Protein: NF1
Neurofibromin (Neurofibromatosis-related protein NF-1) [Cleaved into: Neurofibromin truncated]

Gene: NF1
Organism: Homo sapiens
Interactions: 168
UniProt ID: P21359

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001525 - angiogenesis
GO:0001649 - osteoblast differentiation
GO:0001656 - metanephros development
GO:0001666 - response to hypoxia

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

349121

RASH
GTPase HRas

4

20

Small-scale

0.887

High

349875

RASK
GTPase KRas

3

20

High-throughput

0.827

High

348509

RASN
GTPase NRas

2

20

Small-scale

0.768

High

598465

1433F
14-3-3 protein eta

4

20

Small-scale

0.694

High

598463

IRF8
Interferon regulatory factor 8

4

2

Small-scale

0.683

High

598433

1433B
14-3-3 protein beta/alpha

3

20

High-throughput

0.678

High

598544

CAH14
Carbonic anhydrase 14

3

1

High-throughput

0.667

High

598492

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

2

11

Small-scale

0.653

High

598548

TN13B
Tumor necrosis factor ligand superfamily member 13B

3

0

High-throughput

0.638

High

411593

LCK
Tyrosine-protein kinase Lck

3

19

High-throughput

0.633

High

598423

EPHA1
Ephrin type-A receptor 1

2

10

High-throughput

0.628

High

598531

SCN3B
Sodium channel regulatory subunit beta-3

2

3

High-throughput

0.628

High

598443

5HT6R
5-hydroxytryptamine receptor 6

2

1

Small-scale

0.624

High

564412

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

598451

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

598452

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

598453

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

598456

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

598457

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

598525

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

598538

NGAP
Ras GTPase-activating protein nGAP

1

14

High-throughput

0.618

High

598546

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

20

High-throughput

0.618

High

598437

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

0

High-throughput

0.602

High

598500

SIGL1
SIGLEC family-like protein 1

2

0

High-throughput

0.602

High

598503

F174A
Membrane protein FAM174A

2

0

High-throughput

0.602

High

205038

TGON2
Trans-Golgi network integral membrane protein 2

2

6

High-throughput

0.584

High

337926

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.584

High

598511

FAF2
FAS-associated factor 2

2

1

Small-scale

0.579

High

598495

VSIG1
V-set and immunoglobulin domain-containing protein 1

2

5

High-throughput

0.574

High

598447

LIMK2
LIM domain kinase 2

1

11

Small-scale

0.573

High

598448

TERA
Transitional endoplasmic reticulum ATPase

1

4

Small-scale

0.561

High

598454

1433G
14-3-3 protein gamma

1

20

High-throughput

0.554

High

598455

1433E
14-3-3 protein epsilon

1

7

High-throughput

0.554

High

598458

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.554

High

199503

EFS
Embryonal Fyn-associated substrate

1

7

High-throughput

0.541

High

598427

1433T
14-3-3 protein theta

1

20

High-throughput

0.536

High

598434

CD80
T-lymphocyte activation antigen CD80

1

5

High-throughput

0.536

High

598440

KI67
Proliferation marker protein Ki-67

1

7

High-throughput

0.536

High

598445

EFNA4
Ephrin-A4

1

4

High-throughput

0.536

High

598460

IDD
Integral membrane protein DGCR2/IDD

1

1

High-throughput

0.536

High

598461

EFNB1
Ephrin-B1

1

4

High-throughput

0.536

High

598481

CD226
CD226 antigen

1

11

High-throughput

0.536

High

598501

ARRD4
Arrestin domain-containing protein 4

1

3

High-throughput

0.536

High

598510

ARRD3
Arrestin domain-containing protein 3

1

3

High-throughput

0.536

High

598516

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.536

High

598520

CDHR2
Cadherin-related family member 2

1

5

High-throughput

0.536

High

598522

SEM4C
Semaphorin-4C

1

1

High-throughput

0.536

High

598540

KS6A6
Ribosomal protein S6 kinase alpha-6

1

4

High-throughput

0.536

High

598554

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

High-throughput

0.536

High

394110

A4
Amyloid-beta precursor protein

1

4

Small-scale

0.529

High

598478

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

6

High-throughput

0.515

High

68044

HIDE1
Protein HIDE1

1

0

High-throughput

0.513

High

353045

IL2RA
Interleukin-2 receptor subunit alpha

1

0

High-throughput

0.513

High

362172

GLPA
Glycophorin-A

1

0

High-throughput

0.513

High

454682

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

535791

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.513

High

598424

EVI2A
Protein EVI2A

1

0

High-throughput

0.513

High

598450

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

1

0

High-throughput

0.513

High

598497

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

598513

OPALI
Opalin

1

0

High-throughput

0.513

High

598524

F234A
Protein FAM234A

1

0

High-throughput

0.513

High

598526

PGES2
Prostaglandin E synthase 2

1

0

High-throughput

0.513

High

598536

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.513

High

598539

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.513

High

598435

SDC2
Syndecan-2

1

3

Small-scale

0.508

High

373677

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

12

High-throughput

0.501

High

598429

EPHA2
Ephrin type-A receptor 2

1

20

High-throughput

0.501

High

598432

AKT1
RAC-alpha serine/threonine-protein kinase

1

6

High-throughput

0.501

High

598441

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

13

High-throughput

0.501

High

598442

CLK1
Dual specificity protein kinase CLK1

1

6

High-throughput

0.501

High

598466

SOX4
Transcription factor SOX-4

1

3

High-throughput

0.501

High

166533

DCLK1
Serine/threonine-protein kinase DCLK1

1

17

High-throughput

0.479

High

196400

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

6

High-throughput

0.479

High

209667

PRC1
Protein regulator of cytokinesis 1

1

6

High-throughput

0.479

High

216901

KIF1C
Kinesin-like protein KIF1C

1

8

High-throughput

0.479

High

230843

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

8

High-throughput

0.479

High

237163

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.479

High

253312

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

6

High-throughput

0.479

High

264268

GGYF1
GRB10-interacting GYF protein 1

1

4

High-throughput

0.479

High

279437

FLOT1
Flotillin-1

1

6

High-throughput

0.479

High

316230

NADK
NAD kinase

1

1

High-throughput

0.479

High

345917

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

377089

GCR
Glucocorticoid receptor

1

9

High-throughput

0.479

High

417933

NPM
Nucleophosmin

1

2

High-throughput

0.479

High

430052

PROF1
Profilin-1

1

1

High-throughput

0.479

High

433572

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.479

High

536474

IRF2
Interferon regulatory factor 2

1

2

Small-scale

0.479

High

551937

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

572535

SPI1
Transcription factor PU.1

1

1

Small-scale

0.479

High

588747

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

1

2

High-throughput

0.479

High

598425

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

Small-scale

0.479

High

598426

PTBP1
Polypyrimidine tract-binding protein 1

1

5

High-throughput

0.479

High

598428

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

598430

MPIP2
M-phase inducer phosphatase 2

1

3

High-throughput

0.479

High

598431

MPIP3
M-phase inducer phosphatase 3

1

3

High-throughput

0.479

High

598436

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

598438

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

598439

MUC18
Cell surface glycoprotein MUC18

1

8

High-throughput

0.479

High

598444

SMCA4
Transcription activator BRG1

1

6

Small-scale

0.479

High

598446

EFNB2
Ephrin-B2

1

4

High-throughput

0.479

High

598449

HDAC4
Histone deacetylase 4

1

6

High-throughput

0.479

High

598459

SUMO1
Small ubiquitin-related modifier 1

1

2

Small-scale

0.479

High

598462

CDK16
Cyclin-dependent kinase 16

1

4

High-throughput

0.479

High

598464

CAV1
Caveolin-1

1

6

Small-scale

0.479

High

598467

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

11

High-throughput

0.479

High

598468

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

9

High-throughput

0.479

High

598469

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

8

High-throughput

0.479

High

598471

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

598472

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

11

High-throughput

0.479

High

598473

KCC2G
Calcium/calmodulin-dependent protein kinase type II subunit gamma

1

12

High-throughput

0.479

High

598474

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

11

High-throughput

0.479

High

598475

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

7

High-throughput

0.479

High

598476

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

Small-scale

0.479

High

598477

ZN638
Zinc finger protein 638

1

3

High-throughput

0.479

High

598479

KIF14
Kinesin-like protein KIF14

1

8

High-throughput

0.479

High

598480

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

10

High-throughput

0.479

High

598482

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

598483

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

4

High-throughput

0.479

High

598484

SPD2A
SH3 and PX domain-containing protein 2A

1

8

High-throughput

0.479

High

598485

DEN4C
DENN domain-containing protein 4C

1

5

High-throughput

0.479

High

598487

PKHA7
Pleckstrin homology domain-containing family A member 7

1

15

High-throughput

0.479

High

598488

GGYF2
GRB10-interacting GYF protein 2

1

13

High-throughput

0.479

High

598489

SYDE1
Rho GTPase-activating protein SYDE1

1

9

High-throughput

0.479

High

598490

MYCPP
C-myc promoter-binding protein

1

5

High-throughput

0.479

High

598493

PHLB2
Pleckstrin homology-like domain family B member 2

1

11

High-throughput

0.479

High

598494

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

2

High-throughput

0.479

High

598496

KSR1
Kinase suppressor of Ras 1

1

19

High-throughput

0.479

High

598498

LZTR1
Leucine-zipper-like transcriptional regulator 1

1

3

High-throughput

0.479

High

598499

SIR6
NAD-dependent protein deacylase sirtuin-6

1

5

High-throughput

0.479

High

598502

NAV1
Neuron navigator 1

1

7

High-throughput

0.479

High

598504

F110B
Protein FAM110B

1

2

High-throughput

0.479

High

598505

DEN1A
DENN domain-containing protein 1A

1

7

High-throughput

0.479

High

598507

SRS12
Serine/arginine-rich splicing factor 12

1

7

High-throughput

0.479

High

598508

ESR2
Estrogen receptor beta

1

9

High-throughput

0.479

High

598514

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

20

High-throughput

0.479

High

598515

TESK2
Dual specificity testis-specific protein kinase 2

1

3

High-throughput

0.479

High

598517

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

High-throughput

0.479

High

598518

LPIN3
Phosphatidate phosphatase LPIN3

1

1

High-throughput

0.479

High

598519

RTKN
Rhotekin

1

1

High-throughput

0.479

High

598523

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

598527

TANC2
Protein TANC2

1

7

High-throughput

0.479

High

598528

KI13B
Kinesin-like protein KIF13B

1

8

High-throughput

0.479

High

598529

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

5

High-throughput

0.479

High

598530

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

5

High-throughput

0.479

High

598532

FA53C
Protein FAM53C

1

1

High-throughput

0.479

High

598533

PD1L1
Programmed cell death 1 ligand 1

1

10

High-throughput

0.479

High

598534

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

3

High-throughput

0.479

High

598535

CING
Cingulin

1

8

High-throughput

0.479

High

598537

LIMA1
LIM domain and actin-binding protein 1

1

9

High-throughput

0.479

High

598541

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

3

High-throughput

0.479

High

598542

ZBT21
Zinc finger and BTB domain-containing protein 21

1

2

High-throughput

0.479

High

598543

PPM1H
Protein phosphatase 1H

1

1

High-throughput

0.479

High

598547

GAB2
GRB2-associated-binding protein 2

1

9

High-throughput

0.479

High

598549

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

5

High-throughput

0.479

High

598550

CBY1
Protein chibby homolog 1

1

2

High-throughput

0.479

High

598551

STA13
StAR-related lipid transfer protein 13

1

7

High-throughput

0.479

High

598552

TRAF6
TNF receptor-associated factor 6

1

11

Small-scale

0.479

High

598553

KCTD3
BTB/POZ domain-containing protein KCTD3

1

2

High-throughput

0.479

High

341420

FA12
Coagulation factor XII

1

0

Small-scale

0.458

High

598509

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.458

High

598512

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

598521

OSBL6
Oxysterol-binding protein-related protein 6

1

0

High-throughput

0.458

High

598545

NSF1C
NSFL1 cofactor p47

1

0

Small-scale

0.458

High

598470

SLAF1
Signaling lymphocytic activation molecule

1

8

High-throughput

0.437

High

598486

AN34A
Ankyrin repeat domain-containing protein 34A

1

14

High-throughput

0.437

High

598506

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

11

High-throughput

0.437

High

598491

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

2

0

High-throughput

0.328

High

238840

TPST2
Protein-tyrosine sulfotransferase 2

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024