Protein: RUNX3
Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit)

Gene: RUNX3
Organism: Homo sapiens
Interactions: 60
UniProt ID: Q13761

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1045122

PEBB
Core-binding factor subunit beta

6

8

Small-scale

0.942

High

1045121

RUNX2
Runt-related transcription factor 2

1

2

High-throughput

0.691

High

950174

SMAD3
Mothers against decapentaplegic homolog 3

3

16

Small-scale

0.640

High

998686

EP300
Histone acetyltransferase p300

2

8

Small-scale

0.611

High

1045151

HDAC5
Histone deacetylase 5

2

16

Small-scale

0.594

High

980600

TLE1
Transducin-like enhancer protein 1

1

9

Small-scale

0.582

High

522968

SRC
Proto-oncogene tyrosine-protein kinase Src

1

2

Small-scale

0.578

High

717066

CTNB1
Catenin beta-1

1

2

Small-scale

0.565

High

1045147

TF7L2
Transcription factor 7-like 2

1

6

Small-scale

0.565

High

379380

MYCN
N-myc proto-oncogene protein

1

2

Small-scale

0.561

High

386701

P53
Cellular tumor antigen p53

1

2

Small-scale

0.561

High

804241

NOTC1
Neurogenic locus notch homolog protein 1

1

1

Small-scale

0.561

High

1045145

SP110
Sp110 nuclear body protein

1

1

High-throughput

0.541

High

436712

GLI1
Zinc finger protein GLI1

1

0

Small-scale

0.537

High

631423

BRD2
Bromodomain-containing protein 2

1

9

Small-scale

0.536

High

880719

HDAC4
Histone deacetylase 4

1

16

Small-scale

0.536

High

1045128

FBW12
F-box/WD repeat-containing protein 12

1

2

High-throughput

0.536

High

1045138

PHB2
Prohibitin-2

1

1

High-throughput

0.515

High

808588

YAP1
Transcriptional coactivator YAP1

1

19

Small-scale

0.501

High

307252

RCBT2
RCC1 and BTB domain-containing protein 2

1

0

High-throughput

0.493

High

203681

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

2

Small-scale

0.479

High

244409

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

411714

LCK
Tyrosine-protein kinase Lck

1

2

Small-scale

0.479

High

412182

FYN
Tyrosine-protein kinase Fyn

1

2

Small-scale

0.479

High

569701

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

590905

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

668668

PML
Protein PML

1

6

Small-scale

0.479

High

734436

TCF7
Transcription factor 7

1

7

Small-scale

0.479

High

801873

RECQ1
ATP-dependent DNA helicase Q1

1

4

High-throughput

0.479

High

1033637

IKZF1
DNA-binding protein Ikaros

1

3

Small-scale

0.479

High

1037929

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.479

High

1038359

HDAC1
Histone deacetylase 1

1

10

Small-scale

0.479

High

1045123

SMAD2
Mothers against decapentaplegic homolog 2

1

16

Small-scale

0.479

High

1045124

SMAD1
Mothers against decapentaplegic homolog 1

1

16

Small-scale

0.479

High

1045125

EZH2
Histone-lysine N-methyltransferase EZH2

1

4

Small-scale

0.479

High

1045126

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

Small-scale

0.479

High

1045127

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

1

2

Small-scale

0.479

High

1045129

MEX3B
RNA-binding protein MEX3B

1

1

Small-scale

0.479

High

1045130

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

1

Small-scale

0.479

High

1045135

EGLN2
Prolyl hydroxylase EGLN2

1

1

Small-scale

0.479

High

1045137

CIC
Protein capicua homolog

1

7

High-throughput

0.479

High

1045140

SMAD5
Mothers against decapentaplegic homolog 5

1

16

Small-scale

0.479

High

1045141

FACD2
Fanconi anemia group D2 protein

1

1

Small-scale

0.479

High

1045142

EGLN1
Egl nine homolog 1

1

1

Small-scale

0.479

High

1045143

NANOG
Homeobox protein NANOG

1

3

High-throughput

0.479

High

1045144

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

11

Small-scale

0.479

High

1045146

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

11

Small-scale

0.479

High

1045149

IKZF3
Zinc finger protein Aiolos

1

3

Small-scale

0.479

High

622453

CCND1
G1/S-specific cyclin-D1

1

0

Small-scale

0.464

High

962772

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

986905

SUH
Recombining binding protein suppressor of hairless

1

0

Small-scale

0.458

High

1045131

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

0

Small-scale

0.458

High

1045134

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1045148

FANCI
Fanconi anemia group I protein

1

0

Small-scale

0.458

High

1045150

SUFU
Suppressor of fused homolog

1

0

Small-scale

0.458

High

1045132

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.445

High

798186

KI2L3
Killer cell immunoglobulin-like receptor 2DL3

1

3

Small-scale

0.437

High

1045133

KI3L3
Killer cell immunoglobulin-like receptor 3DL3

1

3

Small-scale

0.437

High

1045139

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

3

Small-scale

0.437

High

1045136

GUCD1
Protein GUCD1

2

0

High-throughput

0.316

High


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Last updated: 15 Jul 2024