Protein: U2AF1
Splicing factor U2AF 35 kDa subunit (U2 auxiliary factor 35 kDa subunit) (U2 small nuclear RNA auxiliary factor 1) (U2 snRNP auxiliary factor small subunit)

Gene: U2AF1
Organism: Homo sapiens
Interactions: 187
UniProt ID: Q01081

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005681 - spliceosomal complex
GO:0006397 - mRNA processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

641723

U2AF2
Splicing factor U2AF 65 kDa subunit

16

9

Small-scale

0.987

High

942599

SRPK2
SRSF protein kinase 2

6

7

High-throughput

0.963

High

963257

SRPK1
SRSF protein kinase 1

4

7

High-throughput

0.909

High

963192

SRSF1
Serine/arginine-rich splicing factor 1

4

6

Small-scale

0.890

High

963212

RNPS1
RNA-binding protein with serine-rich domain 1

3

4

High-throughput

0.837

High

963248

U2AF4
Splicing factor U2AF 26 kDa subunit

2

6

High-throughput

0.811

High

963285

ACINU
Apoptotic chromatin condensation inducer in the nucleus

2

1

High-throughput

0.811

High

925006

TRA2B
Transformer-2 protein homolog beta

2

3

High-throughput

0.783

High

951926

SRSF3
Serine/arginine-rich splicing factor 3

2

7

High-throughput

0.783

High

963216

U1SBP
U11/U12 small nuclear ribonucleoprotein 35 kDa protein

2

5

High-throughput

0.783

High

963188

SRSF2
Serine/arginine-rich splicing factor 2

2

1

Small-scale

0.768

High

963217

LARP7
La-related protein 7

2

3

High-throughput

0.754

High

963199

SF3B2
Splicing factor 3B subunit 2

1

1

High-throughput

0.740

High

833866

CLK2
Dual specificity protein kinase CLK2

1

3

High-throughput

0.740

High

852877

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

1

High-throughput

0.724

High

963213

SF3A2
Splicing factor 3A subunit 2

2

0

Small-scale

0.716

High

835667

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.691

High

963227

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

3

2

High-throughput

0.683

High

88033

D3DU92
RNA-binding protein with serine-rich domain 1

1

4

High-throughput

0.665

High

197003

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

3

High-throughput

0.656

High

516470

PABP1
Polyadenylate-binding protein 1

1

1

High-throughput

0.656

High

958006

RBM10
RNA-binding protein 10

1

2

High-throughput

0.656

High

963287

PRP19
Pre-mRNA-processing factor 19

1

4

High-throughput

0.656

High

963260

SCAFB
Protein SCAF11

2

2

High-throughput

0.628

High

963255

TOE1
Target of EGR1 protein 1

1

0

High-throughput

0.622

High

868432

ATX1
Ataxin-1

2

1

High-throughput

0.621

High

963288

SRPK3
SRSF protein kinase 3

1

9

High-throughput

0.618

High

903891

HNRPK
Heterogeneous nuclear ribonucleoprotein K

2

0

High-throughput

0.618

High

374064

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.618

High

403192

LA
Lupus La protein

1

2

High-throughput

0.618

High

442075

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

5

High-throughput

0.618

High

582230

NUCL
Nucleolin

1

1

High-throughput

0.618

High

903136

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.618

High

963190

EWS
RNA-binding protein EWS

1

1

High-throughput

0.618

High

963195

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.618

High

963198

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.618

High

963205

RBM39
RNA-binding protein 39

1

4

High-throughput

0.618

High

963206

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

1

High-throughput

0.618

High

963253

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.618

High

963286

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.618

High

925853

AP2B1
AP-2 complex subunit beta

3

2

High-throughput

0.616

High

963203

CUL3
Cullin-3

2

1

High-throughput

0.611

High

64852

SRRM4
Serine/arginine repetitive matrix protein 4

2

2

High-throughput

0.606

High

963201

SNW1
SNW domain-containing protein 1

2

1

Small-scale

0.601

High

963262

NECD
Necdin

2

0

High-throughput

0.587

High

963197

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.586

High

963283

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

0

Small-scale

0.586

High

963234

CIR1
Corepressor interacting with RBPJ 1

1

1

Small-scale

0.586

High

227191

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

346543

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

963230

MEPCE
7SK snRNA methylphosphate capping enzyme

2

1

High-throughput

0.584

High

776298

MLH1
DNA mismatch repair protein Mlh1

2

0

High-throughput

0.580

High

963244

ZN417
Zinc finger protein 417

2

0

High-throughput

0.580

High

643327

HMGB2
High mobility group protein B2

2

0

Small-scale

0.577

High

853861

NCBP2
Nuclear cap-binding protein subunit 2

1

1

High-throughput

0.575

High

963214

SF01
Splicing factor 1

1

1

High-throughput

0.575

High

203667

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

1

High-throughput

0.573

High

890610

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

0

Small-scale

0.569

High

917122

H4
Histone H4

2

0

High-throughput

0.559

High

380595

K2C1
Keratin, type II cytoskeletal 1

2

1

High-throughput

0.553

High

963194

AP1B1
AP-1 complex subunit beta-1

2

2

High-throughput

0.553

High

835328

GSK3A
Glycogen synthase kinase-3 alpha

1

2

High-throughput

0.553

High

963239

MINK1
Misshapen-like kinase 1

1

1

High-throughput

0.553

High

963241

NKAP
NF-kappa-B-activating protein

1

0

High-throughput

0.549

High

963243

RP9
Retinitis pigmentosa 9 protein

1

0

Small-scale

0.549

High

522917

SRC
Proto-oncogene tyrosine-protein kinase Src

2

0

High-throughput

0.547

High

963274

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.546

High

717708

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.536

High

963202

CUL1
Cullin-1

1

1

High-throughput

0.536

High

963233

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

963238

CLASR
CLK4-associating serine/arginine rich protein

1

1

High-throughput

0.536

High

963258

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.536

High

307797

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

1

0

Small-scale

0.529

High

963208

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.515

High

850904

HDGF
Hepatoma-derived growth factor

1

0

High-throughput

0.513

High

963225

IFIX
Pyrin and HIN domain-containing protein 1

1

0

High-throughput

0.513

High

963261

TSNAX
Translin-associated protein X

1

0

High-throughput

0.513

High

263597

PR40A
Pre-mRNA-processing factor 40 homolog A

1

2

High-throughput

0.508

High

875609

MFAP1
Microfibrillar-associated protein 1

1

1

High-throughput

0.508

High

912269

SMD1
Small nuclear ribonucleoprotein Sm D1

1

3

High-throughput

0.508

High

963235

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

3

High-throughput

0.508

High

963281

NXF1
Nuclear RNA export factor 1

1

0

Small-scale

0.504

High

791489

HD
Huntingtin

1

0

High-throughput

0.493

High

963229

F10C1
Protein FRA10AC1

1

0

High-throughput

0.486

High

963242

PR38A
Pre-mRNA-splicing factor 38A

1

0

High-throughput

0.486

High

963252

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

0

High-throughput

0.486

High

963221

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.481

High

837933

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

963231

CPEB2
Cytoplasmic polyadenylation element-binding protein 2

1

1

High-throughput

0.481

High

244296

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

294722

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

303175

HEXI1
Protein HEXIM1

1

1

High-throughput

0.479

High

304121

UBR5
E3 ubiquitin-protein ligase UBR5

1

3

High-throughput

0.479

High

319798

HERC2
E3 ubiquitin-protein ligase HERC2

1

3

High-throughput

0.479

High

379301

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

430137

PROF1
Profilin-1

1

1

Small-scale

0.479

High

488683

ARAF
Serine/threonine-protein kinase A-Raf

1

2

High-throughput

0.479

High

801859

RECQ1
ATP-dependent DNA helicase Q1

1

1

High-throughput

0.479

High

961053

HSF1
Heat shock factor protein 1

1

1

High-throughput

0.479

High

963191

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

963193

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

963210

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

963215

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

963232

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.479

High

963236

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

963259

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

963267

DDX23
Probable ATP-dependent RNA helicase DDX23

1

1

High-throughput

0.479

High

963271

DDX24
ATP-dependent RNA helicase DDX24

1

1

High-throughput

0.479

High

963276

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

2

High-throughput

0.479

High

963278

BRD7
Bromodomain-containing protein 7

1

2

High-throughput

0.479

High

963279

ANLN
Anillin

1

1

High-throughput

0.479

High

963224

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

963264

HINFP
Histone H4 transcription factor

1

0

Small-scale

0.460

High

963277

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

0

High-throughput

0.460

High

133442

NOP56
Nucleolar protein 56

1

0

Small-scale

0.458

High

209899

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

233374

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

326592

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

328810

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.458

High

450841

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.458

High

552513

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

569600

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

684638

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

707591

H2B1B
Histone H2B type 1-B

1

0

High-throughput

0.458

High

718763

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

823896

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

869609

TERF1
Telomeric repeat-binding factor 1

1

0

Small-scale

0.458

High

898886

PSME3
Proteasome activator complex subunit 3

1

0

Small-scale

0.458

High

948863

SARNP
SAP domain-containing ribonucleoprotein

1

0

Small-scale

0.458

High

959353

VIGLN
Vigilin

1

0

High-throughput

0.458

High

963196

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.458

High

963200

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

963209

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

963223

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.458

High

963226

ZN746
Zinc finger protein 746

1

0

High-throughput

0.458

High

963237

MILK2
MICAL-like protein 2

1

0

High-throughput

0.458

High

963247

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

963249

CLC4D
C-type lectin domain family 4 member D

1

0

High-throughput

0.458

High

963251

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

963254

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

963263

BARD1
BRCA1-associated RING domain protein 1

1

0

High-throughput

0.458

High

963265

OVOL2
Transcription factor Ovo-like 2

1

0

Small-scale

0.458

High

963266

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

963273

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

963275

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

963280

AATF
Protein AATF

1

0

High-throughput

0.458

High

963282

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

963289

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.458

High

963290

CFA20
Cilia- and flagella-associated protein 20

1

0

Small-scale

0.458

High

125384

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.437

High

963207

CUL7
Cullin-7

1

1

High-throughput

0.437

High

963211

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.437

High

496864

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

963219

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

963270

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

963284

DDX41
Probable ATP-dependent RNA helicase DDX41

1

0

High-throughput

0.426

High

306114

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

1

High-throughput

0.407

High

891086

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

1

High-throughput

0.407

High

963240

CARME
Carnosine N-methyltransferase

4

0

High-throughput

0.364

High

318794

K2C75
Keratin, type II cytoskeletal 75

2

0

High-throughput

0.316

High

963220

EFHC2
EF-hand domain-containing family member C2

2

0

High-throughput

0.316

High

779253

CCNF
Cyclin-F

2

0

High-throughput

0.305

High

161197

VP26C
Vacuolar protein sorting-associated protein 26C

1

0

High-throughput

0.282

High

549569

VEGFA
Vascular endothelial growth factor A, long form

1

0

High-throughput

0.282

High

363086

FINC
Fibronectin

1

0

High-throughput

0.279

Low

483427

RGPD2
RANBP2-like and GRIP domain-containing protein 2

1

0

High-throughput

0.279

Low

888243

MYPR
Myelin proteolipid protein

1

0

High-throughput

0.279

Low

963246

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.265

Low

255691

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.249

Low

298432

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.249

Low

384661

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

391657

H2A1B
Histone H2A type 1-B/E

1

0

High-throughput

0.249

Low

547541

FOLR1
Folate receptor alpha

1

0

High-throughput

0.249

Low

726155

BASI
Basigin

1

0

High-throughput

0.249

Low

908388

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

932106

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.249

Low

963189

IFM3
Interferon-induced transmembrane protein 3

1

0

High-throughput

0.249

Low

963204

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

963218

MIDN
Midnolin

1

0

High-throughput

0.249

Low

963228

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

963245

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

963250

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.249

Low

963256

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

963268

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

963269

TRI31
E3 ubiquitin-protein ligase TRIM31

1

0

High-throughput

0.249

Low

963272

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

963222

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024