Protein: EPHB2
Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]

Gene: EPHB2
Organism: Homo sapiens
Interactions: 192
UniProt ID: P29323

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001540 - amyloid-beta binding
GO:0001655 - urogenital system development
GO:0001933 - negative regulation of protein phosphorylation
GO:0002639 - positive regulation of immunoglobulin production

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

665565

EFNB2
Ephrin-B2

5

20

Small-scale

0.926

High

665144

EPHA2
Ephrin type-A receptor 2

3

19

Small-scale

0.847

High

522803

SRC
Proto-oncogene tyrosine-protein kinase Src

2

20

Small-scale

0.828

High

596362

RASA1
Ras GTPase-activating protein 1

2

20

Small-scale

0.812

High

665558

ABL2
Tyrosine-protein kinase ABL2

2

20

Small-scale

0.757

High

665551

EPHB2
Ephrin type-B receptor 2

2

17

Small-scale

0.755

High

337360

ABL1
Tyrosine-protein kinase ABL1

1

20

Small-scale

0.740

High

665374

EPHA3
Ephrin type-A receptor 3

1

18

Small-scale

0.724

High

665568

EPHA4
Ephrin type-A receptor 4

1

18

High-throughput

0.715

High

426988

CSF1R
Macrophage colony-stimulating factor 1 receptor

1

20

High-throughput

0.691

High

665579

EFNB1
Ephrin-B1

1

20

High-throughput

0.691

High

665605

EPHA7
Ephrin type-A receptor 7

1

18

High-throughput

0.691

High

665648

PSKH2
Serine/threonine-protein kinase H2

1

11

High-throughput

0.691

High

665665

PICK1
PRKCA-binding protein

1

3

High-throughput

0.691

High

665651

SPSB2
SPRY domain-containing SOCS box protein 2

3

12

High-throughput

0.667

High

665569

AFAD
Afadin

1

20

Small-scale

0.656

High

433265

YES
Tyrosine-protein kinase Yes

1

20

Small-scale

0.647

High

665560

CRK
Adapter molecule crk

1

20

Small-scale

0.647

High

665566

EPHB3
Ephrin type-B receptor 3

1

17

High-throughput

0.646

High

665567

EPHB1
Ephrin type-B receptor 1

1

18

High-throughput

0.646

High

665577

RAE1L
mRNA export factor RAE1

1

1

High-throughput

0.646

High

665676

EPHA6
Ephrin type-A receptor 6

1

18

High-throughput

0.646

High

383632

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.621

High

580937

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

10

Small-scale

0.621

High

665646

LRIQ1
Leucine-rich repeat and IQ domain-containing protein 1

1

20

High-throughput

0.618

High

665681

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.618

High

270580

MYCB2
E3 ubiquitin-protein ligase MYCBP2

2

3

High-throughput

0.618

High

472678

FBSP1
F-box/SPRY domain-containing protein 1

2

14

High-throughput

0.618

High

64660

RHG32
Rho GTPase-activating protein 32

1

18

High-throughput

0.618

High

129211

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.618

High

171290

EPHB6
Ephrin type-B receptor 6

1

17

Small-scale

0.618

High

253317

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

13

High-throughput

0.618

High

324742

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

20

High-throughput

0.618

High

349905

RASK
GTPase KRas

1

20

High-throughput

0.618

High

595976

EFNA1
Ephrin-A1

1

20

High-throughput

0.618

High

640048

MOES
Moesin

1

13

High-throughput

0.618

High

647831

MARK3
MAP/microtubule affinity-regulating kinase 3

1

7

High-throughput

0.618

High

655222

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

High-throughput

0.618

High

665552

RYK
Tyrosine-protein kinase RYK

1

20

Small-scale

0.618

High

665554

MERL
Merlin

1

14

High-throughput

0.618

High

665555

RADI
Radixin

1

13

High-throughput

0.618

High

665570

RAB2A
Ras-related protein Rab-2A

1

15

High-throughput

0.618

High

665573

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

665574

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.618

High

665581

ANK2
Ankyrin-2

1

5

High-throughput

0.618

High

665584

NOTC2
Neurogenic locus notch homolog protein 2

1

10

High-throughput

0.618

High

665589

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

20

High-throughput

0.618

High

665590

EPS8
Epidermal growth factor receptor kinase substrate 8

1

20

High-throughput

0.618

High

665591

ANK3
Ankyrin-3

1

5

High-throughput

0.618

High

665592

TP4A2
Protein tyrosine phosphatase type IVA 2

1

12

High-throughput

0.618

High

665595

ROCK1
Rho-associated protein kinase 1

1

10

High-throughput

0.618

High

665596

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.618

High

665597

STIM1
Stromal interaction molecule 1

1

6

High-throughput

0.618

High

665600

SCRIB
Protein scribble homolog

1

20

High-throughput

0.618

High

665604

RAB35
Ras-related protein Rab-35

1

15

High-throughput

0.618

High

665608

ITSN1
Intersectin-1

1

15

Small-scale

0.618

High

665614

PDZ11
PDZ domain-containing protein 11

1

17

High-throughput

0.618

High

665616

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.618

High

665618

RAPH1
Ras-associated and pleckstrin homology domains-containing protein 1

1

16

High-throughput

0.618

High

665628

UNC5B
Netrin receptor UNC5B

1

11

High-throughput

0.618

High

665629

ABI1
Abl interactor 1

1

16

High-throughput

0.618

High

665631

EHBP1
EH domain-binding protein 1

1

8

High-throughput

0.618

High

665642

FERM2
Fermitin family homolog 2

1

3

High-throughput

0.618

High

665643

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

High-throughput

0.618

High

665647

ASPP1
Apoptosis-stimulating of p53 protein 1

1

10

High-throughput

0.618

High

665656

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

12

High-throughput

0.618

High

665659

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

11

High-throughput

0.618

High

665661

PKHA5
Pleckstrin homology domain-containing family A member 5

1

20

High-throughput

0.618

High

665662

PKHA1
Pleckstrin homology domain-containing family A member 1

1

20

High-throughput

0.618

High

665663

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.618

High

665667

LIN7C
Protein lin-7 homolog C

1

20

High-throughput

0.618

High

665679

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

1

15

High-throughput

0.618

High

665680

TNIK
TRAF2 and NCK-interacting protein kinase

1

20

High-throughput

0.618

High

665682

ALK
ALK tyrosine kinase receptor

1

18

Small-scale

0.618

High

665683

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

11

High-throughput

0.618

High

665688

GIT1
ARF GTPase-activating protein GIT1

1

12

Small-scale

0.618

High

665641

SPSB4
SPRY domain-containing SOCS box protein 4

2

12

Small-scale

0.611

High

665670

RN186
E3 ubiquitin-protein ligase RNF186

1

1

Small-scale

0.586

High

665633

LNX1
E3 ubiquitin-protein ligase LNX

1

20

Small-scale

0.553

High

665635

CSKI2
Caskin-2

1

15

High-throughput

0.553

High

665630

MTMRE
Myotubularin-related protein 14

1

2

High-throughput

0.541

High

501728

BIP
Endoplasmic reticulum chaperone BiP

1

14

High-throughput

0.536

High

665578

PRKDC
DNA-dependent protein kinase catalytic subunit

1

6

High-throughput

0.536

High

665610

CDC37
Hsp90 co-chaperone Cdc37

1

17

High-throughput

0.536

High

665563

NU153
Nuclear pore complex protein Nup153

1

7

Small-scale

0.527

High

665593

TADBP
TAR DNA-binding protein 43

1

6

High-throughput

0.515

High

665622

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.515

High

665636

JPH3
Junctophilin-3

1

7

High-throughput

0.515

High

665655

TRI54
Tripartite motif-containing protein 54

1

15

High-throughput

0.504

High

394170

A4
Amyloid-beta precursor protein

1

9

Small-scale

0.501

High

665689

FBX7
F-box only protein 7

1

4

High-throughput

0.501

High

268408

BAF
Barrier-to-autointegration factor

1

6

High-throughput

0.500

High

665557

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

8

High-throughput

0.500

High

665559

EAA1
Excitatory amino acid transporter 1

1

7

High-throughput

0.500

High

665571

RS29
Small ribosomal subunit protein uS14

1

1

High-throughput

0.500

High

665580

TFAM
Transcription factor A, mitochondrial

1

6

High-throughput

0.500

High

665603

OZF
Zinc finger protein OZF

1

4

High-throughput

0.500

High

665624

DYH10
Dynein axonemal heavy chain 10

1

7

High-throughput

0.500

High

665627

TRM2A
tRNA

1

2

High-throughput

0.500

High

665632

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

3

High-throughput

0.500

High

665637

S39A7
Zinc transporter SLC39A7

1

3

High-throughput

0.500

High

665652

NTPCR
Cancer-related nucleoside-triphosphatase

1

8

High-throughput

0.500

High

665654

PDIP3
Polymerase delta-interacting protein 3

1

4

High-throughput

0.500

High

665666

MDN1
Midasin

1

13

High-throughput

0.500

High

665668

FANCI
Fanconi anemia group I protein

1

4

High-throughput

0.500

High

156661

PAHX
Phytanoyl-CoA dioxygenase, peroxisomal

1

0

High-throughput

0.493

High

602496

COMT
Catechol O-methyltransferase

1

0

High-throughput

0.493

High

68541

NUD19
Acyl-coenzyme A diphosphatase NUDT19

1

3

High-throughput

0.479

High

146018

CLD4
Claudin-4

1

2

Small-scale

0.479

High

149554

COPE
Coatomer subunit epsilon

1

4

High-throughput

0.479

High

159900

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

20

High-throughput

0.479

High

168341

SCAM1
Secretory carrier-associated membrane protein 1

1

2

High-throughput

0.479

High

180819

YKT6
Synaptobrevin homolog YKT6

1

7

High-throughput

0.479

High

205079

TGON2
Trans-Golgi network integral membrane protein 2

1

10

High-throughput

0.479

High

216450

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

6

High-throughput

0.479

High

259558

HMMR
Hyaluronan mediated motility receptor

1

6

Small-scale

0.479

High

315524

SC24A
Protein transport protein Sec24A

1

20

High-throughput

0.479

High

315658

SC24B
Protein transport protein Sec24B

1

20

High-throughput

0.479

High

320267

SNP29
Synaptosomal-associated protein 29

1

4

High-throughput

0.479

High

398646

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

2

High-throughput

0.479

High

503499

HSP7C
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.479

High

531732

PDIA4
Protein disulfide-isomerase A4

1

20

High-throughput

0.479

High

542198

PLAK
Junction plakoglobin

1

19

High-throughput

0.479

High

597642

VATB2
V-type proton ATPase subunit B, brain isoform

1

2

High-throughput

0.479

High

623719

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

3

Small-scale

0.479

High

660090

RBL1
Retinoblastoma-like protein 1

1

2

High-throughput

0.479

High

665553

CTNB1
Catenin beta-1

1

16

High-throughput

0.479

High

665556

ADDB
Beta-adducin

1

3

High-throughput

0.479

High

665561

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

1

5

High-throughput

0.479

High

665562

NUMB
Protein numb homolog

1

14

High-throughput

0.479

High

665564

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

6

High-throughput

0.479

High

665572

ARF6
ADP-ribosylation factor 6

1

14

High-throughput

0.479

High

665576

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

665582

KIF23
Kinesin-like protein KIF23

1

4

High-throughput

0.479

High

665583

CAV1
Caveolin-1

1

8

High-throughput

0.479

High

665585

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

3

Small-scale

0.479

High

665586

KLC1
Kinesin light chain 1

1

3

High-throughput

0.479

High

665587

NSUN2
RNA cytosine C(5)-methyltransferase NSUN2

1

4

High-throughput

0.479

High

665588

FCHO2
F-BAR domain only protein 2

1

8

High-throughput

0.479

High

665594

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

3

Small-scale

0.479

High

665601

EI2BA
Translation initiation factor eIF2B subunit alpha

1

4

High-throughput

0.479

High

665602

DIP2A
Disco-interacting protein 2 homolog A

1

10

High-throughput

0.479

High

665606

SC23A
Protein transport protein Sec23A

1

20

High-throughput

0.479

High

665607

SC23B
Protein transport protein Sec23B

1

20

High-throughput

0.479

High

665609

VAMP3
Vesicle-associated membrane protein 3

1

5

High-throughput

0.479

High

665611

OCLN
Occludin

1

6

High-throughput

0.479

High

665612

TB10B
TBC1 domain family member 10B

1

11

High-throughput

0.479

High

665613

Q4LE69
1-phosphatidylinositol 4-kinase

1

5

High-throughput

0.479

High

665615

F1711
Protein FAM171A1

1

10

High-throughput

0.479

High

665617

GRIN3
G protein-regulated inducer of neurite outgrowth 3

1

4

High-throughput

0.479

High

665619

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

7

High-throughput

0.479

High

665620

GRIN1
G protein-regulated inducer of neurite outgrowth 1

1

9

High-throughput

0.479

High

665621

ZFY16
Zinc finger FYVE domain-containing protein 16

1

20

High-throughput

0.479

High

665623

LSR
Lipolysis-stimulated lipoprotein receptor

1

3

High-throughput

0.479

High

665625

M21D2
Nucleotidyltransferase MB21D2

1

4

High-throughput

0.479

High

665634

BRK1
Protein BRICK1

1

3

High-throughput

0.479

High

665638

WASF1
Actin-binding protein WASF1

1

18

High-throughput

0.479

High

665639

SEPT8
Septin-8

1

14

High-throughput

0.479

High

665640

US6NL
USP6 N-terminal-like protein

1

10

High-throughput

0.479

High

665644

SPSB1
SPRY domain-containing SOCS box protein 1

1

12

Small-scale

0.479

High

665645

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

7

High-throughput

0.479

High

665649

NIBA2
Protein Niban 2

1

5

High-throughput

0.479

High

665650

CDCA3
Cell division cycle-associated protein 3

1

8

High-throughput

0.479

High

665671

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

3

Small-scale

0.479

High

665675

DIP2B
Disco-interacting protein 2 homolog B

1

10

High-throughput

0.479

High

665684

BAIP2
BAR/IMD domain-containing adapter protein 2

1

16

High-throughput

0.479

High

665685

NCKP1
Nck-associated protein 1

1

2

High-throughput

0.479

High

665686

NISCH
Nischarin

1

20

High-throughput

0.479

High

665690

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.479

High

665692

WASF2
Actin-binding protein WASF2

1

15

High-throughput

0.479

High

665658

ZDHC6
Palmitoyltransferase ZDHHC6

1

4

High-throughput

0.457

High

665664

TM9S3
Transmembrane 9 superfamily member 3

1

2

High-throughput

0.457

High

665673

HACD3
Very-long-chain

1

5

High-throughput

0.457

High

239798

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

7

High-throughput

0.445

High

326030

TSN15
Tetraspanin-15

1

5

High-throughput

0.445

High

496375

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

665598

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

8

High-throughput

0.445

High

665687

KLDC2
Kelch domain-containing protein 2

1

1

Small-scale

0.445

High

532062

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

3

High-throughput

0.437

High

665575

TBA1B
Tubulin alpha-1B chain

1

11

High-throughput

0.437

High

665599

SEPT6
Septin-6

1

14

High-throughput

0.437

High

665626

PHAR4
Phosphatase and actin regulator 4

1

9

High-throughput

0.437

High

665653

RFIP5
Rab11 family-interacting protein 5

1

3

High-throughput

0.437

High

665657

GCP60
Golgi resident protein GCP60

1

10

High-throughput

0.437

High

665660

GORS2
Golgi reassembly-stacking protein 2

1

7

High-throughput

0.437

High

665672

USE1
Vesicle transport protein USE1

1

2

High-throughput

0.437

High

665674

SEP10
Septin-10

1

13

High-throughput

0.437

High

665677

SEPT3
Neuronal-specific septin-3

1

14

High-throughput

0.437

High

665678

SEPT9
Septin-9

1

14

High-throughput

0.437

High

665691

SRPRB
Signal recognition particle receptor subunit beta

1

20

High-throughput

0.437

High

665669

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

High-throughput

0.268

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024