Protein: CLK1
Dual specificity protein kinase CLK1 (EC 2.7.12.1) (CDC-like kinase 1)

Gene: CLK1
Organism: Homo sapiens
Interactions: 210
UniProt ID: P49759

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0004715 - non-membrane spanning protein tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

833720

SRSF1
Serine/arginine-rich splicing factor 1

7

20

Small-scale

0.965

High

833731

TRA2A
Transformer-2 protein homolog alpha

5

19

High-throughput

0.929

High

833691

CLK2
Dual specificity protein kinase CLK2

5

18

High-throughput

0.927

High

833742

SRSF7
Serine/arginine-rich splicing factor 7

4

20

High-throughput

0.897

High

266940

SRS10
Serine/arginine-rich splicing factor 10

3

20

Small-scale

0.874

High

833706

TRA2B
Transformer-2 protein homolog beta

3

20

High-throughput

0.849

High

833709

SRPK2
SRSF protein kinase 2

2

18

High-throughput

0.812

High

833711

SRSF3
Serine/arginine-rich splicing factor 3

4

20

Small-scale

0.801

High

833690

CLK1
Dual specificity protein kinase CLK1

2

17

Small-scale

0.778

High

833801

SRPK1
SRSF protein kinase 1

1

18

High-throughput

0.735

High

833727

SRSF5
Serine/arginine-rich splicing factor 5

2

20

High-throughput

0.714

High

833728

SRSF6
Serine/arginine-rich splicing factor 6

2

20

High-throughput

0.714

High

145975

SH2B2
SH2B adapter protein 2

2

14

High-throughput

0.700

High

833717

SRS11
Serine/arginine-rich splicing factor 11

1

9

High-throughput

0.691

High

833721

SRSF4
Serine/arginine-rich splicing factor 4

1

20

High-throughput

0.691

High

833838

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

3

High-throughput

0.691

High

833736

RBM39
RNA-binding protein 39

2

20

High-throughput

0.687

High

64850

SRRM4
Serine/arginine repetitive matrix protein 4

3

1

High-throughput

0.654

High

212115

HTSF1
17S U2 SnRNP complex component HTATSF1

1

20

High-throughput

0.647

High

453221

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

18

High-throughput

0.647

High

550344

ZEP1
Zinc finger protein 40

1

6

High-throughput

0.647

High

582139

NUCL
Nucleolin

1

11

High-throughput

0.647

High

745096

RBMX
RNA-binding motif protein, X chromosome

1

20

High-throughput

0.647

High

833695

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

20

High-throughput

0.647

High

833725

RLF
Zinc finger protein Rlf

1

2

High-throughput

0.647

High

833726

ROA0
Heterogeneous nuclear ribonucleoprotein A0

1

19

High-throughput

0.647

High

833730

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

19

Small-scale

0.647

High

833739

KIF14
Kinesin-like protein KIF14

1

11

High-throughput

0.647

High

833749

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

4

High-throughput

0.647

High

833750

SMBT2
Scm-like with four MBT domains protein 2

1

3

High-throughput

0.647

High

833802

RBM15
RNA-binding protein 15

1

20

High-throughput

0.647

High

833803

MINT
Msx2-interacting protein

1

18

High-throughput

0.647

High

833813

UBL5
Ubiquitin-like protein 5

1

3

Small-scale

0.647

High

833821

PATZ1
POZ-, AT hook-, and zinc finger-containing protein 1

1

3

High-throughput

0.647

High

833827

CDK12
Cyclin-dependent kinase 12

1

16

High-throughput

0.647

High

833830

ANFY1
Rabankyrin-5

1

3

High-throughput

0.647

High

833811

DOCK9
Dedicator of cytokinesis protein 9

1

3

High-throughput

0.625

High

833740

SAFB1
Scaffold attachment factor B1

1

20

Small-scale

0.621

High

283290

PDE9A
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

3

4

High-throughput

0.616

High

833701

KR107
Keratin-associated protein 10-7

3

9

High-throughput

0.616

High

833810

STK31
Serine/threonine-protein kinase 31

1

0

High-throughput

0.614

High

833765

ZCH18
Zinc finger CCCH domain-containing protein 18

3

20

High-throughput

0.612

High

833771

CLASR
CLK4-associating serine/arginine rich protein

3

9

High-throughput

0.600

High

833704

1433G
14-3-3 protein gamma

3

20

High-throughput

0.599

High

833774

PR38A
Pre-mRNA-splicing factor 38A

2

1

High-throughput

0.594

High

155789

UN13B
Protein unc-13 homolog B

1

5

High-throughput

0.579

High

257039

DJC13
DnaJ homolog subfamily C member 13

1

5

High-throughput

0.579

High

833696

MYOM1
Myomesin-1

1

6

High-throughput

0.579

High

833755

DJC24
DnaJ homolog subfamily C member 24

1

2

High-throughput

0.579

High

833759

RAPH1
Ras-associated and pleckstrin homology domains-containing protein 1

1

5

High-throughput

0.579

High

833762

PHLB2
Pleckstrin homology-like domain family B member 2

1

20

High-throughput

0.579

High

833766

MICU3
Calcium uptake protein 3, mitochondrial

1

1

High-throughput

0.579

High

833776

LIPB2
Liprin-beta-2

1

12

High-throughput

0.579

High

833825

RASLC
Ras-like protein family member 12

1

4

High-throughput

0.579

High

833839

ZN148
Zinc finger protein 148

1

2

High-throughput

0.579

High

353389

PIGR
Polymeric immunoglobulin receptor

1

0

High-throughput

0.578

High

833741

U2AFM
U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2

1

4

High-throughput

0.555

High

833788

SRS12
Serine/arginine-rich splicing factor 12

1

20

High-throughput

0.555

High

833805

SRSF8
Serine/arginine-rich splicing factor 8

1

14

High-throughput

0.555

High

833700

KR106
Keratin-associated protein 10-6

2

9

High-throughput

0.553

High

833782

LNX1
E3 ubiquitin-protein ligase LNX

2

8

High-throughput

0.553

High

833792

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

12

High-throughput

0.553

High

397844

ISG15
Ubiquitin-like protein ISG15

1

5

High-throughput

0.553

High

833697

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

10

High-throughput

0.536

High

364660

TRFL
Lactotransferrin

1

0

High-throughput

0.513

High

153605

ANM5
Protein arginine N-methyltransferase 5

1

8

High-throughput

0.508

High

231021

AT10A
Phospholipid-transporting ATPase VA

1

6

High-throughput

0.501

High

241478

H2B1K
Histone H2B type 1-K

1

5

High-throughput

0.501

High

265397

KTNA1
Katanin p60 ATPase-containing subunit A1

1

11

High-throughput

0.501

High

268631

SF3B1
Splicing factor 3B subunit 1

1

5

High-throughput

0.501

High

308182

LC7L3
Luc7-like protein 3

1

5

Small-scale

0.501

High

359761

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

9

High-throughput

0.501

High

417195

ENOA
Alpha-enolase

1

2

High-throughput

0.501

High

418049

NPM
Nucleophosmin

1

5

High-throughput

0.501

High

518612

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.501

High

594716

ATP4A
Potassium-transporting ATPase alpha chain 1

1

5

High-throughput

0.501

High

598442

NF1
Neurofibromin

1

6

High-throughput

0.501

High

603834

RS4Y1
Small ribosomal subunit protein eS4, Y isoform 1

1

1

High-throughput

0.501

High

684517

STIP1
Stress-induced-phosphoprotein 1

1

7

High-throughput

0.501

High

785757

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.501

High

805880

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.501

High

833705

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

14

High-throughput

0.501

High

833708

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1

4

High-throughput

0.501

High

833710

PRKDC
DNA-dependent protein kinase catalytic subunit

1

4

High-throughput

0.501

High

833712

CENPE
Centromere-associated protein E

1

9

High-throughput

0.501

High

833713

KIF23
Kinesin-like protein KIF23

1

10

High-throughput

0.501

High

833718

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

5

High-throughput

0.501

High

833729

PPIG
Peptidyl-prolyl cis-trans isomerase G

1

6

High-throughput

0.501

High

833732

CUL3
Cullin-3

1

11

High-throughput

0.501

High

833737

FAT1
Protocadherin Fat 1

1

5

High-throughput

0.501

High

833748

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

20

High-throughput

0.501

High

833761

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

10

High-throughput

0.501

High

833763

ABCAD
ATP-binding cassette sub-family A member 13

1

1

High-throughput

0.501

High

833769

SRRM1
Serine/arginine repetitive matrix protein 1

1

20

High-throughput

0.501

High

833786

GEMI5
Gem-associated protein 5

1

13

High-throughput

0.501

High

833790

PHF3
PHD finger protein 3

1

4

High-throughput

0.501

High

833798

YTDC1
YTH domain-containing protein 1

1

6

High-throughput

0.501

High

833800

PRPK
EKC/KEOPS complex subunit TP53RK

1

7

High-throughput

0.501

High

833809

SSBP3
Single-stranded DNA-binding protein 3

1

6

High-throughput

0.501

High

833812

CRNL1
Crooked neck-like protein 1

1

9

High-throughput

0.501

High

833815

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

3

High-throughput

0.501

High

833819

RD21L
Double-strand-break repair protein rad21-like protein 1

1

1

High-throughput

0.501

High

833832

ZO2
Tight junction protein ZO-2

1

3

High-throughput

0.501

High

833836

SRRM2
Serine/arginine repetitive matrix protein 2

1

20

High-throughput

0.501

High

833837

CTND2
Catenin delta-2

1

17

High-throughput

0.501

High

833841

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

2

High-throughput

0.501

High

833842

TR150
Thyroid hormone receptor-associated protein 3

1

20

High-throughput

0.501

High

833845

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

9

High-throughput

0.489

High

216471

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

7

High-throughput

0.489

High

623527

AKAP5
A-kinase anchor protein 5

1

1

High-throughput

0.489

High

833703

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

3

High-throughput

0.489

High

833719

KLC1
Kinesin light chain 1

1

6

High-throughput

0.489

High

833752

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

1

High-throughput

0.489

High

833784

BPIB1
BPI fold-containing family B member 1

1

1

High-throughput

0.489

High

833796

SAHH3
Adenosylhomocysteinase 3

1

7

High-throughput

0.489

High

833822

BPIA1
BPI fold-containing family A member 1

1

1

High-throughput

0.489

High

833834

DMBT1
Deleted in malignant brain tumors 1 protein

1

1

High-throughput

0.489

High

833772

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.486

High

261439

NCOR1
Nuclear receptor corepressor 1

1

16

Small-scale

0.481

High

833777

TDRD9
ATP-dependent RNA helicase TDRD9

1

11

High-throughput

0.481

High

833807

DDX23
Probable ATP-dependent RNA helicase DDX23

1

9

High-throughput

0.481

High

833823

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

2

High-throughput

0.481

High

833824

BCLF1
Bcl-2-associated transcription factor 1

1

18

Small-scale

0.481

High

409030

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.480

High

670817

PRDX5
Peroxiredoxin-5, mitochondrial

1

0

High-throughput

0.480

High

833699

ARPC4
Actin-related protein 2/3 complex subunit 4

1

0

High-throughput

0.480

High

833722

SLFN5
Schlafen family member 5

1

0

High-throughput

0.480

High

833723

ELP6
Elongator complex protein 6

1

0

High-throughput

0.480

High

833760

MYCPP
C-myc promoter-binding protein

1

0

High-throughput

0.480

High

833789

IP6K1
Inositol hexakisphosphate kinase 1

1

0

High-throughput

0.480

High

833835

DBR1
Lariat debranching enzyme

1

0

High-throughput

0.480

High

324278

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

659908

ERCC5
DNA excision repair protein ERCC-5

1

11

High-throughput

0.479

High

833702

PSME3
Proteasome activator complex subunit 3

1

2

High-throughput

0.479

High

833707

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.479

High

833733

TF2H3
General transcription factor IIH subunit 3

1

2

High-throughput

0.479

High

833746

Q59FZ7
DNA-repair protein complementing XP-G cells variant

1

11

High-throughput

0.479

High

833768

CUL9
Cullin-9

1

4

High-throughput

0.479

High

833808

HIRP3
HIRA-interacting protein 3

1

4

High-throughput

0.479

High

833833

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

833799

ZN830
Zinc finger protein 830

1

0

High-throughput

0.460

High

175409

GRM6
Metabotropic glutamate receptor 6

1

1

High-throughput

0.457

High

177840

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.457

High

203025

COCH
Cochlin

1

1

High-throughput

0.457

High

276115

SPI2
Serpin I2

1

5

High-throughput

0.457

High

382240

ARLY
Argininosuccinate lyase

1

1

High-throughput

0.457

High

443053

ITA5
Integrin alpha-5

1

1

High-throughput

0.457

High

573612

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

6

Small-scale

0.457

High

792174

ECE1
Endothelin-converting enzyme 1

1

1

High-throughput

0.457

High

833692

NU153
Nuclear pore complex protein Nup153

1

20

High-throughput

0.457

High

833714

DSC2
Desmocollin-2

1

4

High-throughput

0.457

High

833724

DPYD
Dihydropyrimidine dehydrogenase [NADP(+)]

1

2

High-throughput

0.457

High

833734

CKAP5
Cytoskeleton-associated protein 5

1

6

High-throughput

0.457

High

833735

MAP7
Ensconsin

1

19

High-throughput

0.457

High

833743

HCDH
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

1

2

High-throughput

0.457

High

833744

SHRM1
Protein Shroom1

1

2

High-throughput

0.457

High

833756

CWC27
Spliceosome-associated protein CWC27 homolog

1

1

High-throughput

0.457

High

833778

PPHLN
Periphilin-1

1

2

High-throughput

0.457

High

833779

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.457

High

833781

GSDMB
Gasdermin-B

1

1

High-throughput

0.457

High

833783

CF251
Cilia- and flagella-associated protein 251

1

6

High-throughput

0.457

High

833785

PK1L1
Polycystin-1-like protein 1

1

1

High-throughput

0.457

High

833787

FBF1
Fas-binding factor 1

1

20

High-throughput

0.457

High

833804

ACOX2
Peroxisomal acyl-coenzyme A oxidase 2

1

2

High-throughput

0.457

High

833814

ASXL3
Putative Polycomb group protein ASXL3

1

18

High-throughput

0.457

High

833816

CAD23
Cadherin-23

1

5

High-throughput

0.457

High

833817

SPTN4
Spectrin beta chain, non-erythrocytic 4

1

12

High-throughput

0.457

High

833826

CELR3
Cadherin EGF LAG seven-pass G-type receptor 3

1

5

High-throughput

0.457

High

833828

HPBP1
Hsp70-binding protein 1

1

8

High-throughput

0.457

High

833829

ARHGC
Rho guanine nucleotide exchange factor 12

1

2

High-throughput

0.457

High

833840

ICE1
Little elongation complex subunit 1

1

2

High-throughput

0.457

High

833844

MTCL1
Microtubule cross-linking factor 1

1

19

High-throughput

0.457

High

833846

TLN2
Talin-2

1

19

High-throughput

0.457

High

697723

TF2H1
General transcription factor IIH subunit 1

1

3

High-throughput

0.437

High

833715

ENL
Protein ENL

1

16

High-throughput

0.437

High

833806

ATGA1
Autophagy-related protein 101

1

2

High-throughput

0.437

High

833818

PININ
Pinin

1

3

High-throughput

0.437

High

833847

TNPO3
Transportin-3

1

6

Small-scale

0.437

High

365354

PRB2
Basic salivary proline-rich protein 2

1

3

High-throughput

0.407

High

833716

PRB3
Basic salivary proline-rich protein 3

1

5

High-throughput

0.407

High

833698

PIGP
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P

1

0

High-throughput

0.282

High

833791

SYMPK
Symplekin

1

0

High-throughput

0.279

Low

833793

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.279

Low

833693

PSN2
Presenilin-2

1

0

High-throughput

0.269

Low

231354

EREP2
Protein ENTREP2

1

0

High-throughput

0.261

Low

275339

ZMY10
Zinc finger MYND domain-containing protein 10

1

0

High-throughput

0.261

Low

380178

THY1
Thy-1 membrane glycoprotein

1

0

High-throughput

0.261

Low

833694

HNMT
Histamine N-methyltransferase

1

0

High-throughput

0.261

Low

833738

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.261

Low

833745

ERFE
Erythroferrone

1

0

High-throughput

0.261

Low

833747

S35D3
Solute carrier family 35 member D3

1

0

High-throughput

0.261

Low

833751

SCAR3
Scavenger receptor class A member 3

1

0

High-throughput

0.261

Low

833753

RUSD3
Mitochondrial mRNA pseudouridine synthase RPUSD3

1

0

High-throughput

0.261

Low

833754

CA094
Uncharacterized protein C1orf94

1

0

High-throughput

0.261

Low

833757

PXDC2
Plexin domain-containing protein 2

1

0

High-throughput

0.261

Low

833758

CF20D
Protein CFAP20DC

1

0

High-throughput

0.261

Low

833764

FHI2B
FHF complex subunit HOOK-interacting protein 2B

1

0

High-throughput

0.261

Low

833767

SAM9L
Sterile alpha motif domain-containing protein 9-like

1

0

High-throughput

0.261

Low

833770

TEX11
Testis-expressed protein 11

1

0

High-throughput

0.261

Low

833773

SVOP
Synaptic vesicle 2-related protein

1

0

High-throughput

0.261

Low

833780

LINES
Protein Lines homolog 1

1

0

High-throughput

0.261

Low

833794

MTBP
Mdm2-binding protein

1

0

High-throughput

0.261

Low

833795

CEP95
Centrosomal protein of 95 kDa

1

0

High-throughput

0.261

Low

833797

PLAT5
Phospholipase A and acyltransferase 5

1

0

High-throughput

0.261

Low

833820

CDCP1
CUB domain-containing protein 1

1

0

High-throughput

0.261

Low

833831

REV1
DNA repair protein REV1

1

0

High-throughput

0.261

Low

833843

VWA7
von Willebrand factor A domain-containing protein 7

1

0

High-throughput

0.261

Low

833848

CP46A
Cholesterol 24-hydroxylase

1

0

High-throughput

0.261

Low

833775

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024