Protein: GSDME
Gasdermin-E (Inversely correlated with estrogen receptor expression 1) (ICERE-1) (Non-syndromic hearing impairment protein 5) [Cleaved into: Gasdermin-E, N-terminal (GSDME-NT); Gasdermin-E, C-terminal (GSDME-CT)]

Gene: GSDME
Organism: Homo sapiens
Interactions: 51
UniProt ID: O60443

Gene Ontology (top 5):
GO:0002839 - positive regulation of immune response to tumor cell
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

234315

SCN2B
Sodium channel subunit beta-2

3

0

High-throughput

0.638

High

234324

EPHA1
Ephrin type-A receptor 1

2

1

High-throughput

0.628

High

234339

PLEC
Plectin

2

1

High-throughput

0.628

High

234344

GPAT4
Glycerol-3-phosphate acyltransferase 4

2

1

High-throughput

0.628

High

161483

S27A2
Long-chain fatty acid transport protein 2

2

0

High-throughput

0.602

High

234348

SIGL1
SIGLEC family-like protein 1

2

0

High-throughput

0.602

High

234351

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

2

0

High-throughput

0.602

High

234352

TIFA
TRAF-interacting protein with FHA domain-containing protein A

2

0

High-throughput

0.580

High

234321

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.541

High

234341

BTNL9
Butyrophilin-like protein 9

1

1

High-throughput

0.536

High

234355

CEP63
Centrosomal protein of 63 kDa

1

1

High-throughput

0.536

High

152726

ITBP1
Integrin beta-1-binding protein 1

1

0

High-throughput

0.518

High

234322

PTN
Pleiotrophin

1

0

High-throughput

0.518

High

68035

HIDE1
Protein HIDE1

1

0

High-throughput

0.513

High

234317

GLPA
Glycophorin-A

1

0

High-throughput

0.513

High

234320

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

234325

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.513

High

234326

CD70
CD70 antigen

1

0

High-throughput

0.513

High

234332

EFNB1
Ephrin-B1

1

0

High-throughput

0.513

High

234340

KLC3
Kinesin light chain 3

1

0

High-throughput

0.513

High

234346

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.513

High

234349

F174A
Membrane protein FAM174A

1

0

High-throughput

0.513

High

234353

HVCN1
Voltage-gated hydrogen channel 1

1

0

High-throughput

0.513

High

234354

RUSF1
RUS family member 1

1

0

High-throughput

0.513

High

234356

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

234359

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.513

High

234360

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.513

High

234323

FLNA
Filamin-A

1

1

Small-scale

0.479

High

234333

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

2

Small-scale

0.479

High

234336

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

2

Small-scale

0.479

High

234342

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

234345

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

1

Small-scale

0.479

High

153504

ANM5
Protein arginine N-methyltransferase 5

1

0

Small-scale

0.458

High

234316

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

234318

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

234327

MYH9
Myosin-9

1

0

Small-scale

0.458

High

234329

FAS
Fatty acid synthase

1

0

Small-scale

0.458

High

234330

KIF11
Kinesin-like protein KIF11

1

0

Small-scale

0.458

High

234331

ACTG
Actin, cytoplasmic 2

1

0

Small-scale

0.458

High

234334

OTUD4
OTU domain-containing protein 4

1

0

Small-scale

0.458

High

234337

MVP
Major vault protein

1

0

Small-scale

0.458

High

234338

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

234350

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

234358

BIRC6
Baculoviral IAP repeat-containing protein 6

1

0

High-throughput

0.458

High

234328

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

0

High-throughput

0.426

High

234347

ZSC29
Zinc finger and SCAN domain-containing protein 29

2

0

High-throughput

0.328

High

234357

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

2

0

High-throughput

0.328

High

234314

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.279

Low

234319

QCR6
Cytochrome b-c1 complex subunit 6, mitochondrial

1

0

High-throughput

0.279

Low

234335

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.279

Low

234343

B3GN8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024