Protein: MDHC
Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase)

Gene: MDHC, MDH1
Organism: Homo sapiens
Interactions: 103
UniProt ID: P40925

Gene Ontology (top 5):
GO:0004470 - malic enzyme activity
GO:0005615 - extracellular space
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005813 - centrosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

777425

MDHC
Malate dehydrogenase, cytoplasmic

1

13

Small-scale

0.647

High

226737

PRKN
E3 ubiquitin-protein ligase parkin

3

13

Small-scale

0.640

High

334152

LDHA
L-lactate dehydrogenase A chain

1

14

High-throughput

0.618

High

338063

EGFR
Epidermal growth factor receptor

2

4

Small-scale

0.608

High

383663

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

1

High-throughput

0.576

High

777456

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

8

High-throughput

0.571

High

777432

TERF1
Telomeric repeat-binding factor 1

1

2

High-throughput

0.568

High

386237

P53
Cellular tumor antigen p53

1

3

Small-scale

0.561

High

777431

TTC3
E3 ubiquitin-protein ligase TTC3

1

4

High-throughput

0.541

High

170288

TIF1A
Transcription intermediary factor 1-alpha

1

5

High-throughput

0.536

High

201252

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

High-throughput

0.536

High

359724

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

4

High-throughput

0.536

High

437958

HS90B
Heat shock protein HSP 90-beta

1

9

Small-scale

0.536

High

496481

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.536

High

777443

KPCZ
Protein kinase C zeta type

1

4

High-throughput

0.536

High

777453

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

1

High-throughput

0.536

High

777470

KPCD2
Serine/threonine-protein kinase D2

1

4

High-throughput

0.536

High

777483

SAR1B
Small COPII coat GTPase SAR1B

1

4

High-throughput

0.536

High

777478

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.518

High

639687

IKBA
NF-kappa-B inhibitor alpha

1

2

High-throughput

0.515

High

176400

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

0

High-throughput

0.513

High

777454

HSPB2
Heat shock protein beta-2

1

2

High-throughput

0.508

High

777426

MAOX
NADP-dependent malic enzyme

1

1

Small-scale

0.505

High

777435

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.501

High

777445

MPP3
MAGUK p55 subfamily member 3

1

2

High-throughput

0.494

High

595123

LMNB1
Lamin-B1

1

5

High-throughput

0.489

High

777461

MYLK4
Myosin light chain kinase family member 4

1

6

High-throughput

0.489

High

513540

PYC
Pyruvate carboxylase, mitochondrial

1

2

Small-scale

0.484

High

726632

FUS
RNA-binding protein FUS

1

4

High-throughput

0.481

High

777466

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

3

Small-scale

0.481

High

62720

DDTL
D-dopachrome decarboxylase-like protein

1

1

High-throughput

0.479

High

160422

AURKA
Aurora kinase A

1

3

High-throughput

0.479

High

166677

CE290
Centrosomal protein of 290 kDa

1

5

High-throughput

0.479

High

329454

AGR2
Anterior gradient protein 2 homolog

1

3

High-throughput

0.479

High

340795

KAD1
Adenylate kinase isoenzyme 1

1

3

High-throughput

0.479

High

373820

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

431615

HS90A
Heat shock protein HSP 90-alpha

1

9

Small-scale

0.479

High

569323

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

668484

PML
Protein PML

1

8

High-throughput

0.479

High

681707

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

Small-scale

0.479

High

724178

MSX2
Homeobox protein MSX-2

1

2

High-throughput

0.479

High

749177

BRCA1
Breast cancer type 1 susceptibility protein

1

6

High-throughput

0.479

High

777427

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

777428

SYAC
Alanine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

777429

GSK3B
Glycogen synthase kinase-3 beta

1

7

High-throughput

0.479

High

777430

GDIR1
Rho GDP-dissociation inhibitor 1

1

1

High-throughput

0.479

High

777433

TERA
Transitional endoplasmic reticulum ATPase

1

7

High-throughput

0.479

High

777436

UBC12
NEDD8-conjugating enzyme Ubc12

1

3

High-throughput

0.479

High

777438

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

777440

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

5

Small-scale

0.479

High

777442

HSF1
Heat shock factor protein 1

1

4

High-throughput

0.479

High

777444

TADBP
TAR DNA-binding protein 43

1

9

Small-scale

0.479

High

777446

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

777449

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

6

High-throughput

0.479

High

777451

EMC2
ER membrane protein complex subunit 2

1

2

High-throughput

0.479

High

777452

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

777455

IF44L
Interferon-induced protein 44-like

1

2

High-throughput

0.479

High

777457

TET5C
Terminal nucleotidyltransferase 5C

1

2

High-throughput

0.479

High

777459

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

777465

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

6

High-throughput

0.479

High

777467

ANM1
Protein arginine N-methyltransferase 1

1

7

High-throughput

0.479

High

777468

BAG1
BAG family molecular chaperone regulator 1

1

3

High-throughput

0.479

High

777469

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

8

High-throughput

0.479

High

777472

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.479

High

777474

NMRL1
NmrA-like family domain-containing protein 1

1

3

High-throughput

0.479

High

777477

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

777479

PD1L1
Programmed cell death 1 ligand 1

1

2

High-throughput

0.479

High

777480

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

738728

SPB5
Serpin B5

1

0

Small-scale

0.460

High

260009

TBCA
Tubulin-specific chaperone A

1

0

High-throughput

0.458

High

344949

CYTN
Cystatin-SN

1

0

Small-scale

0.458

High

376072

CYTB
Cystatin-B

1

0

High-throughput

0.458

High

714787

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

777434

MTPN
Myotrophin

1

0

High-throughput

0.458

High

777439

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.458

High

777441

CYC
Cytochrome c

1

0

High-throughput

0.458

High

777447

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

777464

DDX55
ATP-dependent RNA helicase DDX55

1

0

High-throughput

0.458

High

528710

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.445

High

717514

BMI1
Polycomb complex protein BMI-1

1

10

High-throughput

0.445

High

777437

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

3

High-throughput

0.445

High

777458

PKHA7
Pleckstrin homology domain-containing family A member 7

1

12

High-throughput

0.445

High

777471

ATG5
Autophagy protein 5

1

1

High-throughput

0.445

High

225560

PCDH7
Protocadherin-7

1

2

High-throughput

0.437

High

244053

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.437

High

384416

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.437

High

552124

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

650555

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

719860

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

777450

RBM39
RNA-binding protein 39

1

4

High-throughput

0.437

High

777462

EMC5
ER membrane protein complex subunit 5

1

1

High-throughput

0.437

High

777463

EMC1
ER membrane protein complex subunit 1

1

2

High-throughput

0.437

High

777476

SLX9
Ribosome biogenesis protein SLX9 homolog

1

1

High-throughput

0.437

High

777482

AAR2
Protein AAR2 homolog

1

3

High-throughput

0.437

High

777448

DAG1
Dystroglycan 1

1

0

Small-scale

0.426

High

110837

H7C1K6
Interferon induced protein 44 like

1

2

High-throughput

0.407

High

401562

JUN
Transcription factor Jun

1

10

High-throughput

0.407

High

436874

ACM2
Muscarinic acetylcholine receptor M2

1

0

High-throughput

0.282

High

777475

LT4R2
Leukotriene B4 receptor 2

1

0

High-throughput

0.282

High

777473

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.279

Low

777460

CSMD2
CUB and sushi domain-containing protein 2

1

0

High-throughput

0.269

Low

777481

FA50B
Protein FAM50B

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024