Protein: TOM40
Mitochondrial import receptor subunit TOM40 (Mitochondrial import site protein ISP42) (Translocase of outer membrane 40 kDa subunit)

Gene: TOM40
Organism: Saccharomyces cerevisiae S288C
Interactions: 99
UniProt ID: P23644

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005742 - mitochondrial outer membrane translocase complex
GO:0005758 - mitochondrial intermembrane space
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

661815

SAM50
Sorting assembly machinery 50 kDa subunit

6

1

Small-scale

0.947

High

661806

TOM22
Mitochondrial import receptor subunit TOM22

29

0

Small-scale

0.941

High

417031

VDAC1
Non-selective voltage-gated ion channel 1

5

1

Small-scale

0.906

High

661808

SAM37
Sorting assembly machinery 37 kDa subunit

6

0

Small-scale

0.887

High

661817

TOM5
Mitochondrial import receptor subunit TOM5

4

0

Small-scale

0.831

High

661813

TOM7
Mitochondrial import receptor subunit TOM7

4

0

Small-scale

0.828

High

661783

TOM20
Mitochondrial import receptor subunit TOM20

11

2

Small-scale

0.758

High

451992

TOM70
Mitochondrial import receptor subunit TOM70

8

2

Small-scale

0.741

High

574851

SAM35
Sorting assembly machinery 35 kDa subunit

7

0

Small-scale

0.715

High

661781

TOM6
Mitochondrial import receptor subunit TOM6

2

0

Small-scale

0.699

High

661779

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

6

0

Small-scale

0.688

High

661787

MIC60
MICOS complex subunit MIC60

5

0

Small-scale

0.682

High

613748

MDM10
Mitochondrial distribution and morphology protein 10

4

0

Small-scale

0.649

High

578889

HSC82
ATP-dependent molecular chaperone HSC82

3

2

Small-scale

0.640

High

661821

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

3

0

Small-scale

0.628

High

661802

VDAC2
Non-selective voltage-gated ion channel 2

1

1

Small-scale

0.618

High

661764

TOM40
Mitochondrial import receptor subunit TOM40

1

0

Small-scale

0.614

High

661785

MIA40
Mitochondrial intermembrane space import and assembly protein 40

2

0

Small-scale

0.592

High

392268

HSP82
ATP-dependent molecular chaperone HSP82

2

2

Small-scale

0.584

High

661765

SIS1
Protein SIS1

2

1

Small-scale

0.584

High

661772

HS104
Heat shock protein 104

2

1

Small-scale

0.584

High

661792

XDJ1
DnaJ protein homolog XDJ1

2

1

High-throughput

0.584

High

661789

TCD1
tRNA threonylcarbamoyladenosine dehydratase 1

2

1

High-throughput

0.576

High

523118

HSP71
Heat shock protein SSA1

2

1

Small-scale

0.571

High

661775

YME1
Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1

2

3

High-throughput

0.571

High

661825

YHM2
Citrate/oxoglutarate carrier protein

2

2

High-throughput

0.571

High

661810

JAC1
J-type co-chaperone JAC1, mitochondrial

2

0

Small-scale

0.560

High

661818

TIM10
Mitochondrial import inner membrane translocase subunit TIM10

2

0

Small-scale

0.560

High

510220

HSP77
Import motor subunit, mitochondrial

2

0

High-throughput

0.559

High

661767

CDC48
Cell division control protein 48

2

0

Small-scale

0.559

High

661823

MIX17
Mitochondrial intermembrane space cysteine motif-containing protein MIX17

2

0

Small-scale

0.559

High

661812

TIM21
Mitochondrial import inner membrane translocase subunit TIM21

2

0

Small-scale

0.547

High

661830

VAM6
Vacuolar morphogenesis protein 6

2

1

Small-scale

0.533

High

661799

SSB2
Ribosome-associated molecular chaperone SSB2

2

0

High-throughput

0.528

High

441041

KAPA
cAMP-dependent protein kinase type 1

1

0

Small-scale

0.480

High

661771

HRR25
Casein kinase I homolog HRR25

1

0

Small-scale

0.480

High

661784

NDK
Nucleoside diphosphate kinase

1

0

Small-scale

0.480

High

661828

TAZ
Tafazzin

1

0

Small-scale

0.480

High

661829

SYM1
Protein SYM1

1

0

Small-scale

0.480

High

661835

EMR1
ERMES regulator 1

1

0

Small-scale

0.480

High

366938

ATPB
ATP synthase subunit beta, mitochondrial

1

1

High-throughput

0.479

High

452823

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

453110

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

1

High-throughput

0.479

High

453251

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

1

High-throughput

0.479

High

525970

HSP72
Heat shock protein SSA2

1

1

Small-scale

0.479

High

594882

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

613527

ADT2
ADP,ATP carrier protein 2

1

2

Small-scale

0.479

High

661766

MAS5
Mitochondrial protein import protein MAS5

1

1

Small-scale

0.479

High

661774

SCM4
Protein SCM4

1

1

Small-scale

0.479

High

661776

BCS1
Mitochondrial chaperone BCS1

1

2

Small-scale

0.479

High

661780

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.479

High

661786

TCD2
tRNA threonylcarbamoyladenosine dehydratase 2

1

1

High-throughput

0.479

High

661794

AFG3
Mitochondrial inner membrane m-AAA protease component YTA10

1

2

High-throughput

0.479

High

661800

YTA12
Mitochondrial inner membrane m-AAA protease component YTA12

1

2

High-throughput

0.479

High

661803

DJP1
DnaJ-like protein 1

1

1

Small-scale

0.479

High

661804

PHB1
Prohibitin-1

1

1

High-throughput

0.479

High

661807

PHB2
Prohibitin-2

1

1

High-throughput

0.479

High

661827

ATG33
Autophagy-related protein 33

1

1

High-throughput

0.479

High

661833

AHA1
Hsp90 co-chaperone AHA1

1

1

Small-scale

0.479

High

357812

QCR7
Cytochrome b-c1 complex subunit 7, mitochondrial

1

0

High-throughput

0.458

High

360868

COX6
Cytochrome c oxidase subunit 6, mitochondrial

1

0

High-throughput

0.458

High

382834

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

399798

COX4
Cytochrome c oxidase subunit 4, mitochondrial

1

0

High-throughput

0.458

High

431982

ATPF
ATP synthase subunit 4, mitochondrial

1

0

High-throughput

0.458

High

452632

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

0

High-throughput

0.458

High

482184

ATPO
ATP synthase subunit 5, mitochondrial

1

0

High-throughput

0.458

High

647011

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

661778

DLD1
D-lactate dehydrogenase [cytochrome] 1, mitochondrial

1

0

High-throughput

0.458

High

661782

PTH2
Peptidyl-tRNA hydrolase 2

1

0

Small-scale

0.458

High

661788

MRX3
MIOREX complex component 3

1

0

High-throughput

0.458

High

661790

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.458

High

661791

PSD1
Phosphatidylserine decarboxylase proenzyme 1, mitochondrial

1

0

Small-scale

0.458

High

661793

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.458

High

661795

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

661796

RSP5
E3 ubiquitin-protein ligase RSP5

1

0

Small-scale

0.458

High

661798

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

0

High-throughput

0.458

High

661801

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.458

High

661809

UFD1
Ubiquitin fusion degradation protein 1

1

0

Small-scale

0.458

High

661811

MCY1
Putative mitochondrial cysteine synthase

1

0

High-throughput

0.458

High

661814

RCF2
Respiratory supercomplex factor 2, mitochondrial

1

0

High-throughput

0.458

High

661819

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.458

High

661820

PT191
Mitochondrial protein PET191

1

0

Small-scale

0.458

High

661822

UGO1
Mitochondrial fusion and transport protein UGO1

1

0

Small-scale

0.458

High

661826

UBX2
UBX domain-containing protein 2

1

0

Small-scale

0.458

High

661831

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

661834

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

0

High-throughput

0.458

High

661836

DPH3
Diphthamide biosynthesis protein 3

1

0

Small-scale

0.458

High

661797

PIC2
Mitochondrial phosphate carrier protein 2

1

2

High-throughput

0.445

High

585590

STI1
Heat shock protein STI1

1

2

Small-scale

0.437

High

661832

HSP42
Heat shock protein 42

1

1

Small-scale

0.437

High

661777

YME2
Mitochondrial escape protein 2

1

0

High-throughput

0.426

High

661769

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.282

High

661768

PRR1
Serine/threonine-protein kinase PRR1

1

0

Small-scale

0.261

Low

661770

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

661773

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.249

Low

661805

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

661816

H3
Histone H3

1

0

High-throughput

0.249

Low

661824

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025