Protein: SPSB4
SPRY domain-containing SOCS box protein 4 (SSB-4)

Gene: SPSB4
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q96A44

Gene Ontology (top 5):
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0016567 - protein ubiquitination
GO:0019005 - SCF ubiquitin ligase complex
GO:0035556 - intracellular signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1072273

ELOC
Elongin-C

5

6

Small-scale

0.933

High

1274007

CUL5
Cullin-5

4

20

Small-scale

0.903

High

776777

STAT3
Signal transducer and activator of transcription 3

1

7

High-throughput

0.691

High

1043503

CUL4B
Cullin-4B

1

20

High-throughput

0.691

High

1283437

SPSB1
SPRY domain-containing SOCS box protein 1

1

14

High-throughput

0.691

High

1283445

ASPP1
Apoptosis-stimulating of p53 protein 1

1

16

High-throughput

0.691

High

1283467

SH2B1
SH2B adapter protein 1

1

11

High-throughput

0.691

High

1072410

ELOB
Elongin-B

3

4

Small-scale

0.667

High

1283441

PAWR
PRKC apoptosis WT1 regulator protein

2

4

Small-scale

0.619

High

163632

BTAF1
TATA-binding protein-associated factor 172

1

15

High-throughput

0.618

High

1217269

ANKY2
Ankyrin repeat and MYND domain-containing protein 2

1

20

High-throughput

0.618

High

592820

NR1D1
Nuclear receptor subfamily 1 group D member 1

2

11

Small-scale

0.611

High

665641

EPHB2
Ephrin type-B receptor 2

2

12

Small-scale

0.611

High

1283474

RBX2
RING-box protein 2

2

8

Small-scale

0.611

High

718522

NOS2
Nitric oxide synthase, inducible

2

7

Small-scale

0.595

High

164143

ARHGA
Rho guanine nucleotide exchange factor 10

1

20

High-throughput

0.536

High

196333

PJA2
E3 ubiquitin-protein ligase Praja-2

1

2

High-throughput

0.536

High

231879

MARH6
E3 ubiquitin-protein ligase MARCHF6

1

1

High-throughput

0.536

High

241703

F262
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

1

8

High-throughput

0.536

High

270435

KS6A5
Ribosomal protein S6 kinase alpha-5

1

13

High-throughput

0.536

High

312640

ARI2
E3 ubiquitin-protein ligase ARIH2

1

16

High-throughput

0.536

High

313946

PIGN
GPI ethanolamine phosphate transferase 1

1

5

High-throughput

0.536

High

542404

PLAK
Junction plakoglobin

1

19

High-throughput

0.536

High

673893

NMT1
Glycylpeptide N-tetradecanoyltransferase 1

1

2

High-throughput

0.536

High

717268

CTNB1
Catenin beta-1

1

14

High-throughput

0.536

High

872615

EPHB1
Ephrin type-B receptor 1

1

12

High-throughput

0.536

High

992378

KLC1
Kinesin light chain 1

1

11

High-throughput

0.536

High

1017550

KIF5A
Kinesin heavy chain isoform 5A

1

20

High-throughput

0.536

High

1022962

CDC16
Cell division cycle protein 16 homolog

1

10

High-throughput

0.536

High

1048953

UBE4A
Ubiquitin conjugation factor E4 A

1

3

High-throughput

0.536

High

1050486

DOCK1
Dedicator of cytokinesis protein 1

1

19

High-throughput

0.536

High

1055003

FAT1
Protocadherin Fat 1

1

15

High-throughput

0.536

High

1056717

PUM1
Pumilio homolog 1

1

7

High-throughput

0.536

High

1201864

TAXB1
Tax1-binding protein 1

1

20

High-throughput

0.536

High

1202917

PARG
Poly(ADP-ribose) glycohydrolase

1

1

High-throughput

0.536

High

1219573

UBR1
E3 ubiquitin-protein ligase UBR1

1

3

High-throughput

0.536

High

1243060

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

1

8

High-throughput

0.536

High

1245285

PJA1
E3 ubiquitin-protein ligase Praja-1

1

2

High-throughput

0.536

High

1252107

PUM2
Pumilio homolog 2

1

7

High-throughput

0.536

High

1257009

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

20

High-throughput

0.536

High

1267949

TBCD5
TBC1 domain family member 5

1

8

High-throughput

0.536

High

1273256

ARHG2
Rho guanine nucleotide exchange factor 2

1

18

High-throughput

0.536

High

1283439

RN185
E3 ubiquitin-protein ligase RNF185

1

13

High-throughput

0.536

High

1283448

PI3R4
Phosphoinositide 3-kinase regulatory subunit 4

1

13

High-throughput

0.536

High

1283449

TTC1
Tetratricopeptide repeat protein 1

1

14

High-throughput

0.536

High

1283450

MIC25
MICOS complex subunit MIC25

1

1

High-throughput

0.536

High

1283453

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

14

High-throughput

0.536

High

1283454

LHPP
Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

1

3

High-throughput

0.536

High

1283455

KLC2
Kinesin light chain 2

1

12

High-throughput

0.536

High

1283456

SIK2
Serine/threonine-protein kinase SIK2

1

8

High-throughput

0.536

High

1283457

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

12

High-throughput

0.536

High

1283458

DOCK5
Dedicator of cytokinesis protein 5

1

13

High-throughput

0.536

High

1283461

AGO3
Protein argonaute-3

1

6

High-throughput

0.536

High

1283468

FANCI
Fanconi anemia group I protein

1

2

High-throughput

0.536

High

1283475

FBX5
F-box only protein 5

1

1

High-throughput

0.536

High

1283476

FZR1
Fizzy-related protein homolog

1

12

High-throughput

0.536

High

1283478

UBP24
Ubiquitin carboxyl-terminal hydrolase 24

1

16

High-throughput

0.536

High

750395

COIL
Coilin

1

0

High-throughput

0.513

High

1054268

SLBP
Histone RNA hairpin-binding protein

1

0

High-throughput

0.513

High

1062919

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.513

High

1138037

RN220
E3 ubiquitin-protein ligase RNF220

1

0

High-throughput

0.513

High

1283438

APC16
Anaphase-promoting complex subunit 16

1

0

High-throughput

0.513

High

772101

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.493

High

152320

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

8

High-throughput

0.489

High

158335

PCD17
Protocadherin-17

1

16

High-throughput

0.489

High

196488

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

10

High-throughput

0.489

High

225662

PCDH7
Protocadherin-7

1

20

High-throughput

0.489

High

299576

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

1

12

High-throughput

0.489

High

311269

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

2

High-throughput

0.489

High

438829

SRPRA
Signal recognition particle receptor subunit alpha

1

5

High-throughput

0.489

High

537175

CBPM
Carboxypeptidase M

1

3

High-throughput

0.489

High

580252

CADH2
Cadherin-2

1

14

High-throughput

0.489

High

587362

ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2

1

9

High-throughput

0.489

High

602275

CD9
CD9 antigen

1

6

High-throughput

0.489

High

993897

PCDH1
Protocadherin-1

1

20

High-throughput

0.489

High

1015779

KIF1A
Kinesin-like protein KIF1A

1

20

High-throughput

0.489

High

1048641

DSG2
Desmoglein-2

1

16

High-throughput

0.489

High

1049383

URB2
Unhealthy ribosome biogenesis protein 2 homolog

1

1

High-throughput

0.489

High

1074558

CDSN
Corneodesmosin

1

1

High-throughput

0.489

High

1075067

MARE2
Microtubule-associated protein RP/EB family member 2

1

3

High-throughput

0.489

High

1088584

MIC60
MICOS complex subunit MIC60

1

2

High-throughput

0.489

High

1119213

MBRL
Membralin

1

2

High-throughput

0.489

High

1120750

ACSM3
Acyl-coenzyme A synthetase ACSM3, mitochondrial

1

6

High-throughput

0.489

High

1126170

MTX3
Metaxin-3

1

2

High-throughput

0.489

High

1166660

LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3

1

13

High-throughput

0.489

High

1167031

FAT4
Protocadherin Fat 4

1

16

High-throughput

0.489

High

1188228

NUP54
Nucleoporin p54

1

8

High-throughput

0.489

High

1236749

PCD20
Protocadherin-20

1

20

High-throughput

0.489

High

1250855

PCD19
Protocadherin-19

1

14

High-throughput

0.489

High

1255521

FAT3
Protocadherin Fat 3

1

17

High-throughput

0.489

High

1257300

SHRM3
Protein Shroom3

1

2

High-throughput

0.489

High

1271388

PCSK5
Proprotein convertase subtilisin/kexin type 5

1

8

High-throughput

0.489

High

1283442

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

1

15

High-throughput

0.489

High

1283443

MAGD4
Melanoma-associated antigen D4

1

11

High-throughput

0.489

High

1283444

PCD16
Protocadherin-16

1

20

High-throughput

0.489

High

1283446

SFXN2
Sideroflexin-2

1

4

High-throughput

0.489

High

1283447

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

5

High-throughput

0.489

High

1283451

NUP58
Nucleoporin p58/p45

1

3

High-throughput

0.489

High

1283452

DDA1
DET1- and DDB1-associated protein 1

1

2

High-throughput

0.489

High

1283459

LRC40
Leucine-rich repeat-containing protein 40

1

10

High-throughput

0.489

High

1283460

SFXN1
Sideroflexin-1

1

4

High-throughput

0.489

High

1283462

PCDH9
Protocadherin-9

1

20

High-throughput

0.489

High

1283463

PCD18
Protocadherin-18

1

16

High-throughput

0.489

High

1283464

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

16

High-throughput

0.489

High

1283465

NGRN
Neugrin

1

2

High-throughput

0.489

High

1283469

CELR1
Cadherin EGF LAG seven-pass G-type receptor 1

1

15

High-throughput

0.489

High

1283470

CELR3
Cadherin EGF LAG seven-pass G-type receptor 3

1

16

High-throughput

0.489

High

1283471

SACS
Sacsin

1

1

High-throughput

0.489

High

1283472

FPRP
Prostaglandin F2 receptor negative regulator

1

16

High-throughput

0.489

High

1283473

PCD10
Protocadherin-10

1

16

High-throughput

0.489

High

1283477

PCDGK
Protocadherin gamma-C3

1

9

High-throughput

0.489

High

1283479

SAM50
Sorting and assembly machinery component 50 homolog

1

1

High-throughput

0.489

High

1283480

KCTD3
BTB/POZ domain-containing protein KCTD3

1

8

High-throughput

0.489

High

1283481

PCDGL
Protocadherin gamma-C4

1

10

High-throughput

0.489

High

1283482

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

4

High-throughput

0.489

High

1283483

SRPRB
Signal recognition particle receptor subunit beta

1

12

High-throughput

0.489

High

1283466

DDX4
Probable ATP-dependent RNA helicase DDX4

1

13

Small-scale

0.472

High

441549

MET
Hepatocyte growth factor receptor

1

20

Small-scale

0.437

High

484322

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

12

High-throughput

0.407

High

63788

CC85C
Coiled-coil domain-containing protein 85C

1

0

High-throughput

0.279

Low

225205

BNI3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

1

0

High-throughput

0.279

Low

1162407

CNST
Consortin

1

0

High-throughput

0.279

Low

1283440

TECT2
Tectonic-2

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024