Protein: WEE1
Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase)

Gene: WEE1
Organism: Homo sapiens
Interactions: 89
UniProt ID: P30291

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000226 - microtubule cytoskeleton organization
GO:0000287 - magnesium ion binding
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

414766

CDK1
Cyclin-dependent kinase 1

5

20

Small-scale

0.919

High

673257

PLK1
Serine/threonine-protein kinase PLK1

4

18

Small-scale

0.914

High

625157

CDK2
Cyclin-dependent kinase 2

3

20

Small-scale

0.865

High

538479

CCNB1
G2/mitotic-specific cyclin-B1

2

9

Small-scale

0.799

High

673264

CSK2B
Casein kinase II subunit beta

2

1

Small-scale

0.789

High

673246

AKT1
RAC-alpha serine/threonine-protein kinase

1

17

Small-scale

0.761

High

673304

FBW1B
F-box/WD repeat-containing protein 11

7

14

Small-scale

0.745

High

673266

CCNA1
Cyclin-A1

1

9

Small-scale

0.724

High

673306

CC14A
Dual specificity protein phosphatase CDC14A

1

6

Small-scale

0.724

High

673247

1433B
14-3-3 protein beta/alpha

4

20

Small-scale

0.703

High

646654

1433T
14-3-3 protein theta

4

20

Small-scale

0.697

High

673260

1433G
14-3-3 protein gamma

4

20

High-throughput

0.694

High

62483

ZN316
Zinc finger protein 316

1

5

High-throughput

0.691

High

565106

ZNF8
Zinc finger protein 8

1

9

High-throughput

0.691

High

673299

RBAK
RB-associated KRAB zinc finger protein

1

5

High-throughput

0.691

High

673263

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.684

High

673307

FBW1A
F-box/WD repeat-containing protein 1A

3

14

Small-scale

0.678

High

673268

1433F
14-3-3 protein eta

3

20

High-throughput

0.667

High

317412

YETS4
YEATS domain-containing protein 4

4

0

High-throughput

0.664

High

673245

WEE1
Wee1-like protein kinase

1

17

Small-scale

0.647

High

673284

BRSK2
Serine/threonine-protein kinase BRSK2

1

16

Small-scale

0.647

High

673273

SKP2
S-phase kinase-associated protein 2

2

6

Small-scale

0.634

High

673248

1433S
14-3-3 protein sigma

2

20

High-throughput

0.633

High

673274

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

4

Small-scale

0.629

High

673288

CCYL1
Cyclin-Y-like protein 1

1

3

High-throughput

0.618

High

226623

PRKN
E3 ubiquitin-protein ligase parkin

1

18

High-throughput

0.618

High

586581

CSK22
Casein kinase II subunit alpha'

1

20

Small-scale

0.618

High

673251

CCNF
Cyclin-F

1

15

High-throughput

0.618

High

673255

KC1A
Casein kinase I isoform alpha

1

16

High-throughput

0.618

High

673265

CSK21
Casein kinase II subunit alpha

1

20

Small-scale

0.618

High

673296

NEK6
Serine/threonine-protein kinase Nek6

1

17

High-throughput

0.618

High

673298

KI13B
Kinesin-like protein KIF13B

1

8

High-throughput

0.618

High

673305

BRPF3
Bromodomain and PHD finger-containing protein 3

2

3

High-throughput

0.611

High

162428

XPO1
Exportin-1

2

13

Small-scale

0.584

High

673282

PAXI1
PAX-interacting protein 1

2

4

Small-scale

0.584

High

673297

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

15

Small-scale

0.561

High

673302

ERRFI
ERBB receptor feedback inhibitor 1

1

9

Small-scale

0.561

High

673278

H2B2E
Histone H2B type 2-E

1

17

Small-scale

0.536

High

178115

IPO8
Importin-8

1

8

High-throughput

0.536

High

312190

IPO7
Importin-7

1

9

High-throughput

0.536

High

469953

H2AZ
Histone H2A.Z

1

20

High-throughput

0.536

High

531045

EF2
Elongation factor 2

1

5

High-throughput

0.536

High

673249

ARRB2
Beta-arrestin-2

1

7

High-throughput

0.536

High

673262

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

1

High-throughput

0.536

High

673267

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

11

High-throughput

0.536

High

673272

TIF1B
Transcription intermediary factor 1-beta

1

12

High-throughput

0.536

High

673276

PCBP1
Poly(rC)-binding protein 1

1

11

High-throughput

0.536

High

673277

AINX
Alpha-internexin

1

19

High-throughput

0.536

High

673279

CE350
Centrosome-associated protein 350

1

19

High-throughput

0.536

High

673285

WDFY3
WD repeat and FYVE domain-containing protein 3

1

7

High-throughput

0.536

High

673300

POGK
Pogo transposable element with KRAB domain

1

8

High-throughput

0.536

High

443352

VIME
Vimentin

1

20

High-throughput

0.515

High

673259

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.513

High

673252

EPS15
Epidermal growth factor receptor substrate 15

1

8

High-throughput

0.501

High

673254

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

15

High-throughput

0.501

High

124775

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

3

High-throughput

0.489

High

673292

CDCA3
Cell division cycle-associated protein 3

1

0

Small-scale

0.480

High

164356

TRI66
Tripartite motif-containing protein 66

1

12

High-throughput

0.479

High

229630

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

18

High-throughput

0.479

High

377122

GCR
Glucocorticoid receptor

1

16

High-throughput

0.479

High

386168

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

506523

BCR
Breakpoint cluster region protein

1

11

High-throughput

0.479

High

672773

CDC27
Cell division cycle protein 27 homolog

1

11

High-throughput

0.479

High

673250

MCM4
DNA replication licensing factor MCM4

1

7

High-throughput

0.479

High

673253

CRK
Adapter molecule crk

1

8

Small-scale

0.479

High

673256

MCM2
DNA replication licensing factor MCM2

1

10

High-throughput

0.479

High

673261

1433E
14-3-3 protein epsilon

1

9

High-throughput

0.479

High

673269

EP300
Histone acetyltransferase p300

1

7

High-throughput

0.479

High

673271

CDC16
Cell division cycle protein 16 homolog

1

11

High-throughput

0.479

High

673283

CLAP1
CLIP-associating protein 1

1

7

High-throughput

0.479

High

673287

SIR6
NAD-dependent protein deacylase sirtuin-6

1

4

High-throughput

0.479

High

673289

FBXW7
F-box/WD repeat-containing protein 7

1

15

Small-scale

0.479

High

673294

CECR2
Chromatin remodeling regulator CECR2

1

4

High-throughput

0.479

High

673301

CING
Cingulin

1

18

High-throughput

0.479

High

673303

APC7
Anaphase-promoting complex subunit 7

1

11

High-throughput

0.479

High

673308

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.479

High

673309

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

3

High-throughput

0.479

High

673275

NPAT
Protein NPAT

1

0

Small-scale

0.458

High

673281

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

673291

MUS81
Crossover junction endonuclease MUS81

1

0

Small-scale

0.458

High

673293

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.458

High

673280

DEN4C
DENN domain-containing protein 4C

1

2

High-throughput

0.437

High

673310

KCTD3
BTB/POZ domain-containing protein KCTD3

1

3

High-throughput

0.437

High

673286

RUSC2
AP-4 complex accessory subunit RUSC2

1

0

High-throughput

0.279

Low

673258

ATP5E
ATP synthase subunit epsilon, mitochondrial

1

0

High-throughput

0.249

Low

673270

NU160
Nuclear pore complex protein Nup160

1

0

High-throughput

0.249

Low

673290

CC138
Coiled-coil domain-containing protein 138

1

0

High-throughput

0.249

Low

673295

CPLN1
Ciliogenesis and planar polarity effector 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024