Protein: VPP1
V-type proton ATPase 116 kDa subunit a 1 (V-ATPase 116 kDa subunit a 1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar adenosine triphosphatase subunit Ac116) (Vacuolar proton pump subunit 1) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1)

Gene: VPP1, ATP6V0A1
Organism: Homo sapiens
Interactions: 157
UniProt ID: Q93050

Gene Ontology (top 5):
GO:0000220 - vacuolar proton-transporting V-type ATPase, V0 domain
GO:0005765 - lysosomal membrane
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

899994

VA0D1
V-type proton ATPase subunit d 1

3

12

High-throughput

0.861

High

175614

VA0E1
V-type proton ATPase subunit e 1

2

3

High-throughput

0.811

High

648059

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

2

9

High-throughput

0.811

High

1274159

VPP2
V-type proton ATPase 116 kDa subunit a 2

2

6

High-throughput

0.811

High

597741

VATC1
V-type proton ATPase subunit C 1

2

8

High-throughput

0.789

High

1237951

VA0D2
V-type proton ATPase subunit d 2

2

12

High-throughput

0.789

High

275077

RENR
Renin receptor

5

4

High-throughput

0.722

High

260090

VATG1
V-type proton ATPase subunit G 1

1

7

High-throughput

0.691

High

736122

VATE1
V-type proton ATPase subunit E 1

1

5

High-throughput

0.691

High

1035679

VPP3
V-type proton ATPase 116 kDa subunit a 3

1

6

High-throughput

0.691

High

1274152

VATH
V-type proton ATPase subunit H

1

2

High-throughput

0.691

High

547352

VATB1
V-type proton ATPase subunit B, kidney isoform

4

9

High-throughput

0.686

High

554351

MUC1
Mucin-1

3

2

High-throughput

0.667

High

1244213

T185A
Transmembrane protein 185A

3

1

High-throughput

0.667

High

1274132

SERC2
Serine incorporator 2

3

1

High-throughput

0.667

High

299192

CSCL1
CSC1-like protein 1

2

3

High-throughput

0.628

High

314447

NPT2B
Sodium-dependent phosphate transport protein 2B

2

1

High-throughput

0.628

High

353300

CD4
T-cell surface glycoprotein CD4

2

1

High-throughput

0.628

High

842272

BCAM
Basal cell adhesion molecule

2

4

High-throughput

0.628

High

1079841

VAS1
V-type proton ATPase subunit S1

2

5

High-throughput

0.628

High

1088386

VATF
V-type proton ATPase subunit F

2

6

High-throughput

0.628

High

1160503

MEAK7
MTOR-associated protein MEAK7

2

1

High-throughput

0.628

High

1223553

K2013
Uncharacterized protein KIAA2013

2

4

High-throughput

0.628

High

1234062

TM199
Transmembrane protein 199

2

4

High-throughput

0.628

High

1274160

VATD
V-type proton ATPase subunit D

2

5

High-throughput

0.628

High

318296

VATG2
V-type proton ATPase subunit G 2

1

7

High-throughput

0.618

High

121201

LEG8
Galectin-8

2

6

High-throughput

0.611

High

354875

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

2

1

High-throughput

0.611

High

447278

HXB5
Homeobox protein Hox-B5

2

1

High-throughput

0.611

High

597688

VATB2
V-type proton ATPase subunit B, brain isoform

2

9

High-throughput

0.611

High

793415

MUC18
Cell surface glycoprotein MUC18

2

4

High-throughput

0.611

High

750880

VATA
V-type proton ATPase catalytic subunit A

2

2

High-throughput

0.601

High

1127095

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

2

High-throughput

0.574

High

1068491

KPCD1
Serine/threonine-protein kinase D1

2

2

High-throughput

0.571

High

723000

HRH1
Histamine H1 receptor

1

1

High-throughput

0.541

High

1274124

SEH1
Nucleoporin SEH1

1

1

High-throughput

0.541

High

62216

ARRD5
Arrestin domain-containing protein 5

1

1

High-throughput

0.536

High

206398

LTOR5
Ragulator complex protein LAMTOR5

1

1

High-throughput

0.536

High

206590

S26A4
Pendrin

1

1

High-throughput

0.536

High

365222

FRIH
Ferritin heavy chain

1

1

High-throughput

0.536

High

449336

LEG1
Galectin-1

1

6

High-throughput

0.536

High

505447

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

1

High-throughput

0.536

High

572425

LEG3
Galectin-3

1

6

High-throughput

0.536

High

665305

EPHA2
Ephrin type-A receptor 2

1

1

High-throughput

0.536

High

823279

MRP
MARCKS-related protein

1

1

High-throughput

0.536

High

844667

RAB5C
Ras-related protein Rab-5C

1

3

High-throughput

0.536

High

845136

RAB7A
Ras-related protein Rab-7a

1

3

High-throughput

0.536

High

850586

VAMP7
Vesicle-associated membrane protein 7

1

1

High-throughput

0.536

High

873300

EMP3
Epithelial membrane protein 3

1

1

High-throughput

0.536

High

874714

AQP5
Aquaporin-5

1

4

High-throughput

0.536

High

1032069

UT1
Urea transporter 1

1

1

High-throughput

0.536

High

1035194

ROCK1
Rho-associated protein kinase 1

1

1

High-throughput

0.536

High

1079394

VAMP3
Vesicle-associated membrane protein 3

1

5

High-throughput

0.536

High

1139804

PLPP4
Phospholipid phosphatase 4

1

1

High-throughput

0.536

High

1152019

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.536

High

1168525

RN19B
E3 ubiquitin-protein ligase RNF19B

1

2

High-throughput

0.536

High

1204226

F131B
Protein FAM131B

1

1

High-throughput

0.536

High

1223416

ZDH23
Palmitoyltransferase ZDHHC23

1

2

High-throughput

0.536

High

1260978

SFT2A
Vesicle transport protein SFT2A

1

1

High-throughput

0.536

High

1274128

CC115
Coiled-coil domain-containing protein 115

1

3

High-throughput

0.536

High

1274131

MYADM
Myeloid-associated differentiation marker

1

1

High-throughput

0.536

High

1274136

SLK
STE20-like serine/threonine-protein kinase

1

1

High-throughput

0.536

High

1274143

ANLN
Anillin

1

1

High-throughput

0.536

High

1274144

ARL8B
ADP-ribosylation factor-like protein 8B

1

3

High-throughput

0.536

High

1274146

M4A12
Membrane-spanning 4-domains subfamily A member 12

1

1

High-throughput

0.536

High

1274148

GPC5D
G-protein coupled receptor family C group 5 member D

1

1

High-throughput

0.536

High

1274153

TBD
Tubulin delta chain

1

1

High-throughput

0.536

High

1274154

FZD10
Frizzled-10

1

1

High-throughput

0.536

High

1274158

GOT1B
Vesicle transport protein GOT1B

1

1

High-throughput

0.536

High

1274161

KC1G3
Casein kinase I isoform gamma-3

1

2

High-throughput

0.536

High

124633

CLIC1
Chloride intracellular channel protein 1

1

0

High-throughput

0.518

High

307906

SNX4
Sorting nexin-4

1

0

High-throughput

0.518

High

865067

TTC3
E3 ubiquitin-protein ligase TTC3

1

0

High-throughput

0.518

High

157628

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.513

High

168194

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1

0

High-throughput

0.513

High

523099

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

High-throughput

0.513

High

573839

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.513

High

640730

CTNA2
Catenin alpha-2

1

0

High-throughput

0.513

High

664111

T2EB
Transcription initiation factor IIE subunit beta

1

0

High-throughput

0.513

High

793202

PI2R
Prostacyclin receptor

1

0

High-throughput

0.513

High

802368

5HT3A
5-hydroxytryptamine receptor 3A

1

0

High-throughput

0.513

High

960914

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.513

High

1129193

S35D3
Solute carrier family 35 member D3

1

0

High-throughput

0.513

High

1221309

S35F2
Solute carrier family 35 member F2

1

0

High-throughput

0.513

High

1224320

AGRG5
Adhesion G-protein coupled receptor G5

1

0

High-throughput

0.513

High

1270110

TFG
Protein TFG

1

0

High-throughput

0.513

High

1272183

ARHG1
Rho guanine nucleotide exchange factor 1

1

0

High-throughput

0.513

High

1274137

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

1274139

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.513

High

1274147

NSMA2
Sphingomyelin phosphodiesterase 3

1

0

High-throughput

0.513

High

1274156

LTOR2
Ragulator complex protein LAMTOR2

1

0

High-throughput

0.513

High

1274157

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.513

High

1274133

CYH2
Cytohesin-2

1

4

Small-scale

0.501

High

1114048

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

1

3

High-throughput

0.489

High

1234854

TTC9C
Tetratricopeptide repeat protein 9C

1

3

High-throughput

0.489

High

1274126

BT3L4
Transcription factor BTF3 homolog 4

1

1

High-throughput

0.489

High

119474

LEG9
Galectin-9

1

6

High-throughput

0.479

High

167994

NPC1
NPC intracellular cholesterol transporter 1

1

4

High-throughput

0.479

High

205789

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

228272

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

283232

RGS20
Regulator of G-protein signaling 20

1

1

High-throughput

0.479

High

385302

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

436442

RHOC
Rho-related GTP-binding protein RhoC

1

4

High-throughput

0.479

High

545543

RAC2
Ras-related C3 botulinum toxin substrate 2

1

5

High-throughput

0.479

High

564639

RHOQ
Rho-related GTP-binding protein RhoQ

1

6

High-throughput

0.479

High

580441

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

1

1

High-throughput

0.479

High

852580

RND2
Rho-related GTP-binding protein RhoN

1

7

High-throughput

0.479

High

894285

CDC42
Cell division control protein 42 homolog

1

6

High-throughput

0.479

High

900770

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

1069633

STK38
Serine/threonine-protein kinase 38

1

2

High-throughput

0.479

High

1076696

RHOH
Rho-related GTP-binding protein RhoH

1

7

High-throughput

0.479

High

1233909

EMC5
ER membrane protein complex subunit 5

1

2

High-throughput

0.479

High

1236941

EMC1
ER membrane protein complex subunit 1

1

2

High-throughput

0.479

High

1255977

RN128
E3 ubiquitin-protein ligase RNF128

1

3

High-throughput

0.479

High

1269295

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1274127

SNX27
Sorting nexin-27

1

1

High-throughput

0.479

High

1274138

DNJC5
DnaJ homolog subfamily C member 5

1

2

High-throughput

0.479

High

1274140

RHOJ
Rho-related GTP-binding protein RhoJ

1

7

High-throughput

0.479

High

1274141

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1274142

RHOF
Rho-related GTP-binding protein RhoF

1

6

High-throughput

0.479

High

1274150

DNJ5B
DnaJ homolog subfamily C member 5B

1

2

High-throughput

0.479

High

322966

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

387243

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

417383

ENOA
Alpha-enolase

1

0

High-throughput

0.458

High

422073

LDHB
L-lactate dehydrogenase B chain

1

0

Small-scale

0.458

High

1066491

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1119579

MIDN
Midnolin

1

0

High-throughput

0.458

High

1165820

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1274134

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.458

High

1274149

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

1274151

NUFP1
FMR1-interacting protein NUFIP1

1

0

High-throughput

0.458

High

497401

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.445

High

1044020

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.445

High

1153321

PKHA7
Pleckstrin homology domain-containing family A member 7

1

7

High-throughput

0.445

High

1199983

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

1

High-throughput

0.445

High

1274155

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

1156658

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1171103

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

1274135

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.437

High

240126

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.426

High

1042216

CUL3
Cullin-3

1

0

High-throughput

0.426

High

1047196

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

1274129

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.426

High

72198

B3KSW4
Regulator of G protein signaling 20

1

1

High-throughput

0.407

High

1055907

ZN267
Zinc finger protein 267

1

0

High-throughput

0.282

High

1274130

PUS7
Pseudouridylate synthase 7 homolog

1

0

High-throughput

0.279

Low

1274145

CUED1
CUE domain-containing protein 1

1

0

High-throughput

0.279

Low

1151802

ABLM2
Actin-binding LIM protein 2

1

0

High-throughput

0.251

Low

553361

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

651876

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

721088

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1062608

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.249

Low

1080204

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

1108800

CEA21
Carcinoembryonic antigen-related cell adhesion molecule 21

1

0

High-throughput

0.249

Low

1126119

MKS3
Meckelin

1

0

High-throughput

0.249

Low

1274125

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.249

Low

1103067

ATG2A
Autophagy-related protein 2 homolog A

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024