Protein: CD44
CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)

Gene: CD44
Organism: Homo sapiens
Interactions: 226
UniProt ID: P16070

Gene Ontology (top 5):
GO:0004888 - transmembrane signaling receptor activity
GO:0004896 - cytokine receptor activity
GO:0005518 - collagen binding
GO:0005540 - hyaluronic acid binding
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

530365

CSPG2
Versican core protein

4

9

Small-scale

0.910

High

555064

CD44
CD44 antigen

2

9

Small-scale

0.768

High

337876

EGFR
Epidermal growth factor receptor

6

5

Small-scale

0.721

High

507830

FGFR1
Fibroblast growth factor receptor 1

4

6

Small-scale

0.694

High

555096

KPCI
Protein kinase C iota type

4

3

High-throughput

0.691

High

555088

MERL
Merlin

4

5

Small-scale

0.690

High

383584

ERBB2
Receptor tyrosine-protein kinase erbB-2

4

5

Small-scale

0.676

High

555141

SQSTM
Sequestosome-1

4

0

High-throughput

0.670

High

555130

KPCZ
Protein kinase C zeta type

3

3

Small-scale

0.633

High

447014

FGF2
Fibroblast growth factor 2

2

1

High-throughput

0.628

High

449175

LEG1
Galectin-1

2

6

High-throughput

0.628

High

555076

FGFR2
Fibroblast growth factor receptor 2

2

6

High-throughput

0.628

High

555107

ECHB
Trifunctional enzyme subunit beta, mitochondrial

2

1

High-throughput

0.628

High

555150

LAMA3
Laminin subunit alpha-3

2

5

High-throughput

0.628

High

555167

FGRL1
Fibroblast growth factor receptor-like 1

2

6

High-throughput

0.628

High

555170

VANG1
Vang-like protein 1

2

1

High-throughput

0.628

High

555172

SNX33
Sorting nexin-33

2

1

High-throughput

0.628

High

555182

SNX18
Sorting nexin-18

2

1

High-throughput

0.628

High

555213

GMEB2
Glucocorticoid modulatory element-binding protein 2

2

2

High-throughput

0.628

High

555215

VANG2
Vang-like protein 2

2

1

High-throughput

0.628

High

522750

SRC
Proto-oncogene tyrosine-protein kinase Src

2

7

Small-scale

0.624

High

555217

XCT
Cystine/glutamate transporter

3

0

Small-scale

0.619

High

555079

MOES
Moesin

2

4

Small-scale

0.611

High

119143

LEG9
Galectin-9

2

6

Small-scale

0.611

High

62555

TCAF2
TRPM8 channel-associated factor 2

2

0

High-throughput

0.602

High

555126

AMPD2
AMP deaminase 2

2

0

High-throughput

0.602

High

555138

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

2

0

High-throughput

0.602

High

555162

ATG9A
Autophagy-related protein 9A

2

0

High-throughput

0.602

High

555169

CAMKV
CaM kinase-like vesicle-associated protein

2

0

High-throughput

0.602

High

555187

CQ080
Mitochondrial nucleoid-associated protein 1

2

0

High-throughput

0.602

High

555190

OSBL8
Oxysterol-binding protein-related protein 8

2

0

High-throughput

0.602

High

555206

S39A9
Zinc transporter ZIP9

2

0

High-throughput

0.602

High

380236

HG2A
HLA class II histocompatibility antigen gamma chain

2

1

Small-scale

0.595

High

441421

MET
Hepatocyte growth factor receptor

2

5

Small-scale

0.595

High

546916

EZRI
Ezrin

2

5

Small-scale

0.595

High

555092

TGFR1
TGF-beta receptor type-1

2

2

Small-scale

0.595

High

555184

HBEGF
Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor

2

0

Small-scale

0.592

High

555077

CD9
CD9 antigen

2

3

Small-scale

0.588

High

349852

RASK
GTPase KRas

2

7

High-throughput

0.584

High

411583

LCK
Tyrosine-protein kinase Lck

2

7

Small-scale

0.584

High

555070

CEBPB
CCAAT/enhancer-binding protein beta

2

1

Small-scale

0.584

High

555120

RHOB
Rho-related GTP-binding protein RhoB

2

17

High-throughput

0.584

High

555095

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

2

1

High-throughput

0.574

High

555102

CLCN7
H(+)/Cl(-) exchange transporter 7

2

1

High-throughput

0.574

High

555228

GMEB1
Glucocorticoid modulatory element-binding protein 1

2

1

High-throughput

0.574

High

182079

PDPK1
3-phosphoinositide-dependent protein kinase 1

2

2

High-throughput

0.571

High

362782

FINC
Fibronectin

1

12

Small-scale

0.561

High

555209

ARHGC
Rho guanine nucleotide exchange factor 12

1

2

Small-scale

0.561

High

555134

HYAL2
Hyaluronidase-2

2

0

Small-scale

0.559

High

72375

B3KW44
tRNA N(3)-methylcytidine methyltransferase

2

1

High-throughput

0.558

High

155522

TNPO2
Transportin-2

2

1

High-throughput

0.558

High

555072

IBP3
Insulin-like growth factor-binding protein 3

2

2

Small-scale

0.550

High

555160

MARK2
Serine/threonine-protein kinase MARK2

1

0

Small-scale

0.537

High

121100

LEG8
Galectin-8

1

6

High-throughput

0.536

High

449524

HMGB1
High mobility group protein B1

1

1

High-throughput

0.536

High

555071

LEG3
Galectin-3

1

6

High-throughput

0.536

High

555106

EMP3
Epithelial membrane protein 3

1

1

High-throughput

0.536

High

555166

SYNPO
Synaptopodin

1

2

High-throughput

0.536

High

555178

MYO19
Unconventional myosin-XIX

1

1

High-throughput

0.536

High

555186

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

3

High-throughput

0.536

High

121437

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

0

High-throughput

0.513

High

555069

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

555075

FLNA
Filamin-A

1

0

High-throughput

0.513

High

555090

MYH9
Myosin-9

1

0

High-throughput

0.513

High

555122

DYL1
Dynein light chain 1, cytoplasmic

1

0

High-throughput

0.513

High

555156

CDC73
Parafibromin

1

0

High-throughput

0.513

High

555192

NAA50
N-alpha-acetyltransferase 50

1

0

High-throughput

0.513

High

555212

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.513

High

555227

IRAK3
Interleukin-1 receptor-associated kinase 3

1

0

High-throughput

0.513

High

373637

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.501

High

515322

CDK4
Cyclin-dependent kinase 4

1

1

High-throughput

0.501

High

555066

PGFRA
Platelet-derived growth factor receptor alpha

1

6

High-throughput

0.501

High

555078

FGFR4
Fibroblast growth factor receptor 4

1

6

High-throughput

0.501

High

555081

EPHA2
Ephrin type-A receptor 2

1

6

High-throughput

0.501

High

555084

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

High-throughput

0.501

High

555097

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

4

High-throughput

0.501

High

555098

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

4

High-throughput

0.501

High

555100

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

4

High-throughput

0.501

High

555125

CDK6
Cyclin-dependent kinase 6

1

1

High-throughput

0.501

High

555135

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

4

Small-scale

0.501

High

555136

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

4

High-throughput

0.501

High

555204

LATS2
Serine/threonine-protein kinase LATS2

1

3

High-throughput

0.501

High

547678

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

1

High-throughput

0.489

High

555149

DREB
Drebrin

1

1

High-throughput

0.489

High

555164

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

1

High-throughput

0.489

High

555185

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.489

High

555218

AKT3
RAC-gamma serine/threonine-protein kinase

1

2

High-throughput

0.489

High

555222

CRBG1
Beta/gamma crystallin domain-containing protein 1

1

2

High-throughput

0.489

High

169238

MDM4
Protein Mdm4

1

0

High-throughput

0.480

High

555082

CCND2
G1/S-specific cyclin-D2

1

0

High-throughput

0.480

High

555093

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.480

High

555137

GRM1
Metabotropic glutamate receptor 1

1

0

High-throughput

0.480

High

555147

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.480

High

555151

ABCB5
ATP-binding cassette sub-family B member 5

1

0

High-throughput

0.480

High

120296

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

148360

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.479

High

177123

MOT5
Monocarboxylate transporter 5

1

2

Small-scale

0.479

High

179082

MOT4
Monocarboxylate transporter 4

1

2

Small-scale

0.479

High

205005

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

237466

TLR2
Toll-like receptor 2

1

1

Small-scale

0.479

High

308381

KI20A
Kinesin-like protein KIF20A

1

3

High-throughput

0.479

High

348496

RASN
GTPase NRas

1

7

High-throughput

0.479

High

349106

RASH
GTPase HRas

1

6

High-throughput

0.479

High

411984

FYN
Tyrosine-protein kinase Fyn

1

7

Small-scale

0.479

High

436144

RHOC
Rho-related GTP-binding protein RhoC

1

14

High-throughput

0.479

High

448875

MMP7
Matrilysin

1

9

Small-scale

0.479

High

501643

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.479

High

545194

RAC2
Ras-related C3 botulinum toxin substrate 2

1

13

High-throughput

0.479

High

555067

LYAM2
E-selectin

1

11

Small-scale

0.479

High

555068

RHOQ
Rho-related GTP-binding protein RhoQ

1

17

High-throughput

0.479

High

555074

RAB4A
Ras-related protein Rab-4A

1

2

High-throughput

0.479

High

555083

UFO
Tyrosine-protein kinase receptor UFO

1

8

Small-scale

0.479

High

555091

BASI
Basigin

1

1

Small-scale

0.479

High

555099

MUC18
Cell surface glycoprotein MUC18

1

2

High-throughput

0.479

High

555101

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

2

Small-scale

0.479

High

555103

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

555104

VAV2
Guanine nucleotide exchange factor VAV2

1

1

Small-scale

0.479

High

555105

MOT1
Monocarboxylate transporter 1

1

2

Small-scale

0.479

High

555108

ARL4C
ADP-ribosylation factor-like protein 4C

1

3

High-throughput

0.479

High

555109

RAB25
Ras-related protein Rab-25

1

1

High-throughput

0.479

High

555110

RAC3
Ras-related C3 botulinum toxin substrate 3

1

15

High-throughput

0.479

High

555111

CDC42
Cell division control protein 42 homolog

1

17

High-throughput

0.479

High

555115

RHOA
Transforming protein RhoA

1

16

High-throughput

0.479

High

555116

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

555119

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.479

High

555121

RAC1
Ras-related C3 botulinum toxin substrate 1

1

15

High-throughput

0.479

High

555124

RHOG
Rho-related GTP-binding protein RhoG

1

13

High-throughput

0.479

High

555127

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

555132

EP300
Histone acetyltransferase p300

1

2

Small-scale

0.479

High

555140

ROCK1
Rho-associated protein kinase 1

1

2

Small-scale

0.479

High

555142

BMPR2
Bone morphogenetic protein receptor type-2

1

2

Small-scale

0.479

High

555143

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

555144

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

555145

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

5

Small-scale

0.479

High

555146

RHOH
Rho-related GTP-binding protein RhoH

1

16

High-throughput

0.479

High

555158

MOB2
MOB kinase activator 2

1

1

High-throughput

0.479

High

555161

RHOU
Rho-related GTP-binding protein RhoU

1

19

High-throughput

0.479

High

555168

ARL14
ADP-ribosylation factor-like protein 14

1

1

High-throughput

0.479

High

555173

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

555175

ARHG1
Rho guanine nucleotide exchange factor 1

1

5

Small-scale

0.479

High

555179

RHOV
Rho-related GTP-binding protein RhoV

1

16

High-throughput

0.479

High

555183

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

2

Small-scale

0.479

High

555188

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

5

High-throughput

0.479

High

555194

RHOJ
Rho-related GTP-binding protein RhoJ

1

17

High-throughput

0.479

High

555197

ECT2
Protein ECT2

1

3

High-throughput

0.479

High

555198

RHOF
Rho-related GTP-binding protein RhoF

1

19

High-throughput

0.479

High

555203

SAR1A
Small COPII coat GTPase SAR1A

1

5

High-throughput

0.479

High

555220

RNF11
RING finger protein 11

1

1

Small-scale

0.479

High

555223

TRAF6
TNF receptor-associated factor 6

1

2

High-throughput

0.479

High

153869

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

0

Small-scale

0.458

High

167832

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

171191

CTDSL
CTD small phosphatase-like protein

1

0

High-throughput

0.458

High

233194

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

314839

FMNL1
Formin-like protein 1

1

0

Small-scale

0.458

High

322141

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

345846

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

417138

ENOA
Alpha-enolase

1

0

Small-scale

0.458

High

503378

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

506868

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.458

High

530403

ITA4
Integrin alpha-4

1

0

Small-scale

0.458

High

555086

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

555087

CTNA1
Catenin alpha-1

1

0

Small-scale

0.458

High

555089

MSX2
Homeobox protein MSX-2

1

0

High-throughput

0.458

High

555094

STAT3
Signal transducer and activator of transcription 3

1

0

Small-scale

0.458

High

555114

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

555118

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

555129

TF65
Transcription factor p65

1

0

Small-scale

0.458

High

555155

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

555163

HUNIN
Humanin

1

0

Small-scale

0.458

High

555174

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

555177

OTUB1
Ubiquitin thioesterase OTUB1

1

0

Small-scale

0.458

High

555193

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

555195

EHD1
EH domain-containing protein 1

1

0

Small-scale

0.458

High

555200

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

555202

ANLN
Anillin

1

0

High-throughput

0.458

High

555214

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.458

High

555221

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

126908

WASL
Actin nucleation-promoting factor WASL

1

2

Small-scale

0.445

High

326019

TSN15
Tetraspanin-15

1

3

High-throughput

0.445

High

326267

TSN12
Tetraspanin-12

1

4

Small-scale

0.445

High

555117

TSN5
Tetraspanin-5

1

3

High-throughput

0.445

High

555131

COEA1
Collagen alpha-1(XIV) chain

1

11

Small-scale

0.445

High

555123

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

555148

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

555157

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

555159

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.437

High

555210

PHRF1
PHD and RING finger domain-containing protein 1

1

3

High-throughput

0.437

High

555165

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

1

Small-scale

0.428

High

437257

4F2
Amino acid transporter heavy chain SLC3A2

1

0

Small-scale

0.426

High

555112

ARP3
Actin-related protein 3

1

0

Small-scale

0.426

High

555113

ARP2
Actin-related protein 2

1

0

Small-scale

0.426

High

555191

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

555065

ANK1
Ankyrin-1

1

2

Small-scale

0.408

High

92519

E9PJ24
PHD and ring finger domains 1

1

2

High-throughput

0.407

High

555153

Q4LE60
TNPO2 variant protein

1

1

High-throughput

0.407

High

555196

METL8
tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial

1

1

High-throughput

0.407

High

376150

ANXA1
Annexin A1

1

0

Small-scale

0.391

High

230715

AQR
RNA helicase aquarius

2

0

High-throughput

0.328

High

236195

PRP17
Pre-mRNA-processing factor 17

2

0

High-throughput

0.328

High

555133

TF3C1
General transcription factor 3C polypeptide 1

2

0

High-throughput

0.328

High

555171

TF3C2
General transcription factor 3C polypeptide 2

2

0

High-throughput

0.328

High

555176

TF3C6
General transcription factor 3C polypeptide 6

2

0

High-throughput

0.328

High

555181

TEFM
Transcription elongation factor, mitochondrial

2

0

High-throughput

0.328

High

555199

SYF1
Pre-mRNA-splicing factor SYF1

2

0

High-throughput

0.328

High

555201

PRD10
PR domain zinc finger protein 10

2

0

High-throughput

0.328

High

555208

TM160
Transmembrane protein 160

2

0

High-throughput

0.328

High

555211

PARP2
Poly [ADP-ribose] polymerase 2

2

0

High-throughput

0.328

High

555226

TF3C3
General transcription factor 3C polypeptide 3

2

0

High-throughput

0.328

High

555229

MTCH2
Mitochondrial carrier homolog 2

2

0

High-throughput

0.328

High

259414

NIPS2
Protein NipSnap homolog 2

1

0

High-throughput

0.279

Low

555180

MBOA7
Lysophospholipid acyltransferase 7

1

0

High-throughput

0.279

Low

555207

RBM22
Pre-mRNA-splicing factor RBM22

1

0

High-throughput

0.279

Low

555216

ISY1
Pre-mRNA-splicing factor ISY1 homolog

1

0

High-throughput

0.279

Low

555219

MAN1
Inner nuclear membrane protein Man1

1

0

High-throughput

0.279

Low

555224

MB212
Protein mab-21-like 2

1

0

High-throughput

0.279

Low

555225

TF3C5
General transcription factor 3C polypeptide 5

1

0

High-throughput

0.279

Low

555080

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

0

High-throughput

0.261

Low

555085

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.261

Low

555189

GLIS2
Zinc finger protein GLIS2

1

0

High-throughput

0.261

Low

555073

EGR1
Early growth response protein 1

1

0

Small-scale

0.249

Low

555128

CREM
cAMP-responsive element modulator

1

0

Small-scale

0.249

Low

555152

FBX43
F-box only protein 43

1

0

Small-scale

0.249

Low

555154

MARH8
E3 ubiquitin-protein ligase MARCHF8

1

0

Small-scale

0.249

Low

555205

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.249

Low

555139

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024