Protein: ECM1
Extracellular matrix protein 1 (Secretory component p85)

Gene: ECM1
Organism: Homo sapiens
Interactions: 132
UniProt ID: Q16610

Gene Ontology (top 5):
GO:0001503 - ossification
GO:0001525 - angiogenesis
GO:0001938 - positive regulation of endothelial cell proliferation
GO:0001960 - negative regulation of cytokine-mediated signaling pathway
GO:0002020 - protease binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

660513

GRN
Progranulin

3

0

Small-scale

0.622

High

1083766

GMCL1
Germ cell-less protein-like 1

3

1

High-throughput

0.609

High

351532

ANF
Natriuretic peptides A

2

0

High-throughput

0.602

High

1080575

ZIC1
Zinc finger protein ZIC 1

2

0

High-throughput

0.602

High

1027847

MMRN1
Multimerin-1

2

0

High-throughput

0.585

High

363185

FINC
Fibronectin

2

0

Small-scale

0.580

High

67089

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.580

High

158286

LIN7A
Protein lin-7 homolog A

2

0

High-throughput

0.580

High

207321

FRS3
Fibroblast growth factor receptor substrate 3

2

0

High-throughput

0.580

High

270986

GCM2
Chorion-specific transcription factor GCMb

2

0

High-throughput

0.580

High

556448

ITB4
Integrin beta-4

2

0

High-throughput

0.580

High

678917

HXC8
Homeobox protein Hox-C8

2

0

High-throughput

0.580

High

679352

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

2

0

High-throughput

0.580

High

815685

TNFL6
Tumor necrosis factor ligand superfamily member 6

2

0

High-throughput

0.580

High

993254

ACTN3
Alpha-actinin-3

2

0

High-throughput

0.580

High

397711

CFAI
Complement factor I

2

0

High-throughput

0.576

High

1016954

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

1

1

Small-scale

0.573

High

1083746

KRA53
Keratin-associated protein 5-3

2

1

High-throughput

0.553

High

1083788

UBQL2
Ubiquilin-2

2

1

High-throughput

0.553

High

1083789

UBQL1
Ubiquilin-1

2

1

High-throughput

0.553

High

658958

MK01
Mitogen-activated protein kinase 1

1

1

High-throughput

0.536

High

1083770

SRPK1
SRSF protein kinase 1

1

1

High-throughput

0.520

High

1083794

IRAK3
Interleukin-1 receptor-associated kinase 3

1

0

High-throughput

0.518

High

201343

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

265659

E2F6
Transcription factor E2F6

1

0

High-throughput

0.513

High

275013

RENR
Renin receptor

1

0

High-throughput

0.513

High

365199

FRIH
Ferritin heavy chain

1

0

High-throughput

0.513

High

433369

YES
Tyrosine-protein kinase Yes

1

0

High-throughput

0.513

High

517947

CO6A1

1

0

High-throughput

0.513

High

602845

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.513

High

676744

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

0

High-throughput

0.513

High

822274

KC1D
Casein kinase I isoform delta

1

0

High-throughput

0.513

High

871019

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

High-throughput

0.513

High

1026917

PAK2
Serine/threonine-protein kinase PAK 2

1

0

High-throughput

0.513

High

1041009

CUL1
Cullin-1

1

0

High-throughput

0.513

High

1083745

TRI68
E3 ubiquitin-protein ligase TRIM68

1

0

High-throughput

0.513

High

1083748

AMTN
Amelotin

1

0

High-throughput

0.513

High

647593

MK03
Mitogen-activated protein kinase 3

1

1

High-throughput

0.489

High

682428

3HIDH
3-hydroxyisobutyrate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

1083739

GLYR1
Cytokine-like nuclear factor N-PAC

1

1

High-throughput

0.489

High

1083751

CTU1
Cytoplasmic tRNA 2-thiolation protein 1

1

1

High-throughput

0.489

High

1083771

SH23A
SH2 domain-containing protein 3A

1

1

High-throughput

0.489

High

1083779

SNTG1
Gamma-1-syntrophin

1

1

High-throughput

0.489

High

1045074

LAMB3
Laminin subunit beta-3

1

0

Small-scale

0.484

High

394793

A4
Amyloid-beta precursor protein

1

0

Small-scale

0.480

High

540466

IL2RB
Interleukin-2 receptor subunit beta

1

1

Small-scale

0.479

High

1083775

TRI31
E3 ubiquitin-protein ligase TRIM31

1

1

High-throughput

0.479

High

869470

ATN1
Atrophin-1

1

1

High-throughput

0.464

High

1083786

RERE
Arginine-glutamic acid dipeptide repeats protein

1

1

High-throughput

0.464

High

168798

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

0

Small-scale

0.458

High

346903

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

1022108

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

1063819

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

1083760

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1083762

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1083784

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

1083792

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

1083793

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

434651

TSP1
Thrombospondin-1

1

1

Small-scale

0.457

High

724372

FBN2
Fibrillin-2 [Cleaved into: Placensin]

1

1

Small-scale

0.457

High

1045113

LAMC2
Laminin subunit gamma-2

1

1

Small-scale

0.457

High

787650

PI4KA
Phosphatidylinositol 4-kinase alpha

1

2

High-throughput

0.445

High

1083740

Q4LE69
1-phosphatidylinositol 4-kinase

1

2

High-throughput

0.437

High

1083749

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

200824

ZSC12
Zinc finger and SCAN domain-containing protein 12

1

0

High-throughput

0.426

High

1083759

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

2

High-throughput

0.407

High

883416

CF298
Cilia- and flagella-associated protein 298

3

0

High-throughput

0.347

High

1083780

TB22B
TBC1 domain family member 22B

2

0

High-throughput

0.328

High

716581

CAH8
Carbonic anhydrase-related protein

2

0

High-throughput

0.318

High

992167

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

2

0

High-throughput

0.318

High

1083765

MITOK
Mitochondrial potassium channel

2

0

High-throughput

0.318

High

259941

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

2

0

High-throughput

0.316

High

278457

SPF27
Pre-mRNA-splicing factor SPF27

2

0

High-throughput

0.316

High

327070

GPAN1
G patch domain and ankyrin repeat-containing protein 1

2

0

High-throughput

0.316

High

448672

RU1C
U1 small nuclear ribonucleoprotein C

2

0

High-throughput

0.316

High

903724

LMO4
LIM domain transcription factor LMO4

2

0

High-throughput

0.316

High

1023467

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

2

0

High-throughput

0.316

High

1083738

KLH38
Kelch-like protein 38

2

0

High-throughput

0.316

High

1083743

LCE2A
Late cornified envelope protein 2A

2

0

High-throughput

0.316

High

1083752

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

0

High-throughput

0.316

High

1083764

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

2

0

High-throughput

0.316

High

1083768

SAM11
Sterile alpha motif domain-containing protein 11

2

0

High-throughput

0.316

High

1083774

KRA93
Keratin-associated protein 9-3

2

0

High-throughput

0.316

High

1083776

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.316

High

1083777

A1CF
APOBEC1 complementation factor

2

0

High-throughput

0.316

High

1083782

AIRIM
AFG2-interacting ribosome maturation factor

2

0

High-throughput

0.316

High

1083790

GLCNE
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

2

0

High-throughput

0.316

High

225193

BNI3L
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like

1

0

High-throughput

0.282

High

843696

FXR1
RNA-binding protein FXR1

1

0

High-throughput

0.282

High

1083742

CPTP
Ceramide-1-phosphate transfer protein

1

0

High-throughput

0.282

High

213897

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

0

High-throughput

0.279

Low

236939

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

0

High-throughput

0.279

Low

246111

RNH1
Ribonuclease H1

1

0

High-throughput

0.279

Low

584604

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

0

High-throughput

0.279

Low

624437

CCNC
Cyclin-C

1

0

High-throughput

0.279

Low

771988

VHL
von Hippel-Lindau disease tumor suppressor

1

0

High-throughput

0.279

Low

882741

STX17
Syntaxin-17

1

0

High-throughput

0.279

Low

1052852

FASTK
Fas-activated serine/threonine kinase

1

0

High-throughput

0.279

Low

1060399

SL9A5
Sodium/hydrogen exchanger 5

1

0

High-throughput

0.279

Low

1068438

CDK10
Cyclin-dependent kinase 10

1

0

High-throughput

0.279

Low

1083737

CTU2
Cytoplasmic tRNA 2-thiolation protein 2

1

0

High-throughput

0.279

Low

1083741

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.279

Low

1083744

AHDC1
Transcription factor Gibbin

1

0

High-throughput

0.279

Low

1083747

CV039
Synaptic plasticity regulator PANTS

1

0

High-throughput

0.279

Low

1083750

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.279

Low

1083753

PLCZ1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

1

0

High-throughput

0.279

Low

1083754

CDKL3
Cyclin-dependent kinase-like 3

1

0

High-throughput

0.279

Low

1083756

S35F2
Solute carrier family 35 member F2

1

0

High-throughput

0.279

Low

1083757

YAF2
YY1-associated factor 2

1

0

High-throughput

0.279

Low

1083758

FRMD1
FERM domain-containing protein 1

1

0

High-throughput

0.279

Low

1083761

ZDH19
Palmitoyltransferase ZDHHC19

1

0

High-throughput

0.279

Low

1083763

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

1083767

RNPC3
RNA-binding region-containing protein 3

1

0

High-throughput

0.279

Low

1083769

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.279

Low

1083772

P4K2A
Phosphatidylinositol 4-kinase type 2-alpha

1

0

High-throughput

0.279

Low

1083773

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.279

Low

1083781

RFOX1
RNA binding protein fox-1 homolog 1

1

0

High-throughput

0.279

Low

1083783

RM39
Large ribosomal subunit protein mL39

1

0

High-throughput

0.279

Low

1083791

NSG2
Neuronal vesicle trafficking-associated protein 2

1

0

High-throughput

0.279

Low

1083795

ATP23
Mitochondrial inner membrane protease ATP23 homolog

1

0

High-throughput

0.279

Low

1083755

DDIAS
DNA damage-induced apoptosis suppressor protein

1

0

Small-scale

0.251

Low

100802

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

205443

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

246572

MCE1
mRNA-capping enzyme

1

0

High-throughput

0.249

Low

390918

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

529181

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.249

Low

779498

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

818095

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.249

Low

1046054

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.249

Low

1083778

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.249

Low

1083785

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.249

Low

1083787

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024