Protein: PASK
PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1)

Gene: PASK
Organism: Homo sapiens
Interactions: 170
UniProt ID: Q96RG2

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

170297

AURKA
Aurora kinase A

3

18

High-throughput

0.861

High

242655

PRKN
E3 ubiquitin-protein ligase parkin

3

16

High-throughput

0.855

High

1401309

PASK
PAS domain-containing serine/threonine-protein kinase

3

17

Small-scale

0.827

High

1276060

ZN550
Zinc finger protein 550

2

1

High-throughput

0.811

High

920210

PLK1
Serine/threonine-protein kinase PLK1

2

17

High-throughput

0.754

High

1252599

DEFI8
Differentially expressed in FDCP 8 homolog

2

9

High-throughput

0.726

High

1401310

RSLAB
Ras-like protein family member 10B

2

15

High-throughput

0.726

High

783646

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

18

High-throughput

0.691

High

905650

IRAK1
Interleukin-1 receptor-associated kinase 1

1

8

High-throughput

0.691

High

1148010

SF3B3
Splicing factor 3B subunit 3

1

4

High-throughput

0.691

High

1279278

PODN
Podocan

1

2

High-throughput

0.691

High

1316621

CDK20
Cyclin-dependent kinase 20

1

6

High-throughput

0.691

High

1401312

NPAS1
Neuronal PAS domain-containing protein 1

1

3

High-throughput

0.691

High

1401331

NLK
Serine/threonine-protein kinase NLK

1

10

High-throughput

0.691

High

942192

WNT4
Protein Wnt-4

4

6

High-throughput

0.691

High

1316052

TRM2A
tRNA

3

2

High-throughput

0.667

High

1401339

KLK5
Kallikrein-5

3

4

High-throughput

0.667

High

291857

STK16
Serine/threonine-protein kinase 16

1

17

High-throughput

0.665

High

772518

IRS1
Insulin receptor substrate 1

1

7

Small-scale

0.647

High

1095445

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

19

Small-scale

0.647

High

567958

PRG2
Bone marrow proteoglycan

4

1

High-throughput

0.630

High

208885

ZBT24
Zinc finger and BTB domain-containing protein 24

1

1

High-throughput

0.618

High

272400

OBSL1
Obscurin-like protein 1

1

1

High-throughput

0.618

High

461837

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

468710

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

831276

CCNF
Cyclin-F

1

8

High-throughput

0.618

High

854242

KI67
Proliferation marker protein Ki-67

1

4

High-throughput

0.618

High

856877

BAG6
Large proline-rich protein BAG6

1

9

High-throughput

0.618

High

891294

GSK3A
Glycogen synthase kinase-3 alpha

1

20

High-throughput

0.618

High

891750

GSK3B
Glycogen synthase kinase-3 beta

1

20

High-throughput

0.618

High

948167

DJB13
DnaJ homolog subfamily B member 13

1

14

High-throughput

0.618

High

1134036

ZN638
Zinc finger protein 638

1

3

High-throughput

0.618

High

1206957

CEP78
Centrosomal protein of 78 kDa

1

3

High-throughput

0.618

High

1401319

ZN768
Zinc finger protein 768

1

1

High-throughput

0.618

High

1401336

ZBT21
Zinc finger and BTB domain-containing protein 21

1

1

High-throughput

0.618

High

1401338

NINL
Ninein-like protein

1

7

High-throughput

0.618

High

1232378

SFRP4
Secreted frizzled-related protein 4

2

1

High-throughput

0.611

High

1401326

EMIL3
EMILIN-3

2

5

High-throughput

0.611

High

1401334

AGO2
Protein argonaute-2

2

9

High-throughput

0.611

High

1330860

FRMD1
FERM domain-containing protein 1

3

15

High-throughput

0.604

High

1401317

IQCN
IQ domain-containing protein N

2

0

High-throughput

0.602

High

469825

CATG
Cathepsin G

2

5

High-throughput

0.601

High

1372501

KPBB
Phosphorylase b kinase regulatory subunit beta

1

0

Small-scale

0.593

High

1204194

ZN628
Zinc finger protein 628

1

0

High-throughput

0.586

High

1252657

ZN574
Zinc finger protein 574

1

0

High-throughput

0.586

High

315909

RECQ4
ATP-dependent DNA helicase Q4

2

2

High-throughput

0.584

High

1401325

IGSF5
Immunoglobulin superfamily member 5

1

0

High-throughput

0.578

High

472119

MET
Hepatocyte growth factor receptor

1

12

Small-scale

0.575

High

144108

WNT7A
Protein Wnt-7a

2

6

High-throughput

0.574

High

1279020

TAFA3
Chemokine-like protein TAFA-3

2

1

High-throughput

0.574

High

945906

INHBE
Inhibin beta E chain

2

2

High-throughput

0.549

High

964098

IPKA
cAMP-dependent protein kinase inhibitor alpha

1

0

Small-scale

0.546

High

66807

C2C4B
C2 calcium-dependent domain-containing protein 4B

1

1

High-throughput

0.536

High

483680

WNT2
Protein Wnt-2

1

6

High-throughput

0.536

High

576255

PO2F1
POU domain, class 2, transcription factor 1

1

1

High-throughput

0.536

High

848060

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

1

High-throughput

0.536

High

1091197

FOXD4
Forkhead box protein D4

1

3

High-throughput

0.536

High

1179240

ERC6L
DNA excision repair protein ERCC-6-like

1

2

High-throughput

0.536

High

1187855

FX4L6
Forkhead box protein D4-like 6

1

2

High-throughput

0.536

High

1338653

NOXO1
NADPH oxidase organizer 1

1

12

High-throughput

0.536

High

1357727

TRI41
E3 ubiquitin-protein ligase TRIM41

1

4

High-throughput

0.536

High

1370568

FGF11
Fibroblast growth factor 11

1

4

High-throughput

0.536

High

1396474

WDR90
WD repeat-containing protein 90

1

5

High-throughput

0.536

High

1401313

PTN18
Tyrosine-protein phosphatase non-receptor type 18

1

9

High-throughput

0.536

High

1401329

KLH14
Kelch-like protein 14

1

4

High-throughput

0.536

High

820724

CEAM6
Cell adhesion molecule CEACAM6

1

0

High-throughput

0.517

High

633773

PSB1
Proteasome subunit beta type-1

1

3

High-throughput

0.515

High

643997

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

High-throughput

0.515

High

965172

WDR5
WD repeat-containing protein 5

1

7

High-throughput

0.515

High

630941

RAB4A
Ras-related protein Rab-4A

1

7

Small-scale

0.514

High

1086477

KCNH2
Voltage-gated inwardly rectifying potassium channel KCNH2

1

11

Small-scale

0.514

High

229065

AKAP8
A-kinase anchor protein 8

1

0

High-throughput

0.513

High

289804

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.513

High

774794

TIMP3
Metalloproteinase inhibitor 3

1

0

High-throughput

0.513

High

903086

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

1

0

High-throughput

0.513

High

1006290

CTG1B
Cancer/testis antigen 1

1

0

High-throughput

0.513

High

1100636

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

0

High-throughput

0.513

High

1163936

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.513

High

1310326

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1331297

ENDOV
Endonuclease V

1

0

High-throughput

0.513

High

1401320

PIF1
ATP-dependent DNA helicase PIF1

1

0

High-throughput

0.513

High

1401332

FBX10
F-box only protein 10

1

0

High-throughput

0.513

High

699833

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

8

Small-scale

0.501

High

335368

CCN6
Cellular communication network factor 6

1

1

High-throughput

0.489

High

634795

GRAH
Granzyme H

1

5

High-throughput

0.489

High

1240319

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

3

High-throughput

0.489

High

1260655

ATS13
A disintegrin and metalloproteinase with thrombospondin motifs 13

1

2

High-throughput

0.489

High

1324510

FA43A
Protein FAM43A

1

5

High-throughput

0.489

High

1347782

F110D
Protein FAM110D

1

1

High-throughput

0.489

High

1401316

WN10A
Protein Wnt-10a

1

6

High-throughput

0.489

High

1401318

KLK15
Kallikrein-15

1

4

High-throughput

0.489

High

1401333

TF3C4
General transcription factor 3C polypeptide 4

1

1

High-throughput

0.489

High

1401337

CCL26
C-C motif chemokine 26

1

1

High-throughput

0.489

High

593193

CREB1
Cyclic AMP-responsive element-binding protein 1

1

2

Small-scale

0.484

High

173253

XPO1
Exportin-1

1

7

High-throughput

0.479

High

174589

TRI66
Tripartite motif-containing protein 66

1

9

High-throughput

0.479

High

225850

AP1G1
AP-1 complex subunit gamma-1

1

5

High-throughput

0.479

High

290380

RFPL2
Ret finger protein-like 2

1

5

High-throughput

0.479

High

321638

PRP6
Pre-mRNA-processing factor 6

1

1

High-throughput

0.479

High

613439

VINC
Vinculin

1

5

High-throughput

0.479

High

896618

VASP
Vasodilator-stimulated phosphoprotein

1

3

High-throughput

0.479

High

1114069

CUL3
Cullin-3

1

7

High-throughput

0.479

High

1124527

MAP7
Ensconsin

1

11

High-throughput

0.479

High

1227305

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.479

High

1228517

TENS3
Tensin-3

1

2

High-throughput

0.479

High

1290476

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

5

High-throughput

0.479

High

1365339

CNOT9
CCR4-NOT transcription complex subunit 9

1

2

High-throughput

0.479

High

1368937

GOGA1
Golgin subfamily A member 1

1

6

High-throughput

0.479

High

1369741

RAD50
DNA repair protein RAD50

1

8

High-throughput

0.479

High

1401321

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1401335

AGO1
Protein argonaute-1

1

9

High-throughput

0.479

High

1401341

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

1

High-throughput

0.479

High

979155

RS6
Small ribosomal subunit protein eS6

1

0

Small-scale

0.464

High

215850

P52K
52 kDa repressor of the inhibitor of the protein kinase

1

0

High-throughput

0.458

High

327634

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

1110696

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.458

High

1193466

CCD14
Coiled-coil domain-containing protein 14

1

0

High-throughput

0.458

High

1211335

NOL9
Polynucleotide 5'-hydroxyl-kinase NOL9

1

0

High-throughput

0.458

High

1293645

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

1335454

HJURP
Holliday junction recognition protein

1

0

High-throughput

0.458

High

1393258

SENP5
Sentrin-specific protease 5

1

0

High-throughput

0.458

High

1401314

B9D2
B9 domain-containing protein 2

1

0

High-throughput

0.458

High

1401315

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.458

High

1401328

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.458

High

1401340

LAS1L
Ribosomal biogenesis protein LAS1L

1

0

High-throughput

0.458

High

297672

PIAS1
E3 SUMO-protein ligase PIAS1

1

3

Small-scale

0.445

High

386126

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

8

Small-scale

0.445

High

415802

HSPB1
Heat shock protein beta-1

1

7

Small-scale

0.445

High

437311

K2C8
Keratin, type II cytoskeletal 8

1

2

Small-scale

0.445

High

530248

TAU
Microtubule-associated protein tau

1

12

Small-scale

0.445

High

568693

GYS1
Glycogen [starch] synthase, muscle

1

1

Small-scale

0.445

High

572845

NCF1
Neutrophil cytosol factor 1

1

12

Small-scale

0.445

High

591938

F261
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

1

8

Small-scale

0.445

High

634589

LMNB1
Lamin-B1

1

8

Small-scale

0.445

High

663568

CMA1
Chymase

1

5

High-throughput

0.445

High

915918

PDX1
Pancreas/duodenum homeobox protein 1

1

5

Small-scale

0.445

High

996298

EF1A1
Elongation factor 1-alpha 1

1

5

Small-scale

0.445

High

1133406

NFAC4
Nuclear factor of activated T-cells, cytoplasmic 4

1

8

Small-scale

0.445

High

1159356

FRDA
Frataxin, mitochondrial

1

1

Small-scale

0.445

High

1250826

RFIP1
Rab11 family-interacting protein 1

1

8

Small-scale

0.445

High

1401323

4ET
Eukaryotic translation initiation factor 4E transporter

1

1

Small-scale

0.445

High

1401327

S39A9
Zinc transporter ZIP9

1

1

High-throughput

0.445

High

1203893

NOM1
Nucleolar MIF4G domain-containing protein 1

1

4

High-throughput

0.437

High

1401311

DCR1C
Protein artemis

1

1

High-throughput

0.437

High

1401330

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.426

High

143754

WN10B
Protein Wnt-10b

1

6

High-throughput

0.407

High

167462

WNT9A
Protein Wnt-9a

1

6

High-throughput

0.407

High

387744

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

1

Small-scale

0.407

High

628447

KLK2
Kallikrein-2

1

4

High-throughput

0.407

High

942163

WNT3A
Protein Wnt-3a

1

6

High-throughput

0.407

High

1010968

BAT1
b(0,+)-type amino acid transporter 1

1

3

High-throughput

0.407

High

1200300

FBLN7
Fibulin-7

1

6

High-throughput

0.407

High

1355964

NET5
Netrin-5

1

2

High-throughput

0.407

High

1401324

S22AB
Solute carrier family 22 member 11

1

2

High-throughput

0.407

High

1401322

CG069
Putative uncharacterized protein PKD1L1-AS1

2

0

High-throughput

0.328

High

1362047

DNS2B
Deoxyribonuclease-2-beta

2

0

High-throughput

0.318

High

70904

ZBBX
Zinc finger B-box domain-containing protein 1

1

0

High-throughput

0.279

Low

1025945

NDP
Norrin

1

0

High-throughput

0.279

Low

1103106

MFAP5
Microfibrillar-associated protein 5

1

0

High-throughput

0.279

Low

1165378

ODAPH
Odontogenesis associated phosphoprotein

1

0

High-throughput

0.279

Low

1211555

F120S
Uncharacterized protein FAM120AOS

1

0

High-throughput

0.279

Low

1312664

IQCF2
IQ domain-containing protein F2

1

0

High-throughput

0.279

Low

1216582

PR14L
Protein PRR14L

1

0

High-throughput

0.249

Low

1219464

SLX4I
Protein SLX4IP

1

0

Small-scale

0.249

Low

1356436

TF3C2
General transcription factor 3C polypeptide 2

1

0

High-throughput

0.249

Low

378648

IL2RA
Interleukin-2 receptor subunit alpha

1

0

Small-scale

0.232

Low

399615

VTNC
Vitronectin

1

0

Small-scale

0.232

Low

1234026

S35E4
Solute carrier family 35 member E4

1

0

High-throughput

0.232

Low

1309399

SPNS2
Sphingosine-1-phosphate transporter SPNS2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025