Protein: Q7K306
cyclin-dependent kinase (EC 2.7.11.22)

Gene: Q7K306, Cdk4
Organism: Drosophila melanogaster
Interactions: 91
UniProt ID: Q7K306

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000307 - cyclin-dependent protein kinase holoenzyme complex
GO:0004693 - cyclin-dependent protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1265577

Q7KUZ5
Cyclin D, isoform D

3

20

Small-scale

0.829

High

1265590

CYCG
Cyclin G

2

20

Small-scale

0.775

High

356649

PLK4
Serine/threonine-protein kinase PLK4

1

12

High-throughput

0.656

High

660446

CDK2
Cyclin-dependent kinase 2

1

14

High-throughput

0.656

High

668156

CCNC
Cyclin-C

1

20

High-throughput

0.656

High

931752

CCNE
G1/S-specific cyclin-E

1

20

High-throughput

0.656

High

1264363

GLIS2
Zinc finger protein GLIS2 homolog

1

6

High-throughput

0.656

High

1265592

Q961D1
Cyclin-K

1

20

High-throughput

0.656

High

1265604

Q9VGK8
Tyrosine-protein kinase

1

16

High-throughput

0.656

High

1265616

MSIR6
RNA-binding protein Musashi homolog Rbp6

1

7

High-throughput

0.656

High

1265620

Q9VZP3
Cyclin J, isoform A

1

20

High-throughput

0.656

High

1265623

SF3B3
Splicing factor 3B subunit 3

1

3

High-throughput

0.656

High

303994

O76513
Cyclin-H

1

20

High-throughput

0.621

High

1265588

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

1

3

High-throughput

0.621

High

1265611

Q9VS55
CTCF

1

1

High-throughput

0.621

High

195965

O17144
Cyclin-H

1

20

High-throughput

0.590

High

263519

MK38B
Mitogen-activated protein kinase p38b

1

20

High-throughput

0.590

High

660391

CDK1
Cyclin-dependent kinase 1

1

14

High-throughput

0.590

High

875364

CDK5
Cyclin-dependent kinase 5 homolog

1

15

High-throughput

0.590

High

878733

MAPK2
MAP kinase-activated protein kinase 2

1

8

High-throughput

0.590

High

1020007

JNK
Stress-activated protein kinase JNK

1

20

High-throughput

0.590

High

1172953

CSKP
Peripheral plasma membrane protein CASK

1

1

High-throughput

0.590

High

1265585

HIPPO
Serine/threonine-protein kinase hippo

1

12

High-throughput

0.590

High

1265587

Q8TA44
CTCF

1

1

High-throughput

0.590

High

1265595

Q9I7T8
PAN2-PAN3 deadenylation complex subunit PAN3

1

1

High-throughput

0.590

High

1265617

Q9VXM1
LD22957p

1

20

High-throughput

0.590

High

1069811

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

7

High-throughput

0.587

High

1265596

CEG1A
Centaurin-gamma-1A

1

2

High-throughput

0.587

High

1265622

Q9W0A7
Ras-related protein Rab-36

1

1

High-throughput

0.587

High

51809

GUS
Protein gustavus

1

7

High-throughput

0.508

High

304784

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

12

High-throughput

0.508

High

458221

DFD
Homeotic protein deformed

1

11

High-throughput

0.508

High

478803

BCD
Homeotic protein bicoid

1

7

High-throughput

0.508

High

559038

PP12
Serine/threonine-protein phosphatase alpha-2 isoform

1

14

High-throughput

0.508

High

609104

CRN
Protein crooked neck

1

3

High-throughput

0.508

High

756452

ECR
Ecdysone receptor

1

8

High-throughput

0.508

High

786369

2ABA
Protein phosphatase PP2A 55 kDa regulatory subunit

1

4

High-throughput

0.508

High

1058972

GELS
Gelsolin

1

3

High-throughput

0.508

High

1173847

ER
Protein enhancer of rudimentary

1

2

High-throughput

0.508

High

1176176

RAD51
DNA repair protein Rad51 homolog

1

1

High-throughput

0.508

High

1264646

Q7K148
Proteasome subunit beta

1

5

High-throughput

0.508

High

1265576

ACOX1
Acyl-coenzyme A oxidase 1

1

2

High-throughput

0.508

High

1265580

Q8MLW7
X-box-binding protein 1

1

11

High-throughput

0.508

High

1265584

CSN3
COP9 signalosome complex subunit 3

1

3

High-throughput

0.508

High

1265591

Q95U38
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

1

High-throughput

0.508

High

1265593

Q9I7L0
LP01847p

1

3

High-throughput

0.508

High

1265601

FANCM
DEAD-box ATP-dependent DNA helicase Fancm

1

4

High-throughput

0.508

High

1265606

Q9VL21
LD11652p

1

4

High-throughput

0.508

High

1265607

Q9VL27
Alpha-galactosidase

1

1

High-throughput

0.508

High

1265615

Q9VUD3
GH07353p

1

11

High-throughput

0.508

High

1265626

Q9W1S5
Proteasome subunit beta

1

4

High-throughput

0.508

High

55645

A1Z9I6
Uncharacterized protein, isoform A

1

0

High-throughput

0.486

High

1052546

RSMB
Small nuclear ribonucleoprotein-associated protein B

1

0

High-throughput

0.486

High

1172281

NELFD
Negative elongation factor D

1

0

High-throughput

0.486

High

1265586

Q8T965
Prefoldin subunit 3

1

0

High-throughput

0.486

High

1265594

Q9I7M1
Olfactory-specific 9

1

0

High-throughput

0.486

High

1265597

DAN
Protein distal antenna

1

0

High-throughput

0.486

High

1265598

Q9VCU8
LD15939p

1

0

High-throughput

0.486

High

1265612

FRY
Protein furry

1

0

High-throughput

0.486

High

1265613

Q9VTM2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

0

High-throughput

0.486

High

1265619

LTOR4
Ragulator complex protein LAMTOR4 homolog

1

0

High-throughput

0.486

High

1265621

ECD
Protein ecdysoneless

1

0

High-throughput

0.486

High

1265628

Q9W3F1
RE21057p

1

0

High-throughput

0.486

High

85020

B7Z143
Protein interacting with Ttk69 and Sin3A, isoform D

1

1

High-throughput

0.481

High

1265579

PANG2
Protein pangolin, isoform J

1

11

High-throughput

0.481

High

1265599

Q9VD04
Uncharacterized protein, isoform B

1

8

High-throughput

0.481

High

1265609

Q9VQ95
Testis EndoG-Like 3

1

1

High-throughput

0.481

High

1265625

Q9W1H7
Putative homeodomain protein

1

4

High-throughput

0.481

High

120313

M9PD17
Gigas, isoform B

1

3

Small-scale

0.479

High

1172558

STAT
Signal transducer and transcription activator

1

1

Small-scale

0.479

High

234844

O46070
EG:25E8.4 protein

1

1

High-throughput

0.464

High

1265603

Q9VGI6
FI06048p

1

3

High-throughput

0.464

High

1265608

POLZ2
DNA polymerase zeta subunit 2

1

1

High-throughput

0.464

High

1265610

Q9VRQ4
LD47944p

1

1

High-throughput

0.464

High

1265624

Q9W0Y0
RE57840p

1

1

High-throughput

0.464

High

303724

O76136
Homeodomain protein

1

9

High-throughput

0.457

High

1265581

Q8MS22
RE41430p

1

1

High-throughput

0.457

High

1265600

Q9VD05
RT01151p

1

7

High-throughput

0.457

High

1265618

FBXW7
F-box/WD repeat-containing protein 7

1

9

High-throughput

0.457

High

53302

A1Z7M3
Notopleural, isoform A

1

3

High-throughput

0.439

High

121537

M9PFH3
Uncharacterized protein, isoform D

1

1

High-throughput

0.439

High

1265605

Q9VL01
Phenoloxidase-activating factor 2

1

3

High-throughput

0.439

High

1019790

PANG1
Protein pangolin, isoforms A/H/I/S

1

8

High-throughput

0.417

High

1265578

Q86PE8
Phenoloxidase-activating factor 2

1

3

High-throughput

0.417

High

1265614

Q9VU23
Uncharacterized protein, isoform E

1

1

High-throughput

0.417

High

235069

LIP3
Lipase 3

1

0

High-throughput

0.265

Low

1265582

Q8SXL5
RE09177p

1

0

High-throughput

0.265

Low

1265583

Q8SXV4
RH68528p

1

0

High-throughput

0.265

Low

1265589

PGPLA
Peptidoglycan-recognition protein LA

1

0

High-throughput

0.265

Low

1265602

Q9VFA3
Uncharacterized protein, isoform A

1

0

High-throughput

0.265

Low

1265627

Q9W239
FI14129p

1

0

High-throughput

0.265

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025