Protein: LOX5
Polyunsaturated fatty acid 5-lipoxygenase (EC 1.13.11.-) (Arachidonate 5-lipoxygenase) (5-LO) (5-lipoxygenase) (EC 1.13.11.34)

Gene: LOX5, ALOX5
Organism: Homo sapiens
Interactions: 81
UniProt ID: P09917

Gene Ontology (top 5):
GO:0001937 - negative regulation of endothelial cell proliferation
GO:0002232 - leukocyte chemotaxis involved in inflammatory response
GO:0002523 - leukocyte migration involved in inflammatory response
GO:0002540 - leukotriene production involved in inflammatory response
GO:0004051 - arachidonate 5-lipoxygenase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

456362

CEP63
Centrosomal protein of 63 kDa

5

1

High-throughput

0.725

High

456324

COTL1
Coactosin-like protein

6

0

Small-scale

0.706

High

456359

RUND1
RUN domain-containing protein 1

2

0

High-throughput

0.679

High

456373

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

4

0

High-throughput

0.679

High

456370

DICER
Endoribonuclease Dicer

2

1

Small-scale

0.633

High

456316

NFKB2
Nuclear factor NF-kappa-B p100 subunit

2

3

High-throughput

0.628

High

456322

MTMR3
Myotubularin-related protein 3

2

1

High-throughput

0.628

High

456326

RB3GP
Rab3 GTPase-activating protein catalytic subunit

2

1

High-throughput

0.628

High

456327

KS6A2
Ribosomal protein S6 kinase alpha-2

2

2

High-throughput

0.628

High

456331

AMOT
Angiomotin

2

2

High-throughput

0.628

High

456339

TRI65
E3 ubiquitin-protein ligase TRIM65

2

2

High-throughput

0.628

High

456361

KI16B
Kinesin-like protein KIF16B

2

1

High-throughput

0.628

High

456363

KKCC2
Calcium/calmodulin-dependent protein kinase kinase 2

2

3

High-throughput

0.628

High

456366

MTMR4
Myotubularin-related protein 4

2

1

High-throughput

0.628

High

456372

RNF6
E3 ubiquitin-protein ligase RNF6

2

5

High-throughput

0.628

High

456340

HIPL2
HHIP-like protein 2

2

0

High-throughput

0.626

High

456310

MAPK2
MAP kinase-activated protein kinase 2

2

1

Small-scale

0.602

High

456315

GRB2
Growth factor receptor-bound protein 2

2

9

Small-scale

0.602

High

297221

DDHD2
Phospholipase DDHD2

2

0

High-throughput

0.602

High

456306

TPP2
Tripeptidyl-peptidase 2

2

0

High-throughput

0.602

High

456323

CKAP5
Cytoskeleton-associated protein 5

2

0

High-throughput

0.602

High

456328

ITSN1
Intersectin-1

2

0

High-throughput

0.602

High

456330

ERC6L
DNA excision repair protein ERCC-6-like

2

0

High-throughput

0.602

High

456334

PMF1
Polyamine-modulated factor 1

2

0

High-throughput

0.602

High

456341

KDM3B
Lysine-specific demethylase 3B

2

0

High-throughput

0.602

High

456355

MADD
MAP kinase-activating death domain protein

2

0

High-throughput

0.602

High

456356

PSMF1
Proteasome inhibitor PI31 subunit

2

0

High-throughput

0.602

High

456358

PLPL2
Patatin-like phospholipase domain-containing protein 2

2

0

High-throughput

0.602

High

456365

OSB11
Oxysterol-binding protein-related protein 11

2

0

High-throughput

0.602

High

456369

TBD2B
TBC1 domain family member 2B

2

0

High-throughput

0.602

High

456301

DHB1
17-beta-hydroxysteroid dehydrogenase type 1

2

0

High-throughput

0.580

High

456308

LCN1
Lipocalin-1

2

0

High-throughput

0.580

High

456338

CC174
Coiled-coil domain-containing protein 174

2

0

High-throughput

0.580

High

456367

TBCD7
TBC1 domain family member 7

2

0

High-throughput

0.580

High

456349

CE57L
Centrosomal protein CEP57L1

2

1

High-throughput

0.578

High

456319

DMWD
Dystrophia myotonica WD repeat-containing protein

2

1

High-throughput

0.574

High

456318

REL
Proto-oncogene c-Rel

1

3

High-throughput

0.573

High

456329

LTC4S
Leukotriene C4 synthase

1

3

Small-scale

0.561

High

456347

AMOL1
Angiomotin-like protein 1

1

3

High-throughput

0.536

High

456303

AL5AP
Arachidonate 5-lipoxygenase-activating protein

1

3

Small-scale

0.527

High

456311

MEOX1
Homeobox protein MOX-1

1

2

High-throughput

0.523

High

456307

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.513

High

456314

ALR
FAD-linked sulfhydryl oxidase ALR

1

0

High-throughput

0.513

High

456320

CDC16
Cell division cycle protein 16 homolog

1

0

High-throughput

0.513

High

433223

YES
Tyrosine-protein kinase Yes

1

6

Small-scale

0.501

High

442762

HCK
Tyrosine-protein kinase HCK

1

6

Small-scale

0.501

High

454788

FGR
Tyrosine-protein kinase Fgr

1

6

Small-scale

0.501

High

456302

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

2

Small-scale

0.501

High

456321

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

1

Small-scale

0.501

High

456343

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.493

High

393985

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

398455

PPBT
Alkaline phosphatase, tissue-nonspecific isozyme

1

0

Small-scale

0.480

High

456305

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

1

Small-scale

0.479

High

456317

TF65
Transcription factor p65

1

3

Small-scale

0.479

High

456332

RN123
E3 ubiquitin-protein ligase RNF123

1

2

High-throughput

0.479

High

456368

IKZF3
Zinc finger protein Aiolos

1

1

Small-scale

0.479

High

456333

Q6FHY5
MEOX2 protein

1

2

High-throughput

0.470

High

456336

Q6P2R3
C6orf182 protein

1

1

High-throughput

0.470

High

456304

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

Small-scale

0.458

High

456313

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

Small-scale

0.458

High

456345

NAL10
NACHT, LRR and PYD domains-containing protein 10

1

0

Small-scale

0.458

High

456312

MEOX2
Homeobox protein MOX-2

1

2

High-throughput

0.439

High

456346

NUTM1
NUT family member 1

3

0

High-throughput

0.348

High

456350

SYCE1
Synaptonemal complex central element protein 1

2

0

High-throughput

0.341

High

456309

LSS
Lanosterol synthase

2

0

High-throughput

0.328

High

456325

COG2
Conserved oligomeric Golgi complex subunit 2

2

0

High-throughput

0.328

High

456335

ARMX5
Armadillo repeat-containing X-linked protein 5

2

0

High-throughput

0.328

High

456342

ERMP1
Endoplasmic reticulum metallopeptidase 1

2

0

High-throughput

0.328

High

456344

TEDC1
Tubulin epsilon and delta complex protein 1

2

0

High-throughput

0.328

High

456351

PALS1
Protein PALS1

2

0

High-throughput

0.328

High

456353

SLAI1
SLAIN motif-containing protein 1

2

0

High-throughput

0.328

High

456357

NICA
Nicastrin

2

0

High-throughput

0.328

High

456364

MND1
Meiotic nuclear division protein 1 homolog

2

0

High-throughput

0.328

High

456371

NEUR3
Sialidase-3

2

0

High-throughput

0.328

High

62684

OOEP
Oocyte-expressed protein homolog

2

0

High-throughput

0.316

High

212034

GATC
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

2

0

High-throughput

0.316

High

456348

CJ067
Uncharacterized protein C10orf67, mitochondrial

2

0

High-throughput

0.316

High

456337

PDXD2
Putative pyridoxal-dependent decarboxylase domain-containing protein 2

2

0

High-throughput

0.288

High

456360

TV23C
Golgi apparatus membrane protein TVP23 homolog C

1

0

High-throughput

0.279

Low

456354

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

0

Small-scale

0.251

Low

456352

ZN433
Zinc finger protein 433

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024