Protein: PRD16
Histone-lysine N-methyltransferase PRDM16 (EC 2.1.1.367) (PR domain zinc finger protein 16) (PR domain-containing protein 16) (Transcription factor MEL1) (MDS1/EVI1-like gene 1)

Gene: PRD16, PRDM16
Organism: Homo sapiens
Interactions: 188
UniProt ID: Q9HAZ2

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

884248

KLF3
Krueppel-like factor 3

2

20

High-throughput

0.754

High

1268302

ZN516
Zinc finger protein 516

1

8

High-throughput

0.691

High

1032624

CTBP1
C-terminal-binding protein 1

4

8

High-throughput

0.683

High

309263

SPDEF
SAM pointed domain-containing Ets transcription factor

3

2

High-throughput

0.667

High

1089383

LONF1
LON peptidase N-terminal domain and RING finger protein 1

1

11

High-throughput

0.621

High

1335034

NEK6
Serine/threonine-protein kinase Nek6

1

6

High-throughput

0.621

High

279890

TRIO
Triple functional domain protein

1

1

High-throughput

0.618

High

505296

EGR2
E3 SUMO-protein ligase EGR2

1

19

High-throughput

0.618

High

586992

CSK22
Casein kinase II subunit alpha'

1

5

High-throughput

0.618

High

934489

CSK21
Casein kinase II subunit alpha

1

7

High-throughput

0.618

High

1297790

ZN512
Zinc finger protein 512

1

17

High-throughput

0.618

High

1335032

PRD16
Histone-lysine N-methyltransferase PRDM16

1

8

High-throughput

0.618

High

1335053

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.618

High

881300

CTBP2
C-terminal-binding protein 2

2

8

High-throughput

0.611

High

950289

SMAD3
Mothers against decapentaplegic homolog 3

2

13

Small-scale

0.601

High

997911

RBBP4
Histone-binding protein RBBP4

1

5

High-throughput

0.597

High

129052

PLK4
Serine/threonine-protein kinase PLK4

1

0

High-throughput

0.589

High

1078668

SMAD2
Mothers against decapentaplegic homolog 2

2

13

Small-scale

0.584

High

521309

SKI
Ski oncogene

2

0

Small-scale

0.559

High

147806

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

2

High-throughput

0.536

High

920699

RS26
Small ribosomal subunit protein eS26

1

1

High-throughput

0.536

High

1223942

RCOR2
REST corepressor 2

1

7

High-throughput

0.536

High

1309503

TBA1C
Tubulin alpha-1C chain

1

2

High-throughput

0.536

High

1335045

RCOR1
REST corepressor 1

1

7

High-throughput

0.536

High

1086322

H31T
Histone H3.1t

1

14

High-throughput

0.515

High

1273889

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

High-throughput

0.501

High

714773

TRY3
Trypsin-3

1

1

High-throughput

0.489

High

1335035

S10AE
Protein S100-A14

1

6

High-throughput

0.489

High

1335041

DMBT1
Deleted in malignant brain tumors 1 protein

1

2

High-throughput

0.489

High

640629

DDX6
Probable ATP-dependent RNA helicase DDX6

1

3

High-throughput

0.481

High

770686

TXLNA
Alpha-taxilin

1

8

High-throughput

0.481

High

827279

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.481

High

1223082

CCD13
Coiled-coil domain-containing protein 13

1

8

High-throughput

0.481

High

1311957

TCHP
Trichoplein keratin filament-binding protein

1

1

High-throughput

0.481

High

1335044

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

20

High-throughput

0.481

High

117829

MYO1C
Unconventional myosin-Ic

1

8

High-throughput

0.479

High

133683

NOP56
Nucleolar protein 56

1

3

High-throughput

0.479

High

149747

COPE
Coatomer subunit epsilon

1

1

High-throughput

0.479

High

176862

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

1

High-throughput

0.479

High

197831

CRX
Cone-rod homeobox protein

1

2

High-throughput

0.479

High

198725

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.479

High

209483

PLRG1
Pleiotropic regulator 1

1

3

High-throughput

0.479

High

215691

AKAP8
A-kinase anchor protein 8

1

2

High-throughput

0.479

High

229499

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

5

High-throughput

0.479

High

258204

DNJB6
DnaJ homolog subfamily B member 6

1

9

High-throughput

0.479

High

261012

H2AY
Core histone macro-H2A.1

1

3

High-throughput

0.479

High

266062

PSIP1
PC4 and SFRS1-interacting protein

1

5

High-throughput

0.479

High

296143

MTA2
Metastasis-associated protein MTA2

1

7

High-throughput

0.479

High

328659

MBD3
Methyl-CpG-binding domain protein 3

1

2

High-throughput

0.479

High

390541

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

High-throughput

0.479

High

420886

H2B1J
Histone H2B type 1-J

1

3

High-throughput

0.479

High

427926

CAN1
Calpain-1 catalytic subunit

1

1

High-throughput

0.479

High

437478

4F2
Amino acid transporter heavy chain SLC3A2

1

1

High-throughput

0.479

High

441154

CY1
Cytochrome c1, heme protein, mitochondrial

1

1

High-throughput

0.479

High

455891

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.479

High

502567

BIP
Endoplasmic reticulum chaperone BiP

1

7

High-throughput

0.479

High

505906

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

1

High-throughput

0.479

High

508723

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.479

High

525066

XRCC5
X-ray repair cross-complementing protein 5

1

2

High-throughput

0.479

High

538743

HXB2
Homeobox protein Hox-B2

1

1

High-throughput

0.479

High

564190

HSP76
Heat shock 70 kDa protein 6

1

4

High-throughput

0.479

High

571777

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

3

High-throughput

0.479

High

594976

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

1

High-throughput

0.479

High

623382

AT5F1
ATP synthase F(0) complex subunit B1, mitochondrial

1

1

High-throughput

0.479

High

686068

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.479

High

709059

MCM7
DNA replication licensing factor MCM7

1

2

High-throughput

0.479

High

722295

RFC1
Replication factor C subunit 1

1

1

High-throughput

0.479

High

727928

SOX6
Transcription factor SOX-6

1

12

High-throughput

0.479

High

730360

PRS7
26S proteasome regulatory subunit 7

1

4

High-throughput

0.479

High

785412

ELK3
ETS domain-containing protein Elk-3

1

2

High-throughput

0.479

High

787014

MTREX
Exosome RNA helicase MTR4

1

5

High-throughput

0.479

High

806180

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.479

High

807846

MAP1B
Microtubule-associated protein 1B

1

2

High-throughput

0.479

High

809439

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

3

High-throughput

0.479

High

816106

ATPO
ATP synthase subunit O, mitochondrial

1

1

High-throughput

0.479

High

827601

EFTU
Elongation factor Tu, mitochondrial

1

2

High-throughput

0.479

High

843914

FXR1
RNA-binding protein FXR1

1

6

High-throughput

0.479

High

844251

FXR2
RNA-binding protein FXR2

1

6

High-throughput

0.479

High

853476

IMA1
Importin subunit alpha-1

1

7

High-throughput

0.479

High

863336

COPB
Coatomer subunit beta

1

1

High-throughput

0.479

High

863567

COPA
Coatomer subunit alpha

1

1

High-throughput

0.479

High

876901

NP1L1
Nucleosome assembly protein 1-like 1

1

6

High-throughput

0.479

High

882160

GSC
Homeobox protein goosecoid

1

2

High-throughput

0.479

High

888443

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

2

High-throughput

0.479

High

896825

ARP3
Actin-related protein 3

1

2

High-throughput

0.479

High

896976

ARP2
Actin-related protein 2

1

3

High-throughput

0.479

High

897127

ACTZ
Alpha-centractin

1

3

High-throughput

0.479

High

905741

RS7
Small ribosomal subunit protein eS7

1

1

High-throughput

0.479

High

906603

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

8

High-throughput

0.479

High

912383

SMD1
Small nuclear ribonucleoprotein Sm D1

1

1

High-throughput

0.479

High

924168

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

2

High-throughput

0.479

High

931004

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

7

High-throughput

0.479

High

931876

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.479

High

933625

TBA4A
Tubulin alpha-4A chain

1

2

High-throughput

0.479

High

935257

H31
Histone H3.1

1

14

High-throughput

0.479

High

960979

CLH1
Clathrin heavy chain 1

1

1

High-throughput

0.479

High

966773

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

3

High-throughput

0.479

High

974002

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

3

High-throughput

0.479

High

991887

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

3

High-throughput

0.479

High

996904

SSRP1
FACT complex subunit SSRP1

1

9

High-throughput

0.479

High

1016328

TBL3
Transducin beta-like protein 3

1

1

High-throughput

0.479

High

1027271

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.479

High

1031953

MTA1
Metastasis-associated protein MTA1

1

7

High-throughput

0.479

High

1038726

HDAC1
Histone deacetylase 1

1

7

High-throughput

0.479

High

1042575

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1049529

SAFB2
Scaffold attachment factor B2

1

1

High-throughput

0.479

High

1054597

RBM39
RNA-binding protein 39

1

3

High-throughput

0.479

High

1055636

MCM6
DNA replication licensing factor MCM6

1

2

High-throughput

0.479

High

1059881

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

4

High-throughput

0.479

High

1062401

CND2
Condensin complex subunit 2

1

1

High-throughput

0.479

High

1083396

RBBP7
Histone-binding protein RBBP7

1

4

High-throughput

0.479

High

1087715

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

1

High-throughput

0.479

High

1114363

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

14

High-throughput

0.479

High

1131405

HP1B3
Heterochromatin protein 1-binding protein 3

1

1

High-throughput

0.479

High

1174663

H32
Histone H3.2

1

14

High-throughput

0.479

High

1184657

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

1

High-throughput

0.479

High

1201456

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

3

High-throughput

0.479

High

1205817

P66A
Transcriptional repressor p66-alpha

1

4

High-throughput

0.479

High

1230822

NUP93
Nuclear pore complex protein Nup93

1

1

High-throughput

0.479

High

1246371

THOC2
THO complex subunit 2

1

4

High-throughput

0.479

High

1262822

PHIP
PH-interacting protein

1

5

High-throughput

0.479

High

1263976

P66B
Transcriptional repressor p66-beta

1

4

High-throughput

0.479

High

1270453

HDAC2
Histone deacetylase 2

1

7

High-throughput

0.479

High

1273281

ARHG2
Rho guanine nucleotide exchange factor 2

1

2

High-throughput

0.479

High

1287497

AP2M1
AP-2 complex subunit mu

1

3

High-throughput

0.479

High

1290505

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

2

High-throughput

0.479

High

1299377

RBM14
RNA-binding protein 14

1

5

High-throughput

0.479

High

1303048

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

4

High-throughput

0.479

High

1303765

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.479

High

1305019

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.479

High

1311930

SOX7
Transcription factor SOX-7

1

11

High-throughput

0.479

High

1312815

TBB6
Tubulin beta-6 chain

1

1

High-throughput

0.479

High

1314078

GNL3
Guanine nucleotide-binding protein-like 3

1

3

High-throughput

0.479

High

1315707

AP1M1
AP-1 complex subunit mu-1

1

3

High-throughput

0.479

High

1327357

NAT10
RNA cytidine acetyltransferase

1

1

High-throughput

0.479

High

1328087

DDX47
Probable ATP-dependent RNA helicase DDX47

1

8

High-throughput

0.479

High

1331177

SENP3
Sentrin-specific protease 3

1

1

High-throughput

0.479

High

1332971

WDR26
WD repeat-containing protein 26

1

1

High-throughput

0.479

High

1335042

BAZ1B
Tyrosine-protein kinase BAZ1B

1

16

High-throughput

0.479

High

1335046

TPX2
Targeting protein for Xklp2

1

1

High-throughput

0.479

High

1335047

MAGD2
Melanoma-associated antigen D2

1

4

High-throughput

0.479

High

1335048

RTRAF
RNA transcription, translation and transport factor protein

1

1

High-throughput

0.479

High

1335049

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

1

High-throughput

0.479

High

1335051

NOP58
Nucleolar protein 58

1

3

High-throughput

0.479

High

1335052

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

1

High-throughput

0.479

High

1335054

SP16H
FACT complex subunit SPT16

1

1

High-throughput

0.479

High

1335055

DDX49
Probable ATP-dependent RNA helicase DDX49

1

7

High-throughput

0.479

High

62115

BTBDH
BTB/POZ domain-containing protein 17

1

1

High-throughput

0.470

High

153244

ACOT8
Acyl-coenzyme A thioesterase 8

1

0

High-throughput

0.460

High

612502

XPA
DNA repair protein complementing XP-A cells

1

0

High-throughput

0.460

High

987472

MTG8
Protein CBFA2T1

1

0

High-throughput

0.460

High

1254175

MIPO1
Mirror-image polydactyly gene 1 protein

1

0

High-throughput

0.460

High

1299859

LENG8
Leukocyte receptor cluster member 8

1

0

High-throughput

0.460

High

1306591

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.460

High

1312887

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.460

High

1314164

RIOK2
Serine/threonine-protein kinase RIO2

1

0

High-throughput

0.460

High

1335037

TEX10
Testis-expressed protein 10

1

0

High-throughput

0.460

High

553759

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

565039

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.458

High

652298

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

721489

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

966293

TFAP4
Transcription factor AP-4

1

0

Small-scale

0.458

High

1292033

LTV1
Protein LTV1 homolog

1

0

High-throughput

0.458

High

1318099

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.458

High

1335038

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.458

High

1335039

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.458

High

214671

MYO1B
Unconventional myosin-Ib

1

4

High-throughput

0.437

High

393356

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

4

High-throughput

0.437

High

532220

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

1

High-throughput

0.437

High

561688

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

4

High-throughput

0.437

High

577695

SON
Protein SON

1

3

High-throughput

0.437

High

778294

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

1

High-throughput

0.437

High

1052619

RCN2
Reticulocalbin-2

1

6

High-throughput

0.437

High

1088658

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.437

High

1135338

ATD3B
ATPase family AAA domain-containing protein 3B

1

3

High-throughput

0.437

High

1335036

ATD3A
ATPase family AAA domain-containing protein 3A

1

2

High-throughput

0.437

High

1335040

ABCF2
ATP-binding cassette sub-family F member 2

1

1

High-throughput

0.437

High

1335043

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

1

High-throughput

0.437

High

1335050

DLGP4
Disks large-associated protein 4

1

0

High-throughput

0.279

Low

1223479

CF206
Cilia- and flagella-associated protein 206

1

0

High-throughput

0.251

Low

1273402

GLMN
Glomulin

1

0

High-throughput

0.251

Low

130602

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.249

Low

266826

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

0

High-throughput

0.249

Low

279208

ATP5H
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.249

Low

579615

ATP5J
ATP synthase-coupling factor 6, mitochondrial

1

0

High-throughput

0.249

Low

879719

ATPK
ATP synthase subunit f, mitochondrial

1

0

High-throughput

0.249

Low

1335033

TM165
Putative divalent cation/proton antiporter TMEM165

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024