

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

724048

K1C9
Keratin, type I cytoskeletal 9

1

20

High-throughput

0.479

High

729047

K22E
Keratin, type II cytoskeletal 2 epidermal

1

11

High-throughput

0.479

High

734550

TRI23
E3 ubiquitin-protein ligase TRIM23

1

5

High-throughput

0.479

High

751518

GRP75
Stress-70 protein, mitochondrial

1

10

High-throughput

0.479

High

787867

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.479

High

787872

DYN2
Dynamin-2

1

10

Small-scale

0.479

High

787878

RD23A
UV excision repair protein RAD23 homolog A

1

10

Small-scale

0.479

High

787892

KRT83
Keratin, type II cuticular Hb3

1

12

High-throughput

0.479

High

787893

KRT85
Keratin, type II cuticular Hb5

1

13

High-throughput

0.479

High

787894

DAB2
Disabled homolog 2

1

18

Small-scale

0.479

High

787898

SC6A3
Sodium-dependent dopamine transporter

1

4

Small-scale

0.479

High

787899

K1C17
Keratin, type I cytoskeletal 17

1

20

High-throughput

0.479

High

787901

PRDX1
Peroxiredoxin-1

1

2

High-throughput

0.479

High

787908

HDAC1
Histone deacetylase 1

1

5

High-throughput

0.479

High

787910

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

9

High-throughput

0.479

High

787911

KT33B
Keratin, type I cuticular Ha3-II

1

20

High-throughput

0.479

High

787912

K1H2
Keratin, type I cuticular Ha2

1

20

High-throughput

0.479

High

787915

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.479

High

787916

NONO
Non-POU domain-containing octamer-binding protein

1

1

High-throughput

0.479

High

787922

OCLN
Occludin

1

2

Small-scale

0.479

High

787928

K2C79
Keratin, type II cytoskeletal 79

1

11

High-throughput

0.479

High

787931

LMTK1
Serine/threonine-protein kinase LMTK1

1

20

High-throughput

0.479

High

787934

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.479

High

787936

RFIP2
Rab11 family-interacting protein 2

1

11

Small-scale

0.479

High

787937

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

787940

K2C73
Keratin, type II cytoskeletal 73

1

12

High-throughput

0.479

High

787941

MIB1
E3 ubiquitin-protein ligase MIB1

1

14

High-throughput

0.479

High

787944

STK40
Serine/threonine-protein kinase 40

1

2

Small-scale

0.479

High

787945

RHG18
Rho GTPase-activating protein 18

1

3

High-throughput

0.479

High

787951

NECP1
Adaptin ear-binding coat-associated protein 1

1

5

High-throughput

0.479

High

787955

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

787956

KRT35
Keratin, type I cuticular Ha5

1

20

High-throughput

0.479

High

787964

TRI56
E3 ubiquitin-protein ligase TRIM56

1

10

High-throughput

0.479

High

787969

EPN3
Epsin-3

1

20

Small-scale

0.479

High

787971

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

16

Small-scale

0.479

High

787972

DNJC5
DnaJ homolog subfamily C member 5

1

5

High-throughput

0.479

High

787979

KRT82
Keratin, type II cuticular Hb2

1

13

High-throughput

0.479

High

787988

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

787996

DCAF1
DDB1- and CUL4-associated factor 1

1

5

High-throughput

0.479

High

351294

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

Small-scale

0.458

High

353271

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.458

High

428070

TBB5
Tubulin beta chain

1

0

High-throughput

0.458

High

530483

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

778959

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

787871

VASP
Vasodilator-stimulated phosphoprotein

1

0

High-throughput

0.458

High

787883

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.458

High

787887

H4
Histone H4

1

0

High-throughput

0.458

High

787896

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.458

High

787914

IMB1
Importin subunit beta-1

1

0

Small-scale

0.458

High

787927

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

787967

KRA93
Keratin-associated protein 9-3

1

0

High-throughput

0.458

High

787984

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

236198

PRP17
Pre-mRNA-processing factor 17

1

6

High-throughput

0.457

High

787879

AF10
Protein AF-10

1

3

High-throughput

0.457

High

787880

AF17
Protein AF-17

1

3

High-throughput

0.457

High

787962

LMTK3
Serine/threonine-protein kinase LMTK3

1

20

High-throughput

0.457

High

787900

FMR1
Fragile X messenger ribonucleoprotein 1

1

6

High-throughput

0.457

High

61732

A6H8W8
Intersectin 2

1

18

High-throughput

0.445

High

69204

A9UF07
non-specific protein-tyrosine kinase

1

9

High-throughput

0.445

High

280491

KT33A
Keratin, type I cuticular Ha3-I

1

20

High-throughput

0.445

High

383669

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

10

Small-scale

0.445

High

717524

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.445

High

787930

PKHA7
Pleckstrin homology domain-containing family A member 7

1

14

High-throughput

0.445

High

232030

KDM1A
Lysine-specific histone demethylase 1A

1

2

High-throughput

0.437

High

650573

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

787906

RFA4
Replication protein A 30 kDa subunit

1

3

High-throughput

0.437

High

787965

RNF26
E3 ubiquitin-protein ligase RNF26

1

4

Small-scale

0.437

High

787976

PALMD
Palmdelphin

1

1

High-throughput

0.408

High

787949

TAC2N
Tandem C2 domains nuclear protein

1

2

High-throughput

0.373

High

787947

S2541
Mitochondrial carrier protein SCaMC-3L

3

0

High-throughput

0.347

High

787881

SCOT1
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

2

0

High-throughput

0.328

High

787950

IN80E
INO80 complex subunit E

1

0

High-throughput

0.279

Low

787968

RPB1B
DNA-directed RNA polymerase II subunit RPB11-b1

1

0

High-throughput

0.279

Low

787938

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

787957

PF21A
PHD finger protein 21A

1

0

High-throughput

0.249

Low

787992

RCOR1
REST corepressor 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024