Protein: EXOC8
Exocyst complex component 8 (Exocyst complex 84 kDa subunit)

Gene: EXOC8
Organism: Homo sapiens
Interactions: 161
UniProt ID: Q8IYI6

Gene Ontology (top 5):
GO:0000145 - exocyst
GO:0000281 - mitotic cytokinesis
GO:0005770 - late endosome
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1315117

EXOC2
Exocyst complex component 2

5

2

Small-scale

0.930

High

1315153

EXOC7
Exocyst complex component 7

4

2

High-throughput

0.903

High

539888

RALB
Ras-related protein Ral-B

7

4

Small-scale

0.749

High

1315112

EXOC4
Exocyst complex component 4

4

2

Small-scale

0.704

High

137248

EXOC5
Exocyst complex component 5

4

1

High-throughput

0.699

High

1315148

IKZF3
Zinc finger protein Aiolos

4

1

High-throughput

0.698

High

1315101

EXOC6
Exocyst complex component 6

3

3

High-throughput

0.675

High

1315156

EXC6B
Exocyst complex component 6B

3

3

High-throughput

0.675

High

475628

K1C19
Keratin, type I cytoskeletal 19

3

4

High-throughput

0.667

High

252883

EXOC3
Exocyst complex component 3

3

1

High-throughput

0.667

High

171507

S27A2
Long-chain fatty acid transport protein 2

3

2

High-throughput

0.662

High

262262

SCN2B
Sodium channel regulatory subunit beta-2

3

1

High-throughput

0.650

High

1315139

EXOC1
Exocyst complex component 1

3

0

High-throughput

0.646

High

1143407

PCM1
Pericentriolar material 1 protein

3

0

High-throughput

0.639

High

1315149

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

3

0

High-throughput

0.639

High

1315140

OCAD1
OCIA domain-containing protein 1

3

0

High-throughput

0.634

High

640217

EPHA1
Ephrin type-A receptor 1

2

1

High-throughput

0.628

High

1315128

EHD4
EH domain-containing protein 4

2

1

High-throughput

0.628

High

1315132

EHD1
EH domain-containing protein 1

2

1

High-throughput

0.628

High

1315136

MBIP1
MAP3K12-binding inhibitory protein 1

2

0

High-throughput

0.623

High

300588

KRT36
Keratin, type I cuticular Ha6

2

5

High-throughput

0.615

High

300418

KRT34
Keratin, type I cuticular Ha4

2

5

High-throughput

0.606

High

572063

TRI27
Zinc finger protein RFP

2

1

High-throughput

0.606

High

623434

RO52
E3 ubiquitin-protein ligase TRIM21

2

1

High-throughput

0.606

High

1031004

K22O
Keratin, type II cytoskeletal 2 oral

2

1

High-throughput

0.606

High

699562

IL1R2
Interleukin-1 receptor type 2

2

0

High-throughput

0.602

High

1095557

LIPA1
Liprin-alpha-1

2

0

High-throughput

0.602

High

1146381

LRC41
Leucine-rich repeat-containing protein 41

2

0

High-throughput

0.602

High

1315097

SIGL1
SIGLEC family-like protein 1

2

0

High-throughput

0.602

High

1315157

3BP1
SH3 domain-binding protein 1

2

0

High-throughput

0.602

High

1126718

BECN1
Beclin-1

2

0

Small-scale

0.595

High

1312099

TARG1
Trafficking regulator of GLUT4 1

2

0

High-throughput

0.585

High

1315152

CAH14
Carbonic anhydrase 14

2

0

High-throughput

0.585

High

164005

NDC80
Kinetochore protein NDC80 homolog

2

0

High-throughput

0.580

High

567180

ZNF35
Zinc finger protein 35

2

0

High-throughput

0.580

High

635087

CAN3
Calpain-3

2

0

High-throughput

0.580

High

708988

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.580

High

1063420

GOGA2
Golgin subfamily A member 2

2

0

High-throughput

0.580

High

1096587

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

2

0

High-throughput

0.580

High

1238545

RINT1
RAD50-interacting protein 1

2

0

High-throughput

0.580

High

1246481

BL1S2
Biogenesis of lysosome-related organelles complex 1 subunit 2

2

0

High-throughput

0.580

High

1251859

SCAR5
Scavenger receptor class A member 5

2

0

High-throughput

0.580

High

1315105

CCHCR
Coiled-coil alpha-helical rod protein 1

2

0

High-throughput

0.580

High

1315120

SYT17
Synaptotagmin-17

2

0

High-throughput

0.580

High

1315123

RUSC1
AP-4 complex accessory subunit RUSC1

2

0

High-throughput

0.580

High

1315133

MARH7
E3 ubiquitin-protein ligase MARCHF7

2

0

High-throughput

0.580

High

1315134

VP37B
Vacuolar protein sorting-associated protein 37B

2

0

High-throughput

0.580

High

1315135

DMAP1
DNA methyltransferase 1-associated protein 1

2

0

High-throughput

0.580

High

1315137

F217B
Protein FAM217B

2

0

High-throughput

0.580

High

1315142

STMN3
Stathmin-3

2

0

High-throughput

0.580

High

1315155

LZTS1
Leucine zipper putative tumor suppressor 1

2

0

High-throughput

0.580

High

1315158

ATP23
Mitochondrial inner membrane protease ATP23 homolog

2

0

High-throughput

0.580

High

388243

GLPA
Glycophorin-A

2

0

High-throughput

0.576

High

69391

WASH1
WASH complex subunit 1

2

0

Small-scale

0.575

High

1146033

K1H1
Keratin, type I cuticular Ha1

1

5

High-throughput

0.573

High

363547

EGFR
Epidermal growth factor receptor

2

0

Small-scale

0.559

High

587136

ITF2
Transcription factor 4

2

1

High-throughput

0.553

High

1121271

TRI14
Tripartite motif-containing protein 14

2

2

High-throughput

0.553

High

1276131

NUP54
Nucleoporin p54

2

1

High-throughput

0.553

High

1315098

ZSCA4
Zinc finger and SCAN domain-containing protein 4

2

2

High-throughput

0.553

High

1315118

HTF4
Transcription factor 12

2

1

High-throughput

0.553

High

1315126

TRI54
Tripartite motif-containing protein 54

2

3

High-throughput

0.553

High

1315144

TFP11
Tuftelin-interacting protein 11

2

1

High-throughput

0.553

High

436937

K1C18
Keratin, type I cytoskeletal 18

1

5

High-throughput

0.541

High

618069

K1C15
Keratin, type I cytoskeletal 15

1

4

High-throughput

0.541

High

777404

K1C20
Keratin, type I cytoskeletal 20

1

6

High-throughput

0.541

High

279186

ULK1
Serine/threonine-protein kinase ULK1

1

0

Small-scale

0.537

High

1315103

R3GEF
Guanine nucleotide exchange factor for Rab-3A

1

0

High-throughput

0.536

High

169643

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

0

High-throughput

0.518

High

1232837

Q6GMQ7
Vacuolar protein sorting-associated protein 16 homolog

1

1

High-throughput

0.515

High

564038

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

858788

BRCC3
Lys-63-specific deubiquitinase BRCC36

1

0

High-throughput

0.513

High

879805

NPY2R
Neuropeptide Y receptor type 2

1

0

High-throughput

0.513

High

914294

EFNA4
Ephrin-A4

1

0

High-throughput

0.513

High

990477

1433Z
14-3-3 protein zeta/delta

1

0

High-throughput

0.513

High

1315094

PALS1
Protein PALS1

1

0

High-throughput

0.513

High

1315121

TMM43
Transmembrane protein 43

1

0

High-throughput

0.513

High

1315127

DERL2
Derlin-2

1

0

High-throughput

0.513

High

1315145

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.513

High

271278

CPNE3
Copine-3

1

0

High-throughput

0.493

High

860267

RS9
Small ribosomal subunit protein uS4

1

0

High-throughput

0.493

High

539819

RALA
Ras-related protein Ral-A

1

3

Small-scale

0.481

High

1149521

CDSN
Corneodesmosin

1

1

High-throughput

0.481

High

1315129

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

1

High-throughput

0.481

High

46370

A0A1U9X8X8
Corneodesmosin

1

1

High-throughput

0.470

High

320400

SASH1
SAM and SH3 domain-containing protein 1

1

0

Small-scale

0.460

High

335736

RPGF3
Rap guanine nucleotide exchange factor 3

1

0

High-throughput

0.460

High

412235

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

955962

RAB8A
Ras-related protein Rab-8A

1

0

High-throughput

0.458

High

1106602

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

1113644

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1249002

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1249412

OLFM4
Olfactomedin-4

1

0

High-throughput

0.458

High

1252888

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

Small-scale

0.458

High

1315099

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1315100

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

1

0

Small-scale

0.458

High

1315108

RUBIC
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein

1

0

Small-scale

0.458

High

1315131

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1315141

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1315146

SEPT9
Septin-9

1

0

Small-scale

0.458

High

1048365

ACVR1
Activin receptor type-1

1

1

High-throughput

0.445

High

1153410

CD226
CD226 antigen

1

1

High-throughput

0.445

High

1240897

S27A4
Long-chain fatty acid transport protein 4

1

2

High-throughput

0.445

High

1243627

S27A1
Long-chain fatty acid transport protein 1

1

2

High-throughput

0.445

High

1254570

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

437730

HEPS
Serine protease hepsin

1

0

High-throughput

0.426

High

760764

CD68
Macrosialin

1

0

High-throughput

0.426

High

934844

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.426

High

1227034

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

1315109

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.426

High

1315114

AURKB
Aurora kinase B

1

0

High-throughput

0.426

High

1315143

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.426

High

1315147

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.426

High

1315151

FZD10
Frizzled-10

1

0

High-throughput

0.426

High

1315154

XCT
Cystine/glutamate transporter

1

0

High-throughput

0.426

High

628424

KLK2
Kallikrein-2

1

1

High-throughput

0.407

High

1293859

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

1

High-throughput

0.407

High

1315096

USBP1
Harmonin-binding protein USHBP1

3

0

High-throughput

0.353

High

1091945

SEC20
Vesicle transport protein SEC20

2

0

High-throughput

0.328

High

137336

ELL2
RNA polymerase II elongation factor ELL2

2

0

High-throughput

0.316

High

506749

PRR35
Proline-rich protein 35

2

0

High-throughput

0.316

High

1103082

ZN177
Zinc finger protein 177

2

0

High-throughput

0.316

High

1152920

NAB2
NGFI-A-binding protein 2

2

0

High-throughput

0.316

High

1158027

SNPC1
snRNA-activating protein complex subunit 1

2

0

High-throughput

0.316

High

1180460

C19L2
CWF19-like protein 2

2

0

High-throughput

0.316

High

1204192

ZN628
Zinc finger protein 628

2

0

High-throughput

0.316

High

1205870

MTUS2
Microtubule-associated tumor suppressor candidate 2

2

0

High-throughput

0.316

High

1213000

SKT
Sickle tail protein homolog

2

0

High-throughput

0.316

High

1230857

BICRL
BRD4-interacting chromatin-remodeling complex-associated protein-like

2

0

High-throughput

0.316

High

1233834

GRAM4
GRAM domain-containing protein 4

2

0

High-throughput

0.316

High

1258132

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

2

0

High-throughput

0.316

High

1314588

IHO1
Interactor of HORMAD1 protein 1

2

0

High-throughput

0.316

High

1315092

SYCE1
Synaptonemal complex central element protein 1

2

0

High-throughput

0.316

High

1315093

AN36B
Ankyrin repeat domain-containing protein 36B

2

0

High-throughput

0.316

High

1315104

MIPO1
Mirror-image polydactyly gene 1 protein

2

0

High-throughput

0.316

High

1315106

MYOZ3
Myozenin-3

2

0

High-throughput

0.316

High

1315107

MB3L1
Methyl-CpG-binding domain protein 3-like 1

2

0

High-throughput

0.316

High

1315111

ZN566
Zinc finger protein 566

2

0

High-throughput

0.316

High

1315113

ESS2
Splicing factor ESS-2 homolog

2

0

High-throughput

0.316

High

1315115

BORC6
BLOC-1-related complex subunit 6

2

0

High-throughput

0.316

High

1315116

ZC21A
Zinc finger C2HC domain-containing protein 1A

2

0

High-throughput

0.316

High

1315119

UQCC2
Ubiquinol-cytochrome c reductase complex assembly factor 2

2

0

High-throughput

0.316

High

1315122

KIFC3
Kinesin-like protein KIFC3

2

0

High-throughput

0.316

High

1315124

BEX2
Protein BEX2

2

0

High-throughput

0.316

High

1315125

PBX4
Pre-B-cell leukemia transcription factor 4

2

0

High-throughput

0.316

High

1315130

GO45
Golgin-45

2

0

High-throughput

0.316

High

1315138

TB22B
TBC1 domain family member 22B

2

0

High-throughput

0.316

High

1315150

ISY1
Pre-mRNA-splicing factor ISY1 homolog

2

0

High-throughput

0.316

High

1315091

CE57L
Centrosomal protein CEP57L1

1

0

High-throughput

0.299

High

1206404

EFHC2
EF-hand domain-containing family member C2

1

0

High-throughput

0.292

High

283504

TAD2A
Transcriptional adapter 2-alpha

1

0

High-throughput

0.282

High

1154537

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.282

High

932342

ARSF
Arylsulfatase F

1

0

High-throughput

0.279

Low

1012341

RT15
Small ribosomal subunit protein uS15m

1

0

High-throughput

0.269

Low

1315095

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low

1315102

LNX1
E3 ubiquitin-protein ligase LNX

1

0

Small-scale

0.251

Low

1004804

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1096750

RFA4
Replication protein A 30 kDa subunit

1

0

High-throughput

0.249

Low

1186211

CEA21
Cell adhesion molecule CEACAM21

1

0

High-throughput

0.249

Low

1315110

ESR2
Estrogen receptor beta

1

0

High-throughput

0.249

Low

1219511

ANR22
Ankyrin repeat domain-containing protein 22

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025